Allergic asthma
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Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma Open
clinicaltrialsregister.eu Identifier: 2010-018621-19.
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Allergen immunotherapy for allergic asthma: A systematic review and meta‐analysis Open
Background To inform the development of the European Academy of Allergy and Clinical Immunology's ( EAACI ) Guidelines on Allergen Immunotherapy ( AIT ) for allergic asthma, we assessed the evidence on the effectiveness, cost‐effectiveness…
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Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper Open
Background Allergen immunotherapy ( AIT ) is an effective treatment for allergic rhinoconjunctivitis ( AR ) with or without asthma. It is important to note that due to the complex interaction between patient, allergy triggers, symptomatolo…
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Alternatively activated macrophages; a double-edged sword in allergic asthma Open
Background Macrophages are heterogenous phagocytic cells with an important role in the innate immunity. They are, also, significant contributors in the adaptive immune system. Macrophages are the most abundant immune cells in the lung duri…
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Increased prevalence of allergic asthma from 1996 to 2006 and further to 2016—results from three population surveys Open
Summary Background During the latter half of the 20th century, the prevalence of asthma and many other allergic diseases has increased. Information on asthma prevalence trends among adults after 2010, especially regarding studies separatin…
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Sublingual immunotherapy provides long‐term relief in allergic rhinitis and reduces the risk of asthma: A retrospective, real‐world database analysis Open
Background Allergy immunotherapy ( AIT ) is the only treatment for allergic rhinitis ( AR ) and/or allergic asthma ( AA ) with long‐term efficacy. However, there are few real‐life data on the progression of AR and/or AA in patients receivi…
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Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma Open
Calcilytics reduce airway hyperresponsiveness and inflammation and may represent effective asthma therapeutics.
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Recent developments in the role of reactive oxygen species in allergic asthma Open
Allergic asthma has a global prevalence, morbidity, and mortality. Many environmental factors, such as pollutants and allergens, are highly relevant to allergic asthma. The most important pathological symptom of allergic asthma is airway i…
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The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders Open
Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic inflammation and allergic diseases. They exert their biological effects by binding to specific G-protein-coupled receptors. Each LT receptor subtype exhibi…
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Effects of particulate matter on allergic respiratory diseases Open
The health impact of airborne particulate matter (PM) has long been a concern to clinicians, biologists, and the general public. With many epidemiological studies confirming the association of PM with allergic respiratory diseases, an incr…
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Perspectives in allergen immunotherapy: 2019 and beyond Open
The seventh “Future of the Allergists and Specific Immunotherapy (FASIT)” workshop held in 2019 provided a platform for global experts from academia, allergy clinics, regulatory authorities and industry to review current developments in th…
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‘Real-life’ effectiveness studies of omalizumab in adult patients with severe allergic asthma: systematic review Open
We reviewed 24 'real-life' effectiveness studies of omalizumab in the treatment of severe allergic asthma that included 4117 unique patients from 32 countries with significant heterogeneity in patients, clinicians and settings. The evidenc…
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Real‐world benefits of allergen immunotherapy for birch pollen‐associated allergic rhinitis and asthma Open
Background Real‐world evidence is sparse on the benefits of allergen immunotherapy [ AIT ; subcutaneous/sublingual immunotherapy ( SCIT / SLIT )], the only disease‐modifying intervention for allergic rhinitis ( AR ) with long‐term efficacy…
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Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice Open
Allergic asthma is characterized by elevated levels of IgE antibodies, type 2 cytokines such as interleukin-4 (IL-4) and IL-13, airway hyperresponsiveness (AHR), mucus hypersecretion and eosinophilia. Approved therapeutic monoclonal antibo…
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Equine asthma: Integrative biologic relevance of a recently proposed nomenclature Open
The term “equine asthma” has been proposed as a unifying descriptor of inflammatory airway disease (IAD), recurrent airway obstruction (RAO), and summer pasture‐associated obstructive airway disease. Whilst the term will increase comprehen…
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Fevipiprant, an oral prostaglandin DP<sub>2</sub>receptor (CRTh2) antagonist, in allergic asthma uncontrolled on low-dose inhaled corticosteroids Open
