Immunoglobulin E ≈ Immunoglobulin E
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EAACI Molecular Allergology User's Guide Open
The availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled ‘component‐resolved diagnosis’ ( CRD ). The European Academy of All…
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Allergic rhinitis Open
Allergic rhinitis (AR) is caused by immunoglobulin E (IgE)-mediated reactions to inhaled allergens and is one of the most common chronic conditions globally. AR often co-occurs with asthma and conjunctivitis and is a global health problem …
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<span>EAACI</span> Guidelines on allergen immunotherapy: IgE‐mediated food allergy Open
Food allergy can result in considerable morbidity, impairment of quality of life, and healthcare expenditure. There is therefore interest in novel strategies for its treatment, particularly food allergen immunotherapy ( FA ‐ AIT ) through …
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Type 2 immunity in the skin and lungs Open
There has been extensive progress in understanding the cellular and molecular mechanisms of inflammation and immune regulation in allergic diseases of the skin and lungs during the last few years. Asthma and atopic dermatitis (AD) are typi…
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Identification of a T follicular helper cell subset that drives anaphylactic IgE Open
Thirteen is the charm in anaphylaxis Immunoglobulin E (IgE) is a type of antibody associated with allergies and response to parasites such as worms. When high-affinity, allergen-specific IgE binds its target, it can cross-link receptors on…
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Quercetin and Its Anti-Allergic Immune Response Open
Quercetin is the great representative of polyphenols, flavonoids subgroup, flavonols. Its main natural sources in foods are vegetables such as onions, the most studied quercetin containing foods, and broccoli; fruits (apples, berry crops, …
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Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation Open
Background Dupilumab, a fully human monoclonal antibody that binds IL‐4Rα and inhibits signaling of both IL‐4 and IL‐13, has shown efficacy across multiple diseases with underlying type 2 signatures and is approved for treatment of asthma,…
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Allergen immunotherapy for IgE‐mediated food allergy: a systematic review and meta‐analysis Open
Background The European Academy of Allergy and Clinical Immunology ( EAACI ) is developing Guidelines for Allergen Immunotherapy ( AIT ) for IgE‐mediated Food Allergy. To inform the development of clinical recommendations, we sought to cri…
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Different activation signals induce distinct mast cell degranulation strategies Open
Mast cells (MCs) influence intercellular communication during inflammation by secreting cytoplasmic granules that contain diverse mediators. Here, we have demonstrated that MCs decode different activation stimuli into spatially and tempora…
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Revisiting <span>T</span>ype 2‐high and <span>T</span>ype 2‐low airway inflammation in asthma: current knowledge and therapeutic implications Open
Summary Asthma is a complex respiratory disorder characterized by marked heterogeneity in individual patient disease triggers and response to therapy. Several asthma phenotypes have now been identified, each defined by a unique interaction…
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The Effects of Secretory IgA in the Mucosal Immune System Open
Immunoglobulin A (IgA) is the most abundant antibody isotype in the mucosal immune system. Structurally, IgA in the mucosal surface is a polymeric structure, while serum IgA is monomeric. Secretory IgA (sIgA) is one of the polymeric IgAs c…
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Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies Open
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression. The lesional skin of AD exhi…
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The role of allergen‐specific IgE, IgG and IgA in allergic disease Open
Immunoglobulin E (IgE)‐mediated allergy is the most common hypersensitivity disease affecting more than 30% of the population. Exposure to even minute quantities of allergens can lead to the production of IgE antibodies in atopic individua…
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Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria Open
The monoclonal anti-immunoglobulin E (IgE) antibody, omalizumab, was the first drug approved for use in patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) who remain symptomatic despite H1 -antihistamine treatment. Omalizumab…
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Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study Open
Omalizumab is a monoclonal anti-IgE antibody used to treat severe allergic asthma (SAA). The aim of the STELLAIR study was to determine the importance of pre-treatment blood eosinophil count as a predictive measure for response to omalizum…
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Wheat allergy: diagnosis and management Open
Antonella Cianferoni Department of Pediatrics, Division of Allergy and Immunology, The Childrens Hospital of Philadelphia, PA, USA Abstract: Triticum aestivum (bread wheat) is the most widely grown crop worldwide. In genetically predispose…
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Effects of Omalizumab on Rhinovirus Infections, Illnesses, and Exacerbations of Asthma Open
In children with allergic asthma, treatment with omalizumab decreased the duration of RV infections, viral shedding, and the risk of RV illnesses. These findings provide direct evidence that blocking IgE decreases susceptibility to RV infe…
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Ligelizumab for Chronic Spontaneous Urticaria Open
A higher percentage of patients had complete control of symptoms of chronic spontaneous urticaria with ligelizumab therapy of 72 mg or 240 mg than with omalizumab or placebo. (Funded by Novartis Pharma; ClinicalTrials.gov number, NCT024773…
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Type 2 inflammation in asthma and other airway diseases Open
Chronic inflammatory airway diseases, including asthma, chronic rhinosinusitis, eosinophilic COPD and allergic rhinitis are a global health concern. Despite the coexistence of these diseases and their common pathophysiology, they are often…
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Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma Open
Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the a…
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Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity Open
Eosinophilic esophagitis (EoE) is a chronic disease characterized clinically by symptoms of esophageal dysfunction and histologically by eosinophil-predominant inflammation. EoE is frequently associated with concomitant atopic diseases and…
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Induction of Interleukin-10 Producing Dendritic Cells As a Tool to Suppress Allergen-Specific T Helper 2 Responses Open
Dendritic cells (DCs) are gatekeepers of the immune system that control induction and polarization of primary, antigen-specific immune responses. Depending on their maturation/activation status, the molecules expressed on their surface, an…
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The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update Open
Gluten-related disorders have recently been reclassified with an emerging scientific literature supporting the concept of non-celiac gluten sensitivity (NCGS). New research has specifically addressed prevalence, immune mechanisms, the reco…
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Autoimmune Theories of Chronic Spontaneous Urticaria Open
Urticaria (hives) is a highly prevalent skin disorder that can occur with or without associated angioedema. Chronic spontaneous urticaria (CSU) is a condition which persists for more than 6 weeks in duration and occurs in the absence of an…
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Immune pathomechanism and classification of drug hypersensitivity Open
Drug hypersensitivity reactions ( DHR ) are based on distinct mechanisms and are clinically heterogeneous. Taking into account that also off‐target activities of drugs may lead to stimulations of immune or inflammatory cells, three forms o…
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Current Understanding of Asthma Pathogenesis and Biomarkers Open
Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations) and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have been made to dissect the cellular and molecular mechanisms of …
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New clinical diagnostic criteria for allergic bronchopulmonary aspergillosis/mycosis and its validation Open
The new diagnostic criteria, compared with existing criteria, showed better sensitivity and specificity for diagnosing ABPA/ABPM.
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A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma Open
Asthma is a high-prevalence disease, still accounting for mortality and high direct and indirect costs. It is now recognized that, despite the implementation of guidelines, a large proportion of cases remain not controlled. Certainly, adhe…
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Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses Open
IL-6 excess is central to the pathogenesis of multiple inflammatory conditions and is targeted in clinical practice by immunotherapy that blocks the IL-6 receptor encoded by IL6R. We describe two patients with homozygous mutations in IL6R …
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<span>EAACI</span> guidelines on the diagnosis of <span>IgE</span>‐mediated food allergy Open
This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE‐mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) ap…