Multicellular organism
View article: Rules of life at the interface of calcium signaling and mechanobiology
Rules of life at the interface of calcium signaling and mechanobiology Open
Living systems process a broad range of internal and external stimuli, respond to environmental constraints, and adapt to various conditions through tight coordination between signaling networks and cellular mechanics. Among these, calcium…
View article: A Critical Re-evaluation of "Bridging Single Cells to Organs: Mesoscale Modules as Fundamental Units of Tissue Function" by Chen et al., Cell 2025; doi: 10.1016/j.cell.2025.10.012
A Critical Re-evaluation of "Bridging Single Cells to Organs: Mesoscale Modules as Fundamental Units of Tissue Function" by Chen et al., Cell 2025; doi: 10.1016/j.cell.2025.10.012 Open
This deposit contains a Matters Arising–style critical commentary on the paper “Bridging Single Cells to Organs: Mesoscale Modules as Fundamental Units of Tissue Function” by Chen Y, Germain RN, Hunter GL, et al. (Cell, 2025). The commenta…
View article: PULSAR: a Foundation Model for Multi-scale and Multicellular Biology
PULSAR: a Foundation Model for Multi-scale and Multicellular Biology Open
Biology emerges from interactions across physical scales, where molecular interactions drive cellular states, which in turn orchestrate multicellular tissue functions that collectively define health and disease. However, current computatio…
View article: Next-Generation Skin Regeneration: Multicellular 3D Bioprinting and Biomimetic Bioinks for Advanced Cutaneous Reconstruction
Next-Generation Skin Regeneration: Multicellular 3D Bioprinting and Biomimetic Bioinks for Advanced Cutaneous Reconstruction Open
Regenerative dermatology and 3D skin bioprinting have advanced rapidly over the past decade, offering new possibilities for restoring complex cutaneous architecture beyond the limitations of traditional grafting techniques. This review syn…
View article: EV <i>trace</i> : tracing extracellular vesicles-associated proteins in recipient cells using stable isotope labeling
EV <i>trace</i> : tracing extracellular vesicles-associated proteins in recipient cells using stable isotope labeling Open
Release and uptake of extracellular vesicles (EVs) is a highly conserved means of communication used by cells across all kingdoms of life. These nano-sized vesicles transfer messages encoded in proteins and nucleic acids and play a role in…
View article: Mapping embryonic mouse lung development using enhanced spatial transcriptomics
Mapping embryonic mouse lung development using enhanced spatial transcriptomics Open
The mature mammalian lung contains ~50 different cell types that are located in precise positions along and around the airway epithelial tree. Here, we investigated how these spatial patterns are progressively established during developmen…
View article: <i>LEAFY</i> demonstrates functions in reproductive development of the gametophyte but not the sporophyte of the fern <i>Ceratopteris richardii</i>
<i>LEAFY</i> demonstrates functions in reproductive development of the gametophyte but not the sporophyte of the fern <i>Ceratopteris richardii</i> Open
Flowers are a key reproductive innovation of the angiosperms. Seed plant reproductive axes (including flowers) evolved as reproductively specialized shoots of the land plant diploid sporophyte, with the gamete-producing haploid gametophyte…
View article: The novel GlcNAc 6-phosphate dehydratase NagS governs a metabolic checkpoint that controls nutrient signaling in Streptomyces
The novel GlcNAc 6-phosphate dehydratase NagS governs a metabolic checkpoint that controls nutrient signaling in Streptomyces Open
Streptomyces bacteria are renowned for their multicellular lifestyle and as Nature’s medicine makers, producing the majority of the clinical antibiotics. A landmark event during early development is the lytic dismantling of the substrate m…
View article: Spatial segregation and cross-kingdom interactions drive stingless bee hive microbiome assembly
Spatial segregation and cross-kingdom interactions drive stingless bee hive microbiome assembly Open
Studying host-associated microbiome assembly is key to understanding microbial and host evolution and health. While honey bee microbiome have been a central model for such investigations among pollinators, they overlook the diversity of eu…
View article: Polyploid giant cancer cells (PGCC): short-term return to multicellularity
Polyploid giant cancer cells (PGCC): short-term return to multicellularity Open
Background Polyploidization is associated with progression of cancer, making cancer cells more dangerous. The common polyploid cancer cells constitute a considerable part of tumors (up to 56% in metastases). The giant polyploid cancer cell…
