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Advances in single chain technology Open
This review summarizes the recent advances in single chain technology for the construction of soft nano-objectsviachain compaction, and their envisioned applications.
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Single-chain polymer nanoparticles in controlled drug delivery and targeted imaging Open
As a relatively new class of materials, single-chain polymer nanoparticles (SCNPs) just entered the field of (biomedical) applications, with recent advances in polymer science enabling the formation of bio-inspired nanosized architectures.…
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Controlled Sol–Gel Transitions by Actuating Molecular Machine Based Supramolecular Polymers Open
The implementation of artificial molecular machines in polymer science is an important objective that challenges chemists and physicists in order to access an entirely new class of smart materials. To design such systems, the amplification…
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Advances in Single-Chain Nanoparticles for Catalysis Applications Open
Enzymes are the most efficient catalysts known for working in an aqueous environment near room temperature. The folding of individual polymer chains to functional single-chain nanoparticles (SCNPs) offers many opportunities for the develop…
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Pd-complex driven formation of single-chain nanoparticles Open
The preparation and in-depth characterization of well-defined, palladium(ii) crosslinked single-chain nanoparticles (Pd-SCNPs) is reported. In addition, a novel procedure for interpreting the SEC chromatograms of SCNPs by log-normal distri…
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Electrostatic correlations and the polyelectrolyte self energy Open
We address the effects of chain connectivity on electrostaticfluctuations in polyelectrolyte solutions using a field-theoretic, renormalizedGaussian fluctuation (RGF) theory. As in simple electrolyte solutions [Z.-G. Wang,Phys. Rev. E 81, …
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Macromolecular Superstructures: A Future Beyond Single Chain Nanoparticles Open
Over the last 100 years polymer chemistry has flourished in all areas and enabled control over synthetic polymer architectures – including chain lengths, dispersity and monomer sequences. Compared to the architectures of biomacromolecules,…
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Controlling Chain Coupling and Single‐Chain Ligation by Two Colours of Visible Light Open
While photochemical synthesis offers access to spatiotemporal reaction control, its potential to selectively address specific reactions by the colour of light is usually limited by ubiquitous spectral absorption overlaps of the reactive gr…
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Switching single chain magnet behavior<i>via</i>photoinduced bidirectional metal-to-metal charge transfer Open
The on/off-switching of single-chain magnetic behavior tuned through bidirectional light irradiation.
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Boosting axiality in stable high-coordinate Dy(<span>iii</span>) single-molecule magnets Open
A combined synthetic, structural, magnetic and computational study gives insight into improving the single-molecule magnet behaviour of stable high-coordinate Dy(iii) complexes.
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Efficient Synthesis of Single-Chain Globules Mimicking the Morphology and Polymerase Activity of Metalloenzymes Open
Endowing unimolecular soft nanoobjects with biomimetic functions is attracting significant interest in the emerging field of single-chain technology. Inspired by the compartmentalized structure and polymerase activity of metalloenzymes, co…
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Chain rotation significantly reduces thermal conductivity of single-chain polymers Open
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Strengths and limitations of size exclusion chromatography for investigating single chain folding – current status and future perspectives Open
Synthetic approaches for Single-Chain Nanoparticles (SCNPs) developed rapidly during the last decade, opening a multitude of avenues for the design of functional macromolecular chains able to collapse into defined nanoparticles. However, t…
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Synthesis of Metallopolymers and Direct Visualization of the Single Polymer Chain Open
During the past few decades, the study of the single polymer chain has attracted considerable attention with the goal of exploring the structure-property relationship of polymers. It still, however, remains challenging due to the variabili…
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Counting loops in sidechain-crosslinked polymers from elastic solids to single-chain nanoparticles Open
The vast differences in material properties accessible via crosslinking of sidechain-functionalized polymers are driven by topology.
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Improved single-chain-magnet behavior in a biradical-based nitronyl nitroxide-Cu–Dy chain Open
The first example of nitronyl nitroxide biradical bridged 3d–4f complex exhibiting single-chain magnet behavior.
