Cholesterol 7 alpha-hydroxylase
View article: Dietary chenodeoxycholic acid alleviates cottonseed oil-induced hepatic lipid deposition and inflammation in juvenile black seabream (Acanthopagrus schlegelii)
Dietary chenodeoxycholic acid alleviates cottonseed oil-induced hepatic lipid deposition and inflammation in juvenile black seabream (Acanthopagrus schlegelii) Open
The present work conducted an eight-week feeding trail for exploring the dietary chenodeoxycholic acid (CA) affected lipid deposition and inflammation induced by cottonseed oil (CO) within juvenile black seabream (Acanthopagrus schlegelii)…
View article: Lactiplantibacillus plantarum Lp20 Alleviates High Fat Diet-Induced Obesity in Mice via Its Bile Salt Hydrolase Activity
Lactiplantibacillus plantarum Lp20 Alleviates High Fat Diet-Induced Obesity in Mice via Its Bile Salt Hydrolase Activity Open
Background: Obesity is a highly prevalent chronic disease characterized by excessive weight gain and fat accumulation. There is growing evidence that Lactiplantibacillus plantarum strains with bile salt hydrolase (BSH) activity are effecti…
View article: <i>Sargassum fusiforme</i> polysaccharides modulate gut microbiota and metabolites to regulate hyperlipidemia in mice fed a high-fat diet
<i>Sargassum fusiforme</i> polysaccharides modulate gut microbiota and metabolites to regulate hyperlipidemia in mice fed a high-fat diet Open
Hyperlipidemia complications caused by obesity are a hot issue threatening human health worldwide, and there is an urgent need to explore low-toxicity health foods for intervention. Sargassum fusiforme polysaccharides (SFPS) display choles…
View article: Regulatory effects of Sini-San on bile acid homeostasis in the enterohepatic circulation of mice with liver fibrosis
Regulatory effects of Sini-San on bile acid homeostasis in the enterohepatic circulation of mice with liver fibrosis Open
Background Sini-San (SNS), a classical traditional Chinese medicinal formula, has demonstrated promising potential in mitigating the progression of liver fibrosis (LF). Increasing evidence highlights that disruption of bile acids (BAs) hom…
View article: Stachyose AttenuatesHepatic Cholesterol Depositionin Nonalcoholic Fatty Liver Mice via Gut Microbiota-Driven Bile AcidProfile Remodeling
Stachyose AttenuatesHepatic Cholesterol Depositionin Nonalcoholic Fatty Liver Mice via Gut Microbiota-Driven Bile AcidProfile Remodeling Open
Nonalcoholic fatty liver disease (NAFLD), driven by liver lipid accumulation, presents a global health challenge. Bile acid metabolism critically regulates cholesterol homeostasis, but whether prebiotic stachyose can modulate it for NAFLD …
View article: Screening Cholesterol-Lowering <i>Lactiplantibacillusplantarum</i> through <i>In Vitro</i> Experiments,Whole Genomics Analysis, and <i>In Silico</i> Approaches:From the Perspective of Bile Salt Hydrolase and Cholesterol
Screening Cholesterol-Lowering <i>Lactiplantibacillusplantarum</i> through <i>In Vitro</i> Experiments,Whole Genomics Analysis, and <i>In Silico</i> Approaches:From the Perspective of Bile Salt Hydrolase and Cholesterol Open
Hypercholesterolemia is a cardiovascular condition resulting from elevated cholesterol levels. This study screened seven Lactiplantibacillus plantarum strains with efficient cholesterol (CHOL)-lowering abilities and investigated the…
View article: To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux
To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux Open
Aim of the study To investigate the effect of Ruanjian Qingmai granules (RJQM) on arteriosclerotic obliterans (ASO) and identify its potential bioactive components. Materials and methods Separate zebrafish atherosclerosis models and cellul…
View article: Table 1_To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux.docx
Table 1_To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux.docx Open
Aim of the study To investigate the effect of Ruanjian Qingmai granules (RJQM) on arteriosclerotic obliterans (ASO) and identify its potential bioactive components. Materials and methods Separate zebrafish atherosclerosis models and cellul…
View article: Investigating the role of genetic variations of <i>ABCB1</i> (rs1045642) and <i>CYP7A1</i> (rs3808607) genes on serum lipid level among Malaysian male patients treated with atorvastatin
Investigating the role of genetic variations of <i>ABCB1</i> (rs1045642) and <i>CYP7A1</i> (rs3808607) genes on serum lipid level among Malaysian male patients treated with atorvastatin Open
The allele frequency of the heterozygous group was higher in both studied SNPs. The variant allele of gene ABCB1 and the reference allele of CYP7A1 showed a more favorable lipid profile.