View article: Mad28, a conserved actin-like protein in deep-branching magnetotactic bacteria, exhibits cell curvature-dependent localization
Mad28, a conserved actin-like protein in deep-branching magnetotactic bacteria, exhibits cell curvature-dependent localization Open
Magnetotactic bacteria (MTB) synthesize magnetic bacterial organelles called magnetosomes, which enable them to navigate along the geomagnetic field in aquatic environments. The actin-like cytoskeletal protein MamK forms filaments that ass…
View article: Modeling Bioelectric State Transitions in Glial Cells: An ASAL-Inspired Computational Approach to Glioblastoma Initiation
Modeling Bioelectric State Transitions in Glial Cells: An ASAL-Inspired Computational Approach to Glioblastoma Initiation Open
Understanding how glioblastoma (GBM) emerges from initially healthy glial tissue requires models that integrate bioelectrical, metabolic, and multicellular dynamics. This work introduces an ASAL-inspired agent-based framework that simulate…
View article: Modeling Bioelectric State Transitions in Glial Cells: An ASAL-Inspired Computational Approach to Glioblastoma Initiation
Modeling Bioelectric State Transitions in Glial Cells: An ASAL-Inspired Computational Approach to Glioblastoma Initiation Open
Understanding how glioblastoma (GBM) emerges from initially healthy glial tissue requires models that integrate bioelectrical, metabolic, and multicellular dynamics. This work introduces an ASAL-inspired agent-based framework that simulate…
View article: The Evolution of Large Organism Size: Disparate Physiologies Share a Foundation at the Smallest Physical Scales
The Evolution of Large Organism Size: Disparate Physiologies Share a Foundation at the Smallest Physical Scales Open
Life is defined by self-governing networks of molecules changing conformation cyclically to convert thermodynamic motion into directional work that creates structure. A spectrum of scale, from nanoscopic to macroscopic, involves a shift fr…
View article: PROTEINS RELATED TO PATHOGENESIS OF DISEASES, VIRAL PROTEINS, CELL DIVISION, SIGNALLING AND CHROMATIN PROCESSES
PROTEINS RELATED TO PATHOGENESIS OF DISEASES, VIRAL PROTEINS, CELL DIVISION, SIGNALLING AND CHROMATIN PROCESSES Open
The outstanding research questions of our BAG (now expanded to 9 PIs) focus on proteins and their complexes involved in a variety of processes, ranging from cell homeostasis (from gene regulation to folding quality control, from energy met…
View article: Origin of Intelligence: A Full-Scale Planetary Simulation of Prebiotic Chemistry, Cellular Evolution, Neural Emergence, and Cognitive Threshold Formation
Origin of Intelligence: A Full-Scale Planetary Simulation of Prebiotic Chemistry, Cellular Evolution, Neural Emergence, and Cognitive Threshold Formation Open
This study presents a comprehensive, end-to-end planetary simulation tracing the complete emergence of intelligence — from prebiotic chemistry to protocells, early metabolism, cellular diversification, neural networks, multicellular organi…
View article: Construction of a reporter plasmid for monitoring of geoA regulation in Myxococcus virescens during predation
Construction of a reporter plasmid for monitoring of geoA regulation in Myxococcus virescens during predation Open
Geosmin is a volatile, earthy-smelling metabolite produced by diverse microbial taxa, including myxobacteria. In aquaculture production, this compound may cause off-flavor in fish but knowledge of the ecological function of this compound i…
View article: A Quantitative Printability Framework for Programmable Assembly of Pre‐Vascular Patterns via Laser‐Induced Forward Transfer
A Quantitative Printability Framework for Programmable Assembly of Pre‐Vascular Patterns via Laser‐Induced Forward Transfer Open
The defined vascularization of complex and intricate tissue constructs remains an unmet need in tissue engineering and regenerative medicine. While large constructs require vasculature for oxygen, nutrient supply, and waste clearance, thei…
View article: Synergistic effects of proteinaceous pheromone and nitrogen starvation on male gametogenesis in the anisogamous volvocine alga Eudorina
Synergistic effects of proteinaceous pheromone and nitrogen starvation on male gametogenesis in the anisogamous volvocine alga Eudorina Open
In volvocine algae, gametogenesis is triggered by different cues depending on the species and their sexual systems. In isogamous unicellular organisms such as Chlamydomonas reinhardtii , which produce gametes of equal size and morphology, …
View article: Origin of Intelligence: A Full-Scale Planetary Simulation of Prebiotic Chemistry, Cellular Evolution, Neural Emergence, and Cognitive Threshold Formation
Origin of Intelligence: A Full-Scale Planetary Simulation of Prebiotic Chemistry, Cellular Evolution, Neural Emergence, and Cognitive Threshold Formation Open
