Myristoylation
View article: SUMOylation-dependent degradation of nucleocapsid is responsible for <i>Pestivirus</i> uncoating
SUMOylation-dependent degradation of nucleocapsid is responsible for <i>Pestivirus</i> uncoating Open
Classical swine fever virus (CSFV), a highly virulent member of the Pestivirus genus, is one of the most significant pathogens within this group. Although uncoating is a prerequisite for productive infection, the molecular determinants orc…
View article: Regelwerk zur Bedeutungsbildung, Syntax und Konsistenz ohne Wörter
Regelwerk zur Bedeutungsbildung, Syntax und Konsistenz ohne Wörter Open
Dieses Dokument stellt ein strukturbasiertes Regelwerk zur Verarbeitung von Sprache ohne klassische Grammatik, Wörterbuch oder symbolische Modelle bereit. Es richtet sich an Systeme, die Sprache über Muster, Zustände und Resonanzverläufe i…
View article: Regelwerk zur Bedeutungsbildung, Syntax und Konsistenz ohne Wörter
Regelwerk zur Bedeutungsbildung, Syntax und Konsistenz ohne Wörter Open
Dieses Dokument stellt ein strukturbasiertes Regelwerk zur Verarbeitung von Sprache ohne klassische Grammatik, Wörterbuch oder symbolische Modelle bereit. Es richtet sich an Systeme, die Sprache über Muster, Zustände und Resonanzverläufe i…
View article: Identification of a Linear B-Cell Epitope in the African Swine Fever Virus pE248R Protein Targeted by Monoclonal Antibodies
Identification of a Linear B-Cell Epitope in the African Swine Fever Virus pE248R Protein Targeted by Monoclonal Antibodies Open
African swine fever virus (ASFV) is the only member of the family Asfarviridae and can cause African swine fever, a disease with a consistently high mortality rate. The pE248R protein, a myristoylated integral membrane protein of ASFV, is …
View article: Divergent functions of late ESCRT components in Giardia lamblia: Insights from subcellular distributions and protein interactions
Divergent functions of late ESCRT components in Giardia lamblia: Insights from subcellular distributions and protein interactions Open
Giardia lamblia , a human gut pathogen, possesses a minimal ESCRT (Endosomal Sorting Complex Required for Transport) machinery. Paradoxically, there are multiple paralogues of some late-ESCRT components- three paralogues for Vps4, GlVps4a,…
View article: CSIG-10. MARCKS EFFECTOR DOMAIN PHOSPHORYLATION STATE AS A REGULATOR OF TUNNELING NANOTUBES IN GLIOBLASTOMA AND NORMAL HUMAN ASTROCYTE BIOLOGY
CSIG-10. MARCKS EFFECTOR DOMAIN PHOSPHORYLATION STATE AS A REGULATOR OF TUNNELING NANOTUBES IN GLIOBLASTOMA AND NORMAL HUMAN ASTROCYTE BIOLOGY Open
BACKGROUND Glioblastoma (GBM) is well known to interact with surrounding tumor and stromal cells in a variety of ways to maintain its pathogenicity. Emerging evidence has identified tunneling nanotubes (TNTs), dynamic actin-rich structures…
View article: Correction: Elucidating the role of N‑myristoylation in the excessive membrane localization of PD‑L1 in hypoxic cancers and developing a novel NMT1 inhibitor for combination with immune checkpoint blockade therapy
Correction: Elucidating the role of N‑myristoylation in the excessive membrane localization of PD‑L1 in hypoxic cancers and developing a novel NMT1 inhibitor for combination with immune checkpoint blockade therapy Open
View article: Biomembranal Myristoyl-Phosphatidylcholine as a Potential Target of the Cell Injury Activity of Vitamin D Decomposition Products in Eukaryotic Cells
Biomembranal Myristoyl-Phosphatidylcholine as a Potential Target of the Cell Injury Activity of Vitamin D Decomposition Products in Eukaryotic Cells Open
Background: Vitamin D decomposition products target a myristic acid sidechain of the predominant glycerophospholipid constructed in the biomembranes of Helicobacter pylori, causing gastric cancer in humans, and disrupt the membrane structu…
View article: NAC couples protein synthesis with nascent polypeptide myristoylation on the ribosome
NAC couples protein synthesis with nascent polypeptide myristoylation on the ribosome Open
N-glycine myristoylation allows for reversible association of newly synthesized proteins with membranes to regulate essential functions such as cellular signaling and stress responses. This process can be catalyzed during protein synthesis…