Dose-related efficacy and safety of fevipiprant (QAW039), an oral DP 2 (CRTh2) receptor antagonist, was assessed in patients with allergic asthma uncontrolled by low-dose inhaled corticosteroids (ICS). Adult patients were randomised to 12 …
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The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study Open
Mobile technology has been used to appraise allergic rhinitis control, but more data are needed. To better assess the importance of mobile technologies in rhinitis control, the ARIA (Allergic Rhinitis and its Impact on Asthma) score rangin…
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Resveratrol Attenuates Allergic Asthma and Associated Inflammation in the Lungs Through Regulation of miRNA-34a That Targets FoxP3 in Mice Open
Asthma is a chronic inflammatory disease of airways mediated by T-helper 2 (Th2) cells involving complex signaling pathways. Although resveratrol has previously been shown to attenuate allergic asthma, the role of miRNA in this process has…
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Phenotyping asthma, rhinitis and eczema in <span>M</span>e<span>DALL</span> population‐based birth cohorts: an allergic comorbidity cluster Open
Background Asthma, rhinitis and eczema often co‐occur in children, but their interrelationships at the population level have been poorly addressed. We assessed co‐occurrence of childhood asthma, rhinitis and eczema using unsupervised stati…
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Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma Open
Allergen-triggered inflammation drives a TNF-dependent innate memory, which may perpetuate and exacerbate chronic type 2 airway inflammation and thus represents a target for asthma therapy.
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<i>Nrf2</i> reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function Open
Asthma development and pathogenesis are influenced by the interactions of airway epithelial cells and innate and adaptive immune cells in response to allergens. Oxidative stress is an important mediator of asthmatic phenotypes in these cel…
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Applications and mechanisms of immunotherapy in allergic rhinitis and asthma Open
Clinical and immunologic tolerance are hallmarks of successful allergen immunotherapy (AIT). Clinical benefits such as reduced symptoms, pharmacotherapy intake and improvement of quality of life persist following cessation of treatment. Su…
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Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life Open
Asthma is a heterogeneous and complex condition characterized by chronic airway inflammation, which may be clinically stratified into three main phenotypes: type 2 (T2) low, T2-high allergic, and T2-high non-allergic asthma. This real-worl…
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IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma Open
Allergic rhinitis (AR) is a common disorder of the upper airway, while asthma is a disease affecting the lower airway and both diseases are usually comorbid. Interleukin (IL)-4 and IL-13 are critical cytokines in the induction of the patho…
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Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma Open
House dust mite (HDM) challenge is commonly used in murine models of allergic asthma for preclinical pathophysiological studies. However, few studies define objective readouts or biomarkers in this model. In this study we characterized imm…
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Differential control of CD4<sup>+</sup> T‐cell subsets by the PD‐1/PD‐L1 axis in a mouse model of allergic asthma Open
Studies examining the role of PD‐1 family members in allergic asthma have yielded conflicting results. Using a mouse model of allergic asthma, we demonstrate that blockade of PD‐1/PD‐L1 has distinct influences on different CD4 + T‐cell sub…
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Short- and long-term real-world effectiveness of omalizumab in severe allergic asthma: systematic review of 42 studies published 2008-2018 Open
Omalizumab is a recombinant monoclonal anti-IgE antibody approved in the US as add-on treatment in moderate-to-severe allergic asthma (in severe allergic asthma [SAA] in Europe). A 2016 review of 24 real-world effectiveness studies in SAA …
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Chinese guideline on sublingual immunotherapy for allergic rhinitis and asthma Open
The present guideline on sublingual immunotherapy (SLIT) for allergic rhinitis (AR) and allergic asthma (AS) has been developed by a panel of experts on behalf of the Chinese Society of Allergy to guide the clinical practice of SLIT in Chi…
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Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews Open
AIT has the potential to achieve reductions in symptom and medication scores, but there is no clear or consistent evidence that measures of lung function can be improved. Bearing in mind the limitations of synthesizing evidence from system…
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Allergen Immunotherapy in Asthma Open
Allergen immunotherapy (AIT) is a specific treatment involving the administration of relevant allergens to allergic patients, with subtypes including subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). In asthma, AIT usi…