Diagnostic biomarker
View article
miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges Open
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although considerable progress has been made in the diagnosis, treatment and prognosis of CVD, there is still a critical need for novel diagnostic…
View article
Biomarkers of sepsis: time for a reappraisal Open
Introduction Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic functions. In a previous review, we identified 3370 references reporting on 178 different biomarkers related to sepsis. In the present review, we eva…
View article
CSF and blood biomarkers for Parkinson's disease Open
In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the…
View article
What is an ROC curve? Open
The paper by Body et al is concerned with the evaluation of decision aids, which can be used to identify potential acute coronary syndromes (ACS) in the ED. The authors previously developed the Manchester Acute Coronary Syndromes model (MA…
View article
Recent advances in gastric cancer early diagnosis Open
Gastric cancer (GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are l…
View article
Challenges in Exosome Isolation and Analysis in Health and Disease Open
A growing body of evidence emphasizes the important role exosomes in different physiological and pathological conditions. Exosomes, virus-size extracellular vesicles (EVs), carry a complex molecular cargo, which is actively processed in th…
View article
Fluorescent Probes for Disease Diagnosis Open
The identification and detection of disease-related biomarkers is essential for early clinical diagnosis, evaluating disease progression, and for the development of therapeutics. Possessing the advantages of high sensitivity and selectivit…
View article
<span>MicroRNAs</span> in heart failure: from biomarker to target for therapy Open
MicroRNAs ( miRNAs ) are increasingly recognized to play important roles in cardiovascular diseases, including heart failure. These small, non‐coding RNAs have been identified in tissue and are involved in several pathophysiological proces…
View article
Integrated microbiome and metabolome analysis reveals a novel interplay between commensal bacteria and metabolites in colorectal cancer Open
Rationale: Colorectal cancer (CRC) is a malignant tumor with the third highest morbidity rate among all cancers. Driven by the host's genetic makeup and environmental exposures, the gut microbiome and its metabolites have been implicated a…
View article
Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer Diagnostics Open
Cancers have a high mortality rate due to lack of suitable specific early diagnosis tumor biomarkers. Emerging evidence is accumulating that lncRNAs (long noncoding RNAs) are involved in tumorigenesis, tumor cells proliferation, invasion, …
View article
The Origin and Functions of Exosomes in Cancer Open
Exosomes are nanovesicles having a maximum size of 150 nm and is a newly emerging focus in various fields of research. Its role in cargo trafficking along with its differential expression is associated with the disrupted homeostasis and pr…
View article
Obesity subtypes, related biomarkers & heterogeneity Open
Obesity is a serious medical condition worldwide, which needs new approaches and recognized international consensus in treating diseases leading to morbidity. The aim of this review was to examine heterogeneous links among the various phen…
View article
Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges Open
Extracellular vesicles (EVs) are small, lipid‐bound particles containing nucleic acid and protein cargo which are excreted from cells under a variety of normal and pathological conditions. EVs have garnered substantial research interest in…
View article
Identification of Serum Exosomal hsa-circ-0004771 as a Novel Diagnostic Biomarker of Colorectal Cancer Open
Background: Exosomal circular RNAs (circRNAs) in peripheral blood are considered as emerging diagnostic biomarkers of cancers. Owing to the lack of sensitive and specific biomarkers, a large number of colorectal cancer (CRC) patients were …
View article
The decade of exosomal long RNA species: an emerging cancer antagonist Open
Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have become a strong focus of invest…
View article
Novel Diagnostic Biomarkers in Colorectal Cancer Open
Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease associated with a number of genetic or somatic mutations. …
View article
Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers Open
Cancer related exosomes are nano-size membrane vesicles that play important roles in tumor microenvironment. Emerging evidence indicates that exosomes can load unique cargoes, including proteins and nucleic acids that reflect the condition…
View article
Emerging roles of exosomal miRNAs in diabetes mellitus Open
Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids, proteins, and metabolites. Exosomes transfer substances and informatio…
View article
Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases Open
Exosomes are small membrane-bound vesicles of endocytic origin that are actively secreted. The potential of exosomes as effective communicators of biological signaling in myocardial function has previously been investigated, and a recent e…
View article
MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing Open
In the pursuit of improved diagnostic tests for infectious diseases, several classes of molecules have been scrutinized as prospective biomarkers. Small (18-22 nucleotide), non-coding RNA transcripts called microRNAs (miRNAs) have emerged …
View article
Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases Open
Galectin-3 is a β-galactoside-binding lectin which is important in numerous biological activities in various organs, including cell proliferation, apoptotic regulation, inflammation, fibrosis, and host defense. Galectin-3 is predominantly …
View article
Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents Open
Exosomes are small bilipid layer-enclosed extracellular vesicles that can be found in tissues and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes are involved in various central nervous system (CNS) di…
View article
Non-Exosomal and Exosomal Circulatory MicroRNAs: Which Are More Valid as Biomarkers? Open
MicroRNAs (miRNAs) are a group of small non-coding RNAs with approximately 19-25 nucleotides that are involved in regulating a range of developmental and physiological processes. Non-exosomal circulating and exosomal miRNAs have also been …
View article
New Blood Biomarkers for the Diagnosis of AFP-Negative Hepatocellular Carcinoma Open
An early diagnosis of hepatocellular carcinoma (HCC) followed by effective treatment is currently critical for improving the prognosis and reducing the associated economic burden. Alpha-fetoprotein (AFP) is the most widely used biomarker f…
View article
Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives Open
Background: Early and accurate diagnosis of endometriosis is crucial for the management of this benign, yet debilitating pathology. Despite the advances of modern medicine, there is no common ground regarding the pathophysiology of this di…
View article
MicroRNAs as potential biomarkers for the diagnosis of glioma: A systematic review and meta‐analysis Open
Glioma is the most common central nervous system tumor and associated with poor prognosis. Identifying effective diagnostic biomarkers for glioma is particularly important in order to guide optimizing treatment. MicroRNAs (miRNAs) have dra…
View article
MicroRNAs as Diagnostic and Prognostic Biomarkers in Ischemic Stroke—A Comprehensive Review and Bioinformatic Analysis Open
Stroke is the second-most common cause of death worldwide. The pathophysiology of ischemic stroke (IS) is related to inflammation, atherosclerosis, blood coagulation, and platelet activation. MicroRNAs (miRNAs) play important roles in phys…
View article
Biomarkers in the Diagnosis and Prognosis of Sarcoidosis: Current Use and Future Prospects Open
Sarcoidosis is a heterogeneous disease in terms of presentation, duration, and severity. Due to this heterogeneity, it is difficult to align treatment decisions. Biomarkers have proved to be useful for the diagnosis and prognosis of many d…
View article
Emerging methods in biomarker identification for extracellular vesicle‐based liquid biopsy Open
Extracellular vesicles (EVs) are released by many cell types and distributed within various biofluids. EVs have a lipid membrane‐confined structure that allows for carrying unique molecular information originating from their parent cells. …
View article
Development of a rapid lateral flow immunoassay test for detection of exosomes previously enriched from cell culture medium and body fluids Open
Exosomes are cell‐secreted nanovesicles (40–200 nm) that represent a rich source of novel biomarkers in the diagnosis and prognosis of certain diseases. Despite the increasingly recognized relevance of these vesicles as biomarkers, their d…