Ocular dominance ≈ Ocular dominance
View article
Removal of Perineuronal Nets Unlocks Juvenile Plasticity Through Network Mechanisms of Decreased Inhibition and Increased Gamma Activity Open
Perineuronal nets (PNNs) are extracellular matrix structures mainly enwrapping parvalbumin-expressing inhibitory neurons. The assembly of PNNs coincides with the end of the period of heightened visual cortex plasticity in juveniles, wherea…
View article
Critical periods in amblyopia Open
The shift in ocular dominance (OD) of binocular neurons induced by monocular deprivation is the canonical model of synaptic plasticity confined to a postnatal critical period. Developmental constraints on this plasticity not only lend stab…
View article
Rapid eye movement sleep promotes cortical plasticity in the developing brain Open
Rapid eye movement sleep plays a critical role in shaping developing circuits in the cerebral cortex.
View article
Neuron class–specific responses govern adaptive myelin remodeling in the neocortex Open
Cellular effects of visual deprivation Myelination speeds the progress of action potentials along neuronal axons. Yang et al. studied changes in myelination in the mouse visual cortex in response to visual experience (see the Perspective b…
View article
Short‐term monocular deprivation alters early components of visual evoked potentials Open
Key points Short‐term monocular deprivation in adult humans produces a perceptual boost of the deprived eye reflecting homeostatic plasticity. Visual evoked potentials (VEPs) to transient stimuli change after 150 min of monocular deprivati…
View article
A new counterintuitive training for adult amblyopia Open
Objectives The aim of this study was to investigate whether short‐term inverse occlusion, combined with moderate physical exercise, could promote the recovery of visual acuity and stereopsis in a group of adult anisometropic amblyopes. Met…
View article
Response to short-term deprivation of the human adult visual cortex measured with 7T BOLD Open
Sensory deprivation during the post-natal ‘critical period’ leads to structural reorganization of the developing visual cortex. In adulthood, the visual cortex retains some flexibility and adapts to sensory deprivation. Here we show that s…
View article
Short-term monocular patching boosts the patched eye’s response in visual cortex Open
We interpret this eye dominance plasticity in adult human visual cortex as homeostatic intrinsic plasticity regulated by an increase of contrast-gain in the patched eye.
View article
Visual Field Testing with Head-Mounted Perimeter ‘imo’ Open
The perimeter imo can obtain VF sensitivity highly compatible to that by the standard automated perimeter. The binocular random single eye test provides a non-occlusion test condition without the examinee being aware of the tested eye.
View article
Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity Open
The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modificat…
View article
Neuregulin-Dependent Regulation of Fast-Spiking Interneuron Excitability Controls the Timing of the Critical Period Open
Maturation of excitatory drive onto fast-spiking interneurons (FS INs) in the visual cortex has been implicated in the control of the timing of the critical period for ocular dominance plasticity. However, the mechanisms that regulate the …
View article
Short-term monocular occlusion produces changes in ocular dominance by a reciprocal modulation of interocular inhibition Open
Ocular dominance can be modulated by short-term monocular deprivation. This changes the contribution that each eye makes to binocular vision, an example of adult cortical neuroplasticity. Optical imaging in primates and psychophysics in hu…
View article
Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1 Open
Brief monocular deprivation (MD) shifts ocular dominance and reduces the density of thalamic synapses in layer 4 of the mouse primary visual cortex (V1). We found that microglial lysosome content is also increased as a result of MD. Previo…
View article
Visual Performance and Optical Quality after Implantation of a New Generation Monofocal Intraocular Lens Open
ICB00 provided superior intermediate vision and comparable distance performance and photic phenomena compared to a standard monofocal IOL.
