Descemet membrane
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Descemet's membrane endothelial keratoplasty (DMEK) versus Descemet's stripping automated endothelial keratoplasty (DSAEK) for corneal endothelial failure Open
This review included studies conducted on people with corneal endothelium failure due to FED for whom both DMEK and DSAEK can be considered, and found low-certainty evidence that DMEK provides some advantage in terms of final BCVA, at the …
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Descemet membrane endothelial keratoplasty Open
Descemet membrane endothelial keratoplasty (DMEK) allows for selective replacement of damaged endothelial cells, using only donor Descemet's membrane with endothelium. However, early adoption by corneal surgeons has been limited (illustrat…
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EK (DLEK, DSEK, DMEK): New Frontier in Cornea Surgery Open
Endothelial keratoplasty (EK) has revolutionized treatment of corneal endothelial dysfunction. Compared with penetrating keratoplasty (PK), EK provides faster and more reliable visual rehabilitation while maintaining the eye's structural i…
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Endothelial Survival After Descemet Membrane Endothelial Keratoplasty Open
Endothelial decay was higher in eyes with a partial graft detachment than in those with attached grafts and lower in eyes with FECD than in those with BK. Endothelial failure only occurred in eyes with concomitant ocular pathology. These r…
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Contact Lens-Assisted Pull-Through Technique for Delivery of Tri-Folded (Endothelium in) DMEK Grafts Minimizes Surgical Time and Cell Loss Open
Delivering DMEK tissue, trifolded with the endothelium inward, reduces surgical trauma to donor cells and facilitates spontaneous unfolding, thus minimizing surgical time.
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Comparison of preservation and transportation protocols for preloaded Descemet membrane endothelial keratoplasty Open
Background/aims Descemet membrane endothelial keratoplasty (DMEK) preparation is technically demanding and is a limiting factor for uptake of this kind of surgery. Supply methods that simplify the procedure for surgeons are key to increasi…
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Association of the Gutta-Induced Microenvironment With Corneal Endothelial Cell Behavior and Demise in Fuchs Endothelial Corneal Dystrophy Open
These findings highlight the important role of guttae in endothelial cell growth, migration, and survival. These data suggest that cell therapy procedures in FECD might be guided by the diameter of the host guttae if subsequent clinical st…
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Association Between Graft Storage Time and Donor Age With Endothelial Cell Density and Graft Adherence After Descemet Membrane Endothelial Keratoplasty Open
We showed an association between graft storage time and ECD decline after DMEK and possibly between donor age and graft detachment. Therefore, donor storage times should be kept as short as possible to improve short-term ECDs. More researc…
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Efficacy and safety of Descemet’s membrane endothelial keratoplasty versus Descemet’s stripping endothelial keratoplasty: A systematic review and meta-analysis Open
Although DMEK is a more technically difficult and challenging procedure, it may represent a safe and more efficient alternative to DSEK for the treatment of corneal endothelial diseases, even during its learning curve.
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Endothelium‐in versus endothelium‐out for Descemet membrane endothelial keratoplasty graft preparation and implantation Open
Purpose To evaluate the difference between endothelium‐in and endothelium‐out for Descemet membrane endothelial keratoplasty (DMEK) preparation and implantation using injection method. Methods The study was a randomized, comparative, insti…
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Descemet’s membrane endothelial keratoplasty is the predominant keratoplasty procedure in Germany since 2016: a report of the DOG-section cornea and its keratoplasty registry Open
Background/aims This retrospective multicentric panel study provides absolute numbers, types of and indications for corneal transplantation in Germany from 2011 to 2021 and sets them into the international context. Methods A questionnaire …
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Feasibility of cell-based therapy combined with descemetorhexis for treating Fuchs endothelial corneal dystrophy in rabbit model Open
Corneal transparency is maintained by the corneal endothelium through its pump and barrier function. Severe corneal endothelial damage results in dysregulation of water flow and eventually causes corneal haziness and deterioration of visua…
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Outcomes of Descemet Membrane Endothelial Keratoplasty in Patients With Previous Glaucoma Surgery Open
Purpose: To evaluate outcomes of Descemet membrane endothelial keratoplasty (DMEK) in eyes with previous trabeculectomy or a drainage device. Methods: This is a retrospective study of 108 consecutive DMEK performed between October 2013 and…
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Differentiating type 1 from type 2 big bubbles in deep anterior lamellar keratoplasty Open
Harminder S Dua,1 Tarek Katamish,2 Dalia G Said,1 Lana A Faraj1 1Section of Academic Ophthalmology, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK; 2Department of Ophthalmology, Cairo University, Cairo, EgyptWe…
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Eye bank versus surgeon prepared DMEK tissues: influence on adhesion and re-bubbling rate Open
Aim To investigate the difference in adhesion and rebubbling rate between eye bank and surgeon prepared Descemet membrane endothelial keratoplasty (DMEK) tissues. Methods Laboratory and clinical retrospective comparative interventional cas…
