In vitro toxicology
View article: Investigating the binding potential of the Melissa officinalis oil against Alzheimer’s targets by molecular docking and in vitro evaluations
Investigating the binding potential of the Melissa officinalis oil against Alzheimer’s targets by molecular docking and in vitro evaluations Open
View article: Прогнозирование вязкости и текучести крови: экспериментальное исследование на in vitro и in silico моделях
Прогнозирование вязкости и текучести крови: экспериментальное исследование на in vitro и in silico моделях Open
Резюме. Введение. Ряд заболеваний и патологических состояний сопровождаются повышением вязкости крови и, следовательно, снижением тканевой перфузии. Вязкость как интегральная гемореологическая характеристика зависит от основных 4 факторов:…
View article: Aotaphenazine, a rare hydrophenazine, targets topoisomerase II with anticancer efficacy: In silico to in vitro evidence
Aotaphenazine, a rare hydrophenazine, targets topoisomerase II with anticancer efficacy: In silico to in vitro evidence Open
Background Topoisomerase II (Topo II) remains a validated target for anticancer therapy, with many clinically used agents acting via DNA intercalation and enzyme inhibition. However, their clinical use is limited by severe toxicity and res…
View article: Synthesis, Bioactivity Evaluation, Molecular Docking, <scp>ADMET</scp> , and Drug‐Likeness Studies of 4‐Chromanone Derivatives Containing a Thiosemicarbazone Moiety as Potential Antioxidants and α‐Glucosidase Inhibitors
Synthesis, Bioactivity Evaluation, Molecular Docking, <span>ADMET</span> , and Drug‐Likeness Studies of 4‐Chromanone Derivatives Containing a Thiosemicarbazone Moiety as Potential Antioxidants and α‐Glucosidase Inhibitors Open
In this study, a novel series of 4‐chromanone derivatives bearing a thiosemicarbazone moiety was rationally designed and efficiently synthesized. The structures of all newly obtained compounds were thoroughly characterized via various spec…
View article: Supplementary Materials for Fu’s cupping physical permeation-enhancement technique for transdermal delivery of chelerythrine: Evaluation using in vitro kinetics and in vivo microdialysis
Supplementary Materials for Fu’s cupping physical permeation-enhancement technique for transdermal delivery of chelerythrine: Evaluation using in vitro kinetics and in vivo microdialysis Open
The data represents supplementary material for 'Fu’s cupping physical permeation-enhancement technique for transdermal delivery of chelerythrine: Evaluation using in vitro kinetics and in vivo microdialysis'."
View article: Supplementary Materials for Fu’s cupping physical permeation-enhancement technique for transdermal delivery of chelerythrine: Evaluation using in vitro kinetics and in vivo microdialysis
Supplementary Materials for Fu’s cupping physical permeation-enhancement technique for transdermal delivery of chelerythrine: Evaluation using in vitro kinetics and in vivo microdialysis Open
The data represents supplementary material for 'Fu’s cupping physical permeation-enhancement technique for transdermal delivery of chelerythrine: Evaluation using in vitro kinetics and in vivo microdialysis'."
View article: REPURPOSING FDA-APPROVED DRUGS AGAINST DENGUE VIRUS: INTEGRATED IN SILICO AND IN VITRO EVALUATION OF FAVIPIRAVIR, IVERMECTIN, AND METFORMIN.
REPURPOSING FDA-APPROVED DRUGS AGAINST DENGUE VIRUS: INTEGRATED IN SILICO AND IN VITRO EVALUATION OF FAVIPIRAVIR, IVERMECTIN, AND METFORMIN. Open
View article: NYMPHE.WP1. Plant Metabolites Exudated Under Pollution Stress in vitro
NYMPHE.WP1. Plant Metabolites Exudated Under Pollution Stress in vitro Open
The dataset includes the results of a metabolomic approach for the identification of the chemical compounds released by root exudation of sunflower plantlets, cultivated in vitro under sterile conditions and exposed to a PHC molecule selec…
View article: In Vitro Evaluation of the Anthelmintic Activity of Rhus coriaria (Sumac) Extract against Marshallagia marshalli
In Vitro Evaluation of the Anthelmintic Activity of Rhus coriaria (Sumac) Extract against Marshallagia marshalli Open
Marshallagia marshalli, a common parasite in domestic and wild ruminants in Iran, causes parasitic gastroenteritis. Chemical medicines like Levamisole are used to treat this infection, but drug-resistant infections have led to research on …
View article: Different Methods Used For In Vitro Antituberculer Activity in Extracts of Flowers of Jasminum Sambac L. Ait.
