Interleukin
View article: LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease
LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease Open
Background: Sjögren’s disease is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands, epithelial stress and barrier fragility, and interferon‑skewed cytokine milieus tha…
View article: Probiotic lactic acid bacteria induce regulatory functions in γδ T cells
Probiotic lactic acid bacteria induce regulatory functions in γδ T cells Open
While the modulatory effects of probiotic LAB on conventional T cells are well documented, its effects on unconventional T cells, including gamma-delta (γδ) T cells, have not yet been fully characterized. In this study, we show that probio…
View article: TCDCA inhibits pyroptosis to alleviate sepsis-related acute hepatic injury via activating TGR5
TCDCA inhibits pyroptosis to alleviate sepsis-related acute hepatic injury via activating TGR5 Open
Introduction Sepsis-related acute liver injury (SALI) is a severe and life-threatening complication in septic patients, for which current therapeutic options are limited. This study aimed to investigate the potential protective role of tau…
View article: Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High‐Sodium Diet With Renal Proinflammatory Pathways
Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High‐Sodium Diet With Renal Proinflammatory Pathways Open
Background High sodium intake is associated with arterial hypertension and cardiovascular disease, through mechanisms that go beyond hemodynamic changes, including endothelial dysfunction, oxidative stress, and induction of a proinflammato…
View article: Chronic Inflammation and Altered Immune Responses in LongCOVID Associate with Neurological Manifestations and Accelerated Aging
Chronic Inflammation and Altered Immune Responses in LongCOVID Associate with Neurological Manifestations and Accelerated Aging Open
There is a subgroup of people infected with the SARS-CoV-2 virus who manifest lingering sequelae (LongC), with neurological symptoms (nLongC). We recruited 86 COVID-19 volunteers, 35 of whom were fully recovered (Cov) and 51 who had neurol…
View article: C‐C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation
C‐C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation Open
Background The dysregulated immune system, which drives chronic vascular inflammation and remodeling, plays a critical role in the pathogenesis of abdominal aortic aneurysm (AAA). CCR4 (C‐C chemokine receptor 4), which is predominantly exp…
View article: Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa
Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa Open
Background The role of plasma and its components in the progression of aortic stenosis (AS) remains insufficiently investigated. This study aimed to assess whether plasma from patients with AS induces oxidative stress and contributes to va…
View article: Angiotensin II, miR-34a, and AGTRAP crosstalk in arterial smooth muscle cells
Angiotensin II, miR-34a, and AGTRAP crosstalk in arterial smooth muscle cells Open
Arterial aging is associated with enhanced angiotensin II (Ang II) signaling via Ang II type 1 receptor (AT1R) and with microRNA-34a (miR-34a) increased expression. AT1R-associated protein (ATRAP/Agtrap) binds to AT1R, promotes its interna…
View article: Supplementary Data from Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity
Supplementary Data from Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity Open
Supplementary figures 1-8 and supplementary table 1
View article: Inflammatory factors collaboratively link Helicobacter pylori-induced gastritis to gastric cancer
Inflammatory factors collaboratively link Helicobacter pylori-induced gastritis to gastric cancer Open
Long-term inflammatory reaction may promote gastric cancer initiation and development through multiple mechanisms. Recent studies have demonstrated that inflammatory mediators play a crucial role in the transition from gastritis to gastric…
View article: Dual signaling cascade regulating gut-lung axis in Interleukin-6/Interleukin-17 for NSCLC immuno pathogenesis
Dual signaling cascade regulating gut-lung axis in Interleukin-6/Interleukin-17 for NSCLC immuno pathogenesis Open
Non-small cell lung cancer is the leading cause of death globally, affecting both men and women. Emerging evidence has highlighted the apparent role of gut microbiota in reshaping the lung microbial community. Notably, imbalances in the gu…
View article: Il fiume di Strabone fino a Noreia (Geogr. V 1, 8)
Il fiume di Strabone fino a Noreia (Geogr. V 1, 8) Open
Nel quinto libro della sua opera, il geografo greco Strabone parla di un fiume che può essere navigato e che segna il confine tra il territorio di Aquileia e quello dei Veneti. Secondo...
View article: Identification of CXCL8 as a potential gene associated with lymph node metastasis in papillary thyroid carcinoma through bioinformatics analysis
Identification of CXCL8 as a potential gene associated with lymph node metastasis in papillary thyroid carcinoma through bioinformatics analysis Open
CXC chemokine ligand 8 (CXCL8) has emerged as a critical mediator in tumorigenesis. This study aims to elucidate the role of CXCL8 in the initiation and progression of papillary thyroid carcinoma (PTC). Comprehensive bioinformatic analyses…
View article: CAR‐DC combined with CAR‐T therapy for relapsed/refractory acute myeloid leukaemia: Research progress and future perspectives
CAR‐DC combined with CAR‐T therapy for relapsed/refractory acute myeloid leukaemia: Research progress and future perspectives Open
Acute myeloid leukaemia (AML) remains the most common type of leukaemia in adults. Despite advances in conventional therapies, high relapse rates persist, underscoring the need for novel approaches such as chimeric antigen receptor T (CAR‐…
View article: Il fiume di Strabone fino a Noreia (Geogr. V 1, 8)
Il fiume di Strabone fino a Noreia (Geogr. V 1, 8) Open
Nel quinto libro della sua opera, il geografo greco Strabone parla di un fiume che può essere navigato e che segna il confine tra il territorio di Aquileia e quello dei Veneti. Secondo...
