Endocannabinoid system
View article: Deep genetic sequencing analyses of the mTOR and endocannabinoid signaling pathways in patients with focal cortical dysplasia identify an unprecedented CNR1 truncating variant
Deep genetic sequencing analyses of the mTOR and endocannabinoid signaling pathways in patients with focal cortical dysplasia identify an unprecedented CNR1 truncating variant Open
View article: Deep genetic sequencing analyses of the mTOR and endocannabinoid signaling pathways in patients with focal cortical dysplasia identify an unprecedented CNR1 truncating variant
Deep genetic sequencing analyses of the mTOR and endocannabinoid signaling pathways in patients with focal cortical dysplasia identify an unprecedented CNR1 truncating variant Open
View article: Deep genetic sequencing analyses of the mTOR and endocannabinoid signaling pathways in patients with focal cortical dysplasia identify an unprecedented CNR1 truncating variant2
Deep genetic sequencing analyses of the mTOR and endocannabinoid signaling pathways in patients with focal cortical dysplasia identify an unprecedented CNR1 truncating variant2 Open
View article: Deep genetic sequencing analyses of the mTOR and endocannabinoid signaling pathways in patients with focal cortical dysplasia identify an unprecedented CNR1 truncating variant2
Deep genetic sequencing analyses of the mTOR and endocannabinoid signaling pathways in patients with focal cortical dysplasia identify an unprecedented CNR1 truncating variant2 Open
View article: THERAPEUTIC POTENTIAL AND PHARMACOLOGICAL INSIGHTS OF CBD GUMMIES: A COMPREHENSIVE REVIEW
THERAPEUTIC POTENTIAL AND PHARMACOLOGICAL INSIGHTS OF CBD GUMMIES: A COMPREHENSIVE REVIEW Open
Cannabidiol (CBD), a non-psychoactive constituent of Cannabis sativa, has gained remarkable scientific and therapeutic attention in recent years. Among its various formulations, CBD gummies have emerged as a popular oral dosage form due to…
View article: CB1 receptor activation and inhibition differentially modulate cognitive deficits and neuropathology in 3xTg-AD mice
CB1 receptor activation and inhibition differentially modulate cognitive deficits and neuropathology in 3xTg-AD mice Open
View article: Lipid Metabolism–Signaling Crosstalk in Metabolic Disease and Aging: Mechanisms and Therapeutic Targets
Lipid Metabolism–Signaling Crosstalk in Metabolic Disease and Aging: Mechanisms and Therapeutic Targets Open
Lipid metabolism and lipid-derived signaling together ensure cellular and systemic homeostasis. Their dysregulation causes obesity, type 2 diabetes, cardiovascular disease, NAFLD/MASH, and neurodegeneration throughout life. This review int…
View article: <scp> S1P <sub>3</sub> </scp> Receptor Mediates the Proinflammatory Effect of the Endocannabinoid 2‐Arachidonoylglycerol in Endometriotic Epithelial Cells
<span> S1P <sub>3</sub> </span> Receptor Mediates the Proinflammatory Effect of the Endocannabinoid 2‐Arachidonoylglycerol in Endometriotic Epithelial Cells Open
Endometriosis is a chronic inflammatory disease characterized by the ectopic implantation of endometrium outside the uterus associated with pelvic pain and infertility. The molecular mechanisms involved in the pathogenesis of endometriosis…
View article: Comparative Analysis of Cannabidiol and Risperidone on Behavioral and Neurochemical Outcomes, and Neurodevelopment Markers in a Zebrafish Model of Embryonic Exposure to Sodium Valproate
Comparative Analysis of Cannabidiol and Risperidone on Behavioral and Neurochemical Outcomes, and Neurodevelopment Markers in a Zebrafish Model of Embryonic Exposure to Sodium Valproate Open
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication deficits, repetitive behaviors, and sensory abnormalities. Sodium valproate (VPA) exposure during embryonic development is a well‐establ…
View article: Endocannabinoids Block Headache and Anxiety Comorbidity via Two-pronged Anterior Insular Projections
Endocannabinoids Block Headache and Anxiety Comorbidity via Two-pronged Anterior Insular Projections Open
View article: Stress-Buffer-Hypothesis: blood endocannabinoids in healthy males under standardized psychosocial stress induction and resting condition
Stress-Buffer-Hypothesis: blood endocannabinoids in healthy males under standardized psychosocial stress induction and resting condition Open
The present study investigates the concentrations of the endocannabinoids under standardized psychosocial stress induction (TSST) and a resting condition in healthy males. Hereby, all endocannabinoids were analyzed under a standardized lab…
View article: Unveiling Hidden Microbial Metabolites for Polypharmacology in Obesity Therapeutics - GLP-1 Updated
