Psychiatric genetics
View article: The “Schizophrenia is 80% Heritable” Fallacy: Deconstructing a 2003 Twin Study Meta-Analysis
The “Schizophrenia is 80% Heritable” Fallacy: Deconstructing a 2003 Twin Study Meta-Analysis Open
The mainstream psychiatry literature contains the ubiquitous and mostly unchallenged claim that schizophrenia is roughly 80% heritable. A 2003 twin study meta-analysis by genetic researchers Patrick F. Sullivan, Kenneth S. Kendler, and Mic…
View article: Exploring community perspectives on autism genetics research: Indications of supportive views and educational needs
Exploring community perspectives on autism genetics research: Indications of supportive views and educational needs Open
Autistic advocates have raised substantial concerns regarding genetics research on autism. It is yet unclear whether these concerns reflect the perspectives of the broader autism community. In sample of 1757 Dutch autistic adults, 445 pare…
View article: Enrichment for heritability in psychiatric disorders and cognitive phenotypes in regions surrounding CEL-induced DEGs at FDR < 0.05.
Enrichment for heritability in psychiatric disorders and cognitive phenotypes in regions surrounding CEL-induced DEGs at FDR < 0.05. Open
Enrichment for heritability in psychiatric disorders and cognitive phenotypes in regions surrounding CEL-induced DEGs at FDR < 0.05.
View article: Genetics of SSRI antidepressant use and relationship to psychiatric and medical traits
Genetics of SSRI antidepressant use and relationship to psychiatric and medical traits Open
Antidepressants are among the most-prescribed drugs worldwide, and selective serotonin reuptake inhibitors (SSRIs) are among the most prescribed antidepressants, most commonly used for major depression. We sought to increase our understand…
View article: Genetic Propensities for Psychiatric Disorders Reveal Distinct Pathways Linking Substance Use and Suicidality
Genetic Propensities for Psychiatric Disorders Reveal Distinct Pathways Linking Substance Use and Suicidality Open
This study investigates how genetic propensity for psychiatric disorders contributes to suicidal ideation or attempts via cannabis or opioid use—the two most commonly used federally controlled substances in the U.S. Using data from over 32…
View article: Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders
Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders Open
View article: A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits
A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits Open
Rare copy number variants (CNVs) are a key component of the genetic basis of psychiatric conditions, but have not been well characterized for most. We conducted a genome-wide CNV analysis across six diagnostic categories (N = 574,965): aut…
View article: Network-pluralistic psychiatry: linking genetics, brain connectivity, and psychosocial context
Network-pluralistic psychiatry: linking genetics, brain connectivity, and psychosocial context Open
The network-pluralistic theory (NPT) of psychiatry represents a groundbreaking framework that integrates recent advances in psychiatric genetics, clinical pharmacogenetics, and sophisticated brain network analysis. This comprehensive model…
View article: The Psychiatric Genomics Consortium: Discoveries and Directions
The Psychiatric Genomics Consortium: Discoveries and Directions Open
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from th…
View article: The Psychiatric Genomics Consortium: Discoveries and Directions
The Psychiatric Genomics Consortium: Discoveries and Directions Open
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from th…
View article: Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes Open
View article: Enhancing the discriminatory power of polygenic scores for ADHD and autism in clinical and non-clinical samples
Enhancing the discriminatory power of polygenic scores for ADHD and autism in clinical and non-clinical samples Open
Background Polygenic scores (PGS) are widely used in psychiatric genetic associations studies due to their predictive power for focal outcomes. However, they lack discriminatory power, in part due to the high degree of genetic overlap betw…
View article: The Eating Disorders Genetics Initiative 2 (EDGI2): study protocol
The Eating Disorders Genetics Initiative 2 (EDGI2): study protocol Open
View article: Supplementary file 1_Genetic predisposition to digital device use and the risk of five psychiatric disorders.docx
Supplementary file 1_Genetic predisposition to digital device use and the risk of five psychiatric disorders.docx Open
Background Psychiatric disorders were observationally related to digital device use, but causality and direction remained unclear. We aimed to uncover the causal links between digital device use and five psychiatric disorders risk utilizin…
View article: Psychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveries
Psychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveries Open
