Fatty acid synthase
View article: Optimal Dietary α-Starch Requirement and Its Effects on Growth and Metabolic Regulation in Chinese Hook Snout Carp (Opsariichthys bidens)
Optimal Dietary α-Starch Requirement and Its Effects on Growth and Metabolic Regulation in Chinese Hook Snout Carp (Opsariichthys bidens) Open
This study investigated the effects of dietary carbohydrate levels on growth performance, body composition, and hepatic expression of metabolic genes in Chinese hook snout carp (Opsariichthys bidens). Fish were fed five isonitrogenous diet…
View article: Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling
Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling Open
Conjugated linoleic acid (CLA) isomers exhibit distinct biological activities in lipid metabolism, yet their roles in regulating mammary lipogenesis remain poorly understood. Understanding how individual CLA isomers influence lipid synthes…
View article: Effect of Ningxiang pig-derived Lactobacillus reuteri supplementation on the growth performance, lipid metabolism, and gut microbiota of finishing pigs
Effect of Ningxiang pig-derived Lactobacillus reuteri supplementation on the growth performance, lipid metabolism, and gut microbiota of finishing pigs Open
Background While the pivotal role of the gut microbiota in lipid metabolism has been well established, the specific contributions of bacterial strains isolated from native Chinese pig breeds to lipid metabolic regulation remain largely uni…
View article: Arabidopsis root lipid droplets are hubs for membrane homeostasis under heat stress, and triterpenoid synthesis and storage
Arabidopsis root lipid droplets are hubs for membrane homeostasis under heat stress, and triterpenoid synthesis and storage Open
Summary Plant lipid droplets (LDs) and their associated proteins have numerous subcellular and physiological functions. While considerable progress has been made for LDs in many tissues, the function and composition of LDs in roots remain …
View article: hnRNP A1 inhibits colorectal cancer tumorigenesis and progression by regulating fatty acid metabolism and RNA stability
hnRNP A1 inhibits colorectal cancer tumorigenesis and progression by regulating fatty acid metabolism and RNA stability Open
Increasing evidence indicates that RNA-binding proteins and the reprogramming of lipid metabolism play crucial roles in tumorigenesis. However, the extent to which members of these families contribute, and whether targeting metabolic genes…
View article: The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Open
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is now recognized as the leading cause of chronic liver disease worldwide. MASLD spans a spectrum ranging from…
View article: Effects of dietary protein levels on lipid metabolism and intestinal health of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ Epinephelus lanceolatus) fed high-lipid diets
Effects of dietary protein levels on lipid metabolism and intestinal health of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ Epinephelus lanceolatus) fed high-lipid diets Open
View article: Dietary chenodeoxycholic acid alleviates cottonseed oil-induced hepatic lipid deposition and inflammation in juvenile black seabream (Acanthopagrus schlegelii)
Dietary chenodeoxycholic acid alleviates cottonseed oil-induced hepatic lipid deposition and inflammation in juvenile black seabream (Acanthopagrus schlegelii) Open
The present work conducted an eight-week feeding trail for exploring the dietary chenodeoxycholic acid (CA) affected lipid deposition and inflammation induced by cottonseed oil (CO) within juvenile black seabream (Acanthopagrus schlegelii)…
View article: Serum fatty acid synthase and GLP-1 levels in prostate cancer and benign prostatic hyperplasia
Serum fatty acid synthase and GLP-1 levels in prostate cancer and benign prostatic hyperplasia Open
Objectives This study aimed to investigate the differences in serum fatty acid synthase (FASN) and glucagon-like peptide-1 (GLP-1) levels among patients diagnosed with prostate cancer, benign prostatic hyperplasia (BPH), and healthy contro…
View article: 3-Acetyl-11-Keto-Beta-Boswellic Acid Inhibits Adipogenesis by Suppressing Autophagy and Inducing AMPK Phosphorylation in 3T3-L1 Cells
3-Acetyl-11-Keto-Beta-Boswellic Acid Inhibits Adipogenesis by Suppressing Autophagy and Inducing AMPK Phosphorylation in 3T3-L1 Cells Open
Background/Aims: Adipogenesis, a process involving preadipocyte differentiation and lipid droplet accumulation, is linked to obesity. 3-Acetyl-11-keto-beta-boswellic acid (AKBA), a frankincense-derived triterpene, has anti-inflammatory and…
View article: Design of a Multienzyme Derived from Mouse Fatty Acid Synthase for the Compartmentalized Production of 2‐Pyrone Polyketides