View article
Comparing visual acuity, range of vision and spectacle independence in the extended range of vision and monofocal intraocular lens Open
Importance This study is the first to compare the extended range of vision (ERV) intraocular lens (IOL) targeted at micro‐monovision to a monofocal targeted at binocular emmetropia. Background Compares visual acuity, range of vision and sp…
View article
Long-term Monocular Deprivation during Juvenile Critical Period Disrupts Binocular Integration in Mouse Visual Thalamus Open
Study of the neural deficits caused by mismatched binocular vision in early childhood has predominantly focused on circuits in the primary visual cortex (V1). Recent evidence has revealed that neurons in mouse dorsolateral geniculate nucle…
View article
Cortical Balance Between ON and OFF Visual Responses Is Modulated by the Spatial Properties of the Visual Stimulus Open
The primary visual cortex of carnivores and primates is dominated by the OFF visual pathway and responds more strongly to dark than light stimuli. Here, we demonstrate that this cortical OFF dominance is modulated by the size and spatial f…
View article
Strabismus and the Oculomotor System: Insights from Macaque Models Open
Disrupting binocular vision in infancy leads to strabismus and oftentimes to a variety of associated visual sensory deficits and oculomotor abnormalities. Investigation of this disorder has been aided by the development of various animal m…
View article
Arc restores juvenile plasticity in adult mouse visual cortex Open
Significance Neuronal plasticity peaks early in life during critical periods and normally declines with age, but the molecular changes that underlie this decline are not fully understood. Using the mouse visual cortex as a model, we found …
View article
Binocular visual training to promote recovery from monocular deprivation Open
Abnormal early visual experience often leads to poor vision, a condition called amblyopia. Two recent approaches to treating amblyopia include binocular therapies and intensive visual training. These reflect the emerging view that amblyopi…
View article
Lateralization of behavior in dairy cows in response to conspecifics and novel persons Open
The right brain hemisphere, connected to the left eye, coordinates fight and flight behaviors in a wide variety of vertebrate species. We investigated whether left eye vision predominates in dairy cows' interactions with other cows and hum…
View article
Neural architectures for stereo vision Open
Stereoscopic vision delivers a sense of depth based on binocular information but additionally acts as a mechanism for achieving correspondence between patterns arriving at the left and right eyes. We analyse quantitatively the cortical arc…
View article
p75 Neurotrophin Receptor Activation Regulates the Timing of the Maturation of Cortical Parvalbumin Interneuron Connectivity and Promotes Juvenile-like Plasticity in Adult Visual Cortex Open
By virtue of their extensive axonal arborization and perisomatic synaptic targeting, cortical inhibitory parvalbumin (PV) cells strongly regulate principal cell output and plasticity and modulate experience-dependent refinement of cortical…
View article
Rivalry-Like Neural Activity in Primary Visual Cortex in Anesthetized Monkeys Open
Two incongruent images viewed by the two eyes cause binocular rivalry, during which observers perceive continuous alternations between these two visual images. Previous studies in both humans and monkeys have shown that the primary visual …
View article
Sensory Eye Dominance: Relationship Between Eye and Brain Open
Eye dominance refers to the preference to use one eye more than the fellow eye to accomplish a task. However, the dominant eye revealed can be task dependent especially when the tasks are as diverse as instructing the observer to sight a t…
View article
Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g Open
The non-cell autonomous transfer of OTX2 homeoprotein transcription factor into juvenile mouse cerebral cortex regulates parvalbumin interneuron maturation and critical period timing. By analyzing gene expression in primary visual cortex o…
View article
Optical treatment of amblyopia in older children and adults is essential prior to enrolment in a clinical trial Open
Purpose Optical treatment alone can improve visual acuity ( VA ) in children with amblyopia, thus clinical trials investigating additional amblyopia therapies (such as patching or videogames) for children require a preceding optical treatm…
View article
Current Management of Childhood Amblyopia Open
Amblyopia is defined as the reduction of best-corrected visual acuity of one or both eyes caused by conditions that affect normal visual development. The basic strategy to treat amblyopia is to obtain a clear retinal image in each eye and …
View article
Major Vault Protein, a Candidate Gene in 16p11.2 Microdeletion Syndrome, Is Required for the Homeostatic Regulation of Visual Cortical Plasticity Open
Microdeletion of a region in chromosome 16p11.2 increases susceptibility to autism. Although this region contains exons of 29 genes, disrupting only a small segment of the region, which spans five genes, is sufficient to cause autistic tra…
View article
Experience-dependent structural plasticity at pre- and postsynaptic sites of layer 2/3 cells in developing visual cortex Open
The developing brain can respond quickly to altered sensory experience by circuit reorganization. During a critical period in early life, neurons in the primary visual cortex rapidly lose responsiveness to an occluded eye and come to respo…