Unveiling Hidden Microbial Metabolites for Polypharmacology in Obesity Therapeutics - GLP-1 Updated Open
Industrial-Scale Microbiome Mining (ISMM) reveals low-abundance microbial small molecules that appear to coordinate multiple human appetite and energy-balance nodes within a single, orally oriented scaffold—raising satiety and energy expen…
View article: Anandamide-Induced Neuroprotection of Cortical Neurons Relies on Metabolic/Redox Regulation and Mitochondrial Dynamics
Anandamide-Induced Neuroprotection of Cortical Neurons Relies on Metabolic/Redox Regulation and Mitochondrial Dynamics Open
Mitochondrial disruption is a key mechanism in the etiology of neurodegenerative diseases. Promoting mitochondrial dynamics and renewal of the mitochondrial network can restore its function and sustain neuronal viability. Although a growin…
View article: CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer
CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer Open
Cytochrome P450 (CYP) 4X1 and soluble epoxide hydrolase (sEH), the key enzymes responsible for endocannabinoid oxidative metabolism, have been implicated in inflammation and cancer. However, the precise role of CYP4X1 and sEH in tumor immu…
View article: Inhibition of fatty acid binding protein 5 prevents stress-induced anxiogenic and depressive-like symptoms through modulation of hippocampal neurogenesis, cannabinoid and neurotrophic signaling in the limbic circuitry
Inhibition of fatty acid binding protein 5 prevents stress-induced anxiogenic and depressive-like symptoms through modulation of hippocampal neurogenesis, cannabinoid and neurotrophic signaling in the limbic circuitry Open
The endocannabinoid (eCB) system modulates many biological processes, including adult neurogenesis, emotional behaviour and stress-related signaling pathways. Intrinsic levels of eCB ligands, such as anandamide, are regulated in part, by f…
View article: Insights into cannabinoid receptor 2 (CB2) anterograde trafficking and pharmacological chaperoning
Insights into cannabinoid receptor 2 (CB2) anterograde trafficking and pharmacological chaperoning Open
Cannabinoid Receptor 2 (CB 2 ) is a promising therapeutic target for modulating inflammation. Canonical signalling responses to receptor ligands are critically dependent on cell surface receptor expression. However, it is also now apprecia…
View article: Cannabis-enriched oral <i>Actinomyces</i> induces anxiety-like behavior via impairing mitochondria and GABA signaling
Cannabis-enriched oral <i>Actinomyces</i> induces anxiety-like behavior via impairing mitochondria and GABA signaling Open
The human oral microbiome is increasingly recognized as a contributor to brain health, yet its mechanisms remain unclear. Our previous work revealed that oral Actinomyces species was enriched in chronic cannabis smokers. Here, we show oral…
View article: Effect of Central Injection of Anandamide on LPS-Dependent Suppression of GnRH/LH Secretion in Ewes During the Follicular Phase of the Estrous Cycle
Effect of Central Injection of Anandamide on LPS-Dependent Suppression of GnRH/LH Secretion in Ewes During the Follicular Phase of the Estrous Cycle Open
The study investigated the effects of intracerebroventricular (ICV) administration of the endocannabinoid anandamide (AEA) on suppression of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) secretion during lipopolysaccharide…
View article: Cannabidiol inhibits TGF-β1-induced epithelial-mesenchymal transition in human conjunctival epithelial cells by interrupting TGF-β/Smad signaling
Cannabidiol inhibits TGF-β1-induced epithelial-mesenchymal transition in human conjunctival epithelial cells by interrupting TGF-β/Smad signaling Open
Epithelial-mesenchymal transition (EMT) plays a significant role in conjunctival fibrosis-related pathologies and has emerged as a promising therapeutic target for managing conjunctival fibrosis. Cannabidiol (CBD), a predominant non-psycho…
View article: Activity of protein kinase C controls the efficacy of cannabinoid receptor type 1 in the medial prefrontal cortex after neuropathic pain
Activity of protein kinase C controls the efficacy of cannabinoid receptor type 1 in the medial prefrontal cortex after neuropathic pain Open
Many patients with chronic pain conditions suffer from depression. In our previous report, we found that afferent noxious inputs after painful nerve injury compromise activity-dependent endocannabinoid (eCB) signaling in the medial prefron…
View article: Adaptive Serum Biochemistry Responses to Ethanol Administration in a Mouse Model: Implications for Metabolic Regulation Under Analgesia
