Microbubbles
View article: Mineral Carbonation of Red Mud Using CO2 Microbubbles under Ambient Conditions
Mineral Carbonation of Red Mud Using CO2 Microbubbles under Ambient Conditions Open
This study investigated the mineral carbonation and neutralization behavior of red mud (RM) using CO2 microbubbles (CO2 MBs) under ambient temperature and pressure conditions, and further assessed the feasibility of u…
View article: A Comparative Study of Sononeoperfusion Effects Induced by Diagnostic and Therapeutic Ultrasound‐Stimulated Microbubbles
A Comparative Study of Sononeoperfusion Effects Induced by Diagnostic and Therapeutic Ultrasound‐Stimulated Microbubbles Open
Objectives The sononeoperfusion effect involves the use of ultrasound‐stimulated microbubbles (USMB) to enhance tumor perfusion, which may alleviate hypoxic conditions within solid tumors. This study aimed to compare this effect induced by…
View article: Transferrin-Functionalized Liposomes Enhance MAPT-ASO Transport Across a 3D Blood–Brain Barrier Microvascular Network Model
Transferrin-Functionalized Liposomes Enhance MAPT-ASO Transport Across a 3D Blood–Brain Barrier Microvascular Network Model Open
Tau pathology is a defining hallmark of Alzheimer’s disease (AD), closely associated with cognitive decline. Antisense oligonucleotides targeting the tau-encoding gene MAPT (MAPT-ASO) have shown promise in clinical trials, but their therap…
View article: Next-Generation Percutaneous Catheter–Based Closed-Loop Perfusion Concept Enables High-Precision Organ Delivery of Advanced Therapies
Next-Generation Percutaneous Catheter–Based Closed-Loop Perfusion Concept Enables High-Precision Organ Delivery of Advanced Therapies Open
View article: Acoustic Detection of Intracranial Cavitation Induced by Blunt Impacts in Polyacrylamide Human Head Models Across Varying Orientations
Acoustic Detection of Intracranial Cavitation Induced by Blunt Impacts in Polyacrylamide Human Head Models Across Varying Orientations Open
Purpose Traumatic brain injury remains a major health concern among civilians and military personnel, with intracranial cavitation hypothesized as a damage mechanism during blunt impacts. Methods This study examines cavitation bubble activ…
View article: Feasibility of ultrasound-mediated blood–brain barrier opening in sheep using sonolucent cranial implants
Feasibility of ultrasound-mediated blood–brain barrier opening in sheep using sonolucent cranial implants Open
Drug delivery to the brain presents a major hurdle in developing treatments for neurological disorders. A noninvasive strategy addressing this is transcranial focused ultrasound with microbubbles (FUS+MB) that transiently opens …
View article: Electrohydrodynamic Behaviour of Charged Cavitation Bubbles in Hybrid Nanofluids: A Mooney–Rivlin Model Approach
Electrohydrodynamic Behaviour of Charged Cavitation Bubbles in Hybrid Nanofluids: A Mooney–Rivlin Model Approach Open
To understand cavitation in complex fluids, especially hybrid nanofluids used in technology and medicine, it is important to grasp the electrostatic forces, viscoelastic effects, and flow behaviour of nanofluids. The main contribution of t…
View article: Tissue-type Differences in Focused Ultrasound and Microbubble-mediated Drug Delivery to the Brain Exist at Vessel Level
Tissue-type Differences in Focused Ultrasound and Microbubble-mediated Drug Delivery to the Brain Exist at Vessel Level Open
View article: Next-Generation Percutaneous Catheter–Based Closed-Loop Perfusion Concept Enables High-Precision Organ Delivery of Advanced Therapies
Next-Generation Percutaneous Catheter–Based Closed-Loop Perfusion Concept Enables High-Precision Organ Delivery of Advanced Therapies Open
Safe and efficient in vivo delivery of advanced therapies (ATs) remains a major challenge hindering their path to clinical adoption. We present a novel, fully percutaneous, catheter-based locoregional perfusion (LRP) system for targeted de…
View article: Quantitative Conspicuity of Pancreatic Canine Insulinoma: A Comparison of Dynamic 4D CT and Dual-Source, Dual-Energy Bolus-Triggered Multiphase CT Imaging
Quantitative Conspicuity of Pancreatic Canine Insulinoma: A Comparison of Dynamic 4D CT and Dual-Source, Dual-Energy Bolus-Triggered Multiphase CT Imaging Open
