Human albumin
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Review: Modifications of Human Serum Albumin and their Binding Effect Open
Human serum albumin (HSA) regulates the transport and availability of numerous chemical compounds and molecules in the blood vascular system. While previous HSA research has found that HSA interacts with specific varieties of ligands, new …
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Human Serum Albumin Aggregation/Fibrillation and its Abilities to Drugs Binding Open
Human serum albumin (HSA) is a protein that transports neutral and acid ligands in the organism. Depending on the environment’s pH conditions, HSA can take one of the five isomeric forms that change its conformation. HSA can form aggregate…
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Serum Albumin Nanoparticles: Problems and Prospects Open
The present paper aims to summarize the results regarding serum albumin-based nanoparticles (NPs) for drug delivery purposes. In particular, it focuses on the relationship between their preparation techniques and synthesis parameters, as w…
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Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs Open
Serum albumin is the major determinant of blood colloidal osmotic pressure acting as a depot and distributor of compounds including drugs. In humans, serum albumin exhibits an unusually long half-life mainly due to protection from cataboli…
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Albumin as a drug: its biological effects beyond volume expansion Open
Albumin is the most abundant and perhaps most important protein in human blood. Research has identified many of albumin's possible roles in modulating acid-base balance, modifying inflammation, maintaining vascular endothelial integrity, a…
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An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics Open
The human albumin variant E505Q/T527M/K573P improves pharmacokinetics of protein-based drugs and facilitates transport across mucosal epithelia.
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A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine Open
Thiol-stable albumin biologics are enabled by controlled, quantitative hydrolysis of maleimide–albumin conjugates, i.e. with no retro-Michael.
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GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs Open
Albumin is derived from human or animal blood, and its ability to bind to a large number of endogenous or exogenous biomolecules makes it an ideal drug carrier. As a result, albumin-based drug delivery systems are increasingly being studie…
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Expert consensus on the use of human serum albumin in critically ill patients Open
Introduction Human serum albumin (HSA) is a non-glycosylated, negatively charged, single-chain polypeptide composed of 585 amino acid residues with a relative molecular mass of 66.438 kD. It is synthesized by the liver at a rate of approxi…
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Serum Albumin Open
Being one of the most abundant proteins in human and other mammals, albumin plays a crucial role in transporting various endogenous and exogenous molecules and maintaining of colloid osmotic pressure of the blood. It is not only the passiv…
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Human albumin solutions in intensive care: A review Open
Albumin plays a key role in the critically ill patient acting as a prognostic marker and as a therapy in the form of human albumin solutions. However, the use of human albumin solution has varied over time with notable differences between …
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The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(<span>ii</span>) from albumin. Implications for copper uptake by Ctr1 Open
The superior Cu(ii) affinity of human copper transporter 1 (hCtr1) drives copper acquisition from human serum albumin (HSA).
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Recent Topics in Chemical and Clinical Research on Glycated Albumin Open
The measuring method for glycated albumin (GA) has been developed as a new glycemic control marker since the beginning of the 21st century. Since GA has an advantage in reflecting glycemic status over a shorter period than hemoglobin A1c (…
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Selectively switching on europium emission in drug site one of human serum albumin Open
A luminescent europium probe has been discovered that binds selectively to drug-site I in human serum albumin, signalled by a ‘switching on’ of europium emission, and accompanied by strong induced circularly polarised luminescence.