Design of a Multienzyme Derived from Mouse Fatty Acid Synthase for the Compartmentalized Production of 2‐Pyrone Polyketides Open
Compartmentalizing biosynthetic pathways is a key objective in protein engineering, particularly in synthetic biology and metabolic engineering. It can improve catalytic efficiency, stabilize reactive intermediates, reduce by‐product forma…
View article: Switching Metazoan Fatty Acid Synthase Between Reducing and Non-reducing Elongation Mode via Programming of the Ketoreductase Domain
Switching Metazoan Fatty Acid Synthase Between Reducing and Non-reducing Elongation Mode via Programming of the Ketoreductase Domain Open
Polyketides constitute a large class of natural products with important biological activities and applications such as antibiotics, antitumor agents, pesticides, and pigments. Their biosynthesis is catalyzed by polyketide synthases (PKSs) …
View article: Chitosan-Mediated Expression of Caenorhabditis elegans fat-1 and fat-2 in Sparus aurata: Short-Term Effects on the Hepatic Fatty Acid Profile, Intermediary Metabolism, and Proinflammatory Factors
Chitosan-Mediated Expression of Caenorhabditis elegans fat-1 and fat-2 in Sparus aurata: Short-Term Effects on the Hepatic Fatty Acid Profile, Intermediary Metabolism, and Proinflammatory Factors Open
A single dose of chitosan-tripolyphosphate (TPP) nanoparticles carrying expression plasmids for fish codon-optimized Caenorhabditis elegans fat-1 and fat-2 was intraperitoneally administered to gilthead seabream (Sparus aurata) to stimulat…
View article: Novel therapeutic strategies for targeting fatty acid oxidation in cancer
Novel therapeutic strategies for targeting fatty acid oxidation in cancer Open
Metabolic rewiring is a defining feature of malignant cells, enabling them to dynamically exploit nutrient resources to meet bioenergetic problems at different growth stages. Beyond the classical Warburg effect, recent studies have shown t…
View article: CircSETD2 impairs hepatic lipid homeostasis in metabolic dysfunction-associated fatty liver disease by binding CPS1
CircSETD2 impairs hepatic lipid homeostasis in metabolic dysfunction-associated fatty liver disease by binding CPS1 Open
Dysregulation of hepatic lipid homeostasis constitutes a core pathogenic mechanism in metabolic dysfunction-associated fatty liver disease (MAFLD); however, the regulatory role of circular RNAs (circRNAs) in this process remains unclear. I…
View article: Bidirectional regulation of lipid metabolism and the tumor microenvironment: new perspectives from mechanism to therapy
Bidirectional regulation of lipid metabolism and the tumor microenvironment: new perspectives from mechanism to therapy Open
The role of lipid metabolism in cancer and immune regulation has received significant attention in recent years. Reprogramming of lipid metabolism is one of the key hallmarks of cancer and plays a critical role in cancer progression by sup…
View article: Bridging the gaps: advanced techniques to unlock lipid function in plant reproductive development
Bridging the gaps: advanced techniques to unlock lipid function in plant reproductive development Open
View article: Targeting bone marrow adipocyte-driven fatty acid metabolism to overcome drug resistance in lung cancer bone metastasis
Targeting bone marrow adipocyte-driven fatty acid metabolism to overcome drug resistance in lung cancer bone metastasis Open
Lung cancer remains a leading cause of cancer-related mortality worldwide, with bone metastasis presenting a significant challenge due to its association with severe skeletal complications and therapy resistance. This study investigates th…
View article: circRNA-02213 Regulates Milk Fat Synthesis in Bovine Mammary Epithelial Cells via ACSS2
circRNA-02213 Regulates Milk Fat Synthesis in Bovine Mammary Epithelial Cells via ACSS2 Open
Background: In the bovine mammary gland, de novo fatty acid synthesis is a critical process for milk fat production, in which acetyl-CoA synthetase 2 (ACSS2) serves as a key enzyme by converting acetate into acetyl-CoA. This metabolic path…
View article: Application of Single-Cell RNA Sequencing Technology: Advancing Targeted Fatty Acids for Antitumor Therapy
Application of Single-Cell RNA Sequencing Technology: Advancing Targeted Fatty Acids for Antitumor Therapy Open
The occurrence and progression of tumors are closely linked to the abnormal metabolic mechanism of fatty acids. In tumor cells, fatty acids are highly expressed and provide molecular structural substances for cells, thereby sustaining tumo…
View article: Assessment of intestinal free fatty acid binding protein 4 (FABP4) in alopecia areata patients (Role of intestinal free fatty acid binding protein 4 in dermatological diseases)