The aim of this retrospective study was to compare lesion conspicuity—the visibility of a lesion relative to surrounding tissue—and CT characteristics of pancreatic insulinomas in dogs using multiphase dual-energy CT (DECT) and dynamic 4D …
View article: Characterization of plasma discharge tube for cancer treatment
Characterization of plasma discharge tube for cancer treatment Open
View article: Magnetic drug-loaded microbubbles for treating lower limb venous thrombosis under controllable rotating magnetic field
Magnetic drug-loaded microbubbles for treating lower limb venous thrombosis under controllable rotating magnetic field Open
Objective This study aimed to develop a poly (lactic-co-glycolic acid) (PLGA)-based magnetic loaded iron oxide (Fe 3 O 4 ) and single-chain urokinase-type plasminogen activator (proUK) for enhancing thrombolysis under a controlled rotating…
View article: Repeated application of transcranial ultrasound maintains spatial and recognition memory in 5xFAD mice with reduction of amyloid-β burden
Repeated application of transcranial ultrasound maintains spatial and recognition memory in 5xFAD mice with reduction of amyloid-β burden Open
Pharmacological removal of amyloid beta protofibrils has emerged as a promising therapeutic strategy to delay the onset of Alzheimer’s disease (AD) symptoms. As a non-pharmacological and noninvasive alternative, transcranial application of…
View article: Optimization strategies for reversible myocardial injury caused by ultrasonic cavitation effects using an orthogonal experimental design
Optimization strategies for reversible myocardial injury caused by ultrasonic cavitation effects using an orthogonal experimental design Open
The aim of this study is to investigate the effect of the optimal parameter combination of ultrasonic cavitation on reversible myocardial injury in rat heart using an orthogonal experimental design. An orthogonal experimental design was us…
View article: The influence of viscoelasticity on the dynamics of encapsulated microbubbles near a rigid surface forced by ultrasound
The influence of viscoelasticity on the dynamics of encapsulated microbubbles near a rigid surface forced by ultrasound Open
View article: Histotripsy-mediated reactive oxygen species generation in vitro
Histotripsy-mediated reactive oxygen species generation in vitro Open
Forms of sonodynamic therapy rely on close interactions between microbubbles and agents to generate cytotoxic reactive oxygen species. Microbubbles are inherently intravascular agents, which limits the therapeutic range for effective distr…
View article: DDEL-28. Systemic delivery of lipid nanoparticles into infiltrating zone of brain tumors following opening the BBB via Magnetic Resonance-Guided Focused Ultrasound in a Swine Model
DDEL-28. Systemic delivery of lipid nanoparticles into infiltrating zone of brain tumors following opening the BBB via Magnetic Resonance-Guided Focused Ultrasound in a Swine Model Open
Current therapeutic for GBM have limited effect on patients’ survival. Previous publications demonstrated that RNAi / CRISPR –PKL1 LNPs effectively delivered locally into glioma rat model. The majority of clinical trials during the last tw…
View article: DDEL-13. Enhanced CNS delivery of therapeutic nanoparticles with focused ultrasound improves treatment efficacy in glioblastoma
DDEL-13. Enhanced CNS delivery of therapeutic nanoparticles with focused ultrasound improves treatment efficacy in glioblastoma Open
BACKGROUND Glioblastoma (GBM) is an aggressive primary malignant brain tumor with limited treatment options. Immunotherapy is a promising treatment modality. One such therapy in development is our novel multilamellar RNA lipid nanoparticle…
View article: CTNI-37. SONOBIRD: A PHASE 3 TRIAL OF BLOOD-BRAIN-BARRIER (BBB) OPENING WITH THE SONOCLOUD-9 IN RECURRENT GLIOBLASTOMA PATIENTS RECEIVING IV CARBOPLATIN
CTNI-37. SONOBIRD: A PHASE 3 TRIAL OF BLOOD-BRAIN-BARRIER (BBB) OPENING WITH THE SONOCLOUD-9 IN RECURRENT GLIOBLASTOMA PATIENTS RECEIVING IV CARBOPLATIN Open
This study aims to determine the efficacy of BBB disruption combined with carboplatin chemotherapy for patients with first recurrence of glioblastoma through a randomized, comparative, multicenter, phase 3 trial. The trial is open for enro…