View article: Polymorphic Variants of Selected Genes Regulating Bile Acid Homeostasis in Women with Intrahepatic Cholestasis of Pregnancy
Polymorphic Variants of Selected Genes Regulating Bile Acid Homeostasis in Women with Intrahepatic Cholestasis of Pregnancy Open
Intrahepatic cholestasis of pregnancy (ICP) is characterized by the onset of pruritus and elevated serum transaminases and bile acids (BA). The key enzyme in BA synthesis is CYP7A1, and its functions are regulated by various nuclear recept…
View article: Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet
Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet Open
Background ATP-binding cassette subfamily A1 (ABCA1) and sterol 27-hydroxylase (CYP27A1) are essential regulators of cholesterol metabolism. However, their tissue-specific roles, particularly in the lung, under high-cholesterol diet (HCD) …
View article: Image 1_Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet.tif
Image 1_Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet.tif Open
Background ATP-binding cassette subfamily A1 (ABCA1) and sterol 27-hydroxylase (CYP27A1) are essential regulators of cholesterol metabolism. However, their tissue-specific roles, particularly in the lung, under high-cholesterol diet (HCD) …
View article: Age‐Independent Hypocholesterolemic Effects of Rice Protein via <scp>FXR</scp> ‐Mediated Stimulation of Cholesterol Elimination
Age‐Independent Hypocholesterolemic Effects of Rice Protein via <span>FXR</span> ‐Mediated Stimulation of Cholesterol Elimination Open
The present study investigated the effect of rice protein (RP) on plasma cholesterol clearance by administering diets containing either casein or RP to growing and adult male Wistar rats over a two‐week period. RP intake markedly upregulat…
View article: Phytosterols InhibitACAT2-Catalyzed Cholesteryl Esterificationin Caco‑2 Cells without Affecting Cholesterol Transporter Genes
Phytosterols InhibitACAT2-Catalyzed Cholesteryl Esterificationin Caco‑2 Cells without Affecting Cholesterol Transporter Genes Open
Phytosterols have long been used to prevent hypercholesterolemia-related diseases, although their effects on intestinal cholesterol metabolism remain elusive. This study applied comparative proteomics to investigate the effects of various …
View article: Pediatric Familial Hypercholesterolemia: Targeting Intestinal Absorption and Other Therapeutic Strategies
Pediatric Familial Hypercholesterolemia: Targeting Intestinal Absorption and Other Therapeutic Strategies Open
Familial hypercholesterolemia (FH) is a genetic disorder marked by significantly elevated levels of low-density lipoprotein cholesterol (LDL-C) since childhood, substantially increasing the risk of premature atherosclerosis and cardiovascu…
View article: ORP2 regulates free cholesterol accumulation in hepatocytes during MASH
ORP2 regulates free cholesterol accumulation in hepatocytes during MASH Open
Background: Cholesterol crystals in hepatocytes are known to strongly associate with human metabolic dysfunction–associated steatohepatitis. However, it remains unclear which molecular pathway(s) regulates free cholesterol accumulation and…
View article: Bile acids affect intestinal barrier function through FXR and TGR5
Bile acids affect intestinal barrier function through FXR and TGR5 Open
Bile acids play a dual role by aiding lipid absorption and acting as signaling molecules by interacting with various receptors. Bile acids are perpetually recycled via enterohepatic circulation and are biotransformation by gut microbiota, …
View article: Computational Elucidationof Sterol Recognition bySREBP Cleavage Activatory Protein
Computational Elucidationof Sterol Recognition bySREBP Cleavage Activatory Protein Open
Intracellular cholesterol homeostasis is regulated by the sterol response element-binding protein (SREBP) pathway through the SREBP cleavage-activating protein (SCAP) and the insulin-induced gene protein (INSIG). Previous studies highlight…
View article: Elevated diurnal CD36 expression disrupts the bile acid synthesis rhythm, leading to cholestatic liver injury and inflammation via the HMGCR/CYP7A1 axis
Elevated diurnal CD36 expression disrupts the bile acid synthesis rhythm, leading to cholestatic liver injury and inflammation via the HMGCR/CYP7A1 axis Open
View article: Nano-Encapsulated Phytosterols Ameliorate Hypercholesterolemia in Mice via Dual Modulation of Cholesterol Metabolism Pathways
Nano-Encapsulated Phytosterols Ameliorate Hypercholesterolemia in Mice via Dual Modulation of Cholesterol Metabolism Pathways Open
Background: The limited bioavailability of free phytosterols restricts their clinical application in managing hypercholesterolemia. This study aimed to develop phytosterol nanoparticles (PNs) to enhance bioactivity and investigate their ch…
