Inner mitochondrial membrane
View article: Dataset about modulation of mitochondrial bioenergetics by phytochemicals: effect on F1FO-ATPase, mitochondrial respiration and permeability transition pore
Dataset about modulation of mitochondrial bioenergetics by phytochemicals: effect on F1FO-ATPase, mitochondrial respiration and permeability transition pore Open
This dataset contains data from the evaluation of the effect of S-allyl cysteine (SAC), Benzyl isothiocyanate (BITC), and Epicatechin (EPC) on mitochondria isolated from porcine hearts. The aim of the research was to verify the modulatory …
View article: An Energetic Trade-Off Between Lactate Oxidation and Mitophagy: A Conceptual Model of Autophagic Switching
An Energetic Trade-Off Between Lactate Oxidation and Mitophagy: A Conceptual Model of Autophagic Switching Open
Lactate has emerged as a central metabolic intermediate with the capacity to support oxidative ATP production when mitochondrial performance is preserved. Under conditions of energetic stability, lactate oxidation contributes to cellular h…
View article: An Energetic Trade-Off Between Lactate Oxidation and Mitophagy: A Conceptual Model of Autophagic Switching
An Energetic Trade-Off Between Lactate Oxidation and Mitophagy: A Conceptual Model of Autophagic Switching Open
Lactate has emerged as a central metabolic intermediate with the capacity to support oxidative ATP production when mitochondrial performance is preserved. Under conditions of energetic stability, lactate oxidation contributes to cellular h…
View article: A Critical Re-Evaluation of "Inhibition of Oligomeric BAX by An Anti-Apoptotic Dimer" by Newman et al., Cell 2025; doi: 10.1016/j.cell.2025.10.037
A Critical Re-Evaluation of "Inhibition of Oligomeric BAX by An Anti-Apoptotic Dimer" by Newman et al., Cell 2025; doi: 10.1016/j.cell.2025.10.037 Open
This work presents a comprehensive and critical evaluation of the article “Inhibition of oligomeric BAX by an anti-apoptotic dimer” by Newman et al. (Cell 2025; doi:10.1016/j.cell.2025.10.037), which proposes a paradigm-shifting model in t…
View article: A Critical Re-Evaluation of "Inhibition of Oligomeric BAX by An Anti-Apoptotic Dimer" by Newman et al., Cell 2025; doi: 10.1016/j.cell.2025.10.037
A Critical Re-Evaluation of "Inhibition of Oligomeric BAX by An Anti-Apoptotic Dimer" by Newman et al., Cell 2025; doi: 10.1016/j.cell.2025.10.037 Open
This work presents a comprehensive and critical evaluation of the article “Inhibition of oligomeric BAX by an anti-apoptotic dimer” by Newman et al. (Cell 2025; doi:10.1016/j.cell.2025.10.037), which proposes a paradigm-shifting model in t…
View article: Exposure to polystyrene nanoparticles induce disruption of mitochondrial homeostasis and impairs trophoblast cell invasion and migration via MDM2/ROCK1 pathway
Exposure to polystyrene nanoparticles induce disruption of mitochondrial homeostasis and impairs trophoblast cell invasion and migration via MDM2/ROCK1 pathway Open
Background Polystyrene nanoparticles (PS-NPs) are recognized as environmental pollutants with potential reproductive toxicity. This study delves into the impacts of PS-NPs exposure on trophoblast cells, specifically examining mitochondrial…
View article: Lactate Routing Between Mitochondria and Autophagy: An Energetic Basis Supporting the Plausibility of Selective Lactatophagy
Lactate Routing Between Mitochondria and Autophagy: An Energetic Basis Supporting the Plausibility of Selective Lactatophagy Open
Lactate is a central intermediate in cellular metabolism and reflects the balance between glycolytic activity, redox state and mitochondrial oxidative capacity. The present work proposes a conceptual framework in which the routing of lacta…
View article: Lactate Routing Between Mitochondria and Autophagy: An Energetic Basis Supporting the Plausibility of Selective Lactatophagy
Lactate Routing Between Mitochondria and Autophagy: An Energetic Basis Supporting the Plausibility of Selective Lactatophagy Open
Lactate is a central intermediate in cellular metabolism and reflects the balance between glycolytic activity, redox state and mitochondrial oxidative capacity. The present work proposes a conceptual framework in which the routing of lacta…
View article: Plant derived and synthetical antihypoxic agents in cardiovascular diseases: Mechanisms, key pathways and therapeutic potential
Plant derived and synthetical antihypoxic agents in cardiovascular diseases: Mechanisms, key pathways and therapeutic potential Open
Antihypoxic drugs are vital for protecting cells from oxygen deprivation in ischemia, stroke and heart failure. Despite their clinical potential, a unified understanding of their mechanisms and optimization strategies remains limited. This…
View article: ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke
ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke Open
