Micronization
View article: Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics
Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics Open
The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active…
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Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules Open
Adequate aqueous solubility has been one of the desired properties while selecting drug molecules and other bio-actives for product development. Often solubility of a drug determines its pharmaceutical and therapeutic performance. Majority…
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Microencapsulation and Nanoencapsulation Using Supercritical Fluid (SCF) Techniques Open
The unique properties of supercritical fluids, in particular supercritical carbon dioxide (CO2), provide numerous opportunities for the development of processes for pharmaceutical applications. One of the potential applications for pharmac…
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Nonthermal physical modification of starch: An overview of recent research into structure and property alterations Open
To tailor the properties and enhance the applicability of starch, various ways of starch modification have been practiced. Among them, physical modification methods (micronization, nonthermal plasma, high-pressure, ultrasonication, pulsed …
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Nanoparticles and Nanocrystals by Supercritical CO2-Assisted Techniques for Pharmaceutical Applications: A Review Open
Many active ingredients currently prescribed show limited therapeutic efficacy, mainly due to their dissolution rate inadequate to treat the pathology of interest. A large drug particle size creates an additional problem if a specific site…
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Influence of liposome encapsulated essential oils on properties of chitosan films Open
The effect of the encapsulation of eugenol and cinnamon leaf essential oil ( CLEO ) in lecithin liposomes on the losses of these compounds during the chitosan film formation process by casting was evaluated. Film‐forming dispersions and fi…
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Comparisons of the micronization, steam explosion, and gamma irradiation treatment on chemical composition, structure, physicochemical properties, and in vitro digestibility of dietary fiber from soybean hulls Open
The objective of this study was to compare the effects of the micronization (MT), steam explosion (SE), and gamma irradiation (GI) treatment on the chemical composition, structure, physicochemical properties, and in vitro digestibility of …
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Alginate-Based Aerogel Particles as Drug Delivery Systems: Investigation of the Supercritical Adsorption and In Vitro Evaluations Open
The present work focuses on the preparation of alginate-based aerogels in the form of particles for their further study as potential drug delivery systems (solid dosage forms). The dripping method was used to prepare certain gel particles,…
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Supercritical Assisted Electrospray: An Improved Micronization Process Open
A new process is proposed that can largely improve classical electrospray (ESPR) atomization, thanks to the addition of supercritical CO2 (SC-CO2) to the liquid mixture, in which a polymer is dissolved, forming an expanded liquid. The cons…
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Technologies to Improve the Solubility, Dissolution and Bioavailability of Poorly Soluble Drugs Open
\n\tCombinatorial chemistry, computational molecular modeling and high throughput screening in drug discovery have significantly increased the number of poorly soluble drugs. About 40% of drugs developed in the past and about 90% of the d…
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Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery Open
Various active compounds isolated from natural sources exhibit remarkable benefits, making them attractive for pharmaceutical and biomedical applications, such as antioxidant, antimicrobial, and anti-inflammatory activities, which contribu…
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Application of Fluids in Supercritical Conditions in the Polymer Industry Open
This article reviews the use of fluids under supercritical conditions in processes related to the modern and innovative polymer industry. The most important processes using supercritical fluids are: extraction, particle formation, microniz…
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Sun protection factor analysis of sunscreens containing titanium dioxide nanoparticles Open
The effect of micronization on sun protection factor (SPF) were tested on two types of titanium dioxide (TiO2) with primary particle sizes of 20 nm and 170 nm. Oil/water creams with 5%, 10%, and 20% concentrations of each type of TiO2 were…
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Self-Assembly of Zein-Based Microcarrier System for Colon-Targeted Oral Drug Delivery Open
The advances in pharmaceutical technology allow for the development of various region-selective delivery systems for oral administration to optimize local and systemic therapy. In this paper, micronization associated with a polymorph modif…
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Supercritical fluid technology for agrifood materials processing Open
Supercritical fluid technology has been applied in the food area for processing and preserving food products and/or monitoring the food quality, with known advantages. The main solvent used at supercritical conditions for food applications…
