Epilepsy surgery
View article: Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery
Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery Open
In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were th…
View article
Defining epileptogenic networks: Contribution of <span>SEEG</span> and signal analysis Open
Summary Epileptogenic networks are defined by the brain regions involved in the production and propagation of epileptic activities. In this review we describe the historical, methodologic, and conceptual bases of this model in the analysis…
View article
Surgery for Drug-Resistant Epilepsy in Children Open
In this single-center trial, children and adolescents with drug-resistant epilepsy who had undergone epilepsy surgery had a significantly higher rate of freedom from seizures and better scores with respect to behavior and quality of life t…
View article
Recommendations for the use of structural magnetic resonance imaging in the care of patients with epilepsy: A consensus report from the International League Against Epilepsy Neuroimaging Task Force Open
Structural magnetic resonance imaging ( MRI ) is of fundamental importance to the diagnosis and treatment of epilepsy, particularly when surgery is being considered. Despite previous recommendations and guidelines, practices for the use of…
View article
Is <span>SEEG</span> safe? A systematic review and meta‐analysis of stereo‐electroencephalography–related complications Open
Summary Objective Stereo‐electroencephalography ( SEEG ) is a procedure performed for patients with intractable epilepsy in order to anatomically define the epileptogenic zone ( EZ ) and the possible related functional cortical areas. By a…
View article
The <span>ILAE</span> consensus classification of focal cortical dysplasia: An update proposed by an ad hoc task force of the <span>ILAE</span> diagnostic methods commission Open
Ongoing challenges in diagnosing focal cortical dysplasia (FCD) mandate continuous research and consensus agreement to improve disease definition and classification. An International League Against Epilepsy (ILAE) Task Force (TF) reviewed …
View article
Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy Open
Summary Objective Evaluate the seizure‐reduction response and safety of mesial temporal lobe ( MTL ) brain‐responsive stimulation in adults with medically intractable partial‐onset seizures of mesial temporal lobe origin. Methods Subjects …
View article
Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections Open
SEE BERNASCONI DOI101093/AWW202 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Temporal lobe epilepsy, the most prevalent form of chronic focal epilepsy, is associated with a high prevalence of cognitive impairment but the responsible underl…
View article
Predicting neurosurgical outcomes in focal epilepsy patients using computational modelling Open
See Eissa and Schevon (doi:10.1093/aww332) for a scientific commentary on this article. Surgery can be a last resort for patients with intractable, medically refractory epilepsy. For many of these patients, however, there is substantial ri…
View article
Diagnostic utility of invasive<span>EEG</span>for epilepsy surgery: Indications, modalities, and techniques Open
Summary Many patients with medically refractory epilepsy now undergo successful surgery based on noninvasive diagnostic information, but intracranial electroencephalography ( IEEG ) continues to be used as increasingly complex cases are co…
View article
Managing drug-resistant epilepsy: challenges and solutions Open
Despite the development of new antiepileptic drugs (AEDs), ~20%-30% of people with epilepsy remain refractory to treatment and are said to have drug-resistant epilepsy (DRE). This multifaceted condition comprises intractable seizures, neur…
View article
Getting the best outcomes from epilepsy surgery Open
Neurosurgery is an underutilized treatment that can potentially cure drug‐refractory epilepsy. Careful, multidisciplinary presurgical evaluation is vital for selecting patients and to ensure optimal outcomes. Advances in neuroimaging have …
View article
Practice guideline summary: Use of fMRI in the presurgical evaluation of patients with epilepsy Open
The use of fMRI may be considered an option for lateralizing language functions in place of intracarotid amobarbital procedure (IAP) in patients with medial temporal lobe epilepsy (MTLE; Level C), temporal epilepsy in general (Level C), or…
View article
What can we do for people with drug-resistant epilepsy? Open
Treatment goals for epilepsy are no seizures, no side effects, as soon as possible, but these goals are too often unmet. Approximately 1 million people in the United States continue to have seizures despite adequate treatment with antiseiz…
View article
High‐frequency oscillations are not better biomarkers of epileptogenic tissues than spikes Open
Objective High‐frequency oscillations (HFOs) in intracerebral EEG (stereoelectroencephalography; SEEG) are considered as better biomarkers of epileptogenic tissues than spikes. How this can be applied at the patient level remains poorly un…
View article
Progressive Cortical Thinning in Patients With Focal Epilepsy Open
Widespread progressive cortical thinning exceeding that seen with normal aging may occur in patients with focal epilepsy. These findings appear to highlight the need to develop epilepsy disease-modifying treatments to disrupt or slow ongoi…
View article
The current place of epilepsy surgery Open
Purpose of review Three randomized controlled trials demonstrate that surgical treatment is safe and effective for drug-resistant epilepsy (DRE), yet fewer than 1% of patients are referred for surgery. This is a review of recent trends in …
View article
Removing high-frequency oscillations Open
On an individual patient level, a prediction of outcome was not possible in all patients. This may be due to the analysis techniques used. Alternatively, HFOs may be less specific for epileptic tissue than earlier studies have indicated.