View article: DDEL-19. A Novel Platform of Paclitaxel-Loaded Microbubbles with Focused Ultrasound for Enhanced Glioblastoma Drug Delivery and Treatment
DDEL-19. A Novel Platform of Paclitaxel-Loaded Microbubbles with Focused Ultrasound for Enhanced Glioblastoma Drug Delivery and Treatment Open
Effective chemotherapy for glioblastoma (GBM) is severely limited by the impermeability of the blood-brain barrier (BBB). Although paclitaxel (PTX) demonstrates potent anti-glioma activity in vitro, its poor BBB penetration precludes its c…
View article: CTNI-42. NAVIGATED FOCUSED ULTRASOUND COMBINED WITH RADIOTHERAPY FOR MALIGNANT GLIOMA: A PILOT CLINICAL STUDY
CTNI-42. NAVIGATED FOCUSED ULTRASOUND COMBINED WITH RADIOTHERAPY FOR MALIGNANT GLIOMA: A PILOT CLINICAL STUDY Open
INTRODUCTION Blood–brain barrier (BBB) remains to be the major obstacle to conquer in treating patients with malignant glioma. Hypoxic tumor microenvironment impaired the effect of radiation induced cell death by Radiation therapy (RT). Fo…
View article: BIOM-54. ENRICHMENT OF BRAIN TUMOR-DERIVED CTDNAS AND MICRORNAS IN BLOOD CIRCULATION IN PATIENTS USING SONOBIOPSY
BIOM-54. ENRICHMENT OF BRAIN TUMOR-DERIVED CTDNAS AND MICRORNAS IN BLOOD CIRCULATION IN PATIENTS USING SONOBIOPSY Open
INTRODUCTION Blood-based liquid biopsy offers a non-invasive alternative to traditional surgical biopsies for brain cancer diagnosis. However, the blood-brain barrier (BBB) often restricts the transfer of brain tumor-derived molecular biom…
View article: Ultrasound-driven programmable artificial muscles
Ultrasound-driven programmable artificial muscles Open
Muscular systems1, the fundamental components of mobility in animals, have sparked innovations across technological and medical fields2,3. Yet artificial muscles suffer from dynamic programmability, scalability and responsiveness owing to …
View article: Impacts of flow velocity and microbubbles on water flushing in a horizontal pipeline
Impacts of flow velocity and microbubbles on water flushing in a horizontal pipeline Open
View article: Hybrid lipidic and fluorinated polymer microbubbles for blood-brain barrier opening: a comparative study with SonoVue
Hybrid lipidic and fluorinated polymer microbubbles for blood-brain barrier opening: a comparative study with SonoVue Open
View article: Focused ultrasound in modern medicine: bioengineering interfaces, molecular effects, and clinical breakthroughs
Focused ultrasound in modern medicine: bioengineering interfaces, molecular effects, and clinical breakthroughs Open
Ultrasound technology, first utilized in 1947–1948 for diagnostic applications in obstetrics and gynecology, has significantly expanded its scope to include both diagnostic and therapeutic uses in modern medicine. The advent of continuous …
View article: The value of contrast-enhanced ultrasound in the follow-up of Bosniak IIF cystic renal lesions
The value of contrast-enhanced ultrasound in the follow-up of Bosniak IIF cystic renal lesions Open
View article: Comparative effects of focused ultrasound and microbubbles on healthy and tumor bearing rat spinal cord
Comparative effects of focused ultrasound and microbubbles on healthy and tumor bearing rat spinal cord Open
View article: Early Detection of Vulnerable Plaques Using Targeted Biosynthetic Nanobubbles
Early Detection of Vulnerable Plaques Using Targeted Biosynthetic Nanobubbles Open
Objectives: Atherosclerosis is a chronic inflammatory disease characterized by complex pathological mechanisms. Early detection of vulnerable plaques is critical for assessing rupture risk and preventing acute cardiovascular events. Conven…
View article: Ultrasound molecular imaging of M2 macrophages for early detection of chronic rejection in heart transplantation
Ultrasound molecular imaging of M2 macrophages for early detection of chronic rejection in heart transplantation Open
Chronic rejection (CR) remains the leading cause of morbidity and mortality in heart transplantation survivors. The primary pathological features of CR encompass cardiac allograft vasculopathy and myocardial fibrosis. Currently, its diagno…