Genetically modified organism
View article: Food Sovereignty vs Food Security: A Rights-based Evaluation Of GMOs in Uganda
Food Sovereignty vs Food Security: A Rights-based Evaluation Of GMOs in Uganda Open
Uganda continues to grapple with food insecurity while navigating the global debate on genetically modified organisms (GMOs). This article evaluates GMOs through a rights-based framework, focusing on the right to adequate food. It argues t…
View article: Food Sovereignty vs Food Security: A Rights-based Evaluation Of GMOs in Uganda
Food Sovereignty vs Food Security: A Rights-based Evaluation Of GMOs in Uganda Open
Uganda continues to grapple with food insecurity while navigating the global debate on genetically modified organisms (GMOs). This article evaluates GMOs through a rights-based framework, focusing on the right to adequate food. It argues t…
View article: Bench to Bedside: Development of a cGMP Process for ORFV Viral Vector Based Vaccines
Bench to Bedside: Development of a cGMP Process for ORFV Viral Vector Based Vaccines Open
The Orf virus (ORFV) has emerged as a promising platform for developing viral vector vaccines and immunotherapeutic approaches, owing to its high transgene capacity, potent immunomodulatory properties, the option for repeated booster vacci…
View article: Editing the kinesin-12 gene affects responses to Bt toxin Cry1Ac in Helicoverpa zea
Editing the kinesin-12 gene affects responses to Bt toxin Cry1Ac in Helicoverpa zea Open
Crops genetically engineered to produce insecticidal proteins from Bacillus thuringiensis (Bt) are used globally to manage key insect pests. However, the evolution of resistance to Bt proteins in at least 11 pest species has reduced the ef…
View article: Genetically encoded biosensor of apoptosis and necrosis reveals the dynamics and biphasic cytotoxicity by Anti-EGFR CAR-T cells
Genetically encoded biosensor of apoptosis and necrosis reveals the dynamics and biphasic cytotoxicity by Anti-EGFR CAR-T cells Open
This study presents the development and validation of a dual genetically encoded fluorescence biosensor system capable of distinguishing apoptosis and necrosis in live cells with high spatial and temporal resolution. The system integrates …
View article: Retraction Note: Genetically modified macrophages accomplish targeted gene delivery to the inflamed brain in transgenic Parkin Q311X(A) mice: importance of administration routes
Retraction Note: Genetically modified macrophages accomplish targeted gene delivery to the inflamed brain in transgenic Parkin Q311X(A) mice: importance of administration routes Open
View article: Wireless in-body sensing through genetically engineered bacteria
Wireless in-body sensing through genetically engineered bacteria Open
This paper introduces a class of wireless implantable sensors that integrate genetically engineered cells capable of detecting specific molecules for continuous monitoring. While synthetic biology enables cells to sense molecular targets, …
View article: Genetically encoded biosensor of apoptosis and necrosis reveals the dynamics and biphasic cytotoxicity by Anti-EGFR CAR-T cells
Genetically encoded biosensor of apoptosis and necrosis reveals the dynamics and biphasic cytotoxicity by Anti-EGFR CAR-T cells Open
This study presents the development and validation of a dual genetically encoded fluorescence biosensor system capable of distinguishing apoptosis and necrosis in live cells with high spatial and temporal resolution. The system integrates …
View article: A Novel Laboratory Protocol for Pollen Viability Assessment to Inform Biosafety Evaluation of Transgenic Rice (Oryza sativa L.)