Different Methods Used For In Vitro Antituberculer Activity in Extracts of Flowers of Jasminum Sambac L. Ait. Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a global public health challenge, worsened by rising drug resistance and limited new therapeutics. Natural products derived from medicinal plants offer a valuable source of n…
View article: Different Methods Used For In Vitro Antituberculer Activity in Extracts of Flowers of Jasminum Sambac L. Ait.
Different Methods Used For In Vitro Antituberculer Activity in Extracts of Flowers of Jasminum Sambac L. Ait. Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a global public health challenge, worsened by rising drug resistance and limited new therapeutics. Natural products derived from medicinal plants offer a valuable source of n…
View article: Synthesis and Evaluation of Novel 5-{[2-Cyano-3-(substituted phenyl)prop-2-enoyl]amino}-2-hydroxy Benzoic Acid
Synthesis and Evaluation of Novel 5-{[2-Cyano-3-(substituted phenyl)prop-2-enoyl]amino}-2-hydroxy Benzoic Acid Open
5-Aminosalicylic acid (5-ASA), also known as mesalamine is extensively used for the treatment of inflammatory conditions like ulcerative colitis (UC), inflammatory bowel disease (IBD) and colorectal cancer. Hence, the current work aimed at…
View article: Phytochemical Profiling and Pharmacological Evaluation of Caesalpinia Bonducella Seed Extracts
Phytochemical Profiling and Pharmacological Evaluation of Caesalpinia Bonducella Seed Extracts Open
In this work, aqueous and methanolic solvents are used to examine the phytochemical makeup and pharmacological potential of Caesalpinia bonducella seed extract. Long acknowledged for their therapeutic value, traditional medical systems lik…
View article: Phytochemical Profiling and Pharmacological Evaluation of Caesalpinia Bonducella Seed Extracts
Phytochemical Profiling and Pharmacological Evaluation of Caesalpinia Bonducella Seed Extracts Open
In this work, aqueous and methanolic solvents are used to examine the phytochemical makeup and pharmacological potential of Caesalpinia bonducella seed extract. Long acknowledged for their therapeutic value, traditional medical systems lik…
View article: The influence of cell culture media and their additives on virus inactivation in vitro
The influence of cell culture media and their additives on virus inactivation in vitro Open
Aim: Comparative inactivation studies with the murine norovirus (MNV) and different test substances showed considerable different results between test laboratories. To decipher the underlying mechanisms of this observation, different virus…
View article: Figure 3 from: Momekov G, Kondeva-Burdina M, Slavchev S (2025) Comparative review of chemical composition and toxicological evaluation of heated tobacco products compared to regular combustible cigarettes. Pharmacia 72: 1-16. https://doi.org/10.3897/pharmacia.72.e174427
Figure 3 from: Momekov G, Kondeva-Burdina M, Slavchev S (2025) Comparative review of chemical composition and toxicological evaluation of heated tobacco products compared to regular combustible cigarettes. Pharmacia 72: 1-16. https://doi.org/10.3897/pharmacia.72.e174427 Open
Figure 3 In vitro toxicological evaluation of HTPs and reference cigarettes 3R4F (CCs). The results show the relative levels of toxic response, where 3R4F is defined as 100 relative units (reference standard).
View article: Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro
Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro Open
Industrial and agricultural chemicals such as pesticides are often considered to have restricted biological activity. Yet, there are concerns regarding their broader toxicity range and impact on human gut microbiota. Here we report a syste…
View article: Replication data for: Effect of Plant Proteins on the in vitro Lipid Digestibility and β-Carotene Bioaccessibility of Oleogels
Replication data for: Effect of Plant Proteins on the in vitro Lipid Digestibility and β-Carotene Bioaccessibility of Oleogels Open
This dataset presents the physicochemical and nutritional characterization of beta-carotene-loaded oleogels in the presence of plant proteins (soy, wheat and pea proteins) during in vitro gastrointestinal digestion. The data includes zeta-…
View article: Anti-inflammatory activity of Acanthospermum australe: Insights from network pharmacology, chemical analysis, and in vitro assays
Anti-inflammatory activity of Acanthospermum australe: Insights from network pharmacology, chemical analysis, and in vitro assays Open
Inflammation plays a crucial role in homeostasis and defense responses; however, exaggerated and chronic inflammation contribute to the development and worsening of various diseases. Acanthospermum australe (Loefl.) Kuntze ( A. australe ) …
View article: Discovery of anti-inflammatory compounds from the stem bark of Garcinia latissima through in vitro and in silico approaches
Discovery of anti-inflammatory compounds from the stem bark of Garcinia latissima through in vitro and in silico approaches Open
