Context (archaeology)
View article: ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R
ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R Open
Summary After more than fifteen years of existence, the R package ape has continuously grown its contents, and has been used by a growing community of users. The release of version 5.0 has marked a leap towards a modern software for evolut…
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Nursing Research - Generating And Assessing Evidence For Nursing Practice Open
Thoroughly updated and revised to emphasize the link between research and evidence-based practice, this Ninth Edition of a classic textbook presents state-of-the-art methods for conducting high-quality studies. The ancillary Resource Manua…
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<b>brms</b>: An <i>R</i> Package for Bayesian Multilevel Models Using <i>Stan</i> Open
The brms package implements Bayesian multilevel models in R using the probabilistic programming language Stan. A wide range of distributions and link functions are supported, allowing users to fit - among others - linear, robust linear, bi…
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The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest Open
Much of the complexity within cells arises from functional and regulatory interactions among proteins. The core of these interactions is increasingly known, but novel interactions continue to be discovered, and the information remains scat…
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An Overview of Heart Rate Variability Metrics and Norms Open
Healthy biological systems exhibit complex patterns of variability that can be described by mathematical chaos. Heart rate variability (HRV) consists of changes in the time intervals between consecutive heartbeats called interbeat interval…
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Deep Convolutional Neural Networks for Computer-Aided Detection: CNN Architectures, Dataset Characteristics and Transfer Learning Open
Remarkable progress has been made in image recognition, primarily due to the availability of large-scale annotated datasets and deep convolutional neural networks (CNNs). CNNs enable learning data-driven, highly representative, hierarchica…
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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research Open
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of in…
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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq Open
Single-cell expression profiles of melanoma Tumors harbor multiple cell types that are thought to play a role in the development of resistance to drug treatments. Tirosh et al. used single-cell sequencing to investigate the distribution of…
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Kaldi Speech Recognition Toolkit Open
—We describe the design of Kaldi, a free, open-source toolkit for speech recognition research. Kaldi provides a speech recognition system based on finite-state transducers (using the freely available OpenFst), together with detailed docume…
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Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians Open
Mendelian randomisation uses genetic variation as a natural experiment to investigate the causal relations between potentially modifiable risk factors and health outcomes in observational data. As with all epidemiological approaches, findi…
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Additive manufacturing of metals Open
This book is an exciting collection of research articles that offer a unique view into the fast developing field of metal additive manufacturing, providing insights into this advanced manufacturing technology. The articles span recent adva…
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In-silico study of accuracy and precision of left-ventricular strain quantification from 3D tagged MRI Open
Cannabis has been used worldwide for centuries for industrial, recreational and medicinal use, however, to date no successful attempts at editing genes involved in cannabinoid biosynthesis have been reported. This study proposes and develo…
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TrackMate: An open and extensible platform for single-particle tracking Open
We present TrackMate, an open source Fiji plugin for the automated, semi-automated, and manual tracking of single-particles. It offers a versatile and modular solution that works out of the box for end users, through a simple and intuitive…
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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research Open
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of in…
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Gene Set Knowledge Discovery with Enrichr Open
Profiling samples from patients, tissues, and cells with genomics, transcriptomics, epigenomics, proteomics, and metabolomics ultimately produces lists of genes and proteins that need to be further analyzed and integrated in the context of…
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Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma Open
In this study, acquired resistance to PD-1 blockade immunotherapy in patients with melanoma was associated with defects in the pathways involved in interferon-receptor signaling and in antigen presentation. (Funded by the National Institut…
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Staging and grading of periodontitis: Framework and proposal of a new classification and case definition Open
Background Authors were assigned the task to develop case definitions for periodontitis in the context of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. The aim of this manuscript is …
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Convolutional Neural Networks for Medical Image Analysis: Full Training or Fine Tuning? Open
Training a deep convolutional neural network (CNN) from scratch is difficult because it requires a large amount of labeled training data and a great deal of expertise to ensure proper convergence. A promising alternative is to fine-tune a …
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Evaluating Effect Size in Psychological Research: Sense and Nonsense Open
Effect sizes are underappreciated and often misinterpreted—the most common mistakes being to describe them in ways that are uninformative (e.g., using arbitrary standards) or misleading (e.g., squaring effect-size rs). We propose that effe…
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Structure, Function, and Evolution of Coronavirus Spike Proteins Open
The coronavirus spike protein is a multifunctional molecular machine that mediates coronavirus entry into host cells. It first binds to a receptor on the host cell surface through its S1 subunit and then fuses viral and host membranes thro…
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Guidelines for Adult Stroke Rehabilitation and Recovery Open
Purpose— The aim of this guideline is to provide a synopsis of best clinical practices in the rehabilitative care of adults recovering from stroke. Methods— Writing group members were nominated by the committee chair on the basis of their …
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tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes Open
High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced t…
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Developing rigor in qualitative research: problems and opportunities within sport and exercise psychology Open
Qualitative research has grown within sport and exercise psychology and is now widely conducted. The purpose of this review is to discuss three commonly used ways to demonstrate rigor when conducting or judging qualitative research in spor…
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Series: Practical guidance to qualitative research. Part 4: Trustworthiness and publishing Open
In the course of our supervisory work over the years we have noticed that qualitative research tends to evoke a lot of questions and worries, so-called frequently asked questions (FAQs). This series of four articles intends to provide novi…
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Career Development and Counseling: Putting Theory and Research to Work Open
This volume is an essential resource for the library of anyone interested in the field of career development, assessment, and counseling and should also prove invaluable for graduate students interested in immersing themselves in some of t…
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Intelligent Manufacturing in the Context of Industry 4.0: A Review Open
Our next generation of industry—Industry 4.0—holds the promise of increased flexibility in manufacturing, along with mass customization, better quality, and improved productivity. It thus enables companies to cope with the challenges of pr…
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Deep Learning for Generic Object Detection: A Survey Open
Object detection, one of the most fundamental and challenging problems in computer vision, seeks to locate object instances from a large number of predefined categories in natural images. Deep learning techniques have emerged as a powerful…
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HMMER web server: 2018 update Open
The HMMER webserver [http://www.ebi.ac.uk/Tools/hmmer] is a free-to-use service which provides fast searches against widely used sequence databases and profile hidden Markov model (HMM) libraries using the HMMER software suite (http://hmme…
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Building dynamic capabilities for digital transformation: An ongoing process of strategic renewal Open
In this qualitative study, we explore how incumbent firms in traditional industries build dynamic capabilities for digital transformation. Digital transformation has been defined as the use of new digital technologies, such as mobile, arti…
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Cellular uptake of nanoparticles: journey inside the cell Open
Cellular association and trafficking of nanoscale materials enables us to both understand and exploit context-dependent phenomena in various disease states, their pathogenesis, and potential therapeutic approaches.