Ischemic stroke
View article: Prehospital intravenous access is associated with decreased door-to-computed tomography and door-to-intravenous thrombolysis time, but not door-to-endovascular therapy time
Prehospital intravenous access is associated with decreased door-to-computed tomography and door-to-intravenous thrombolysis time, but not door-to-endovascular therapy time Open
Introduction Prehospital stroke care can influence in-hospital stroke care, including facilitating earlier diagnosis and treatment. This study sought to determine the association between prehospital IV access and time to computed tomograph…
View article: Combined Preventive and Preconditioning Treatments for the Comorbidity of Alzheimer’s Disease and Ischemic Stroke in a GluN3A Knockout Mouse and a 5xFAD Mouse
Combined Preventive and Preconditioning Treatments for the Comorbidity of Alzheimer’s Disease and Ischemic Stroke in a GluN3A Knockout Mouse and a 5xFAD Mouse Open
Alzheimer’s disease (AD) and stroke have been identified as risk factors for each other. More than half of AD patients suffer stroke attacks and worse ischemic injuries. There has been a lack of research focus and clinical treatment for th…
View article: ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke
ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke Open
Perioperative stroke is a rare but serious complication with a rising incidence in aging populations. Although preclinical studies consistently demonstrate that anesthetics such as sevoflurane can induce neuroprotective preconditioning aga…
View article: Administration of eptifibatide as rescue therapy during mechanical thrombectomy in acute ischemic stroke
Administration of eptifibatide as rescue therapy during mechanical thrombectomy in acute ischemic stroke Open
Background The success of the technical implementation of mechanical thrombectomy (MT) depends on many factors. Considering the experience of the interventional radiologist and the anatomical vascular differences of individual patients, it…
View article: Inflammatory biomarkers in cerebral venous thrombosis versus ischemic stroke: a network meta-analysis
Inflammatory biomarkers in cerebral venous thrombosis versus ischemic stroke: a network meta-analysis Open
Background In cerebrovascular diseases (CVD), the management strategies for ischemic stroke (IS) and cerebral venous thrombosis (CVT) have significant differences, but the underlying inflammation-driven mechanisms in these two conditions h…
View article: Developing a novel evaluation model to assess the performance of base hospitals in China National Stroke Screening Surveys
Developing a novel evaluation model to assess the performance of base hospitals in China National Stroke Screening Surveys Open
Background The China National Stroke Screening Surveys (CNSSS), a decade-long national public health initiative, aims to reduce stroke morbidity and mortality through early detection and intervention. This study develops a novel evaluation…
View article: Systemic inflammation–based hematological indices and 90-day functional outcomes after intravenous thrombolysis in acute ischemic stroke: a systematic review
Systemic inflammation–based hematological indices and 90-day functional outcomes after intravenous thrombolysis in acute ischemic stroke: a systematic review Open
Background Acute ischemic stroke (AIS) is one of the leading causes of mortality and long-term disability worldwide. Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) remains the standard treatment for el…
View article: Characteristics of Intracranial Hemorrhage in Patients on Factor-Xa Inhibitors: Japan Stroke Data Bank
Characteristics of Intracranial Hemorrhage in Patients on Factor-Xa Inhibitors: Japan Stroke Data Bank Open
View article: Age-Related Features of Neuroinflammation: Hidden Association of Neuronal Damage with Activation of Natural Killers in Patients with Ischemic Stroke
Age-Related Features of Neuroinflammation: Hidden Association of Neuronal Damage with Activation of Natural Killers in Patients with Ischemic Stroke Open
Ischemic stroke remains a leading cause of death and disability worldwide, with neuroinflammation playing a central role in its pathogenesis. This study aimed to investigate age-related differences in neuroinflammatory responses in the hum…
View article: Successful implementation of stroke risk screening for sickle cell anemia in the DISPLACE study: results of a cluster randomized trial
Successful implementation of stroke risk screening for sickle cell anemia in the DISPLACE study: results of a cluster randomized trial Open
View article: Evaluating the role of CHG index in predicting stroke risk among adults with varying glucose regulation
Evaluating the role of CHG index in predicting stroke risk among adults with varying glucose regulation Open
Elevated CHG index is linked to higher stroke risk, especially in individuals with NGR and Pre-DM, highlighting the importance of early monitoring and intervention for metabolic dysregulation-related stroke risk.