View article
Stereoelectroencephalography: retrospective analysis of 742 procedures in a single centre Open
This retrospective description of a surgical series is aimed at reporting on indications, methodology, results on seizures, outcome predictors and complications from a 20-year stereoelectroencephalography (SEEG) activity performed at a sin…
View article
<span>MRI</span> ‐negative temporal lobe epilepsy—What do we know? Open
Summary Temporal lobe epilepsy ( TLE ) is the most common focal epilepsy in adults. TLE has a high chance of becoming medically refractory, and as such, is frequently considered for further evaluation and surgical intervention. Up to 30% o…
View article
Corpus callosotomy outcomes in pediatric patients: A systematic review Open
Summary Objective Corpus callosotomy is a palliative neurosurgical treatment for patients with either generalized or multifocal refractory epilepsy and injurious drop attacks. This report aims to systematically review the pediatric literat…
View article
Analysis of Morbidity and Outcomes Associated With Use of Subdural Grids vs Stereoelectroencephalography in Patients With Intractable Epilepsy Open
This direct comparison of large matched cohorts undergoing SEEG and SDE implantation reveals distinctly better procedural morbidity favoring SEEG. These modalities intrinsically evaluate somewhat different populations, with SEEG being more…
View article
Presurgical thalamic “hubness” predicts surgical outcome in temporal lobe epilepsy Open
A thalamic network associated with seizure recurrence may already be established presurgically. Thalamic hubness can serve as a potential biomarker of surgical outcome, outperforming the clinical characteristics commonly used in epilepsy s…
View article
Robot-assisted procedures in pediatric neurosurgery Open
OBJECTIVE During the last 3 decades, robotic technology has rapidly spread across several surgical fields due to the continuous evolution of its versatility, stability, dexterity, and haptic properties. Neurosurgery pioneered the developme…
View article
How to record high‐frequency oscillations in epilepsy: A practical guideline Open
Summary Objective Technology for localizing epileptogenic brain regions plays a central role in surgical planning. Recent improvements in acquisition and electrode technology have revealed that high‐frequency oscillations ( HFO s) within t…
View article
Stereo electroencephalography–guided radiofrequency thermocoagulation (SEEG‐guided RF‐TC) in drug‐resistant focal epilepsy: Results from a 10‐year experience Open
Summary Objective Stereo electroencephalography ( SEEG )–guided radiofrequency thermocoagulation ( SEEG ‐guided RF ‐ TC ) has been proposed since 2004 as a possible treatment of some focal drug‐resistant epilepsy. The aim of this study is …
View article
Stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy Open
Objective To evaluate the outcomes 1 year and longer following stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy in a large series of patients treated over a 5‐year period since introduction of this novel techniqu…
View article
Association of Closed-Loop Brain Stimulation Neurophysiological Features With Seizure Control Among Patients With Focal Epilepsy Open
These findings suggest that RNS effectiveness may be explained by long-term, stimulation-induced modulation of seizure network activity rather than by direct effects on each detected seizure.
View article
Magnetoencephalography for epileptic focus localization in a series of 1000 cases Open
The aim of epilepsy surgery in patients with focal, pharmacoresistant epilepsies is to remove the complete epileptogenic zone to achieve long-term seizure freedom. In addition to a spectrum of diagnostic methods, magnetoencephalography foc…
View article
Deep brain and cortical stimulation for epilepsy Open
Except for one very small RCT, only short-term RCTs on intracranial neurostimulation for epilepsy are available. Compared to sham stimulation, one to three months of anterior thalamic DBS ((multi)focal epilepsy), responsive ictal onset zon…