Biological activity
View article
Bioactive flavonoids in medicinal plants: Structure, activity and biological fate Open
Flavonoids, a class of polyphenol secondary metabolites, are presented broadly in plants and diets. They are believed to have various bioactive effects including anti-viral, anti-inflammatory, cardioprotective, anti-diabetic, anti-cancer, …
View article
Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review Open
Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categori…
View article
Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems Open
Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as drug delivery systems. Along with optimization of physicochemical properties, researchers have focused on surface modification of NPs with bio…
View article
Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS) Open
We have previously reported on classes of compounds that can interfere with bioassays via a number of different mechanisms and termed such compounds Pan Assay INterference compoundS, or PAINS. These compounds were defined on the basis of h…
View article
Synthesis of silver nanoparticles by chemical and biological methods and their antimicrobial properties Open
Biogenic synthesis of nanoparticles offers an attractive alternate to chemical synthesis methods. Various hazard free, eco-friendly methods of synthesis of silver nanoparticles are in operation. In chemical reduction methods, the reducing …
View article
Biologically active γ-lactams: synthesis and natural sources Open
This review surveys the different synthetic and natural sources of biologically active γ-lactam compounds.
View article
Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation Open
It is a common problem in natural product therapeutic lead discovery programs that despite good bioassay results in the initial extract, the active compound(s) may not be isolated during subsequent bioassay-guided purification. Herein, we …
View article
Chemical Structure and Biological Activity of Humic Substances Define Their Role as Plant Growth Promoters Open
Humic substances (HS) are dominant components of soil organic matter and are recognized as natural, effective growth promoters to be used in sustainable agriculture. In recent years, many efforts have been made to get insights on the relat…
View article
Monoterpenes and Their Derivatives—Recent Development in Biological and Medical Applications Open
Monoterpenes, comprising hydrocarbons, are the largest class of plant secondary metabolites and are commonly found in essential oils. Monoterpenes and their derivatives are key ingredients in the design and production of new biologically a…
View article
Thiazole Ring—A Biologically Active Scaffold Open
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, anti…
View article
Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium Open
Despite scientific and clinical advances in the field of pharmacogenomics (PGx), application into routine care remains limited. Opportunely, several implementation studies and programs have been initiated over recent years. This article pr…
View article
Human Metabolites of Cannabidiol: A Review on Their Formation, Biological Activity, and Relevance in Therapy Open
Cannabidiol (CBD), the main nonpsychoactive constituent of Cannabis sativa, has shown a wide range of therapeutically promising pharmacological effects either as a sole drug or in combination with other drugs in adjunctive therapy. However…
View article
Recent advances in the synthesis of biologically and pharmaceutically active quinoline and its analogues: a review Open
Recently, quinoline has become an essential heterocyclic compound due to its versatile applications in the fields of industrial and synthetic organic chemistry.
View article
Oleanolic Acid: Extraction, Characterization and Biological Activity Open
Oleanolic acid, a pentacyclic triterpenoid ubiquitously present in the plant kingdom, is receiving outstanding attention from the scientific community due to its biological activity against multiple diseases. Oleanolic acid is endowed with…
View article
NPASS: natural product activity and species source database for natural product research, discovery and tool development Open
There has been renewed interests in the exploration of natural products (NPs) for drug discovery, and continuous investigations of the therapeutic claims and mechanisms of traditional and herbal medicines. In-silico methods have been emplo…
View article
A Review: The Bioactivities and Pharmacological Applications of Polygonatum sibiricum polysaccharides Open
Traditional Chinese Medicine (TCM) has been widely used in China and is regarded as the most important therapeutic. Polygonatum sibiricum (PS), a natural plant used in traditional Chinese medicine, has various functions associated with a n…
View article
Mechanism of Sijunzi Decoction in the treatment of colorectal cancer based on network pharmacology and experimental validation Open
SJZD can treat CRC through multiple components, multiple targets and multiple pathways. We initially revealed the effective components and molecular mechanisms of SJZD in the treatment of CRC, and we used molecular docking and experiment f…
View article
Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review Open
Aloe vera is a medicinal plant species of the genus Aloe with a long history of usage around the world. Acemannan, considered one of the main bioactive polysaccharides of Aloe vera, possesses immunoregulation, anti-cancer, anti-oxidation, …
View article
Bioactive Constituents of<i>Glycyrrhiza uralensis</i>(Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine Open
Traditional herbal medicines have been reported to possess significant bioactivities. In this investigation, a combined strategy using both phytochemical and biological approaches was conducted to discern the effective components of licori…
View article
Detection and Activity Profiling of Synthetic Cannabinoids and Their Metabolites with a Newly Developed Bioassay Open
Synthetic cannabinoids (SCs) are the largest group of compounds currently monitored in Europe by the EU Early Warning System on new psychoactive substances. Emerging recreational use of these products has led to multiple cases of adverse h…
View article
Advances in Research on the Bioactivity of Alginate Oligosaccharides Open
Alginate is a natural polysaccharide present in various marine brown seaweeds. Alginate oligosaccharide (AOS) is a degradation product of alginate, which has received increasing attention due to its low molecular weight and promising biolo…
View article
Synthesis of Biologically Active Molecules through Multicomponent Reactions Open
Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules,…
View article
A brief review of the biological potential of indole derivatives Open
Background Various bioactive aromatic compounds containing the indole nucleus showed clinical and biological applications. Indole scaffold has been found in many of the important synthetic drug molecules which gave a valuable idea for trea…
View article
2H/4H-Chromenes—A Versatile Biologically Attractive Scaffold Open
2H/4H-chromene (2H/4H-ch) is an important class of heterocyclic compounds with versatile biological profiles, a simple structure, and mild adverse effects. Researchers discovered several routes for the synthesis of a variety of 2H/4H-ch an…
View article
Improving oral bioavailability of cyclic peptides by N-methylation Open
The renaissance of peptides in pharmaceutical industry results from their importance in many biological functions. However, low metabolic stability and the lack of oral availability of most peptides is a certain limitation. Whereas metabol…
View article
Polysaccharides from Traditional Chinese Medicines: Extraction, Purification, Modification, and Biological Activity Open
Traditional Chinese Medicine (TCM) has been used to treat diseases in China for thousands of years. TCM compositions are complex, using as their various sources plants, animals, fungi, and minerals. Polysaccharides are one of the active an…
View article
Chemical Constituents of Bryophytes: Structures and Biological Activity Open
Comparatively little attention has been paid to the bryophytes for use in the human diet or medicine in spite of the presence of 23 000 species globally. Several hundred new compounds have been isolated from the liverworts (Marchantiophyta…
View article
Sources, Extraction and Biomedical Properties of Polysaccharides Open
In the recent era, bioactive compounds from plants have received great attention because of their vital health-related activities, such as antimicrobial activity, antioxidant activity, anticoagulant activity, anti-diabetic activity, UV pro…
View article
Copper Coordination Compounds as Biologically Active Agents Open
Copper-containing coordination compounds attract wide attention due to the redox activity and biogenicity of copper ions, providing multiple pathways of biological activity. The pharmacological properties of metal complexes can be fine-tun…
View article
Pharmacological Potential of Sea Cucumbers Open
This review presents a detailed analysis of published research data focused on the pharmacological activity exerted by biologically active compounds isolated from sea cucumbers belonging to the class of Holothuroidea, phylum Echinodermata.…