Magnetic resonance spectroscopic imaging
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Prostate Magnetic Resonance Imaging and Magnetic Resonance Imaging Targeted Biopsy in Patients with a Prior Negative Biopsy: A Consensus Statement by AUA and SAR Open
Patients receiving a PI-RADS assessment category of 3 to 5 warrant repeat biopsy with image guided targeting. While transrectal ultrasound guided magnetic resonance imaging fusion or in-bore magnetic resonance imaging targeting may be valu…
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Modern Brain Tumor Imaging Open
The imaging and clinical management of patients with brain tumor continue to evolve over time and now heavily rely on physiologic imaging in addition to high-resolution structural imaging. Imaging remains a powerful noninvasive tool to pos…
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Emerging Neuroimaging Biomarkers Across Disease Stage in Parkinson Disease Open
Imaging biomarkers for various stages of PD are readily available to be used as outcome measures in clinical trials and are potentially useful in multimodal combination with routine clinical assessment. This Review provides a critically im…
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Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations Open
Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for monitoring metabolic alterations associated with disease or injury; however, to date, these methods have not had a significant impact on clinical care, and the…
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<i>T</i><sub>1</sub>–<i>T</i><sub>2</sub> Dual-Modal Magnetic Resonance Imaging: From Molecular Basis to Contrast Agents Open
Multimodal imaging strategies integrating manifold images have improved our ability to diagnose, to guide therapy, and to predict outcomes. Magnetic resonance imaging (MRI) is among the most widely used imaging technique in the clinic and …
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Accelerated MR spectroscopic imaging—a review of current and emerging techniques Open
Over more than 30 years in vivo MR spectroscopic imaging (MRSI) has undergone an enormous evolution from theoretical concepts in the early 1980s to the robust imaging technique that it is today. The development of both fast and efficient s…
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Ultra-high resolution brain metabolite mapping at 7 T by short-TR Hadamard-encoded FID-MRSI Open
MRSI in the brain at ≥7 T is a technique of great promise, but has been limited mainly by low B0/B1+-homogeneity, specific absorption rate restrictions, long measurement times, and low spatial resolution. To overcome these limitations, we …
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Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors Open
Hyperpolarized [1-13C]-pyruvate has shown tremendous promise as an agent for imaging tumor metabolism with unprecedented sensitivity and specificity. Imaging hyperpolarized substrates by magnetic resonance is unlike traditional MRI because…
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Comparison of unsupervised classification methods for brain tumor segmentation using multi-parametric MRI Open
Tumor segmentation is a particularly challenging task in high-grade gliomas (HGGs), as they are among the most heterogeneous tumors in oncology. An accurate delineation of the lesion and its main subcomponents contributes to optimal treatm…
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Super-Resolution 1H Magnetic Resonance Spectroscopic Imaging Utilizing Deep Learning Open
Magnetic resonance spectroscopic imaging (SI) is a unique imaging technique that provides biochemical information from in vivo tissues. The 1H spectra acquired from several spatial regions are quantified to yield metabolite concentrations …
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Water and lipid suppression techniques for advanced <sup>1</sup>H MRS and MRSI of the human brain: Experts' consensus recommendations Open
The neurochemical information provided by proton magnetic resonance spectroscopy (MRS) or MR spectroscopic imaging (MRSI) can be severely compromised if strong signals originating from brain water and extracranial lipids are not properly s…
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Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion Open
New magnetic resonance (MR) molecular imaging techniques offer the potential for noninvasive, simultaneous quantification of metabolic and perfusion parameters in tumors. This study applied a three-dimensional dynamic dual-agent hyperpolar…
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Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies Open
Magnetic resonance spectroscopy has demonstrated metabolite changes in neurodegenerative disorders such as Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB); however, their pattern and relationship to clinical symptoms is unclea…
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Development of a symmetric echo planar imaging framework for clinical translation of rapid dynamic hyperpolarized <sup>13</sup>C imaging Open
Purpose To develop symmetric echo planar imaging (EPI) and a reference scan framework for hyperpolarized 13 C metabolic imaging. Methods Symmetric, ramp‐sampled EPI with partial Fourier reconstruction was implemented on a 3T scanner. The f…
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Removal of nuisance signals from limited and sparse <sup>1</sup>H MRSI data using a union‐of‐subspaces model Open
Purpose To remove nuisance signals (e.g., water and lipid signals) for 1 H MRSI data collected from the brain with limited and/or sparse (k, t)‐space coverage. Methods A union‐of‐subspace model is proposed for removing nuisance signals. Th…