View article: Inhibition of human N myristoyltransferase 1 as a strategy to suppress cancer progression driven by myristoylation
Inhibition of human N myristoyltransferase 1 as a strategy to suppress cancer progression driven by myristoylation Open
N-myristoyltransferase 1 (NMT-1) catalyzes the co-translational addition of myristic acid to the N-terminal glycine of substrate proteins, regulating membrane localization and protein-protein interactions essential for oncogenic signaling.…
View article: Elucidating the role of N-myristoylation in the excessive membrane localization of PD-L1 in hypoxic cancers and developing a novel NMT1 inhibitor for combination with immune checkpoint blockade therapy
Elucidating the role of N-myristoylation in the excessive membrane localization of PD-L1 in hypoxic cancers and developing a novel NMT1 inhibitor for combination with immune checkpoint blockade therapy Open
Background Most cancers, including head and neck squamous cell carcinoma (HNSCC), frequently exhibit an approximately 80% lack of response to immune checkpoint blockade (ICB) therapy, largely attributed to hypoxia-induced tumor immune supp…
View article: Mechanism of cotranslational protein N-myristoylation in human cells
Mechanism of cotranslational protein N-myristoylation in human cells Open
N-myristoyltransferases (NMTs) cotranslationally transfer the fatty acid myristic acid to the N terminus of newly synthesized proteins, regulating their function and cellular localization. These enzymes are important drug targets for the t…
View article: Lipid Modification and Membrane Localization of Proteins in Cell-Free System
Lipid Modification and Membrane Localization of Proteins in Cell-Free System Open
Post-translational modifications are an essential process for proper protein function and localization. In particular, lipid modification plays a crucial role in the spatial regulation of proteins functioning on a lipid membrane surface. W…
View article: Lysine myristoylation mediates long-term potentiation via membrane enrichment of synaptic plasticity effectors
Lysine myristoylation mediates long-term potentiation via membrane enrichment of synaptic plasticity effectors Open
Synaptic plasticity underlying long-term memory is associated with the generation of saturated free fatty acids (sFFAs) –particularly myristic acid– from membrane phospholipids by the phospholipase A1 isoform DDHD2. However, the mechanism …
View article: Regulation of Cardiac Fibroblast Signaling by HDAC11-Reversible Myristoylation of an AKAP
Regulation of Cardiac Fibroblast Signaling by HDAC11-Reversible Myristoylation of an AKAP Open
View article: Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover
Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover Open
TMEM106B, a type II transmembrane protein localized on the lysosomal membrane, has been identified as a central player in neurodegeneration and brain aging during the past decade. TMEM106B variants that increase TMEM106B expression levels …
View article: Molecular basis for presentation of N-myristoylated peptides by the chicken YF1∗7.1 molecule
Molecular basis for presentation of N-myristoylated peptides by the chicken YF1∗7.1 molecule Open
View article: Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine Open
RAS is the most frequently mutated oncogene in cancer. RAS proteins show high sequence similarities in their G-domains but are significantly different in their C-terminal hypervariable regions (HVR). These regions interact with the cell me…
View article: Abstract 1498 Regulation of DNA damage response by protein myristoylation
Abstract 1498 Regulation of DNA damage response by protein myristoylation Open
View article: MARCKS as a Target for Pathological Tunneling Nanotubes in Glioblastoma
MARCKS as a Target for Pathological Tunneling Nanotubes in Glioblastoma Open
During glioblastoma (GBM) progression, therapeutic resistance is influenced by a heterogeneous network of tumor- and tumor-promoting cells in the tumor microenvironment. Biological attacks against tumor cells (i.e. chemoradiotherapy) induc…
View article: Mammarenavirus Z Protein Myristoylation and Oligomerization Are Not Required for Its Dose-Dependent Inhibitory Effect on vRNP Activity