Perioperative stroke is a rare but serious complication with a rising incidence in aging populations. Although preclinical studies consistently demonstrate that anesthetics such as sevoflurane can induce neuroprotective preconditioning aga…
View article: Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling
Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling Open
Conjugated linoleic acid (CLA) isomers exhibit distinct biological activities in lipid metabolism, yet their roles in regulating mammary lipogenesis remain poorly understood. Understanding how individual CLA isomers influence lipid synthes…
View article: Effects of Emissions from Heated Tobacco Products and Reference Cigarettes on Gene Expression and Mitochondrial Function in Human Lung Epithelial BEAS-2B Cells
Effects of Emissions from Heated Tobacco Products and Reference Cigarettes on Gene Expression and Mitochondrial Function in Human Lung Epithelial BEAS-2B Cells Open
Heated tobacco products (HTPs) are marketed as lower-risk alternatives to conventional cigarettes; however, their toxicological impacts remain insufficiently characterized. This study evaluated the effects of HTP emissions on gene expressi…
View article: Interconnected roles of mitochondrial carrier proteins ANT, PiT, and UCPs in proton transport
Interconnected roles of mitochondrial carrier proteins ANT, PiT, and UCPs in proton transport Open
Introduction Adenine nucleotide translocase (ANT), phosphate translocase (P i T), and uncoupling proteins (UCPs), all integral to oxidative phosphorylation, are among the carrier proteins of the mitochondrial inner membrane (MIM). While tr…
View article: Metformin promotes mitochondrial integrity through <scp>AMPK</scp> ‐signaling in Leber's hereditary optic neuropathy
Metformin promotes mitochondrial integrity through <span>AMPK</span> ‐signaling in Leber's hereditary optic neuropathy Open
Leber's hereditary optic neuropathy (LHON) is a maternally inherited disorder caused by mitochondrial DNA mutations in complex I of the respiratory chain, leading to impaired ATP production, mitochondrial fragmentation, and oxidative stres…
View article: Mitochondrial NAD <sup>+</sup> gradient sustained by membrane potential and transport
Mitochondrial NAD <sup>+</sup> gradient sustained by membrane potential and transport Open
SLC25A51 is required for the replenishment of free nicotinamide adenine dinucleotide (oxidized form) (NAD + ) into mammalian mitochondria. However, it is not known how SLC25A51 imports this anionic molecule to sustain elevated NAD + concen…
View article: Investigation of mitochondrial phenotypes in motor neurons derived by direct conversion of fibroblasts from familial ALS subjects
Investigation of mitochondrial phenotypes in motor neurons derived by direct conversion of fibroblasts from familial ALS subjects Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of motor neurons, leading to fatal muscle paralysis. Familial forms of ALS (fALS) account for approximately 10% of cases. Alterations of mitochondrial functions…
View article: The dynamic lateral gate of the mitochondrial β-barrel biogenesis machinery is blocked by darobactin A
The dynamic lateral gate of the mitochondrial β-barrel biogenesis machinery is blocked by darobactin A Open
The folding and insertion of β-barrel proteins into the mitochondrial outer membrane is facilitated by the s orting and a ssembly m achinery (SAM) complex. Here we report two 2.8 Å cryo-EM structures of the Thermothelomyces thermophilus SA…
View article: A unified mechanism for mitochondrial damage sensing in PINK1-Parkin–mediated mitophagy
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin–mediated mitophagy Open
Damaged mitochondria can be cleared from the cell by mitophagy, using a pathway formed by the recessive Parkinson’s disease genes PINK1 and Parkin. Whether the pathway senses diverse forms of mitochondrial damage via a common mechanism, ho…
View article: Protocol for investigating mitochondrial structure, function, and metabolism in human cervical cancer cells
Protocol for investigating mitochondrial structure, function, and metabolism in human cervical cancer cells Open
View article: In Vitro and Ultrastructural Evaluation of the Cytotoxic and Antileishmanial Activities of Thiosemicarbazone Compounds Against Promastigotes and Axenic Amastigotes of Leishmania infantum
In Vitro and Ultrastructural Evaluation of the Cytotoxic and Antileishmanial Activities of Thiosemicarbazone Compounds Against Promastigotes and Axenic Amastigotes of Leishmania infantum Open
Leishmaniasis remains a global health challenge, and the search for effective and selective therapeutic agents is crucial. This study evaluated the in vitro antileishmanial and cytotoxic activities of thiosemicarbazone compounds (LT-70, LT…
View article: Copper deficiency disrupts OXPHOS and mitochondrial dynamics through MTCH2-dependent copper trafficking in skeletal muscle
