Lung function
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The impact of PM2.5 on the human respiratory system. Open
Recently, many researchers paid more attentions to the association between air pollution and respiratory system disease. In the past few years, levels of smog have increased throughout China resulting in the deterioration of air quality, r…
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ERS/ATS technical standard on interpretive strategies for routine lung function tests Open
Background Appropriate interpretation of pulmonary function tests (PFTs) involves the classification of observed values as within/outside the normal range based on a reference population of healthy individuals, integrating knowledge of phy…
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2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung Open
This document provides an update to the European Respiratory Society (ERS)/American Thoracic Society (ATS) technical standards for single-breath carbon monoxide uptake in the lung that was last updated in 2005. Although both D LCO (diffusi…
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Abnormal pulmonary function in COVID-19 patients at time of hospital discharge Open
In discharged survivors with COVID-19, impairment of diffusion capacity is the most common abnormality of lung function, followed by restrictive ventilatory defects, which are both associated with the severity of the disease https://bit.ly…
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Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function Open
Although they do not meet the current criteria for COPD, symptomatic current or former smokers with preserved pulmonary function have exacerbations, activity limitation, and evidence of airway disease. They currently use a range of respira…
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Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians Open
There are numerous reference equations available for the single-breath transfer factor of the lung for carbon monoxide ( T LCO ); however, it is not always clear which reference set should be used in clinical practice. The aim of the study…
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Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma Open
Childhood impairment of lung function and male sex were the most significant predictors of abnormal longitudinal patterns of lung-function growth and decline. Children with persistent asthma and reduced growth of lung function are at incre…
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Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase Open
Objective This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase. Methods A retrospective study of COVID-19 patients at the Fifth Affiliated Hospital of Sun Yat-sen Univer…
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Air pollution, lung function and COPD: results from the population-based UK Biobank study Open
Ambient air pollution increases the risk of respiratory mortality, but evidence for impacts on lung function and chronic obstructive pulmonary disease (COPD) is less well established. The aim was to evaluate whether ambient air pollution i…
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Pulmonary function and radiological features 4 months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study Open
Background The infectious coronavirus disease 2019 (COVID-19) pandemic is an ongoing global healthcare challenge. Up to one-third of hospitalised patients develop severe pulmonary complications and acute respiratory distress syndrome. Pulm…
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Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis<i>ex vivo</i> Open
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor prognosis and limited therapeutic options. The incidence of IPF increases with age, and ageing-related mechanisms such as cellular senescence have been proposed as…
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Official ERS technical standard: Global Lung Function Initiative reference values for static lung volumes in individuals of European ancestry Open
Background Measurement of lung volumes across the life course is critical to the diagnosis and management of lung disease. The aim of the study was to use the Global Lung Function Initiative methodology to develop all-age multi-ethnic refe…
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The Global Lung Function Initiative (GLI) Network: bringing the world’s respiratory reference values together Open
The Global Lung Function Initiative (GLI) Network has become the largest resource for reference values for routine lung function testing ever assembled. This article addresses how the GLI Network came about, why it is important, and its cu…
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Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length Open
The risk factors for development of fibrotic-like radiographic abnormalities after severe COVID-19 are incompletely described and the extent to which CT findings correlate with symptoms and physical function after hospitalisation remains u…
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Asthma remission: what is it and how can it be achieved? Open
Asthma treatment goals currently focus on symptom and exacerbation control rather than remission. Remission is not identical to cure, but is a step closer. This review considers the current definitions of remission in asthma, the prevalenc…
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Particulate-Matter Related Respiratory Diseases Open
Particulate matter (PM) is suspended dust that has a diameter of <10 μm and can be inhaled by humans and deposited in the lungs, particularly the alveoli. Recent studies have shown that PM has an adverse effect on respiratory diseases. The…
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Outcomes after lung transplantation Open
With more than 50,000 procedures having been performed worldwide, lung transplantation (LT) has become the standard of care for patients with end-stage chronic respiratory failure. LT leads to dramatic improvements in both pulmonary functi…
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A prospective study of 12-week respiratory outcomes in COVID-19-related hospitalisations Open
The long-term respiratory morbidity of COVID-19 remains unclear. We describe the clinical, radiological and pulmonary function abnormalities that persist in previously hospitalised patients assessed 12 weeks after COVID-19 symptom onset, a…
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Rate of normal lung function decline in ageing adults: a systematic review of prospective cohort studies Open
Objective To conduct a systematic review investigating the normal age-related changes in lung function in adults without known lung disease. Design Systematic review. Data sources MEDLINE, Embase and Cumulative Index to Nursing and Allied …
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COPD immunopathology Open
The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of speci…
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Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post-infection Open
More than half of patients with COVID-19 pneumonia exhibit abnormal lung function 30 days after symptom onset, without clear relationship with pneumonia extent on chest CT. This pleads for systematic and long-term follow-up of patients wit…
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Change in FVC and survival in chronic fibrotic hypersensitivity pneumonitis Open
The predictive value of the decline in FVC by ≥10% on survival in patients with fibrotic hypersensitivity pneumonitis is unknown. Of 112 patients included, 66 (59%) had surgical lung biopsies. Patients with ≥10% decline in predicted FVC af…
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The effect of smartphone usage time on posture and respiratory function Open
[Purpose] The aim of this study was to evaluate the changes in posture and respiratory functions depending on the duration of smartphone usage. [Subjects and Methods] Participants were randomly allocated to 2 groups: group 1 (subjects who …
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Air pollution and chronic obstructive pulmonary disease Open
There is considerable epidemiological evidence indicating that air pollution has adverse effects on human health and is closely related to respiratory diseases, including chronic obstructive pulmonary disease (COPD). These effects, which c…
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In Vitro Models to Study Human Lung Development, Disease and Homeostasis Open
The main function of the lung is to support gas exchange, and defects in lung development or diseases affecting the structure and function of the lung can have fatal consequences. Most of what we currently understand about human lung devel…
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Idiopathic Pulmonary Fibrosis: Data-driven Textural Analysis of Extent of Fibrosis at Baseline and 15-Month Follow-up Open
Purpose To evaluate associations between pulmonary function and both quantitative analysis and visual assessment of thin-section computed tomography (CT) images at baseline and at 15-month follow-up in subjects with idiopathic pulmonary fi…
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Improving Lung Function in Severe Heterogenous Emphysema with the Spiration Valve System (EMPROVE). A Multicenter, Open-Label Randomized Controlled Clinical Trial Open
Rationale: Less invasive, nonsurgical approaches are needed to treat severe emphysema.Objectives: To evaluate the effectiveness and safety of the Spiration Valve System (SVS) versus optimal medical management.Methods: In this multicenter, …
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Associations between blood eosinophils and decline in lung function among adults with and without asthma Open
Eosinophilic inflammation and airway remodelling are characteristic features of asthma, but the association between them is unclear. We assessed associations between blood eosinophils and lung function decline in a population-based cohort …
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Efficacy of pirfenidone in patients with idiopathic pulmonary fibrosis with more preserved lung function Open
This post hoc analysis examined the differences in idiopathic pulmonary fibrosis disease progression and the effects of pirfenidone in patients stratified by more preserved versus less preserved baseline lung function status using forced v…
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Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study Open
Background Recent studies suggest that lung microbiome dysbiosis, the disease associated disruption of the lung microbial community, might play a key role in chronic obstructive pulmonary disease (COPD) exacerbations. However, characterisi…