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Controlling Polymorphism of Carbamazepine Nanoparticles in a Continuous Supercritical-CO<sub>2</sub>-Assisted Spray Drying Process Open
Controlling polymorphism in the transition from batch to continuous crystallization represents a major obstacle for the pharmaceutical industry. This work demonstrates a novel methodology to control the polymorphism of carbamazepine (CBZ) …
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The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character Open
Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly influence the bioa…
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Supercritical fluid technology for solubilization of poorly water soluble drugs via micro- and naonosized particle generation Open
Approximately two-third of the compounds in the pharmaceutical industry were developed through combinatorial chemistry and high throughput screening of particulate solids. Poor solubility and bioavailability of these pharmaceuticals are ch…
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Gastronomy: An extended platform for customized nutrition Open
Gastronomy is a unique field of science that helps us to better understand indigenous varieties of food and cuisines. With the advancement in the field of science, diverged concepts evolved from gastronomy, and food is also viewed from the…
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Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique Open
Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-HIV, and anti-microbial activity. Recently, electrospraying has …
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Micronization of a poorly water-soluble drug, fenofibrate, via supercritical-fluid-assisted spray-drying Open
In the present study, fenofibrate (a model drug with poor aqueous solubility) was micronized using the supercritical-fluid-assisted spray-drying (SA-SD) process to improve dissolution and biopharmaceutical property. Solid-state characteriz…
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Influence of Physiological Gastrointestinal Surfactant Ratio on the Equilibrium Solubility of BCS Class II Drugs Investigated Using a Four Component Mixture Design Open
The absorption of poorly water-soluble drugs is influenced by the luminal gastrointestinal fluid content and composition, which control solubility. Simulated intestinal fluids have been introduced into dissolution testing including endogen…
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Enhancement of hydrogen release kinetics from ethane 1,2 diamineborane (EDAB) by micronization using Supercritical Antisolvent (SAS) precipitation Open
Ethane 1, 2 diamineborane (EDAB) was micronized from THF solutions using Supercritical Antisolvent (SAS) process. The influence of temperature, solute concentration and carbon dioxide fraction on the final properties of EDAB particles was …
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Surface characteristics analysis of fractures induced by supercritical CO2 and water through three-dimensional scanning and scanning electron micrography Open
Morphology of hydraulic fracture surface has significant effects on oil and gas flow, proppant migration and fracture closure, which plays an important role in oil and gas fracturing stimulation. In this paper, we analyzed the fracture sur…
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SIMULTANEOUS COCRYSTALLIZATION AND MICRONIZATION OF PARACETAMOL-DIPICOLINIC ACID COCRYSTAL BY SUPERCRITICAL ANTISOLVENT (SAS) Open
Objective: This present study aims to produce cocrystal of paracetamol (PCA)-dipicolinic acid (DPA) using supercritical antisolvent (SAS) cocrystallization process in order to improve tabletability profile of PCA. Methods: The PCA-DPA …
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Influence of particle size in supercritical carbon dioxide extraction of roselle (Hibiscus sabdariffa) on bioactive compound recovery, extraction rate, diffusivity, and solubility Open
The purpose of this work was to establish the best particle size for recovering high yields of total phenolic compounds (TPC), total anthocyanin compounds(TAC) and total flavonoid compounds (TFC) from roselle ( Hibiscus sabdariffa ) by app…
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Effect of the Micronization of Pulp Fibers on the Properties of Green Composites Open
Green composites, composed of bio-based matrices and natural fibers, are a sustainable alternative for composites based on conventional thermoplastics and glass fibers. In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers …
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Micronization Effects on Structural, Functional, and Antioxidant Properties of Wheat Bran Open
To explore the effect of micronization on the structural, functional, and antioxidant properties of wheat bran, wheat bran with mean particle size (D50) of 46.08, 34.29, 26.51, 26.35, and 26.05 μm were prepared by using an ultrafine pulver…
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Inhalable Spray-Dried Chondroitin Sulphate Microparticles: Effect of Different Solvents on Particle Properties and Drug Activity Open
Spray-drying stands as one of the most used techniques to produce inhalable microparticles, but several parameters from both the process and the used materials affect the properties of the resulting microparticles. In this work, we describ…
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Solubility of digitoxin in supercritical CO2: Experimental study and modeling Open
In this communication, the solubility of digitoxin drug in supercritical CO2 was studied at different operating conditions (311 < T (K) < 343, 120 < P (bar) < 300). The results revealed digitoxin drug solubility (in mole fraction) was betw…