Copper deficiency disrupts OXPHOS and mitochondrial dynamics through MTCH2-dependent copper trafficking in skeletal muscle Open
Copper is an essential trace element required for mitochondrial respiration and cellular metabolism, yet its role in skeletal muscle remains incompletely understood. Here, we show that skeletal muscle-specific deletion of the high-affinity…
View article: Mechanistic toxicity profiling of nicotine-rich e-liquids: mitochondrial and oxidative stress responses in ALI-exposed bronchial cells
Mechanistic toxicity profiling of nicotine-rich e-liquids: mitochondrial and oxidative stress responses in ALI-exposed bronchial cells Open
Combustion byproducts contained in cigarette smoke are considered the main responsible for the occurring of serious chronic diseases. Aerosols from electronic cigarettes contain substantially fewer of these dangerous byproducts, potentiall…
View article: A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes
A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes Open
The majority of mitochondrial proteins are encoded in the nuclear genome and often lack clear targeting signals. Therefore, what constitutes the entire mitochondrial proteome is still unclear. We here build on our previously developed bi-g…
View article: Extended Preservation of Heart Grafts: LYPS Solution Maintains Cardiac Function During 20-Hour Static Cold Storage
Extended Preservation of Heart Grafts: LYPS Solution Maintains Cardiac Function During 20-Hour Static Cold Storage Open
Heart transplantation is severely limited by the shortage of suitable donor grafts, partly due to myocardial vulnerability to ischemia–reperfusion injury and the lack of standardized preservation strategies. Current solutions only partiall…
View article: GV1001, an hTERT-Derived Peptide, Prevents Cisplatin-Induced Nephrotoxicity by Preserving Mitochondrial Function
GV1001, an hTERT-Derived Peptide, Prevents Cisplatin-Induced Nephrotoxicity by Preserving Mitochondrial Function Open
GV1001, a multifunctional peptide, has shown numerous biomedical activities, including antioxidant, anti-inflammatory, anti-Alzheimer’s, and anti-atherosclerotic effects, and protects mitochondria from cytotoxic agents. Cisplatin is a wide…
View article: NAT10 induces N4-acetylcytidine modification of AdipoR1-mediated mitochondrial biogenesis against endothelial-to-mesenchymal transition in hypertension
NAT10 induces N4-acetylcytidine modification of AdipoR1-mediated mitochondrial biogenesis against endothelial-to-mesenchymal transition in hypertension Open
Background Endothelial-to-mesenchymal transition (EndMT) in endothelial dysfunction exacerbates hypertension. However, the regulatory mechanisms underlying EndMT in hypertension are yet to be elucidated. Methods The N-acetyltransferase 10 …
View article: Cell-penetrating peptide-functionalized biomimetic nanovesicles for efficient cataract treatment via enhanced corneal penetration and lens-mitochondria dual targeting
Cell-penetrating peptide-functionalized biomimetic nanovesicles for efficient cataract treatment via enhanced corneal penetration and lens-mitochondria dual targeting Open
Cataract is the leading cause of blindness worldwide. While the oxidative stress homeostasis unbalance of the lens is a key pathological mechanism underlying cataract formation. Due to the lens being deeply embedded behind multiple biologi…
View article: Calcium hydroxide nanoparticles induce apoptotic cell death in human pancreatic cancer cells through over ROS-driven genomic instability and mitochondrial dysfunction
Calcium hydroxide nanoparticles induce apoptotic cell death in human pancreatic cancer cells through over ROS-driven genomic instability and mitochondrial dysfunction Open
The aggressive nature of pancreatic cancer, coupled with the limitations of current treatment options, underscores the urgent need for more effective and targeted therapies. Nanoparticle-based approaches offer promising alternatives, with …
View article: Persistent Oxidation of Mitochondrial and Transmembrane Proteins in Rat Cerebrum and Heart Regardless of Age or Nutrition
Persistent Oxidation of Mitochondrial and Transmembrane Proteins in Rat Cerebrum and Heart Regardless of Age or Nutrition Open
Reactive oxygen species (ROS), inevitable by-products of aerobic metabolism, act both as regulators of signaling pathways and as mediators of oxidative stress and aging-related damage. Protein oxidative post-translational modifications (Ox…
View article: Mitochondrial cargo quality determines the paracrine effects of extracellular vesicles derived from vascular endothelial cells
Mitochondrial cargo quality determines the paracrine effects of extracellular vesicles derived from vascular endothelial cells Open
Cell-derived extracellular vesicles (EV) are mediators of intercellular communication with increased circulating levels of endothelial cell-derived EV (EC-EV) reported in cardiovascular diseases (CVD). The EC-EV ability to elicit either de…