Food allergy ≈ Food allergy
View article
Prevalence and Severity of Food Allergies Among US Adults Open
These data suggest that at least 10.8% (>26 million) of US adults are food allergic, whereas nearly 19% of adults believe that they have a food allergy. Consequently, these findings suggest that it is crucial that adults with suspected foo…
View article
Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants Open
The Enquiring About Tolerance (EAT) study is a randomized controlled trial designed to determine whether early dietary introduction of allergenic foods from three months of age in exclusively breastfed infants induces immune tolerance and …
View article
The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States Open
BACKGROUND: Childhood food allergy (FA) is a life-threatening chronic condition that substantially impairs quality of life. This large, population-based survey estimates childhood FA prevalence and severity of all major allergenic foods. D…
View article
AR101 Oral Immunotherapy for Peanut Allergy Open
In this phase 3 trial of oral immunotherapy in children and adolescents who were highly allergic to peanut, treatment with AR101 resulted in higher doses of peanut protein that could be ingested without dose-limiting symptoms and in lower …
View article
<span>EAACI</span> Guidelines on allergen immunotherapy: IgE‐mediated food allergy Open
Food allergy can result in considerable morbidity, impairment of quality of life, and healthcare expenditure. There is therefore interest in novel strategies for its treatment, particularly food allergen immunotherapy ( FA ‐ AIT ) through …
View article
The Epidemiology of Food Allergy in the Global Context Open
There is a lack of high-quality evidence based on the gold standard of oral food challenges to determine food allergy prevalence. Nevertheless, studies using surrogate measures of food allergy, such as health service utilization and clinic…
View article
High levels of butyrate and propionate in early life are associated with protection against atopy Open
Background Dietary changes are suggested to play a role in the increasing prevalence of allergic diseases and asthma. Short‐chain fatty acids ( SCFA s) are metabolites present in certain foods and are produced by microbes in the gut follow…
View article
Allergen immunotherapy for IgE‐mediated food allergy: a systematic review and meta‐analysis Open
Background The European Academy of Allergy and Clinical Immunology ( EAACI ) is developing Guidelines for Allergen Immunotherapy ( AIT ) for IgE‐mediated Food Allergy. To inform the development of clinical recommendations, we sought to cri…
View article
Effect of Avoidance on Peanut Allergy after Early Peanut Consumption Open
Among children at high risk for allergy in whom peanuts had been introduced in the first year of life and continued until 5 years of age, a 12-month period of peanut avoidance was not associated with an increase in the prevalence of peanut…
View article
Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease Open
In this systematic review, early egg or peanut introduction to the infant diet was associated with lower risk of developing egg or peanut allergy. These findings must be considered in the context of limitations in the primary studies.
View article
EAACI guideline: Preventing the development of food allergy in infants and young children (2020 update) Open
Background This guideline from the European Academy of Allergy and Clinical Immunology (EAACI) recommends approaches to prevent the development of immediate‐onset / IgE‐mediated food allergy in infants and young children. It is an update o…
View article
Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy Open
Both the prevalence and the burden of allergic diseases are considerable with prevalence varying between 1% and 20%. We identified a plethora of studies on asthma, but studies were generally difficult to compare due to the heterogeneity in…
View article
Epidemiology of Cow’s Milk Allergy Open
Immunoglobulin E (IgE)-mediated cow’s milk allergy (CMA) is one of the most common food allergies in infants and young children. CMA can result in anaphylactic reactions, and has long term implications on growth and nutrition. There are se…
View article
The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines Open
Summary Atopic dermatitis often precedes the development of other atopic diseases. The atopic march describes this temporal relationship in the natural history of atopic diseases. Although the pathophysiological mechanisms that underlie th…
View article
Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy Open
ClinicalTrials.gov Identifier: NCT02636699.
View article
Omalizumab for the Treatment of Multiple Food Allergies Open
In persons as young as 1 year of age with multiple food allergies, omalizumab treatment for 16 weeks was superior to placebo in increasing the reaction threshold for peanut and other common food allergens. (Funded by the National Institute…
View article
Wheat allergy: diagnosis and management Open
Antonella Cianferoni Department of Pediatrics, Division of Allergy and Immunology, The Childrens Hospital of Philadelphia, PA, USA Abstract: Triticum aestivum (bread wheat) is the most widely grown crop worldwide. In genetically predispose…
View article
Research Progress in Atopic March Open
The incidence of allergic diseases continues to rise. Cross-sectional and longitudinal studies have indicated that allergic diseases occur in a time-based order: from atopic dermatitis and food allergy in infancy to gradual development int…
View article
New Perspectives in Food Allergy Open
The improvement of the knowledge of the pathophysiological mechanisms underlying the tolerance and sensitization to food antigens has recently led to a radical change in the clinical approach to food allergies. Epidemiological studies show…
View article
Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented? Open
There is increasing evidence regarding the importance of allergic sensitization through the skin. In this review, we provide an overview of the atopic march and immune mechanism underlying the sensitization and effector phase of food aller…
View article
Extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow's milk allergy: 3-year randomized controlled trial Open
EHCF+LGG reduces the incidence of other AMs and hastens the development of oral tolerance in children with IgE-mediated CMA.
View article
A prospective microbiome‐wide association study of food sensitization and food allergy in early childhood Open
Background Alterations in the intestinal microbiome are prospectively associated with the development of asthma; less is known regarding the role of microbiome alterations in food allergy development. Methods Intestinal microbiome samples …
View article
Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity Open
Eosinophilic esophagitis (EoE) is a chronic disease characterized clinically by symptoms of esophageal dysfunction and histologically by eosinophil-predominant inflammation. EoE is frequently associated with concomitant atopic diseases and…
View article
Can we identify patients at risk of life‐threatening allergic reactions to food? Open
Anaphylaxis has been defined as a ‘severe, life‐threatening generalized or systemic hypersensitivity reaction’. However, data indicate that the vast majority of food‐triggered anaphylactic reactions are not life‐threatening. Nonetheless, s…
View article
Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity Open
clinicaltrials.gov Identifier: NCT01675882.
View article
The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype Open
Patients with atopic dermatitis and food allergy have an immature epithelial barrier and type 2 immune activation in their skin.
View article
Frequency of food allergy in Europe: An updated systematic review and meta‐analysis Open
Food allergy (FA) is increasingly reported in Europe, however, the latest prevalence estimates were based on studies published a decade ago. The present work provides the most updated estimates of the prevalence and trends of FA in Europe.…
View article
Prevention of food allergy Open
The past few decades have witnessed an increase in the prevalence of IgE-mediated food allergy (FA). For prevention strategies to be effective, we need to understand the causative factors underpinning this rise. Genetic factors are clearly…
View article
Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018 Open
Objective To describe time trends for hospital admissions due to food anaphylaxis in the United Kingdom over the past 20 years. Design Analysis of national data, 1998-2018. Setting Data relating to hospital admissions for anaphylaxis and d…
View article
<span>EAACI</span> guidelines on the diagnosis of <span>IgE</span>‐mediated food allergy Open
This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE‐mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) ap…