This study presents a comprehensive, end-to-end planetary simulation tracing the complete emergence of intelligence — from prebiotic chemistry to protocells, early metabolism, cellular diversification, neural networks, multicellular organi…
View article: Genome architecture evolution in an invasive copepod species complex
Genome architecture evolution in an invasive copepod species complex Open
Chromosomal fusions are hypothesized to facilitate evolutionary adaptation, but empirical evidence has been scarce. Here, we analyze chromosome-level genome sequences of three sibling species within the copepod Eurytemora affinis species c…
View article: EMERGING INSIGHTS INTO BIOFILM FORMATION AND ITS CONTRIBUTION TO MULTIDRUG RESISTANCE IN PATHOGENIC BACTERIA
EMERGING INSIGHTS INTO BIOFILM FORMATION AND ITS CONTRIBUTION TO MULTIDRUG RESISTANCE IN PATHOGENIC BACTERIA Open
Bacterial biofilms represent highly organized, surface-associated microbial communities that play a critical role in the persistence and recurrence of infectious diseases. Their complex architecture, dominated by an extracellula…
View article: Emergence of chiral multi-armed spirals in an open system of migrating cells under continuous cell supply
Emergence of chiral multi-armed spirals in an open system of migrating cells under continuous cell supply Open
Chirality organize living and active matter systems into striking collective states, yet the principles that govern chiral ordering in open systems, where elements are continuously added or removed, remain unclear. A mutant strain of Dicty…
View article: TYRAY-Functionalized Alginate Bioinks for 3D Bioprinting Support Stem Cell Culture and Endothelial Network Formation
TYRAY-Functionalized Alginate Bioinks for 3D Bioprinting Support Stem Cell Culture and Endothelial Network Formation Open
3D bioprinting is transforming tissue engineering by enabling spatial arrangement of cells and cell aggregates within supportive hydrogels. Among available materials, alginate remains widely used for its biocompatibility, printability, and…
View article: Emergence of chiral multi-armed spirals in an open system of migrating cells under continuous cell supply
Emergence of chiral multi-armed spirals in an open system of migrating cells under continuous cell supply Open
Chirality organize living and active matter systems into striking collective states, yet the principles that govern chiral ordering in open systems, where elements are continuously added or removed, remain unclear. A mutant strain of Dicty…
View article: SHEST: Single-cell-level artificial intelligence from haematoxylin and eosin morphology for cell type prediction and spatial transcriptomics reconstruction
SHEST: Single-cell-level artificial intelligence from haematoxylin and eosin morphology for cell type prediction and spatial transcriptomics reconstruction Open
A comprehensive understanding of cancer progression requires integrating tissue morphol-ogy with spatial molecular profiles. We present SHEST, a multi-task profiling framework that leverages haematoxylin and eosin morphology to predict cel…
View article: The Coordinated Interplay Between MMP13 and Pro-Migratory MMPs in Collective Cell Migration of Zebrafish Keratocytes
The Coordinated Interplay Between MMP13 and Pro-Migratory MMPs in Collective Cell Migration of Zebrafish Keratocytes Open
Collective cell migration (CCM) is a coordinated process involving cell–cell and cell–environment interactions occurring in many physiological systems, including development, wound healing, and metastasis. Using zebrafish keratocytes as a …
View article: Controlled protein synthesis and spatial organisation in microfluidic environments
Controlled protein synthesis and spatial organisation in microfluidic environments Open
Performing cell-free expression (CFE) in tailored microfluidic environments is a powerful tool to investigate the organisation of biosystems from molecular to multicellular scales. While cell-free transcription-translation systems simplify…
View article: Life-cycle-related gene expression patterns in the brown algae
Life-cycle-related gene expression patterns in the brown algae Open
Brown algae are important primary constituents of marine coastal ecosystems, characterised by complex life cycles and various levels of complex multicellular development. However, the molecular processes that underlie development and life …
View article: REVIEW ON APOPTOSIS PATHWAY AND ITS ROLE IN HEALTH
REVIEW ON APOPTOSIS PATHWAY AND ITS ROLE IN HEALTH Open
Apoptosis, or programmed cell death, is a natural process that helps our body to get rid of cells that are no longer needed. It plays a vital role in the normal growth and function of multicellular organisms. When the control of cell death…