Glomerulopathy
View article: Obesity and Kidney Disease: Hidden Consequences of the Epidemic
Obesity and Kidney Disease: Hidden Consequences of the Epidemic Open
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney dis…
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COVID-19–Associated Kidney Injury: A Case Series of Kidney Biopsy Findings Open
Significance Statement AKI is a known complication of severe COVID-19. Autopsy series of patients who died with COVID-19 reported acute tubular necrosis in the kidney, and a few patient reports noted the presence of collapsing glomerulopat…
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Assessment of Tocilizumab (Anti–Interleukin-6 Receptor Monoclonal) as a Potential Treatment for Chronic Antibody-Mediated Rejection and Transplant Glomerulopathy in HLA-Sensitized Renal Allograft Recipients Open
Extending the functional integrity of renal allografts is the primary goal of transplant medicine. The development of donor-specific antibodies (DSAs) posttransplantation leads to chronic active antibody-mediated rejection (cAMR) and trans…
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Classification and Differential Diagnosis of Diabetic Nephropathy Open
Diabetic nephropathy (DN) is a major cause of end-stage renal disease throughout the world in both developed and developing countries. This review briefly introduces the characteristic pathological changes of DN and Tervaert pathological c…
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Donor-Specific Antibodies in Kidney Transplant Recipients Open
Donor-specific antibodies have become an established biomarker predicting antibody-mediated rejection. Antibody-mediated rejection is the leading cause of graft loss after kidney transplant. There are several phenotypes of antibody-mediate…
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Long-Term Outcome of Steroid-Resistant Nephrotic Syndrome in Children Open
We investigated the value of genetic, histopathologic, and early treatment response information in prognosing long-term renal outcome in children with primary steroid-resistant nephrotic syndrome. From the PodoNet Registry, we obtained lon…
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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases Open
Dysregulation of the alternative complement pathway (AP) predisposes individuals to a number of diseases including paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and C3 glomerulopathy. Moreover, glomerular Ig depo…
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Obesity and Kidney Disease Open
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney dis…
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Treatment of B-cell disorder improves renal outcome of patients with monoclonal gammopathy–associated C3 glomerulopathy Open
Key Points Monoclonal gammopathy is associated with C3 glomerulopathy. Specific treatment of the underlying B-cell clone improves renal survival.
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Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy Open
Atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) are associated with dysregulation and overactivation of the complement alternative pathway. Typically, gene analysis for aHUS and C3G is undertaken in small patient numb…
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Cluster Analysis Identifies Distinct Pathogenetic Patterns in C3 Glomerulopathies/Immune Complex–Mediated Membranoproliferative GN Open
Membranoproliferative GN (MPGN) was recently reclassified as alternative pathway complement–mediated C3 glomerulopathy (C3G) and immune complex–mediated membranoproliferative GN (IC-MPGN). However, genetic and acquired alternative pathway …
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Obesity and kidney disease: hidden consequences of the epidemic Open
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for chronic kidney dise…
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Spectrum of biopsy proven renal diseases in Central China: a 10-year retrospective study based on 34,630 cases Open
Chronic kidney diseases have become a major issue worldwide. The spectrum of biopsy proven renal diseases differs between locations and changes over time. It is therefore essential to describe the local epidemiological trends and the preva…
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Standardized classification and reporting of glomerulonephritis Open
A kidney biopsy is done to determine the etiology of the glomerulonephritis (GN) and the severity of the lesion, to identify whether other lesions, related to or not related to the GN, are present on the kidney biopsy and finally to ascert…
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CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy Open
Significance Statement The human CFHR–Factor H gene cluster encodes the five FHR proteins that are emerging complement and immune modulators and the two complement regulators Factor H and FHL1. Genetic and chromosomal alterations in this c…
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Complement Inhibitors in Clinical Trials for Glomerular Diseases Open
Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune co…
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Anti-Factor B and Anti-C3b Autoantibodies in C3 Glomerulopathy and Ig-Associated Membranoproliferative GN Open
In C3 glomerulopathy (C3G), the alternative pathway of complement is frequently overactivated by autoantibodies that stabilize the C3 convertase C3bBb. Anti-C3b and anti-factor B (anti-FB) IgG have been reported in three patients with C3G.…
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THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity Open
Thrombospondin type I domain-containing 7A (THSD7A) is a known antigenic target of autoantibodies leading to primary membranous glomerulopathy and was reported to account for ~10% of phospholipase A2 receptor (PLA2R)-negative membranous gl…
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Obesity‐related glomerulopathy: Current approaches and future perspectives Open
Summary Obesity‐related glomerulopathy (ORG) is a silent comorbidity which is increasing in incidence as the obesity epidemic escalates. ORG is associated with serious health consequences including chronic kidney disease, end‐stage renal d…
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Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1 Open
Podocyte injury is an early event in diabetic kidney disease and is a hallmark of glomerulopathy. MicroRNA-146a (miR-146a) is highly expressed in many cell types under homeostatic conditions, and plays an important anti-inflammatory role i…
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Autophagy is activated to protect against podocyte injury in adriamycin-induced nephropathy Open
Podocytes are highly differentiated epithelial cells wrapping glomerular capillaries to form the filtration barrier in kidneys. As such, podocyte injury or dysfunction is a critical pathogenic event in glomerular disease. Autophagy plays a…
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Nephritic Factors: An Overview of Classification, Diagnostic Tools and Clinical Associations Open
Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation. Classification of these autoantibodies can be clustered acco…
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Obesity and kidney disease: Hidden consequences of the epidemic Open
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney dis…
View article
Both Monoclonal and Polyclonal Immunoglobulin Contingents Mediate Complement Activation in Monoclonal Gammopathy Associated-C3 Glomerulopathy Open
C3 glomerulopathy (C3G) results from acquired or genetic abnormalities in the complement alternative pathway (AP). C3G with monoclonal immunoglobulin (MIg-C3G) was recently included in the spectrum of "monoclonal gammopathy of renal signif…
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Anti-Factor B Antibodies and Acute Postinfectious GN in Children Open
Significance Statement Acute postinfectious GN, the leading cause of acute nephritis in children, associates with transient complement activation of undetermined mechanism. Its clinical features overlap considerably with those of C3 glomer…
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Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys Open
The membrane attack complex—also known as C5b-9—is the end-product of the classical, lectin, and alternative complement pathways. It is thought to play an important role in the pathogenesis of various kidney diseases by causing cellular in…
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Paraprotein–Related Kidney Disease: Kidney Injury from Paraproteins—What Determines the Site of Injury? Open
Disorders of plasma and B cells leading to paraproteinemias are associated with a variety of renal diseases. Understanding the mechanisms of injury and associated nephropathies provides a framework that aids clinicians in prompt diagnosis …
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Obesity and kidney disease: Hidden consequences of the epidemic Open
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney dis…
View article
The Spectrum of Biopsy-Proven Glomerular Diseases among Children in China Open
Export Background and objectives High-quality epidemiologic data on the spectrum of biopsy-proven glomerular diseases among children are limited. This study aimed to determine the profile of and temporal change in biopsy-proven pediatric g…
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Pathology of COVID-19-associated acute kidney injury Open
Acute kidney injury (AKI) is common among hospitalized patients with coronavirus disease 2019 (COVID-19), with the occurrence of AKI ranging from 0.5% to 80%. An improved knowledge of the pathology of AKI in COVID-19 is crucial to mitigate…