Field cancerization
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Accumulation of genetic and epigenetic alterations in normal cells and cancer risk Open
Cancers develop due to the accumulation of genetic and epigenetic alterations. Genetic alterations are induced by aging, mutagenic chemicals, ultraviolet light, and other factors; whereas, epigenetic alterations are mainly by aging and chr…
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Reactive oxygen species: a volatile driver of field cancerization and metastasis Open
Field cancerization and metastasis are the leading causes for cancer recurrence and mortality in cancer patients. The formation of primary, secondary tumors or metastasis is greatly influenced by multifaceted tumor-stroma interactions, in …
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Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck Open
Multiple dysplastic lesions in the esophagus increase the risk of multiple SCCs. Alcohol abstinence reduces the risk of metachronous SCCs. Clinical Trials registry: UMIN000001676 and UMIN000005466.
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From actinic keratosis to squamous cell carcinoma: pathophysiology revisited Open
The precursor of most cutaneous invasive squamous cell carcinomas ( iSCC s) is intraepithelial UV ‐induced damage, known as field cancerization, which can eventually transform into actinic keratosis ( AK ). Although AK is the most common p…
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Epigenetic impact of infection on carcinogenesis: mechanisms and applications Open
Viral and bacterial infections are involved in the development of human cancers, such as liver, nasopharyngeal, cervical, head and neck, and gastric cancers. Aberrant DNA methylation is frequently present in these cancers, and some of the …
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European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 2: emerging indications – field cancerization, photorejuvenation and inflammatory/infective dermatoses Open
In addition to approved indications in non‐melanoma skin cancer in immunocompetent patients, topical photodynamic therapy ( PDT ) has also been studied for its place in the treatment of, as well as its potential to prevent, superficial ski…
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Current therapies for actinic keratosis Open
Actinic keratosis (AK) is a very common skin disease caused by chronic sun damage, which in 75% of cases arises on chronically sun‐exposed areas, such as face, scalp, neck, hands, and forearms. AKs must be considered an early squamous cell…
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Transcriptional Profiles from Paired Normal Samples Offer Complementary Information on Cancer Patient Survival – Evidence from TCGA Pan-Cancer Data Open
Although normal tissue samples adjacent to tumors are sometimes collected from patients in cancer studies, they are often used as normal controls to identify genes differentially expressed between tumor and normal samples. However, it is i…
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The importance of treating the field in actinic keratosis Open
Actinic keratoses (AKs) are intraepithelial atypical proliferations of keratinocytes that develop in skin that has undergone long‐term exposure to ultraviolet radiation. Given the ageing population and an increasing prevalence of AK, the s…
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The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment …
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Field cancerization in breast cancer Open
Breast cancer affects one in seven women worldwide during their lifetime. Widespread mammographic screening programs and education campaigns allow for early detection of the disease, often during its asymptomatic phase. Current practice in…
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Photodynamic Therapy and Non-Melanoma Skin Cancer Open
Non-melanoma skin cancer (NMSC) is the most common malignancy among the Caucasian population. Photodynamic therapy (PDT) is gaining popularity for the treatment of basal cell carcinoma (BCC), Bowen’s disease (BD) and actinic keratosis (AK)…
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Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles Open
Papillary thyroid carcinoma ( PTC ) is the most common adult thyroid malignancy and often presents with multiple anatomically distinct foci within the thyroid, known as multifocal papillary thyroid carcinoma ( MPTC ). The widespread applic…
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Actinic Keratosis and Non-Invasive Diagnostic Techniques: An Update Open
Actinic keratosis represents the earliest manifestation of non-melanoma skin cancer. Because of their risk of progression to invasive squamous cell carcinoma, an earlier diagnosis and treatment are mandatory. Their diagnosis sometimes coul…
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Resection Margins in Head and Neck Cancer Surgery: An Update of Residual Disease and Field Cancerization Open
Surgery is one of the mainstays of head and neck cancer treatment, and aims at radical resection of the tumor with 1 cm tumor-free margins to obtain locoregional control. Surgical margins are evaluated by histopathological examination of t…