View article: Supplementary Figure S12 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Supplementary Figure S12 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies Open
Supplementary Figure S12. Individual tumor growth curves for each treatment group. OCI-Ly18 (DLBCL)-bearing humanized NSG mice were pre-treated with 30 mg/kg Gazyva (Gpt, grey arrow) and treated weekly with escalating doses of CD20-TCB (0.…
View article: Dissecting biomarker networks linking COVID-19 inflammatory drivers, disease severity and thyroid adaptive responses
Dissecting biomarker networks linking COVID-19 inflammatory drivers, disease severity and thyroid adaptive responses Open
Altered thyroid function (TF), especially non - thyroidal illness syndrome (NTIS), is common in hospitalised COVID - 19 patients, but adaptive responses to disease as captured by blood biomarkers in the context of thyroid signal integratio…
View article: The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia Open
Controversies over anti-amyloid immunotherapies underscore the need to elucidate their mechanisms of action. Here we demonstrate that Lecanemab, a leading anti-β-amyloid (Aβ) antibody, mediates amyloid clearance by activating microglial ef…
View article: New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems
New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems Open
As the leading cause of maternal mortality, the pathogenesis of postpartum hemorrhage (PPH), with 60%–70% cases of uterine atony, remains unclear due to a fundamental lack of animal models for studying. Our study develops a novel placenta‐…
View article: Cytokine profile of saliva in adults with focal enamel demineralization after orthodontic treatment
Cytokine profile of saliva in adults with focal enamel demineralization after orthodontic treatment Open
Background and aim the saliva content and correlation with the intensity of caries of proinflammatory cytokines IL-1ß, IL-6, IL-8 and anti-inflammatory cytokines IL-4 and IL-10 were studied in patients with FED after long-term orthodontic …
View article: Antcin K suppresses proinflammatory cytokines expression via the PI3K, Akt and NF-κB pathways in human gingival fibroblasts: implications for periodontitis treatment
Antcin K suppresses proinflammatory cytokines expression via the PI3K, Akt and NF-κB pathways in human gingival fibroblasts: implications for periodontitis treatment Open
Numerous inflammatory cytokines control the pathogenesis of periodontitis, an infectious bacterial disease, via interacting with immune and tissue cells. Antrodia cinnamomea is the origin of the triterpenoid Antcin K, renowned for its immu…
View article: Assessing Peripheral Blood Biomarkers and Predictive Patterns in Multiple Sclerosis Using Cytokines and Immune Gene Expression Profiles in Ocrelizumab-Treated Patients: Tracking Tumor Necrosis Factor
Assessing Peripheral Blood Biomarkers and Predictive Patterns in Multiple Sclerosis Using Cytokines and Immune Gene Expression Profiles in Ocrelizumab-Treated Patients: Tracking Tumor Necrosis Factor Open
Ocrelizumab, a humanized monoclonal anti-CD20 and B cell-depleting antibody, is a disease-modifying therapy for multiple sclerosis (MS), a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system. Ho…
View article: Gene Polymorphism Associated With Acute Respiratory Distress Syndrome (Ards): A Literature Review
Gene Polymorphism Associated With Acute Respiratory Distress Syndrome (Ards): A Literature Review Open
Gene polymorphisms can influence susceptibility, severity, and prognosis of ARDS. Genetic studies in ARDS have evolved from studies focused on candidate genes to studies that rely on a hypothesis-free approach to identify novel loci associ…
View article: Age Versus Immunity: Dietary Influences on Immunosenescence
Age Versus Immunity: Dietary Influences on Immunosenescence Open
Background: Immunosenescence, or the age-related weakening of the immune system, leads to greater susceptibility to chronic diseases, infections, and metabolic disorders. This process involves changes in the number and function of lymphocy…
View article: Correlation analysis on interaction between Interleukin 10 gene and smoking with esophageal cancer risk in a Chinese Han population
Correlation analysis on interaction between Interleukin 10 gene and smoking with esophageal cancer risk in a Chinese Han population Open
View article: Immune cell dynamics, cytokines, and extracellular vesicles in systemic inflammatory response syndrome (SIRS): a multiparametric analysis
Immune cell dynamics, cytokines, and extracellular vesicles in systemic inflammatory response syndrome (SIRS): a multiparametric analysis Open
Background The systemic inflammatory response syndrome (SIRS) is a complex and multifactorial life-threatening reaction triggered by trauma or infection (sepsis). Since the dynamics of immune cells, cytokines and novel markers such as circ…
View article: Effect of Central Injection of Anandamide on LPS-Dependent Suppression of GnRH/LH Secretion in Ewes During the Follicular Phase of the Estrous Cycle
Effect of Central Injection of Anandamide on LPS-Dependent Suppression of GnRH/LH Secretion in Ewes During the Follicular Phase of the Estrous Cycle Open
The study investigated the effects of intracerebroventricular (ICV) administration of the endocannabinoid anandamide (AEA) on suppression of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) secretion during lipopolysaccharide…
View article: Impact of medical history of severe COVID-19 infection on serum cytokine levels and prognosis in patients with sepsis: A prospective observational study
Impact of medical history of severe COVID-19 infection on serum cytokine levels and prognosis in patients with sepsis: A prospective observational study Open
A history of severe COVID-19 may have lasting effects on immune and coagulation dysfunction, potentially influencing sepsis outcomes. This study investigates the impact of severe COVID-19 history on inflammatory markers, coagulation parame…
View article: LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease
LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease Open
Background: Sjögren’s disease is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands, epithelial stress and barrier fragility, and interferon‑skewed cytokine milieus tha…
View article: Proinflammatory markers in women with type 1 diabetes and polycystic ovary syndrome
Proinflammatory markers in women with type 1 diabetes and polycystic ovary syndrome Open
The frequency of polycystic ovary syndrome (PCOS) appears to be higher in women living with type 1 diabetes (T1D). Both diseases are characterized by a mild chronic inflammatory state. The proinflammatory protein profile in this population…