View article: Analysis of 90-day risk factors for poor prognosis in patients with postoperative CT with hyperdense signs after thrombectomy for acute ischemic stroke
Analysis of 90-day risk factors for poor prognosis in patients with postoperative CT with hyperdense signs after thrombectomy for acute ischemic stroke Open
Objective To investigate the risk factors associated with poor 90-day prognosis in patients exhibiting hyperdense signs on the initial CT scan after mechanical thrombectomy for acute ischemic stroke. Methods We conducted a retrospective an…
View article: What is the difference in Venous Thromboembolism (VTE) and Ischaemic Stroke risk between oral and transdermal Menopausal Hormone Therapy (MHT) in women starting treatment after age 60?
What is the difference in Venous Thromboembolism (VTE) and Ischaemic Stroke risk between oral and transdermal Menopausal Hormone Therapy (MHT) in women starting treatment after age 60? Open
Oral Menopausal Hormone Therapy is linked to increased risks of VTE and ischemic stroke in women over 60, whereas transdermal MHT shows lower associated risks for these conditions.
View article: In maintenance antiplatelet therapy for stroke sequelae, is aspirin or clopidogrel better?
In maintenance antiplatelet therapy for stroke sequelae, is aspirin or clopidogrel better? Open
Both aspirin and clopidogrel are effective for secondary prevention of recurrent strokes, with clopidogrel showing a potentially better profile in reducing broader cardiovascular events. Patient-specific factors and genetic considerations …
View article: Neuroimaging with photon-counting computed tomography: A review of clinical applications
Neuroimaging with photon-counting computed tomography: A review of clinical applications Open
Photon-counting computed tomography (PCCT) represents a transformative advancement in neuroimaging, offering superior spatial resolution, spectral imaging capabilities, reduced radiation dose, and enhanced contrast-to-noise ratios. This re…
View article: Lp(a) levels and ischemic stroke recurrence in type 2 diabetes mellitus
Lp(a) levels and ischemic stroke recurrence in type 2 diabetes mellitus Open
View article: Supplementary Table from The Risk of Ischemic Stroke in Head and Neck Cancer Patients and Those Who Were Treated with Radiotherapy: A Population-Based Cohort Study
Supplementary Table from The Risk of Ischemic Stroke in Head and Neck Cancer Patients and Those Who Were Treated with Radiotherapy: A Population-Based Cohort Study Open
Supplementary Table from The Risk of Ischemic Stroke in Head and Neck Cancer Patients and Those Who Were Treated with Radiotherapy: A Population-Based Cohort Study
View article: In maintenance antiplatelet therapy for stroke sequelae, is aspirin or clopidogrel better?
In maintenance antiplatelet therapy for stroke sequelae, is aspirin or clopidogrel better? Open
Both aspirin and clopidogrel are effective for secondary prevention of recurrent strokes, with clopidogrel showing a potentially better profile in reducing broader cardiovascular events. Patient-specific factors and genetic considerations …
View article: What is the difference in Venous Thromboembolism (VTE) and Ischaemic Stroke risk between oral and transdermal Menopausal Hormone Therapy (MHT) in women starting treatment after age 60?
What is the difference in Venous Thromboembolism (VTE) and Ischaemic Stroke risk between oral and transdermal Menopausal Hormone Therapy (MHT) in women starting treatment after age 60? Open
Oral Menopausal Hormone Therapy is linked to increased risks of VTE and ischemic stroke in women over 60, whereas transdermal MHT shows lower associated risks for these conditions.
View article: Supplementary Figure from The Risk of Ischemic Stroke in Head and Neck Cancer Patients and Those Who Were Treated with Radiotherapy: A Population-Based Cohort Study
Supplementary Figure from The Risk of Ischemic Stroke in Head and Neck Cancer Patients and Those Who Were Treated with Radiotherapy: A Population-Based Cohort Study Open
Supplementary Figure from The Risk of Ischemic Stroke in Head and Neck Cancer Patients and Those Who Were Treated with Radiotherapy: A Population-Based Cohort Study
View article: Non-linear association between hepatic steatosis index and 3-month outcomes in patients with acute ischemic stroke
Non-linear association between hepatic steatosis index and 3-month outcomes in patients with acute ischemic stroke Open
This study demonstrates a statistically significant inverse association between the HSI and 3-month unfavorable outcomes in patients with AIS, observed only when HSI values are below 31.78.