Garcinia latissima Miq. has been traditionally used by local communities in Indonesia for wound healing and to relieve itching. A phytochemical investigation of the stem bark of G. latissima led to the isolation of 12 tocotrienol and trite…
View article: Prunus spinosa L. Branches as a New Source of Condensed Tannins: Phytochemical Profile and Antioxidant, Cytotoxic and Genotoxic In Vitro Evaluation
Prunus spinosa L. Branches as a New Source of Condensed Tannins: Phytochemical Profile and Antioxidant, Cytotoxic and Genotoxic In Vitro Evaluation Open
(1) Background: Prunus spinosa L. is known for its polyphenolic profile, including condensed tannins, compounds associated with various biological activities, including antiproliferative effects. Its woody biomass, such as branches, remain…
View article: NanoBRET Tracer Development for Class I Bromodomain Target Engagement in Live Cells
NanoBRET Tracer Development for Class I Bromodomain Target Engagement in Live Cells Open
Epigenetic reader proteins, such as bromodomains, are often associated with diseases such as cancer and inflammation. BET bromodomain inhibitors have been studied extensively; however, non-BET bromodomains are understudied. Moreover, avail…
View article: Improved in vitro propagation of jackfruit (Artocarpus heterophyllus) using uninodal segments: A multi-use plant in Comoros
Improved in vitro propagation of jackfruit (Artocarpus heterophyllus) using uninodal segments: A multi-use plant in Comoros Open
View article: Strategies to Screen and Evaluate Brain Targeting Antibodies Using an iPSC-Derived Blood–Brain Barrier Model
Strategies to Screen and Evaluate Brain Targeting Antibodies Using an iPSC-Derived Blood–Brain Barrier Model Open
Background: Antibodies that cross the blood–brain barrier (BBB) by targeting receptor-mediated transport (RMT) systems can allow efficient drug delivery to the central nervous system (CNS). In order to improve brain uptake of antibodies, t…
View article: Enhanced therapeutics of cabazitaxel via polycarboxylate conjugation: improved solubility, safety, and antitumor efficacy
Enhanced therapeutics of cabazitaxel via polycarboxylate conjugation: improved solubility, safety, and antitumor efficacy Open
Introduction Cabazitaxel (CTX) is a potent anticancer agent whose clinical utility is severely limited by poor aqueous solubility and severe systemic toxicity. To overcome these challenges, we designed and synthesized two water-soluble pol…
View article: Supplementary Materials and Methods from Design and Preclinical Evaluation of a Novel B7-H4–Directed Antibody–Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305
Supplementary Materials and Methods from Design and Preclinical Evaluation of a Novel B7-H4–Directed Antibody–Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305 Open
Surface plasmon resonance; In vitro cytotoxicity assays; In vitro proliferation assays; Internalization assays; Subcellular localization microscopy; Immunoblotting; Statistical analysis
View article: Phytochemical Screening by HRLC–MS/MS (Q-TOF) and Antioxidant and Anti-Inflammatory Properties of Thottea sivarajanii Leaf Extract
Phytochemical Screening by HRLC–MS/MS (Q-TOF) and Antioxidant and Anti-Inflammatory Properties of Thottea sivarajanii Leaf Extract Open
Background: Numerous degenerative diseases are brought on by inflammation and oxidative stress. Metabolites from plants contain anti-inflammatory and antioxidant properties. Indigenous and understudied, Thottea sivarajanii is a significant…
View article: Untargeted Metabolomics Profiling of Ethanolic Extract of Garcinia microphylla Merr. Stem Bark and Evaluation of Antioxidant and Anti- Inflammatory Activities
Untargeted Metabolomics Profiling of Ethanolic Extract of Garcinia microphylla Merr. Stem Bark and Evaluation of Antioxidant and Anti- Inflammatory Activities Open
Garcinia microphylla Merr. is a species within the Garcinia genus that has not been studied yet. This study was conducted to determine the metabolite profile via LC-HRMS in the ethanolic extract of G. microphylla , as well as to analyse To…
View article: Exploring the Role of Onion Derived Polyphenols in Bone Health: A Systematic Review of In Vitro to Human Studies
Exploring the Role of Onion Derived Polyphenols in Bone Health: A Systematic Review of In Vitro to Human Studies Open
Background: We evaluated certain factors relative to onion (Allium spp.) and onion-derived polyphenols. Methods: We searched PubMed, Scopus, and Google Scholar from 2010 to 20 October 2025 without language limits. Eligible designs comprise…
View article: Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively
Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively Open
Background/Objectives: Metabolic enzymes are crucial for the detoxification of exogenously administered drugs, especially enzymes expressed in the intestine and the liver. Recent advancements in analytical methodologies enable sensitive an…