View article: Intravenous Fluids and Acute Kidney Injury
Intravenous Fluids and Acute Kidney Injury Open
Over 50% of the human body is comprised of fluids that are distributed in defined compartments. Although compartmentalized, these fluids are dynamically connected. Fluids, electrolytes, and acid-base balance in each compartment are tightly…
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Diabetic Kidney Disease Open
Diabetic kidney disease develops in approximately 40% of patients who are diabetic and is the leading cause of CKD worldwide. Although ESRD may be the most recognizable consequence of diabetic kidney disease, the majority of patients actua…
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Obesity and Kidney Disease: Hidden Consequences of the Epidemic Open
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney dis…
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Non-Transgenic Mouse Models of Kidney Disease Open
Animal models are essential tools to understand the mechanisms underlying the development and progression of renal disease and to study potential therapeutic approaches. Recently, interventional models suitable to induce acute and chronic …
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Multiorgan and Renal Tropism of SARS-CoV-2 Open
Multiorgan and Renal Tropism of SARS-CoV-2 In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brai...
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Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China Open
Although the respiratory and immune systems are the major targets of Coronavirus Disease 2019 (COVID-19), acute kidney injury and proteinuria have also been observed. Currently, detailed pathologic examination of kidney damage in criticall…
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Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus Open
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by development of autoantibodies to nuclear and cytoplasmic antigens. A small subset of SLE patients who had the typical clinical features of SLE was reported to sho…
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Chronic kidney disease Open
Chronic kidney disease is a progressive disease with no cure and high morbidity and mortality that occurs commonly in the general adult population, especially in people with diabetes and hypertension. Preservation of kidney function can im…
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Renal Mass and Localized Renal Cancer: AUA Guideline Open
Several factors should be considered during counseling/management of patients with clinically localized renal masses, including general health/comorbidities, oncologic potential of the mass, pertinent functional issues and relative efficac…
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Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association Open
Cardiorenal syndrome encompasses a spectrum of disorders involving both the heart and kidneys in which acute or chronic dysfunction in 1 organ may induce acute or chronic dysfunction in the other organ. It represents the confluence of hear…
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Mechanisms of Renal Fibrosis Open
Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half of adults above age 70 and 10% of the world's popu…
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Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association Open
Cardiovascular-kidney-metabolic health reflects the interplay among metabolic risk factors, chronic kidney disease, and the cardiovascular system and has profound impacts on morbidity and mortality. There are multisystem consequences of po…
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Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease Open
Touring the kidney, cell by cell Our kidneys play a critical role in keeping us healthy, a fact of which we are reminded several times each day. This organ's cellular complexity has hindered progress in understanding the mechanisms underly…
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Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults Open
Acute kidney injury is common and is associated with poor outcomes, including increased mortality, among critically ill children and young adults. (Funded by the Pediatric Nephrology Center of Excellence at Cincinnati Children's Hospital M…
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Kidney Stone Disease: An Update on Current Concepts Open
Kidney stone disease is a crystal concretion formed usually within the kidneys. It is an increasing urological disorder of human health, affecting about 12% of the world population. It has been associated with an increased risk of end-stag…
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Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors Open
Pediatric and adult kidney tumors differ Understanding tumor origins and the similarities and differences between organ-specific cancers is important for determining treatment options. Young et al. generated more than 72,000 single-cell tr…
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The immune cell landscape in kidneys of patients with lupus nephritis Open
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from …
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Sepsis associated acute kidney injury Open
Sepsis is defined as organ dysfunction resulting from the host’s deleterious response to infection. One of the most common organs affected is the kidneys, resulting in sepsis associated acute kidney injury (SA-AKI) that contributes to the …
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Covid-19 and Kidney Transplantation Open
Kidney-Transplant Recipients with Covid-19 A cohort of 36 consecutive kidney-transplant recipients had less fever, lower CD3, CD4, and CD8 cell counts, more rapid clinical deterioration, and a high...
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Belatacept and Long-Term Outcomes in Kidney Transplantation Open
Seven years after transplantation, patient and graft survival and the mean eGFR were significantly higher with belatacept (both the more-intensive regimen and the less-intensive regimen) than with cyclosporine. (Funded by Bristol-Myers Squ…
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A 2018 Reference Guide to the Banff Classification of Renal Allograft Pathology Open
The Banff Classification of Allograft Pathology is an international consensus classification for the reporting of biopsies from solid organ transplants. Since its initial conception in 1991 for renal transplants, it has undergone review ev…
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Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma Open
Pembrolizumab treatment led to a significant improvement in disease-free survival as compared with placebo after surgery among patients with kidney cancer who were at high risk for recurrence. (Funded by Merck Sharp and Dohme, a subsidiary…
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Oxidant Mechanisms in Renal Injury and Disease Open
Despite the limited success associated with the application of antioxidants for treatment of kidney injury/disease thus far, preventing the generation and accumulation of ROS and RNS provides an ideal target for potential therapeutic treat…
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Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock Open
clinicaltrials.gov Identifier: ISRCTN 20769191.
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Bioaccumulation of lead (Pb) and its effects on human: A review Open
Lead is a prevalent heavy metal that pollutes the environment and accumulates in the human body via absorption, bioavailability, bioconcentration, and biomagnification disrupts the neurological, skeletal, reproductive, hematopoietic, renal…
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The Novel Coronavirus 2019 epidemic and kidneys Open
Novel Coronavirus disease (COVID-19) is a newly discovered contagious disease caused by severe acute respiratory syndrome (SARS)–coronavirus (CoV)-2 virus, primarily manifesting as an acute respiratory illness with interstitial and alveola…
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Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury Open
Among critically ill patients with acute kidney injury, an accelerated renal-replacement strategy was not associated with a lower risk of death at 90 days than a standard strategy. (Funded by the Canadian Institutes of Health Research and …
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Primary Membranous Nephropathy Open
Membranous nephropathy (MN) is a unique glomerular lesion that is the most common cause of idiopathic nephrotic syndrome in nondiabetic white adults. About 80% of cases are renal limited (primary MN, PMN) and 20% are associated with other …
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Physiology of sweat gland function: The roles of sweating and sweat composition in human health Open
The purpose of this comprehensive review is to: 1) review the physiology of sweat gland function and mechanisms determining the amount and composition of sweat excreted onto the skin surface; 2) provide an overview of the well-established …
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Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology Open
The most common reported reasons for intensive care unit admission for patients with severe coronavirus disease 2019 (COVID-19) are either hypoxemic respiratory failure leading to mechanical ventilation or hypotension requiring vasopressor…