View article: Therapeutic effects of ginseng and its major components on ischaemic stroke in vitro and in silico
Therapeutic effects of ginseng and its major components on ischaemic stroke in vitro and in silico Open
This study elucidates the molecular mechanisms by which ginseng exerts its therapeutic effects on IS. The identification of key active ingredients and their targets offers new insights into the development of effective treatments for IS.
View article: Integrative bioinformatics and machine learning approaches identify inflammation-related genes and drug candidates for future preclinical validation in ischemic stroke
Integrative bioinformatics and machine learning approaches identify inflammation-related genes and drug candidates for future preclinical validation in ischemic stroke Open
This study reveals four inflammation-related genes with preliminary diagnostic value and proposes capecitabine and ruxolitinib as candidate drugs for future preclinical research on IS.
View article: Identification of Six Potential Therapeutic Targets Common to Ischemic Stroke and Vascular Dementia: Genetic Insights From an Integrated Bioinformatics Analysis
Identification of Six Potential Therapeutic Targets Common to Ischemic Stroke and Vascular Dementia: Genetic Insights From an Integrated Bioinformatics Analysis Open
Background The aim was to investigate the potential therapeutic targets for ischemic stroke (IS) and vascular dementia (VD). Methods We assessed the causal effects of 2943 plasma proteins on IS and VD using a two‐sample Mendelian randomiza…
View article: Cerebrospinal fluid-based clinical-radiomics model for predicting treatment prognosis of acute ischemic stroke
Cerebrospinal fluid-based clinical-radiomics model for predicting treatment prognosis of acute ischemic stroke Open
View article: Targeted strategy by curcumin and tideglusib biomimetic nano-systems alleviates oxidative stress and inflammation under ischemic stroke
Targeted strategy by curcumin and tideglusib biomimetic nano-systems alleviates oxidative stress and inflammation under ischemic stroke Open
Ischemic stroke represents one of the leading causes of disability and death worldwide. Neuroprotection aimed at mitigating oxidative stress and inflammation is crucial for improving the prognosis of patients. However, the inadequate accum…
View article: Construction of a diagnostic prediction model for ischemic stroke using lactylation-related genes
Construction of a diagnostic prediction model for ischemic stroke using lactylation-related genes Open
Ischemic stroke (IS) represents the leading global cause of acquired neurological disability and vascular-related mortality. However, diagnostic challenges persist in cases with atypical presentations. Lactylation modification exerts criti…
View article: Safety and Efficacy of Remote Ischaemic Conditioning for Acute Ischaemic Stroke Treated with Mechanical Thrombectomy (RECAST-MT): rationale and design
Safety and Efficacy of Remote Ischaemic Conditioning for Acute Ischaemic Stroke Treated with Mechanical Thrombectomy (RECAST-MT): rationale and design Open
Rationale Adjunctive neuroprotection is a promising strategy for improving functional recovery in patients with acute ischaemic stroke (AIS) treated with mechanical thrombectomy (MT). Remote ischaemic conditioning (RIC) has been shown to b…
View article: Temporal Dynamics of Complement Activation and Outcome in Patients with Acute Ischemic Stroke
Temporal Dynamics of Complement Activation and Outcome in Patients with Acute Ischemic Stroke Open
Immune-mediated inflammatory responses exacerbate brain injury and affect the prognosis in acute ischemic stroke (AIS). We characterized longitudinal complement activation after AIS using serial plasma samples from 10 patients and 8 contro…
View article: Joint impact of stress hyperglycaemic ratio and glycaemic variability in patients with ischaemic stroke and machine learning for mortality prediction
Joint impact of stress hyperglycaemic ratio and glycaemic variability in patients with ischaemic stroke and machine learning for mortality prediction Open
Background The global burden of ischaemic stroke (IS) is high, which is potentially relevant to stress hyperglycemia ratio (SHR) and glycaemic variability (GV). This study aims to evaluate the combined effect of the SHR and GV with predict…