View article: Image 1_Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets.tif
Image 1_Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets.tif Open
Oral bile acids, particularly hyodeoxycholic acid (HDCA), serve as critical drivers for gut microbial community maturation in mice. In the first study, Cy5-labeled HDCA combined with fluorescence imaging revealed rapid gastrointestinal tra…
View article: Yinchenhao Decoction Mitigates Cholestatic Liver Injury in Mice via Gut Microbiota Regulation and Activation of FXR-FGF15 Pathway
Yinchenhao Decoction Mitigates Cholestatic Liver Injury in Mice via Gut Microbiota Regulation and Activation of FXR-FGF15 Pathway Open
Objective: Yinchenhao decoction (YCHD), a classical herbal formula comprising Artemisia capillaris, Gardenia jasminoides, and Rheum palmatum, has been clinically used for over 1000 years to treat cholestasis. However, its mechanism of acti…
View article: Table 1_Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets.docx
Table 1_Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets.docx Open
Oral bile acids, particularly hyodeoxycholic acid (HDCA), serve as critical drivers for gut microbial community maturation in mice. In the first study, Cy5-labeled HDCA combined with fluorescence imaging revealed rapid gastrointestinal tra…
View article: Image 2_Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets.tif
Image 2_Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets.tif Open
Oral bile acids, particularly hyodeoxycholic acid (HDCA), serve as critical drivers for gut microbial community maturation in mice. In the first study, Cy5-labeled HDCA combined with fluorescence imaging revealed rapid gastrointestinal tra…
View article: Image 3_Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets.tif
Image 3_Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets.tif Open
Oral bile acids, particularly hyodeoxycholic acid (HDCA), serve as critical drivers for gut microbial community maturation in mice. In the first study, Cy5-labeled HDCA combined with fluorescence imaging revealed rapid gastrointestinal tra…
View article: Data Sheet 1_Lactobacillus paragasseri HM018 derived from breast milk ameliorates hyperlipidemia in high-cholesterol rats by modulating bile acid metabolism.docx
Data Sheet 1_Lactobacillus paragasseri HM018 derived from breast milk ameliorates hyperlipidemia in high-cholesterol rats by modulating bile acid metabolism.docx Open
Introduction Hyperlipidemia, a prevalent metabolic disorder with rising global incidence, has become a major public health concern. Probiotics allow for a mild intervention strategy for hyperlipidemia management that has garnered increasin…
View article: Lactobacillus paragasseri HM018 derived from breast milk ameliorates hyperlipidemia in high-cholesterol rats by modulating bile acid metabolism
Lactobacillus paragasseri HM018 derived from breast milk ameliorates hyperlipidemia in high-cholesterol rats by modulating bile acid metabolism Open
Introduction Hyperlipidemia, a prevalent metabolic disorder with rising global incidence, has become a major public health concern. Probiotics allow for a mild intervention strategy for hyperlipidemia management that has garnered increasin…
View article: Genome-wide interaction study with body mass index identifies <i>CYP7A1</i> and <i>GIPR</i> as genetic modulators of metabolic dysfunction-associated steatotic liver disease
Genome-wide interaction study with body mass index identifies <i>CYP7A1</i> and <i>GIPR</i> as genetic modulators of metabolic dysfunction-associated steatotic liver disease Open
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) may progress to liver inflammation, fibrosis, cirrhosis and hepatocellular carcinoma. So far, genome-wide association studies explain a small fraction of MAS…
View article: Protective Effect of Obeticholic Acid on Sepsis-Induced Liver Dysfunction via Regulating Bile Acid Homeostasis
Protective Effect of Obeticholic Acid on Sepsis-Induced Liver Dysfunction via Regulating Bile Acid Homeostasis Open
Background/Objectives: Abnormal bile acid (BA) pool may play an important role in inducing liver damage in sepsis. Farnesoid X receptor (FXR) is a main negative feedback regulator of BA metabolism. This study aims to explore the protective…
View article: ASBT governs neonatal bile acid homeostasis early in life despite its strong ileal repression
ASBT governs neonatal bile acid homeostasis early in life despite its strong ileal repression Open
Despite being repressed after birth, ASBT is essential for neonatal bile acid homeostasis. This study reveals that ASBT limits fecal bile acid loss and suppresses hepatic bile acid synthesis in neonates. ASBT-deficient pups showed reduced …