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A retrospective analysis of 25% human serum albumin supplementation in hypoalbuminemic dogs with septic peritonitis. Open
This study describes the influence of 25% human serum albumin (HSA) supplementation on serum albumin level, total protein (TP), colloid osmotic pressure (COP), hospital stay, and survival in dogs with septic peritonitis. Records of 39 dogs…
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Interaction of Citrinin with Human Serum Albumin Open
Citrinin (CIT) is a mycotoxin produced by several Aspergillus, Penicillium, and Monascus species. CIT occurs worldwide in different foods and drinks and causes health problems for humans and animals. Human serum albumin (HSA) is the most a…
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Effective inactivation of a wide range of viruses by pasteurization Open
BACKGROUND Careful selection and testing of plasma reduces the risk of blood‐borne viruses in the starting material for plasma‐derived products. Furthermore, effective measures such as pasteurization at 60°C for 10 hours have been implemen…
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Nephroprotective Potential of Human Albumin Infusion: A Narrative Review Open
Albumin infusion improves renal function in cirrhosis; however, mechanisms are incompletely understood. In clinical practice, human albumin is used in various intensive care unit indications to deal with a wide range of problems, from volu…
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Variations in the Human Serum Albumin Gene: Molecular and Functional Aspects Open
The human albumin gene, the most abundant serum protein, is located in the long arm of chromosome 4, near the centromere, position 4q11–3. It is divided by 14 intervening introns into 15 exons, the last of which is untranslated. To date, 7…
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Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives: Chapter 5 Human Albumin - Revised Open
Chapter 5 ‘Human Albumin' that was suspended on January 10, 2011 has been completed and updated in the present version.
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Role of the Protein Corona Derived from Human Plasma in Cellular Interactions between Nanoporous Human Serum Albumin Particles and Endothelial Cells Open
The presence of a protein corona on various synthetic nanomaterials has been shown to strongly influence how they interact with cells. However, it is unclear if the protein corona also exists on protein particles, and if so, its role in pa…
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Optimising the relaxivities of Mn<sup>2+</sup>complexes by targeting human serum albumin (HSA) Open
The Mn2+complexes of two differently benzyl-substituted 1,4-DO2AM ligands show a strong increase in relaxivity upon human serum albumin binding.
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Self-Interaction of Human Serum Albumin: A Formulation Perspective Open
In the present study, small-angle X-ray scattering (SAXS) and static light scattering (SLS) have been used to study the solution properties and self-interaction of recombinant human serum albumin (rHSA) molecules in three pharmaceutically …
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Human Serum Albumin Facilitates Heme-Iron Utilization by Fungi Open
Heme constitutes a major iron source for microorganisms and particularly for pathogenic microbes; to overcome the iron scarcity in the animal host, many pathogenic bacteria and fungi have developed systems to extract and take up heme from …
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Interaction of human serum albumin with uremic toxins: a thermodynamic study Open
Interaction of uremic toxins with HSA is studied by ITC and understood in terms of thermodynamic driving forces.
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A Novel NiFe2O4/Paper-Based Magnetoelastic Biosensor to Detect Human Serum Albumin Open
For the first time, a novel NiFe2O4/paper-based magnetoelastic (ME) biosensor was developed for rapid, sensitive, and portable detection of human serum albumin (HSA). Due to the uniquely magnetoelastic effect of NiFe2O4 nanoparticles and t…
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Albumin infusion for the critically ill – is it beneficial and, if so, why and how? Open
Human albumin is used for volume expansion and resuscitation and to correct hypoalbuminemia [1]. Hypoalbuminemia is frequent in sepsis and is a strong predictor of mortality and morbidity [2]. Fluid volume expansion and resuscitation of th…
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Unveiling the binding details and esterase-like activity effect of methyl yellow on human serum albumin: spectroscopic and simulation study Open
Details of the interaction between MY and HSA.
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Interaction with Human Serum Proteins Reveals Biocompatibility of Phosphocholine-Functionalized SPIONs and Formation of Albumin-Decorated Nanoparticles Open
Nanoparticles (NPs) are increasingly exploited as diagnostic and therapeutic devices in medicine. Among them, superparamagnetic nanoparticles (SPIONs) represent very promising tools for magnetic resonance imaging, local heaters for hyperth…
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A β-glucuronidase-responsive albumin-binding prodrug programmed for the double release of monomethyl auristatin E Open
Synthesis, in vitro and in vivo biological evaluations of a β-glucuronidase-responsive albumin-binding prodrug bearing a chemical amplifier.