Interaction network
View article: Network-based insights into miR-30a-5p-mediated regulation and EGCG targeting in triple-negative breast cancer
Network-based insights into miR-30a-5p-mediated regulation and EGCG targeting in triple-negative breast cancer Open
Background Triple-negative breast cancer (TNBC) is defined by the absence of ER, PR, and HER2 expression. This limits the targeted therapies, resulting in poor clinical outcomes. Identifying the molecular targets that can be regulated thro…
View article: Code for "Many weak and few strong links: The importance of link strength distributions for stabilising patterns in competition networks"
Code for "Many weak and few strong links: The importance of link strength distributions for stabilising patterns in competition networks" Open
This repository contains all scripts to reproduce the analysis of the manuscript "Many weak and few strong links: The importance of link strength distributions for stabilising patterns in competition networks" (published in Theoretical Eco…
View article: Code for "Many weak and few strong links: The importance of link strength distributions for stabilising patterns in competition networks"
Code for "Many weak and few strong links: The importance of link strength distributions for stabilising patterns in competition networks" Open
This repository contains all scripts to reproduce the analysis of the manuscript "Many weak and few strong links: The importance of link strength distributions for stabilising patterns in competition networks" (published in Theoretical Eco…
View article: Exploring the Mechanism of Platycladi Cacumen in Intervening Androgenetic Alopecia Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation
Exploring the Mechanism of Platycladi Cacumen in Intervening Androgenetic Alopecia Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation Open
As a traditional hair-growth-promoting herb, Platycladi Cacumen(PC) has a long history of folk application in the field of hair loss improvement. Preliminary modern pharmacological studies have suggested that its active components may exer…
View article: The mechanistic role of gitogenin as a treatment for laryngeal cancer: a network pharmacology and experimental analysis
The mechanistic role of gitogenin as a treatment for laryngeal cancer: a network pharmacology and experimental analysis Open
Objective Laryngeal cancer (LC) is a significant and persistent therapeutic challenge worldwide. Gitogenin (GIT), a naturally occurring saponin, has demonstrated anticancer activity in lung cancer. However, its potential effects on LC rema…
View article: Protein interaction network of hub genes.
Protein interaction network of hub genes. Open
Background The incidence of ulcerative colitis (UC) remains high, with an increasing prevalence among elderly patients. Cellular senescence has been widely recognized as a contributor to UC susceptibility; however, the underlying molecula…
View article: Hub gene validation.
Hub gene validation. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: WGCNA Analysis.
WGCNA Analysis. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: Predictive model building and validation.
Predictive model building and validation. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: qT-PCR amplification primers and their sequences.
qT-PCR amplification primers and their sequences. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: Analysis results of DEGs.
Analysis results of DEGs. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: Results of RT-qPCR validation of key genes.
Results of RT-qPCR validation of key genes. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: R code.
R code. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: Experimental design roadmap.
Experimental design roadmap. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: Functional enrichment analysis results.
Functional enrichment analysis results. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: Identification of genes related to cell death.
Identification of genes related to cell death. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: Immune infiltration analysis results.
Immune infiltration analysis results. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: Hub gene screening results.
Hub gene screening results. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: Molecular docking results.
Molecular docking results. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: Drug prediction results.
Drug prediction results. Open
Background Intestinal ischemia–reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs—including pyroptosis and necroptosis—have emerged as key drivers of tissue damage and inflammation. We sought t…
View article: This Fig presents the MAGNET reconstructed cell-cell interaction network derived from spatial transcriptomic cancer data, highlighting potential roles in the tumor microenvironment.
This Fig presents the MAGNET reconstructed cell-cell interaction network derived from spatial transcriptomic cancer data, highlighting potential roles in the tumor microenvironment. Open
It visualizes ligand–receptor interactions within individual clusters(A), while highlighting functional interactions between different clusters (B), and provides detailed insights into interactions among specific cell clusters at the level…
View article: Reconstruction and analysis of the gene network regulating apoptosis in hepatocellular carcinoma based on scRNA-seq data and the AND-System knowledge base
Reconstruction and analysis of the gene network regulating apoptosis in hepatocellular carcinoma based on scRNA-seq data and the AND-System knowledge base Open
Hepatocellular Carcinoma (HCC) is the most common primary liver cancer characterized by rapid progres sion, high mortality rate and therapy resistance. One of the key areas in studying the molecular mechanisms of HCC development is the an…
View article: Droplet-based single-cell pairing for high-throughput interaction mapping of antigen-receptor combinations
Droplet-based single-cell pairing for high-throughput interaction mapping of antigen-receptor combinations Open
Mapping the interaction potential of different variant combinations of viral antigens and human cell receptors and understanding how viral antigen mutations interact with human genetic polymorphisms are critical for predicting infection su…
View article: Table 1_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.xlsx
Table 1_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.xlsx Open
Introduction With increased drug resistance and tumor heterogeneity accounting for limited therapeutic strategies, gastric cancer remains one of the major causes of cancer-related mortality around the globe. Targeting the components of the…
View article: Data Sheet 1_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.docx
Data Sheet 1_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.docx Open
Introduction With increased drug resistance and tumor heterogeneity accounting for limited therapeutic strategies, gastric cancer remains one of the major causes of cancer-related mortality around the globe. Targeting the components of the…
View article: Data Sheet 2_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.docx
Data Sheet 2_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.docx Open
Introduction With increased drug resistance and tumor heterogeneity accounting for limited therapeutic strategies, gastric cancer remains one of the major causes of cancer-related mortality around the globe. Targeting the components of the…
View article: Table 4_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.xlsx
Table 4_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.xlsx Open
Introduction With increased drug resistance and tumor heterogeneity accounting for limited therapeutic strategies, gastric cancer remains one of the major causes of cancer-related mortality around the globe. Targeting the components of the…
View article: Table 2_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.xlsx
Table 2_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.xlsx Open
Introduction With increased drug resistance and tumor heterogeneity accounting for limited therapeutic strategies, gastric cancer remains one of the major causes of cancer-related mortality around the globe. Targeting the components of the…
View article: Table 5_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.xlsx
Table 5_Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.xlsx Open
Introduction With increased drug resistance and tumor heterogeneity accounting for limited therapeutic strategies, gastric cancer remains one of the major causes of cancer-related mortality around the globe. Targeting the components of the…
View article: STRING interaction network analysis of <i>P. falciparum</i> IPKs.
STRING interaction network analysis of <i>P. falciparum</i> IPKs. Open
(A) All putative protein sequences of P. falciparum IPKs were subjected to a STRING database search for pathway analysis and clustered with MCL clustering, in which each cluster is coloured to denote potential interactions of P. …