Background Innovation in psychiatric therapeutics has stagnated on known mechanisms. Psychiatric genome-wide association studies (GWAS) have identified hundreds of genome-wide significant (GWS) loci that have rapidly advanced our understan…
View article: Integrative GWAS Identifies Novel Loci and Genetic Links Between Psychiatric and Metabolic Factors in Anorexia Nervosa
Integrative GWAS Identifies Novel Loci and Genetic Links Between Psychiatric and Metabolic Factors in Anorexia Nervosa Open
Anorexia nervosa (AN) is a complex psychiatric disorder with both psychiatric and metabolic underpinnings. To explore the genetic architecture of AN, we conducted a meta-analysis of AN GWAS data from European and Finnish populations, ident…
View article: Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries
Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries Open
Combining transdiagnostic and disorder-level genetic approaches can improve our understanding of co-occurring conditions and increase the specificity of genetic discovery, which is critical for identifying more effective prevention and tre…
View article: Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders
Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders Open
Psychiatric disorders are complex, polygenic conditions characterized by patterned structural brain alterations. Whether these changes reflect transcriptional dysregulation driven by genetic risk remains unclear. We introduce a novel imagi…
View article: Deep learning-based polygenic scores enhance generalizability of psychiatric disorders prediction
Deep learning-based polygenic scores enhance generalizability of psychiatric disorders prediction Open
Polygenic scores (PGSs) have emerged as promising tools for predicting complex traits from genetic data, however, their predictive performance for psychiatric disorders remains limited and the added value of deep learning (DL) over linear …
View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overl…
View article: Associations of Genetic Liability to Six Psychiatric Disorders With Cardiometabolic Diseases
Associations of Genetic Liability to Six Psychiatric Disorders With Cardiometabolic Diseases Open
IMPORTANCE Individuals with psychiatric disorders have increased risk of cardiometabolic diseases (CMDs). Evaluating how psychiatric genetic liability relates to CMD may clarify mechanisms. OBJECTIVE Identify genetic overlap between psychi…
View article: Neuroscience of Schizotypy: A Translational Perspective From Phenotype to Genetics and Brain Networks
Neuroscience of Schizotypy: A Translational Perspective From Phenotype to Genetics and Brain Networks Open
View article: The Eating Disorders Genetics Initiative 2 (EDGI2): Study Protocol
The Eating Disorders Genetics Initiative 2 (EDGI2): Study Protocol Open
Background: The Eating Disorders Genetics Initiative 2 (EDGI2) is designed to explore the role of genes and environment in anorexia nervosa, bulimia nervosa, binge-eating disorder, and avoidant/restrictive food intake disorder (ARFID) with…
View article: The Psychiatric Genomics Consortium: Discoveries and Directions
The Psychiatric Genomics Consortium: Discoveries and Directions Open
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from th…
View article: Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research Open
View article: Association between maternal genome-wide polygenic scores for psychiatric and neurodevelopmental disorders and perinatal risk factors: A Danish population-based study
Association between maternal genome-wide polygenic scores for psychiatric and neurodevelopmental disorders and perinatal risk factors: A Danish population-based study Open
Importance Adverse perinatal outcomes are common challenges for mothers and their newborns. Epidemiological studies indicate that mothers with psychiatric and neurodevelopmental disorders are at an increased risk of adverse pregnancy and n…
View article: The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders
The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders Open
Psychiatric disorders display high levels of comorbidity and genetic overlap 1,2 . Genomic methods have shown that even for schizophrenia and bipolar disorder, two disorders long-thought to be etiologically distinct 3 , the majority of gen…
View article: Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders
Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders Open
View article: Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity
Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity Open
View article: Optimizing Psychiatric Care through Pharmacogenomics: An Evidence-Based Program to Increase Multi-gene Pharmacogenomic Testing and Provider Competence in Mental Health Settings
Optimizing Psychiatric Care through Pharmacogenomics: An Evidence-Based Program to Increase Multi-gene Pharmacogenomic Testing and Provider Competence in Mental Health Settings Open
Objective: This scholarly project aimed to enhance psychiatric providers' competency, confidence, and knowledge in the PHASER pharmacogenomic (PGx) testing program at the VA San Diego Healthcare System. Background: PGx testing enhances psy…