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A systematic review on multiparametric MR imaging in prostate cancer detection Open
ERC use yielded no additional benefit in terms of prostate cancer detection accuracy compared to multi-channel PAC use (71% versus 68%) while the use of additional functional imaging techniques (DCE-MRI, DWI and MRSI) in a multiparametric …
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Advances in Imaging Brain Metabolism Open
Metabolism is central to neuroimaging because it can reveal pathways by which neuronal and glial cells use nutrients to fuel their growth and function. We focus on advanced magnetic resonance imaging (MRI) and magnetic resonance spectrosco…
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Progress in magnetic Fe <sub>3</sub> O <sub>4</sub> nanomaterials in magnetic resonance imaging Open
At present, high-sensitivity, high-penetration-depth, and accurate tissue resolution clinical imaging effect are required, while computer transverse scanning, microwave imaging, and fluorescence imaging (FL) cannot meet the requirements of…
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(2 + 1)D-CAIPIRINHA accelerated MR spectroscopic imaging of the brain at 7T Open
(2 + 1)-CAIPIRINHA can be implemented for multislice MRSI in the brain, enabling higher accelerations than possible with two-dimensional (2D) parallel imaging methods. An eight-fold acceleration was still feasible in vivo with negligible P…
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Combined Amino Acid Positron Emission Tomography and Advanced Magnetic Resonance Imaging in Glioma Patients Open
Imaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI) provide valuable information about brain tumor patients. Particularly amino acid PET, advanced MRI techniques, and combinations thereof are …
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Density‐weighted concentric circle trajectories for high resolution brain magnetic resonance spectroscopic imaging at 7T Open
Purpose Full‐slice magnetic resonance spectroscopic imaging at T is especially vulnerable to lipid contaminations arising from regions close to the skull. This contamination can be mitigated by improving the point spread function via highe…
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Breast Tissue Metabolism by Magnetic Resonance Spectroscopy Open
Metabolic alterations are known to occur with oncogenesis and tumor progression. During malignant transformation, the metabolism of cells and tissues is altered. Cancer metabolism can be studied using advanced technologies that detect both…
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Application of modern neuroimaging technology in the diagnosis and study of Alzheimer's disease Open
Neurological abnormalities identified via neuroimaging are common in patients with Alzheimer's disease. However, it is not yet possible to easily detect these abnormalities using head computed tomography in the early stages of the disease.…
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Simultaneous mapping of metabolites and individual macromolecular components via ultra‐short acquisition delay <sup>1</sup>H MRSI in the brain at 7T Open
Purpose Short‐echo‐time proton MR spectra at 7T feature nine to 10 distinct macromolecule (MM) resonances that overlap with the signals of metabolites. Typically, a metabolite‐nulled in vivo MM spectrum is included in the quantification`s …
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Constrained Magnetic Resonance Spectroscopic Imaging by Learning Nonlinear Low-Dimensional Models Open
Magnetic resonance spectroscopic imaging (MRSI) is a powerful molecular imaging modality but has very limited speed, resolution, and SNR tradeoffs. Construction of a low-dimensional model to effectively reduce the dimensionality of the ima…
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Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging Open
Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play a fundamental role in elucidating several aspects of t…
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Automated detection of aggressive and indolent prostate cancer on magnetic resonance imaging Open
Purpose While multi‐parametric magnetic resonance imaging (MRI) shows great promise in assisting with prostate cancer diagnosis and localization, subtle differences in appearance between cancer and normal tissue lead to many false positive…
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Lipid suppression via double inversion recovery with symmetric frequency sweep for robust 2D‐GRAPPA‐accelerated MRSI of the brain at 7 T Open
This work presents a new approach for high‐resolution MRSI of the brain at 7 T in clinically feasible measurement times. Two major problems of MRSI are the long scan times for large matrix sizes and the possible spectral contamination by t…
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Density‐weighted concentric rings <i>k</i>‐space trajectory for <sup>1</sup>H magnetic resonance spectroscopic imaging at 7 T Open
It has been shown that density‐weighted (DW) k ‐space sampling with spiral and conventional phase encoding trajectories reduces spatial side lobes in magnetic resonance spectroscopic imaging (MRSI). In this study, we propose a new concentr…
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Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer <i>In Vivo</i> Predicts Efficacy of Targeting the Warburg Effect Open
Purpose: To evaluate the potential of hyperpolarized [1-13C]-pyruvate magnetic resonance spectroscopic imaging (MRSI) of prostate cancer as a predictive biomarker for targeting the Warburg effect. Experimental Design: Two human prostate ca…