Mammarenavirus Z Protein Myristoylation and Oligomerization Are Not Required for Its Dose-Dependent Inhibitory Effect on vRNP Activity Open
Background/Objectives: N-Myristoyltransferase inhibitors (NMTi) represent a novel antiviral strategy against mammarenaviruses such as Lassa and Junin viruses. The Z matrix protein inhibits viral ribonucleoprotein (vRNP) activity in a dose-…
View article: Mammarenavirus Z protein myristoylation and oligomerization are not required for its dose-dependent inhibitory effect on vRNP activity
Mammarenavirus Z protein myristoylation and oligomerization are not required for its dose-dependent inhibitory effect on vRNP activity Open
We have recently documented the use of N-Myristoyltransferase inhibitors (NMTi) as an antiviral strategy against human pathogenic mammarenaviruses, including Lassa and Junin viruses, responsible for the hemorrhagic fever (HF) diseases Lass…
View article: p38 mediated ACSL4 phosphorylation drives stress-induced esophageal squamous cell carcinoma growth through Src myristoylation
p38 mediated ACSL4 phosphorylation drives stress-induced esophageal squamous cell carcinoma growth through Src myristoylation Open
The comprehension of intricate molecular mechanisms underlying how external stimuli promote malignancy is conducive to cancer early prevention. Esophageal squamous cell carcinoma (ESCC) is considered as an external stimuli (hot foods, toba…
View article: Lipid-driven Src self-association modulates its transformation capacity
Lipid-driven Src self-association modulates its transformation capacity Open
Src tyrosine kinase regulates cell growth and adhesion through membrane signaling, and its deregulation is associated with cancer. Although active Src is anchored to the plasma membrane, the role of membrane lipids in its regulation remain…
View article: Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity
Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity Open
Middle-aged obesity, characterized by excessive fat accumulation and systemic energy imbalance, often precedes various health complications. Recent research has unveiled a surprising link between DNA damage response and energy metabolism. …
View article: Author response: Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages
Author response: Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages Open
View article: Data from Zelenirstat Inhibits N-Myristoyltransferases to Disrupt Src Family Kinase Signaling and Oxidative Phosphorylation, Killing Acute Myeloid Leukemia Cells
Data from Zelenirstat Inhibits N-Myristoyltransferases to Disrupt Src Family Kinase Signaling and Oxidative Phosphorylation, Killing Acute Myeloid Leukemia Cells Open
Acute myeloid leukemia (AML) is a hematologic malignancy with limited treatment options and a high likelihood of recurrence after chemotherapy. We studied N-myristoylation, the myristate modification of proteins linked to survival signalin…
View article: Myristoylated Cathelicidin‐DM Fused With ANG1‐7: A Novel Self‐Assembling Antimicrobial Peptide for the Treatment and Mechanism of Diabetic Infected Wounds
Myristoylated Cathelicidin‐DM Fused With ANG1‐7: A Novel Self‐Assembling Antimicrobial Peptide for the Treatment and Mechanism of Diabetic Infected Wounds Open
Diabetic wounds, due to severe vascular dysfunction, persistent inflammatory responses, and susceptibility to microbial infections, exhibit delayed healing and pose a significant challenge to human health. Diabetic wounds face delayed heal…
View article: Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein
Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein Open
Several Old World and New World Mammarenavirus are responsible for hemorrhagic fever in humans. These enveloped viruses have a bi-segmented ambisense RNA genome that encodes four proteins. All Mammarenavirus identified to date share a comm…
View article: Lipid-driven SRC self-association modulates its transformation capacity
Lipid-driven SRC self-association modulates its transformation capacity Open
Src tyrosine kinase is anchored to the plasma membrane, however, the contribution of membrane lipids to its regulation remains elusive. Here we report Src self-association through a lysine cluster in the Src SH4 region mediated by lipids i…