Epigenetics ≈ EpigeneticsEpigenetics
View article: Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy Open
The GABAergic neurotransmission is a highly conserved system that has been attributed to various regulatory events. There has been a notable number of studies on the importance of GABAergic neurotransmission, both excitatory and inhibitory…
View article
An epigenetic biomarker of aging for lifespan and healthspan Open
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporat…
View article
The role of MicroRNAs in human cancer Open
MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that function in regulation of gene expression. Compelling evidences have demonstrated that miRNA expression is dysregulated in human cancer through various mechanisms, including amp…
View article
PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations Open
Summary PhenoScanner is a curated database of publicly available results from large-scale genetic association studies in humans. This online tool facilitates ‘phenome scans’, where genetic variants are cross-referenced for association with…
View article
DNA methylation GrimAge strongly predicts lifespan and healthspan Open
It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful predictor of lifespan. We present here, seven DNAm-based esti…
View article
Molecular principles of metastasis: a hallmark of cancer revisited Open
Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research and the emergence of new paradigms in the stu…
View article
Diversity, Mechanisms, and Significance of Macrophage Plasticity Open
Macrophages are a diverse set of cells present in all body compartments. This diversity is imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); the organ context; by their activation or deactivation by …
View article
Variations in the Prevalence of Obesity Among European Countries, and a Consideration of Possible Causes. Open
Over the last 10 years the prevalence of obesity across the European continent has in general been rising. With the exception of a few countries where a levelling-off can be perceived, albeit at a high level, this upward trend seems likely…
View article
Psoriasis Pathogenesis and Treatment Open
Research on psoriasis pathogenesis has largely increased knowledge on skin biology in general. In the past 15 years, breakthroughs in the understanding of the pathogenesis of psoriasis have been translated into targeted and highly effectiv…
View article
Three-dimensional Epigenome Statistical Model: Genome-wide Chromatin Looping Prediction Open
This study aims to understand through statistical learning the basic biophysical mechanisms behind three-dimensional folding of epigenomes. The 3DEpiLoop algorithm predicts three-dimensional chromatin looping interactions within topologica…
View article
Mechanisms of Multidrug Resistance in Cancer Chemotherapy Open
Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the past decades, chemotherapy still remains the main method for cancer treatment. Depending on the mechanism of a…
View article
Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies Open
Gastric cancer (GC) is one of the most common malignancies worldwide and it is the fourth leading cause of cancer-related death. GC is a multifactorial disease, where both environmental and genetic factors can have an impact on its occurre…
View article
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice Open
Faulty blood cells and heart disease Recent studies have shown that elderly people's blood cells often harbor mutations in genes encoding certain epigenetic regulators. These mutations can lead to clonal expansion of the mutant blood cells…
View article
Mechanisms of ROS Regulation of Plant Development and Stress Responses Open
Plants are subjected to various environmental stresses throughout their life cycle. Reactive oxygen species (ROS) play important roles in maintaining normal plant growth, and improving their tolerance to stress. This review describes the p…
View article
Epigenetic Determinants of Cancer Open
SUMMARYEpigenetic changes are present in all human cancers and are now known to cooperate with genetic alterations to drive the cancer phenotype. These changes involve DNA methylation, histone modifiers and readers, chromatin remodelers, m…
View article
Epigenetic plasticity and the hallmarks of cancer Open
Cancer epigenetics in the driver's seat Recent cancer genome projects unexpectedly highlighted the role of epigenetic alterations in cancer development. About half of human cancers were found to harbor mutations in chromatin proteins. In a…
View article
An environment-dependent transcriptional network specifies human microglia identity Open
Of mice and men's microglia Microglia are immune system cells that function in protecting and maintaining the brain. Gosselin et al. examined the epigenetics and RNA transcripts from single microglial cells and observed consistent profiles…
View article
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade Open
Epigenetic profiling suggests that exhausted T cells are a distinct cell linage.
View article
DNA methylation-based measures of biological age: meta-analysis predicting time to death Open
Estimates of biological age based on DNA methylation patterns, often referred to as "epigenetic age", "DNAm age", have been shown to be robust biomarkers of age in humans. We previously demonstrated that independent of chronological age, e…
View article
Histone Deacetylase Inhibitors as Anticancer Drugs Open
Carcinogenesis cannot be explained only by genetic alterations, but also involves epigenetic processes. Modification of histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the balance b…
View article
The Acidic Tumor Microenvironment as a Driver of Cancer Open
Acidic metabolic waste products accumulate in the tumor microenvironment because of high metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and the relatively well-maintained intracellular pH in…
View article
Histone Modifications and Cancer Open
Histone posttranslational modifications represent a versatile set of epigenetic marks involved not only in dynamic cellular processes, such as transcription and DNA repair, but also in the stable maintenance of repressive chromatin. In thi…
View article
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials Open
Epigenetic alternations concern heritable yet reversible changes in histone or DNA modifications that regulate gene activity beyond the underlying sequence. Epigenetic dysregulation is often linked to human disease, notably cancer. With th…
View article
Regulatory Mechanism of MicroRNA Expression in Cancer Open
Altered gene expression is the primary molecular mechanism responsible for the pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are virtually involved at the post-transcriptional level and bind to 3′ UTR of th…
View article
Epigenetic Signatures of Cigarette Smoking Open
Background— DNA methylation leaves a long-term signature of smoking exposure and is one potential mechanism by which tobacco exposure predisposes to adverse health outcomes, such as cancers, osteoporosis, lung, and cardiovascular disorders…
View article
Navigating the DNA methylation landscape of cancer Open
DNA methylation is a chemical modification that defines cell type and lineage through the control of gene expression and genome stability. Disruption of DNA methylation control mechanisms causes a variety of diseases, including cancer. Can…
View article
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma Open
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene …
View article
The epigenetic landscape of T cell exhaustion Open
Epigenetic profiling suggests that exhausted T cells are a distinct cell linage.
View article
Glutamine reliance in cell metabolism Open
As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, of…
View article
A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer Open
The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result …