A Novel Laboratory Protocol for Pollen Viability Assessment to Inform Biosafety Evaluation of Transgenic Rice (Oryza sativa L.) Open
Rice (Oryza sativa L.) is a vital staple crop, and the environmental risk assessment of transgenic varieties is crucial for formulating biosafety policies. Rice pollen grains are spherical, with an average diameter of 40.03 ± 2.75 μm. This…
View article: The genetically encoded biosensor HyPer7 enables in-line monitoring of H2O2 accumulation dynamics in the methylotrophic yeast <i>Komagataella phaffii</i>
The genetically encoded biosensor HyPer7 enables in-line monitoring of H2O2 accumulation dynamics in the methylotrophic yeast <i>Komagataella phaffii</i> Open
In methylotrophic yeasts such as Komagataella phaffii (syn Pichia pastoris), the initial step of methanol utilization (MUT) by alcohol oxidase (Aox) generates H2O2 as a potentially toxic byproduct. Introduction of the ratiometric, genetica…
View article: Probiotic-based oral vaccine mucosal delivery system enabling genetically encoded dual-antigen arrays
Probiotic-based oral vaccine mucosal delivery system enabling genetically encoded dual-antigen arrays Open
View article: Effects of Transgenic Maize DBN9936 (Cry1Ab+EPSPS) and Maize Borer Feeding on Non-Target Organism Euborellia annulipes Lucas (Dermaptera: Anisolabididae)
Effects of Transgenic Maize DBN9936 (Cry1Ab+EPSPS) and Maize Borer Feeding on Non-Target Organism Euborellia annulipes Lucas (Dermaptera: Anisolabididae) Open
The impacts of transgenic maize on non-target organisms serve as a crucial parameter for evaluating the environmental safety of transgenic maize. In the present study, feeding experiments were carried out on Euborellia annulipes Lucas (Der…
View article: The LAST mile: Evaluating genetic biocontrol as a supplemental tool for eradicating invasive rodents on islands
The LAST mile: Evaluating genetic biocontrol as a supplemental tool for eradicating invasive rodents on islands Open
Invasive rodents cause severe ecosystem degradation on islands and can be challenging to eradicate. Current best-practices rely heavily on the application of toxic oral baits and have led to successful eradications and remarkable recoverie…
View article: Generating CAR γδ T Cells for Effective Targeting of B Lymphomas
Generating CAR γδ T Cells for Effective Targeting of B Lymphomas Open
Chimeric antigen receptor (CAR) T-cell therapy has attracted growing interest in the treatment of various malignancies and represents the most advanced technology to date. This approach involves the use of genetically engineered immune cel…
View article: Retrieving sequences of genetically modified plants from public databases to widen screening approaches
Retrieving sequences of genetically modified plants from public databases to widen screening approaches Open
The development of effective screening methods and implementation of official controls on genetically modified organisms (GMOs) relies heavily on the availability of comprehensive and reliable GMO sequence repositories. Existing GMO databa…
View article: Novel floxed cannabinoid receptor 2 mouse line combines knockout capability with dual fluorescent reporters
Novel floxed cannabinoid receptor 2 mouse line combines knockout capability with dual fluorescent reporters Open
Background The cannabinoid receptor 2 (CB 2 ) is involved in regulating immune responses, yet its specific function in microglia remains poorly defined. This study aimed to generate and validate a microglia-specific, inducible CB 2 knockou…
View article: Biopharming: Transforming Plant System for Pharmaceutical Protein Production
Biopharming: Transforming Plant System for Pharmaceutical Protein Production Open
Biopharming is a novel biotechnological process that involves genetically altering plants to function as natural factories for the manufacture of medicinal proteins and essential compounds. Mammals, microorganisms (bacteria and yeast…
View article: Biopharming: Transforming Plant System for Pharmaceutical Protein Production
Biopharming: Transforming Plant System for Pharmaceutical Protein Production Open
Biopharming is a novel biotechnological process that involves genetically altering plants to function as natural factories for the manufacture of medicinal proteins and essential compounds. Mammals, microorganisms (bacteria and yeast), ins…
View article: In Vivo engineering of transgenic mice for systemic human neutralizing antibody production against staphylococcal enterotoxin B
In Vivo engineering of transgenic mice for systemic human neutralizing antibody production against staphylococcal enterotoxin B Open
Transgenic animal bioreactors provide a complementary strategy to traditional mammalian cell culture systems for the production of therapeutic human monoclonal antibodies (mAbs). Here we present a CRISPR/Cas9-mediated breakthrough in creat…
View article: Efficacy of genetically modified Mycoplasma hyopneumoniae strains and their effect on local and cell-mediated immune responses in pigs.
