Hemodynamics ≈ HemodynamicsHemodynamics
View article
Haemodynamic definitions and updated clinical classification of pulmonary hypertension Open
Since the 1st World Symposium on Pulmonary Hypertension (WSPH) in 1973, pulmonary hypertension (PH) has been arbitrarily defined as mean pulmonary arterial pressure (mPAP) ≥25 mmHg at rest, measured by right heart catheterisation. Recent d…
View article
Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction Open
Background: Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Phenotyping patients into pathophysiologically homogeneous groups may enable better targeting of treatment. Obesity is common in HFpEF and…
View article
Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep Open
Fluid dynamics during sleep During non–rapid eye movement sleep, low-frequency oscillations in neural activity support memory consolidation and neuronal computation. Sleep is also associated with increased interstitial fluid volume and cle…
View article
Risk stratification and medical therapy of pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH) remains a severe clinical condition despite the availability over the past 15 years of multiple drugs interfering with the endothelin, nitric oxide and prostacyclin pathways. The recent progress observ…
View article
Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli Open
On the 400th anniversary of Harvey's Lumleian lectures, this review focuses on “hemodynamic” forces associated with the movement of blood through arteries in humans and the functional and structural adaptations that result from repeated ep…
View article
Sodium Intake and Hypertension Open
The close relationship between hypertension and dietary sodium intake is widely recognized and supported by several studies. A reduction in dietary sodium not only decreases the blood pressure and the incidence of hypertension, but is also…
View article
Prediction of fluid responsiveness: an update Open
In patients with acute circulatory failure, the decision to give fluids or not should not be taken lightly. The risk of overzealous fluid administration has been clearly established. Moreover, volume expansion does not always increase card…
View article
False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward Open
We highlight a significant problem that needs to be considered and addressed when performing functional near-infrared spectroscopy (fNIRS) studies, namely the possibility of inadvertently measuring fNIRS hemodynamic responses that are not …
View article
The Fontan circulation after 45 years: update in physiology Open
The Fontan operation was first performed in 1968. Since then, this operation has been performed on thousands of patients worldwide. Results vary from very good for many decades to very bad with a pleiad of complications and early death. A …
View article
Effect of a Machine Learning–Derived Early Warning System for Intraoperative Hypotension vs Standard Care on Depth and Duration of Intraoperative Hypotension During Elective Noncardiac Surgery Open
ClinicalTrials.gov Identifier: NCT03376347.
View article
Sodium Glucose Cotransporter-2 Inhibition in Heart Failure Open
Despite current established therapy, heart failure (HF) remains a leading cause of hospitalization and mortality worldwide. Novel therapeutic targets are therefore needed to improve the prognosis of patients with HF. The EMPA-REG OUTCOME t…
View article
The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography Open
A unique and highly versatile technique, stress echocardiography (SE) is increasingly recognized for its utility in the evaluation of non-ischaemic heart disease. SE allows for simultaneous assessment of myocardial function and haemodynami…
View article
Dynamic Risk Stratification of Patient Long-Term Outcome After Pulmonary Endarterectomy Open
Background— Chronic thromboembolic pulmonary hypertension results from incomplete resolution of pulmonary emboli. Pulmonary endarterectomy (PEA) is potentially curative, but residual pulmonary hypertension following surgery is common and i…
View article
Fluid overload in the ICU: evaluation and management Open
In critically ill patients, in order to restore cardiac output, systemic blood pressure and renal perfusion an adequate fluid resuscitation is essential. Achieving an appropriate level of volume management requires knowledge of the underly…
View article
Monro-Kellie 2.0: The dynamic vascular and venous pathophysiological components of intracranial pressure Open
For 200 years, the ‘closed box’ analogy of intracranial pressure (ICP) has underpinned neurosurgery and neuro-critical care. Cushing conceptualised the Monro-Kellie doctrine stating that a change in blood, brain or CSF volume resulted in r…
View article
Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction Open
Background Exercise intolerance is common in people with heart failure and preserved ejection fraction (HFpEF). Right ventricular (RV) dysfunction has been shown at rest in HFpEF but little data are available regarding dynamic RV-pulmonary…
View article
Resting-state hemodynamics are spatiotemporally coupled to synchronized and symmetric neural activity in excitatory neurons Open
Significance Resting-state functional connectivity mapping exploits correlations in the functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) signal across the brain. However, results are difficult to interpret w…
View article
Echo-Doppler estimation of left ventricular filling pressure: results of the multicentre EACVI Euro-Filling study Open
The present Euro-Filling study demonstrates that the new 2016 recommendations for assessing LVFP non-invasively are fairly reliable and clinically useful, as well as superior to the 2009 recommendations in estimating invasive LVEDP.