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In Vivo Imaging and Morphometry of the Human Pre-Descemet's Layer and Endothelium With Ultrahigh-Resolution Optical Coherence Tomography Open
Our data indicate that all three layers of the posterior cornea can be clearly visualized in vivo and their thicknesses measured precisely with UHR-OCT. Although the PDL thickness showed large spatial variations, the thickness of the DM an…
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Descemet membrane endothelial keratoplasty (DMEK): an update on safety, efficacy and patient selection Open
Descemet membrane endothelial keratoplasty (DMEK) is gaining popularity worldwide as a procedure to address corneal endothelial dysfunctions. Its perfect anatomical result improves outcomes and expedites visual recovery. This review addres…
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Techniques for Learning Descemet Membrane Endothelial Keratoplasty for Eyes of Asian Patients With Shallow Anterior Chamber Open
Purpose: To describe several essential surgical techniques that overcome difficulties in performing Descemet membrane endothelial keratoplasty (DMEK) for inexperienced surgeons, especially those who perform DMEK on eyes of Asian patients. …
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Risk factors for endothelial cell loss after Descemet membrane endothelial keratoplasty (DMEK) Open
This study aimed to identify the risk factors for endothelial cell density (ECD) loss after Descemet membrane endothelial keratoplasty (DMEK) and analyse whether donor tissues from cold versus organ culture differ in terms of ECD loss afte…
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Incidence of Cystoid Macular Edema After Descemet Membrane Endothelial Keratoplasty Open
Purpose: The incidence of and risk factors for cystoid macular edema (CME) after Descemet membrane endothelial keratoplasty (DMEK) remain uncertain. This study examines the incidence of and risk factors for CME after DMEK. Methods: This re…
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Descemet’s Stripping Automated Endothelial Keratoplasty versus Descemet’s Membrane Endothelial Keratoplasty in the Fellow Eye for Fuchs Endothelial Dystrophy: A Retrospective Study Open
Aim . To evaluate visual outcome and endothelial cell density (ECD) after Descemet’s Membrane Endothelial Keratoplasty (DMEK) in comparison with Descemet’s Stripping Automated Endothelial Keratoplasty (DSAEK) in the fellow eye for Fuchs en…
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Clinical outcomes of pre-loaded ultra-thin DSAEK and pre-loaded DMEK Open
Objective To compare clinical outcomes and complications between pre-loaded ultra-thin Descemet stripping automated endothelialkeratoplasty (pl-UT-DSAEK) and pre-loaded Descemet membrane endothelial keratoplasty (pl-DMEK). Methods and anal…
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The Evolution of Corneal Transplantation Open
BACKGROUND The aim of this study was to investigate the evolution of surgical methods in and leading indications for corneal transplantation from 2005 to 2016. MATERIAL AND METHODS Data from the corneal graft waiting list and from all kera…
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Perceived difficulties and barriers to uptake of Descemet’s membrane endothelial keratoplasty among surgeons Open
Purpose: To determine barriers related to implementation of Descemet's membrane endothelial keratoplasty (DMEK) among corneal surgeons. Methods: This was a multicenter survey study of all corneal surgeons who participated in a DMEK wet lab…
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Use of four asymmetric marks to orient the donor graft during Descemet's membrane endothelial keratoplasty Open
Introduction Maintaining the correct orientation of the donor graft is important during Descemet's membrane endothelial keratoplasty (DMEK). We describe a new method of marking the donor graft prior to DMEK. Methods Twelve eyes of 10 patie…
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Impact of Donor Age on Corneal Endothelium-Descemet Membrane Layer Scroll Formation Open
To correlate corneal endothelium-Descemet membrane (EDM) layer parameters of scroll tightness with donor age, endothelial cell density (ECD), and history of diabetes.Endothelium-Descemet membrane layer scrolls were harvested from 26 corneo…
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Risk Factors for Cystoid Macular Edema After Descemet Membrane Endothelial Keratoplasty Open
Purpose: To investigate factors associated with cystoid macular edema (CME) after Descemet membrane endothelial keratoplasty (DMEK) in Asian eyes. Methods: In this retrospective, interventional, consecutive case series, 77 eyes of 65 patie…
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Global cell-by-cell evaluation of endothelial viability after two methods of graft preparation in Descemet membrane endothelial keratoplasty Open
Eye bank estimations of central endothelial cell density overestimate true cell density after graft preparation in DMEK. A peel method is less damaging and more consistent than a liquid bubble method. Cell loss correlated strongly with the…
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Ultrathin Descemet stripping automated endothelial keratoplasty versus Descemet membrane endothelial keratoplasty: a fellow-eye comparison Open
Background To compare the visual outcome and patients’ satisfaction after ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) performed on fellow eyes of the same…
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Opacification of hydrophilic intraocular lenses after Descemet stripping automated endothelial keratoplasty Open
Repeated exposure to intracameral air, raised IOP, and other patient influences may be major etiological factors for IOL opacification after DSAEK. We advise avoiding hydrophilic acrylic IOL models in patients who may require future endoth…