Efficacy of genetically modified Mycoplasma hyopneumoniae strains and their effect on local and cell-mediated immune responses in pigs. Open
Vaccination against Mycoplasma hyopneumoniae is still carried out worldwide, but unfortunately current commercial vaccines only provide partial protection. Therefore, two M. hyopneumoniae strains were genetically modified by transposon-med…
View article: BIOTECHNOLOGY AS A CATALYST FOR PHYTOREMEDIATION: ENHANCED PLANTS FOR SOIL DECONTAMINATION WITH HEAVY METALS
BIOTECHNOLOGY AS A CATALYST FOR PHYTOREMEDIATION: ENHANCED PLANTS FOR SOIL DECONTAMINATION WITH HEAVY METALS Open
Soil contamination by heavy metals is a critical environmental challenge, demanding effective and sustainable remediation solutions. This integrative review article analyzes how biotechnology has acted as a catalyst for phytoremediation, e…
View article: Beyond Herbicides: Emerging Biotechnology Solutions for Environmentally Safe Weed Management
Beyond Herbicides: Emerging Biotechnology Solutions for Environmentally Safe Weed Management Open
Invasive weeds continue to pose a major threat to global agriculture, causing substantial yield losses, intensifying production costs, and destabilizing ecosystems. The effectiveness of conventional chemical herbicides is inc…
View article: Efficacy of genetically modified Mycoplasma hyopneumoniae strains and their effect on local and cell-mediated immune responses in pigs
Efficacy of genetically modified Mycoplasma hyopneumoniae strains and their effect on local and cell-mediated immune responses in pigs Open
Vaccination against Mycoplasma hyopneumoniae is still carried out worldwide, but unfortunately current commercial vaccines only provide partial protection. Therefore, two M. hyopneumoniae strains were genetically modified by transposon-med…
View article: Rethinking gene-edited crop regulation: advancing a Principle-based framework for modern biotechnology governance
Rethinking gene-edited crop regulation: advancing a Principle-based framework for modern biotechnology governance Open
Gene editing (GEd) technologies are rapidly transforming agricultural biotechnology; however, their regulatory treatment remains ambiguous under international instruments such as the Cartagena Protocol on Biosafety (CPB), which was origina…
View article: Plant-Based Vaccines: Frontier Biotechnology and World Health
Plant-Based Vaccines: Frontier Biotechnology and World Health Open
Plant-based vaccines use genetically modified plants to produce immunogenic proteins capable of triggering protective immune responses in humans and animals. This poster summarizes current methodologies, evidence from systems such as N…
View article: Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9
Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9 Open
Background The golden Syrian hamster is a valuable animal model for studying carcinogenesis, metabolic disorders, cardiovascular diseases, and viral infections due to its biological and pathological similarities to humans. However, the dev…
View article: A systematic review and meta-analysis of liver xenotransplantation from genetically modified pigs to non-human primates
A systematic review and meta-analysis of liver xenotransplantation from genetically modified pigs to non-human primates Open
Objective: This meta-analysis synthesizes preclinical evidence on the safety and efficacy of genetically modified pigs to non-human primates (NHPs) liver xenotransplantation. Summary Background Data: The outcomes of liver xenotransplantati…
View article: Plant-Based Vaccines: Frontier Biotechnology and World Health
Plant-Based Vaccines: Frontier Biotechnology and World Health Open
Plant-based vaccines use genetically modified plants to produce immunogenic proteins capable of triggering protective immune responses in humans and animals. This poster summarizes current methodologies, evidence from systems such as Nicot…
View article: ON THE NONLINEAR DYNAMICS OF INTERACTING GENETICALLY MODIFIED T CELLS AND TUMOR CELLS
ON THE NONLINEAR DYNAMICS OF INTERACTING GENETICALLY MODIFIED T CELLS AND TUMOR CELLS Open
The genetically modified T cells are developing by transfer certain gene into the T cell of the blood sample collected from the tumor patient able to produce expression of T cell receptor (TCR) that having boosted immune response .This TCR…
View article: ON THE NONLINEAR DYNAMICS OF INTERACTING GENETICALLY MODIFIED T CELLS AND TUMOR CELLS
ON THE NONLINEAR DYNAMICS OF INTERACTING GENETICALLY MODIFIED T CELLS AND TUMOR CELLS Open
The genetically modified T cells are developing by transfer certain gene into the T cell of the blood sample collected from the tumor patient able to produce expression of T cell receptor (TCR) that having boosted immune response .This T…