View article
Aortic Dilatation in Patients With Bicuspid Aortic Valve Open
Bicuspid aortic valve (BAV) is the most common congenital cardiac abnormality. BAV aortic dilatation is associated with an increased risk of adverse aortic events and represents a potentially lethal disease and hence a considerable medical…
View article
Heart failure with preserved ejection fraction: from mechanisms to therapies Open
This review aims to provide a translational perspective on recent developments in heart failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential therapies. A key concept in this review is that HFpEF is a …
View article
Regulation of cerebral blood flow and metabolism during exercise Open
New Findings What is the topic of this review? The manuscript collectively combines the experimental observations from >100 publications focusing on the regulation of cerebral blood flow and metabolism during exercise from 1945 to the pres…
View article
Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure Open
Aims The aim of this study is to investigate determinants of left atrial (LA) reservoir and pump strain and if these parameters may serve as non-invasive markers of left ventricular (LV) filling pressure. Methods and results In a multicent…
View article
An official European Respiratory Society statement: pulmonary haemodynamics during exercise Open
There is growing recognition of the clinical importance of pulmonary haemodynamics during exercise, but several questions remain to be elucidated. The goal of this statement is to assess the scientific evidence in this field in order to pr…
View article
Hypertension and Stroke: Update on Treatment Open
Stroke is the second most common cause of mortality worldwide and the third most common cause of disability. Hypertension is the most prevalent risk factor for stroke. Stroke causes and haemodynamic consequences are heterogeneous which mak…
View article
Hemodynamic changes under balloon occlusion of hepatic artery: predictor of the short-term therapeutic effect of balloon-occluded transcatheter arterial chemolipiodolization using miriplatin for hepatocellular carcinoma Open
To clarify the hemodynamic changes under balloon occlusion of the hepatic artery and to identify predictors of the short-term therapeutic effect (TE) after balloon-occluded transcatheter arterial chemoembolization using miriplatin (B-TACE)…
View article
Levosimendan for Hemodynamic Support after Cardiac Surgery Open
In patients who required perioperative hemodynamic support after cardiac surgery, low-dose levosimendan in addition to standard care did not result in lower 30-day mortality than placebo. (Funded by the Italian Ministry of Health; CHEETAH …
View article
Deterioration in right ventricular structure and function over time in patients with heart failure and preserved ejection fraction Open
Aims Prevalent right ventricular (RV) dysfunction (RVD) is associated with increased mortality in patients with heart failure with preserved ejection fraction (HFpEF), but no study has characterized long-term changes in RV structure and fu…
View article
Fluid Shear Stress Sensing by the Endothelial Layer Open
Blood flow produces mechanical frictional forces, parallel to the blood flow exerted on the endothelial wall of the vessel, the so-called wall shear stress (WSS). WSS sensing is associated with several vascular pathologies, but it is first…
View article
Invasive Hemodynamic Assessment and Classification of In-Hospital Mortality Risk Among Patients With Cardiogenic Shock Open
Background: Risk stratifying patients with cardiogenic shock (CS) is a major unmet need. The recently proposed Society for Cardiovascular Angiography and Interventions (SCAI) stages as an approach to identify patients at risk for in-hospit…
View article
Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock Open
In patients with cardiogenic shock, no significant difference between milrinone and dobutamine was found with respect to the primary composite outcome or important secondary outcomes. (Funded by the Innovation Fund of the Alternative Fundi…