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Role of Exosomal miRNA in Bladder Cancer: A Promising Liquid Biopsy Biomarker Open
Bladder cancer (BCa) is the most prevalent neoplasia of the urinary tract. Unfortunately, limited improvements in effective BCa management have meant that it remains a challenging disease. Cystoscopy has been the gold standard for BCa diag…
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Liquid Biopsies in Head and Neck Cancer: Current State and Future Challenges Open
Head and neck cancers are the seventh most frequent malignancy worldwide, consisting of a heterogeneous group of cancers that develop in the oral cavity, pharynx, and larynx, with head and neck squamous cell carcinoma (HNSCC) being the mos…
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Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Skin Imaging in Dermatology Open
Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive optical imaging technique based on a combination of the principles of optical coherence tomography and reflectance confocal microscopy with line-field illumination…
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Recent advances in field cancerization and management of multiple cutaneous squamous cell carcinomas Open
Cutaneous squamous cell carcinoma (SCC) is among the most common cancers in humans, and many patients with SCC will develop multiple tumors within their lifetime. The field cancerization concept, originally proposed over 60 years ago, hypo…
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European consensus‐based interdisciplinary guideline for diagnosis, treatment and prevention of actinic keratoses, epithelial <span>UV</span>‐induced dysplasia and field cancerization on behalf of European Association of Dermato‐Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes) Open
A collaboration of multidisciplinary experts from the European Association of Dermato‐Oncology, the European Dermatology Forum, the European Academy of Dermatology and Venereology, and the European Union of Medical Specialists was formed t…
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Precancer in Ulcerative Colitis: The Role of the Field Effect and its Clinical Implications Open
Cumulative evidence indicates that a significant proportion of cancer evolution may occur before the development of histological abnormalities. While recent improvements in DNA sequencing technology have begun to reveal the presence of the…
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Italian expert consensus for the management of actinic keratosis in immunocompetent patients Open
Actinic keratosis ( AK ) is a common skin disease which can potentially progress to invasive squamous cell carcinoma ( iSCC ). Given that mortality rates and health‐care cost associated with iSCC are substantial, the management of AK repre…
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Genomic Landscape Established by Allelic Imbalance in the Cancerization Field of a Normal Appearing Airway Open
Visually normal cells adjacent to, and extending from, tumors of the lung may carry molecular alterations characteristics of the tumor itself, an effect referred to as airway field of cancerization. This airway field has been postulated as…
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Risk of Invasive Cutaneous Squamous Cell Carcinoma After Different Treatments for Actinic Keratosis Open
ClinicalTrials.gov Identifier: NCT02281682.
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The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection Open
Lung cancer remains the leading cause of cancer-related death due to its advanced stage at diagnosis. Early detection of lung cancer can be improved by better defining who should be screened radiographically and determining which imaging-d…
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Growth hormone in the tumor microenvironment Open
Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and n…
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Epigenetic Field Cancerization in Gastric Cancer: microRNAs as Promising Biomarkers Open
Background: The biological role of microRNAs (miRNAs) in field cancerization is unknown. To investigate the involvement of miRNAs in gastric field cancerization, we evaluated the expression profile of ten miRNAs and their diagnostic value.…
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Integrated transcriptomic analysis of distance-related field cancerization in rectal cancer patients Open
Field cancerization (FC) occurs in various epithelial carcinomas, including colorectal cancer, which indicates that the molecular events in carcinogenesis might occur in normal tissues extending from tumors. However, the transcriptomic cha…
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Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization Open
DCIS: ductal carcinoma in situ; GO: gene ontology; OR: odds ratio; CI: confidence interval; TFBS: transcription factor binding site; LOLA: Locus Overlap Analysis.
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Field Cancerization Is Associated with Tumor Development, T-cell Exhaustion, and Clinical Outcomes in Bladder Cancer Open
Molecular changes in the tissue lining the bladder result in tumor recurrence. Urinary measurements may be used to monitor bladder cancer status and treatment responses.