Photoacoustic Doppler effect
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Photoacoustic/ultrasound dual imaging of human thyroid cancers: an initial clinical study Open
We reported an initial clinical study of in vivo human thyroid by a photoacoustic/ultrasound handheld probe. Our dual-modality system is based on a high-end clinical ultrasound machine. Both healthy and cancerous thyroids were imaged non-i…
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3-D ultrafast doppler imaging applied to the noninvasive mapping of blood vessels in Vivo Open
Ultrafast Doppler imaging was introduced as a technique to quantify blood flow in an entire 2-D field of view, expanding the field of application of ultrasound imaging to the highly sensitive anatomical and functional mapping of blood vess…
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Overview of Ultrasound Detection Technologies for Photoacoustic Imaging Open
Ultrasound detection is one of the major components of photoacoustic imaging systems. Advancement in ultrasound transducer technology has a significant impact on the translation of photoacoustic imaging to the clinic. Here, we present an o…
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Efficient Photoacoustic Conversion in Optical Nanomaterials and Composites Open
Photoacoustic pulses generated by pulsed laser irradiation have the characteristics of high frequency and wide bandwidth, which are desirable for imaging and sensing. Efficient photoacoustic composites have been developed for fabricating p…
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Super-resolution photoacoustic imaging through a scattering wall Open
The use of wavefront shaping to compensate for scattering has brought a renewed interest as a potential solution to imaging through scattering walls. A key to the practicality of any imaging through scattering technique is the capability t…
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Towards non-contact photoacoustic imaging [review] Open
Photoacoustic imaging (PAI) takes advantage of both optical and ultrasound imaging properties to visualize optical absorption with high resolution and contrast. Photoacoustic microscopy (PAM) is usually categorized with all-optical microsc…
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High resolution ultrasound and photoacoustic imaging of single cells Open
High resolution ultrasound and photoacoustic images of stained neutrophils, lymphocytes and monocytes from a blood smear were acquired using a combined acoustic/photoacoustic microscope. Photoacoustic images were created using a pulsed 532…
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Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging Open
Photoacoustic sensing and imaging techniques have been studied widely to explore optical absorption contrast based on nanosecond laser illumination. In this paper, we report a long laser pulse induced dual photoacoustic (LDPA) nonlinear ef…
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Review of Laser-Generated Ultrasound Transmitters and Their Applications to All-Optical Ultrasound Transducers and Imaging Open
Medical ultrasound is an imaging technique that utilizes ultrasonic signals as information carriers, and has wide applications such as seeing internal body structures, finding a source of a disease, and examining pregnant women. The most c…
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High frame rate photoacoustic imaging at 7000 frames per second using clinical ultrasound system Open
Photoacoustic tomography, a hybrid imaging modality combining optical and ultrasound imaging, is gaining attention in the field of medical imaging. Typically, a Q-switched Nd:YAG laser is used to excite the tissue and generate photoacousti…
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Super-resolution photoacoustic imaging via flow-induced absorption fluctuations Open
In deep tissue photoacoustic imaging the spatial resolution is inherently\nlimited by the acoustic wavelength. We present an approach for surpassing the\nacoustic diffraction limit by exploiting temporal fluctuations in the sample\nabsorpt…
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High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7 <i>μ</i>m Open
Intravascular photoacoustic imaging at 1.7 μm spectral band has shown promising capabilities for lipid-rich vulnerable atherosclerotic plaque detection. In this work, we report a high speed catheter-based integrated intravascular photoacou…
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Super-resolution photoacoustic microscopy using blind structured illumination Open
We present a method for enhancing the spatial resolution of optical-absorption-based photoacoustic imaging through or within highly scattering media. The optical speckle pattern that emerges as light propagates through diffuse media provid…
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Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images Open
We have constructed a prototype photoacoustic mammography system (PAM-02) capable of simultaneously acquiring photoacoustic (PA) and ultrasound (US) images. Each PA, US, and fused PA/US image can be acquired over a wide area of the breast …
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High-speed, low-cost, pulsed-laser-diode-based second-generation desktop photoacoustic tomography system Open
Bulky, expensive Nd:YAG lasers are used in conventional photoacoustic tomography (PAT) systems, making them difficult to translate into clinics. Moreover, real-time imaging is not feasible when a single-element ultrasound transducer is use…
