Complement (music)
View article: The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest
The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest Open
Much of the complexity within cells arises from functional and regulatory interactions among proteins. The core of these interactions is increasingly known, but novel interactions continue to be discovered, and the information remains scat…
View article
Complement and microglia mediate early synapse loss in Alzheimer mouse models Open
Too much cleaning up The complement system and microglia seek out and destroy unwanted cellular debris for the peripheral immune system as well as excess synapses in the developing brain. Hong et al. now show how the system may go haywire …
View article
Schizophrenia risk from complex variation of complement component 4 Open
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia's strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and mo…
View article
Tackling the digitalization challenge: how to benefit from digitalization in practice Open
Digitalization has been identified as one of the major trends changing society and business. Digitalization causes changes for companies due to the adoption of digital technologies in the organization or in the operation environment. This …
View article
Keeping It All Going—Complement Meets Metabolism Open
The complement system is an evolutionary old and crucial component of innate immunity, which is key to the detection and removal of invading pathogens. It was initially discovered as a liver-derived sentinel system circulating in serum, th…
View article
Forecasting: theory and practice Open
Forecasting has always been at the forefront of decision making and planning. The uncertainty that surrounds the future is both exciting and challenging, with individuals and organisations seeking to minimise risks and maximise utilities. …
View article
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis Open
The complement system is a critical part of host defense to many bacterial, viral, and fungal infections. It works alongside pattern recognition receptors to stimulate host defense systems in advance of activation of the adaptive immune re…
View article
Mixed-Methods Research: A Discussion on its Types, Challenges, and Criticisms Open
The article positions mixed-method research (MMR) as a principled complementary research method to the traditional quantitative and qualitative research approaches. By situating MMR in an analysis of some of the common research paradigms, …
View article
A Comparative Study on Machine Learning Algorithms for Smart Manufacturing: Tool Wear Prediction Using Random Forests Open
Manufacturers have faced an increasing need for the development of predictive models that predict mechanical failures and the remaining useful life (RUL) of manufacturing systems or components. Classical model-based or physics-based progno…
View article
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice Open
C3 deficiency protects against hippocampal neurodegeneration and cognitive decline in aged APP/PS1 mice despite abundant Aβ plaques.
View article
Utilizing Hirshfeld surface calculations, non-covalent interaction (NCI) plots and the calculation of interaction energies in the analysis of molecular packing Open
The analysis of atom-to-atom and/or residue-to-residue contacts remains a favoured mode of analysing the molecular packing in crystals. In this contribution, additional tools are highlighted as methods for analysis in order to complement t…
View article
Natural Language Processing of Clinical Notes on Chronic Diseases: Systematic Review Open
Efforts are still required to improve (1) progression of clinical NLP methods from extraction toward understanding; (2) recognition of relations among entities rather than entities in isolation; (3) temporal extraction to understand past, …
View article
Modeling and Simulations of Polymers: A Roadmap Open
Molecular modeling and simulations are invaluable tools for the polymer science and engineering community. These computational approaches enable predictions and provide explanations of experimentally observed macromolecular structure, dyna…
View article
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 <sup>+</sup> T cells Open
Innate immune crosstalk in T cells The classical view of immune activation is that innate immune cells, such as macrophages and dendritic cells, recognize invading microbes and then alert adaptive immune cells, such as T cells, to respond.…
View article
Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration Open
Local C3 inhibition with pegcetacoplan resulted in statistically significant reductions in the growth of GA compared with sham treatment. Phase 3 studies will define the efficacy and safety profile further.
View article
Predicting the future of additive manufacturing: A Delphi study on economic and societal implications of 3D printing for 2030 Open
Additive manufacturing (colloquially: 3D printing) is a highly discussed topic. Previous research has argued that this technology not only has profound effects on manufacturing businesses but also on society, which demands new corporate st…
View article
Production of complement components by cells of the immune system Open
Summary The complement system is an important part of the innate immune defence. It contributes not only to local inflammation, removal and killing of pathogens, but it also assists in shaping of the adaptive immune response. Besides a rol…
View article
Semiempirical Quantum Mechanical Methods for Noncovalent Interactions for Chemical and Biochemical Applications Open
Semiempirical (SE) methods can be derived from either Hartree-Fock or density functional theory by applying systematic approximations, leading to efficient computational schemes that are several orders of magnitude faster than ab initio ca…
View article
Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena Open
Evaluating large language model (LLM) based chat assistants is challenging due to their broad capabilities and the inadequacy of existing benchmarks in measuring human preferences. To address this, we explore using strong LLMs as judges to…
View article
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients Open
Significance The new SARS-CoV-2 pandemic leads to COVID-19 with respiratory failure, substantial morbidity, and significant mortality. Overactivation of the innate immune response is postulated to trigger this detrimental process. The comp…
View article
Beyond Accuracy: The Role of Mental Models in Human-AI Team Performance Open
Decisions made by human-AI teams (e.g., AI-advised humans) are increasingly common in high-stakes domains such as healthcare, criminal justice, and finance. Achieving high team performance depends on more than just the accuracy of the AI s…
View article
The complement system in COVID-19: friend and foe? Open
Coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a disruptive health crisis. COVID-19-related morbidity and mortality have been at…
View article
CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma Open
Key Points Response to the CD38-targeting antibody daratumumab is significantly associated with CD38 expression levels on the tumor cells. Resistance to daratumumab is accompanied by increased expression of complement-inhibitory proteins.
View article
High complement levels in astrocyte‐derived exosomes of Alzheimer disease Open
Objective Astrocytes fulfill neuronal trophic roles normally, but are transformed in Alzheimer disease (AD) into A1‐type reactive astrocytes that may destroy neurons through unknown mechanisms. Methods To investigate astrocyte inflammatory…
View article
Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities Open
Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is detected in human sera. Several groups have found global or antigen-spe…
View article
Work practices and challenges in pull-based development Open
The pull-based development model is an emerging way of contributing to distributed software projects that is gaining enormous popularity within the open source software (OSS) world. Previous work has examined this model by focusing on proj…
View article
Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL Open
Key Points The PSI of manufactured CAR T cells was associated with clinical response and toxicities. Monitoring CAR T-cell polyfunctionality as a key product attribute may complement other characteristics including T-cell proliferation.
View article
Conducting interactive experiments online Open
Online labor markets provide new opportunities for behavioral research, but conducting economic experiments online raises important methodological challenges. This particularly holds for interactive designs. In this paper, we provide a met…
View article
Prediction: Coveted, Yet Forsaken? Introducing a Cross‐Validated Predictive Ability Test in Partial Least Squares Path Modeling Open
Management researchers often develop theories and policies that are forward‐looking. The prospective outlook of predictive modeling, where a model predicts unseen or new data, can complement the retrospective nature of causal‐explanatory m…
View article
An Overview of Service Placement Problem in Fog and Edge Computing Open
To support the large and various applications generated by the Internet of Things (IoT), Fog Computing was introduced to complement the Cloud Computing and offer Cloud-like services at the edge of the network with low latency and real-time…