Adaptive Serum Biochemistry Responses to Ethanol Administration in a Mouse Model: Implications for Metabolic Regulation Under Analgesia Open
Analgesia, or reduced pain sensitivity, can result from pharmacological or stress-induced mechanisms, but human studies are limited by complex physiological and psychological variables. This study aimed to evaluate the impact of ethanol co…
View article: Fluoxetine modulates both endocannabinoid and lysophosphatidic acid pathways in a region-specific Manner during alcohol withdrawal in male rats
Fluoxetine modulates both endocannabinoid and lysophosphatidic acid pathways in a region-specific Manner during alcohol withdrawal in male rats Open
Anxiety is a major symptom associated with alcohol withdrawal and a major factor increasing the risk of relapse. Although fluoxetine, a selective serotonin reuptake inhibitor, is used to alleviate these symptoms, its effects on brain lipid…
View article: Adipogenicity-induced human mesenchymal stem cells treated with hemp seed oil stimulate brown-like adipocytes and decrease adipokine levels through the activation of cannabinoid receptor 2 (CB2)
Adipogenicity-induced human mesenchymal stem cells treated with hemp seed oil stimulate brown-like adipocytes and decrease adipokine levels through the activation of cannabinoid receptor 2 (CB2) Open
The endocannabinoid system (ECS) is essential for energy hemostasis, obesity, and other metabolic disorders. Cannabidiol and polyunsaturated fatty acids (PUFAs), which are found in hemp seed oil (HSO), have been found to regulate adipose t…
View article: Computational GWAS Meta Meta Analysis Revealing Cross Talk Between Cannabis CNR1 and DRD2 Receptors Optimizing Long-Term Outcomes for Cannabis Use Disorder (CUD) By Enhancing Dopamine Homeostasis Promoting High-Quality Cannabis Medicinals
Computational GWAS Meta Meta Analysis Revealing Cross Talk Between Cannabis CNR1 and DRD2 Receptors Optimizing Long-Term Outcomes for Cannabis Use Disorder (CUD) By Enhancing Dopamine Homeostasis Promoting High-Quality Cannabis Medicinals Open
This paper presents a shared perspective from scientists and clinicians seeking to harness the therapeutic potential of cannabis while addressing Cannabis Use Disorder (CUD) through reproducible scientific findings. Acute cannabis use may …
View article: COVID-19 is Associated with a Lipid Storm that Worsens in Cases of Severe Pneumonia
COVID-19 is Associated with a Lipid Storm that Worsens in Cases of Severe Pneumonia Open
Severe Coronavirus disease 2019 (COVID-19) is associated with abnormal innate and adaptive immune responses, as well as systemic alterations, including a shift in lipid network. A case–control study was conducted to describe the systemic l…
View article: The Endocannabinoid System in Human Disease: Molecular Signaling, Receptor Pharmacology, and Therapeutic Innovation
The Endocannabinoid System in Human Disease: Molecular Signaling, Receptor Pharmacology, and Therapeutic Innovation Open
The endocannabinoid system (ECS) is a primary regulatory system in human physiology that serves to help maintain homeostasis throughout the nervous system, immune system, and gastrointestinal system. This review has the goal of evaluating …
View article: Brain Science, Bliss, and the Endocannabinoid System
Brain Science, Bliss, and the Endocannabinoid System Open
View article: Perinatal Ethanol Exposure Induces Astrogliosis and Decreases GRP55/PEA-Mediated Neuroprotection in Hippocampal Astrocytes of the 3×Tg Alzheimer’s Animal Model
Perinatal Ethanol Exposure Induces Astrogliosis and Decreases GRP55/PEA-Mediated Neuroprotection in Hippocampal Astrocytes of the 3×Tg Alzheimer’s Animal Model Open
Prenatal ethanol exposure (PEE) alters fetal brain development, potentially increasing the risk of neurodegenerative diseases such as Alzheimer’s disease (AD) later in life. Although glial activation is implicated in AD pathology via canna…
View article: Combination of CBD with minor cannabinoid CBDV suppresses CXCR4 via CB2 receptor and alleviates colitis in mice
Combination of CBD with minor cannabinoid CBDV suppresses CXCR4 via CB2 receptor and alleviates colitis in mice Open
Cannabis extracts, particularly those rich in cannabinoids like cannabidiol (CBD), have shown potential anti-inflammatory properties and are being examined in managing conditions involving inflammation. One proposed mechanism is their modu…
View article: Development and Validation of a Cannabinoid Quantification Method in Oil and Marijuana by UHPLC-MS
Development and Validation of a Cannabinoid Quantification Method in Oil and Marijuana by UHPLC-MS Open