Assessment of intestinal free fatty acid binding protein 4 (FABP4) in alopecia areata patients (Role of intestinal free fatty acid binding protein 4 in dermatological diseases) Open
View article: TMET-60. Dual Pathway Inhibition Triggers Glioblastoma Metabolic Collapse
TMET-60. Dual Pathway Inhibition Triggers Glioblastoma Metabolic Collapse Open
Glioblastoma is an aggressive brain cancer with poor prognosis. Recent evidence implicates metabolic reprogramming, including the hexosamine biosynthetic pathway (HBP) and pentose phosphate pathway (PPP), as critical for tumor survival, th…
View article: TMIC-62. Astrocyte-expressed FASN as a novel candidate drug target for glioblastoma
TMIC-62. Astrocyte-expressed FASN as a novel candidate drug target for glioblastoma Open
BACKGROUND Glioblastoma (GBM) is an aggressive cancer requiring deeper understanding and new therapeutic approaches. The tumoral microenvironment guide cancer cell progression. Our previous studies demonstrated that astrocytes (ACs) enhanc…
View article: Expression of PPAR-alpha and gamma in breast cancer patients and their relationship with the expression of FASN, ACSL4, and ACLY genes
Expression of PPAR-alpha and gamma in breast cancer patients and their relationship with the expression of FASN, ACSL4, and ACLY genes Open
Background and purpose: Peroxisome proliferator-activated receptors alpha and gamma (PPAR-α and PPAR-γ) are nuclear receptor proteins that play a crucial role in the regulation of cellular differentiation, development, metabolism, and tumo…
View article: HSD17β11 regulates PLIN5-ATGL mediated lipolysis, but not hepatic lipid metabolism in mice
HSD17β11 regulates PLIN5-ATGL mediated lipolysis, but not hepatic lipid metabolism in mice Open
Hydroxysteroid 17β dehydrogenase 11 (HSD17β11) is a member of the 17β-HSD family with canonical roles in steroid metabolism. Given its predominant localisation on lipid droplets, we investigated HSD17β11's role in lipid metabolism. In pati…
View article: Phosphatidylcholine regulation via sphingosine kinase 2 inhibition drives immunogenic reprogramming of myeloid-derived suppressor cells 3701
Phosphatidylcholine regulation via sphingosine kinase 2 inhibition drives immunogenic reprogramming of myeloid-derived suppressor cells 3701 Open
Description Immunosuppressive myeloid populations, like myeloid-derived suppressor cells (MDSCs), within the tumor microenvironment (TME), hinder cancer immunotherapy. Targeting this suppression is vital to enhance anti-tumor T cell functi…
View article: Characterization of Triacylglycerol Dynamics and Lipid Metabolism in the Beetle <i>Tribolium castaneum</i>
Characterization of Triacylglycerol Dynamics and Lipid Metabolism in the Beetle <i>Tribolium castaneum</i> Open
Lipids are essential for all organisms, and insects can obtain these macromolecules from their diet or synthesize them from carbohydrates and amino acids. These animals store fatty acids in the form of triacylglycerol in lipid droplets in …
View article: The impact of a fatty acid synthase gene in regulating a complex multifunctional trait essential for survival and sexual communication
The impact of a fatty acid synthase gene in regulating a complex multifunctional trait essential for survival and sexual communication Open
The genetic basis of multi-functional traits shaped by both natural and sexual selection remains poorly understood. In insects, cuticular hydrocarbons (CHCs) are an excellent example of such traits, providing protection against different m…
View article: Wnt Signalling‐Activated <scp>EN2</scp> Promotes the Progression of Glioblastoma by Upregulating Fatty Acid Synthesis Metabolism
Wnt Signalling‐Activated <span>EN2</span> Promotes the Progression of Glioblastoma by Upregulating Fatty Acid Synthesis Metabolism Open
Glioblastoma (GBM) is the most aggressive primary brain tumour, with limited treatment options and a propensity for rapid development of resistance to therapies. Previous studies have indicated that fatty acid metabolic reprogramming is a …
View article: Inhibitory effects of the flavonoids extracted from Pollen Typhae on palmitic acid-induced NLRP3 inflammasome activation in macrophages involving AMPK-mediated lipid metabolism
Inhibitory effects of the flavonoids extracted from Pollen Typhae on palmitic acid-induced NLRP3 inflammasome activation in macrophages involving AMPK-mediated lipid metabolism Open
The findings highlight the ability of PTF and its active component TYP to inhibit PA-induced NLRP3 inflammasome activation in macrophages involving AMPK-mediated lipid metabolism, implying the potential use of PT flavonoid compounds as ant…