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Highly sensitive and miniature microfiber-based ultrasound sensor for photoacoustic tomography Open
A microfiber with large evanescent field encapsulated in PDMS is proposed and demonstrated for ultrasound sensing. The compact size and large evanescent field of microfiber provide an excellent platform for the interaction between optical …
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Fiber-Laser-Based Ultrasound Sensor for Photoacoustic Imaging Open
Photoacoustic imaging, especially for intravascular and endoscopic applications, requires ultrasound probes with miniature size and high sensitivity. In this paper, we present a new photoacoustic sensor based on a small-sized fiber laser. …
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Laser‐Induced Focused Ultrasound for Cavitation Treatment: Toward High‐Precision Invisible Sonic Scalpel Open
Beyond the implementation of the photoacoustic effect to photoacoustic imaging and laser ultrasonics, this study demonstrates a novel application of the photoacoustic effect for high‐precision cavitation treatment of tissue using laser‐ind…
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Tomographic imaging with an ultrasound and LED-based photoacoustic system Open
Pulsed lasers in photoacoustic tomography systems are expensive, which limit their use to a few clinics and small animal labs. We present a method to realize tomographic ultrasound and photoacoustic imaging using a commercial LED-based pho…
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Development of a blood oxygenation phantom for photoacoustic tomography combined with online pO2 detection and flow spectrometry Open
Photoacoustic tomography (PAT) is intrinsically sensitive to blood oxygen saturation (sO2) in vivo. However, making accurate sO2 measurements without knowledge of tissue- and instrumentation-related correction factors is extremely challeng…
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Acoustic impact of the human skull on transcranial photoacoustic imaging Open
With balanced spatial resolution, imaging depth, and functional sensitivity, photoacoustic tomography (PAT) hold great promise for human brain imaging. However, the strong acoustic attenuation and aberration of the human skull (∼8 mm thick…
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Intravascular confocal photoacoustic endoscope with dual-element ultrasonic transducer Open
We have developed an intravascular confocal photoacoustic (PA) endoscope with symmetrically aligned dual-element ultrasonic transducers. By combining focused laser excitation and focused acoustic collection, the intravascular confocal PA e…
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In vivo demonstration of reflection artifact reduction in photoacoustic imaging using synthetic aperture photoacoustic-guided focused ultrasound (PAFUSion) Open
Reflection artifacts caused by acoustic inhomogeneities are a critical problem in epi-mode biomedical photoacoustic imaging. High light fluence beneath the probe results in photoacoustic transients, which propagate into the tissue and refl…
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The Progress in Photoacoustic and Laser Ultrasonic Tomographic Imaging for Biomedicine and Industry: A Review Open
The current paper reviews a set of principles and applications of photoacoustic and laser ultrasonic imaging, developed in the Laser Optoacoustic Laboratories of ILIT RAS, NUST MISiS, and ILC MSU. These applications include combined photoa…
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Photoacoustic Imaging in Oxygen Detection Open
Oxygen level, including blood oxygen saturation (sO2) and tissue oxygen partial pressure (pO2), are crucial physiological parameters in life science. This paper reviews the importance of these two parameters and the detection methods for t…
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Frequency domain photoacoustic and fluorescence microscopy Open
We report on simultaneous frequency domain optical-resolution photoacoustic and fluorescence microscopy with sub-µm lateral resolution. With the help of a blood smear, we show that photoacoustic and fluorescence images provide complementar…
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Classification of blood cells and tumor cells using label‐free ultrasound and photoacoustics Open
A label‐free method that can identify cells in a blood sample using high frequency photoacoustic and ultrasound signals is demonstrated. When the wavelength of the ultrasound or photoacoustic wave is similar to the size of a single cell (f…
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Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography Open
Based on the photoacoustic (PA) effect, PA tomography directly measures specific optical absorption, i.e., absorbed optical energy per unit volume. We recently developed a full-ring ultrasonic transducer array-based photoacoustic computed …
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Photoacoustic imaging systems based on clinical ultrasound platform Open
Photoacoustic imaging has drawn a significant amount of attention due to its unique capacity for functional, metabolic, and molecular imaging, which is achieved by the combination of optical excitation and acoustic detection. With both str…
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Photoacoustic temperature imaging based on multi-wavelength excitation Open
Building further upon the high spatial resolution offered by ultrasonic imaging and the high optical contrast yielded by laser excitation of photoacoustic imaging, and exploiting the temperature dependence of photoacoustic signal amplitude…