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Catalytic single-chain polymeric nanoparticles at work: from ensemble towards single-particle kinetics Open
In this work, we present the design and preparation of catalytic single chain polymeric nanoparticles (SCPNs), their characterization at the ensemble level as well as our progress toward analyzing individual SCPNs with single-molecule fluo…
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Perspective: Single polymer mechanics across the force regimes Open
I review theoretical and experimental results on the force-extension response of single polymers, with a focus on scaling pictures of low-force elastic regimes, and recent measurements of synthetic and biological chains that explore those …
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Effect of Chain Polydispersity on the Elasticity of Disordered Polymer Networks Open
Due to their unique structural and mechanical properties, randomly cross-linked polymer networks play an important role in many different fields, ranging from cellular biology to industrial processes. In order to elucidate how these proper…
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Chiral Supramolecular Nanotubes of Single‐Chain Magnets Open
We report a single‐chain magnet (SCM) made of a terbium(III) building block and a nitronyl‐nitroxide radical (NIT) functionalized with an aliphatic chain. This substitution is targeted to induce a long‐range distortion of the polymeric cha…
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Crowding the Environment of Single-Chain Nanoparticles: A Combined Study by SANS and Simulations Open
We present an investigation by combining small-angle neutron scattering (SANS) and coarse-grained molecular dynamics (MD) simulations on the conformational properties of single-chain nanoparticles (SCNPs) in crowded macromolecular solution…
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Single-Chain Polymer Nanoparticles for Addressing Morphologies and Functions at the Nanoscale: A Review Open
This review discusses recent advances concerning morphologies and functions obtained from single-chain nanoparticles (SCNPs). SCNPs are unimolecular, soft nano-objects consisting of individual polymer chains collapsed to a certain degree b…
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A Single‐Chain Magnet Tape Based on Hexacyanomanganate(III) Open
The tape‐like chain {[(tptz)Mn II (H 2 O)Mn III (CN) 6 ] 2 Mn II (H 2 O) 2 } n ⋅4 n MeOH⋅2 n H 2 O based on the anisotropic building block hexacyanomanganate(III) exhibits long‐range magnetic ordering below 5.1 K as well as single‐chain ma…
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Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors Open
Engineering potent bispecific antibodies from single-chain variable fragments (scFv) remains difficult due to the inherent instability and insufficient binding of scFv's compared to their parental immunoglobulin format. Previously, we desc…
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Self-reporting and refoldable profluorescent single-chain nanoparticles Open
We pioneer the formation of self-reporting and refoldable profluorescent single-chain nanoparticles (SCNPs) via the light-induced reaction (λmax = 320 nm) of nitroxide radicals with a photo-active crosslinker.
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Control and Characterization of the Compactness of Single-Chain Nanoparticles Open
Polymers when self-cross-linked into single-chain nanoparticles bear some resemblance to folded proteins; yet proteins have clear energy landscapes that determine precisely folded structures, while single-chain polymer nanoparticles (SCNPs…
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Air-stable four-coordinate cobalt(<span>ii</span>) single-ion magnets: experimental and <i>ab initio</i> ligand field analyses of correlations between dihedral angles and magnetic anisotropy Open
Magneto-structural correlations for air-stable four-coordinate Co( ii ) complexes reveal the dependence of magnetic properties on the dihedral twist angle and establish valuable design guidelines for achieving high magnetic anisotropy.
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Single-chain polybutadiene organometallic nanoparticles: an experimental and theoretical study Open
High molecular weight polybutadienes and rhodium complexes were used to produce single chain organometallic nanoparticles. A relationship was found between the cis double bond content of the polymer and metal binding kinetics.
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How to link theory and experiment for single-chain magnets beyond the Ising model: magnetic properties modeled from<i>ab initio</i>calculations of molecular fragments Open
Properties of 1D periodic magnetic chains can be described on the basis of results fromab initiomulti-reference calculations performed for individual spin centers, which provides a basis for investigations on their dynamic magnetic propert…
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Cytosolic Delivery of Single-Chain Polymer Nanoparticles Open
Cytosolic delivery of therapeutic agents is key to improving their efficacy, as the therapeutics are primarily active in specific organelles. Single-chain polymer nanoparticles (SCNPs) are a promising nanocarrier platform in biomedical app…