Leukocytosis ≈ Leukocytosis
View article: Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study Open
Objective To delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died. Design Retrospective case series. Setting Tongji Hospital in Wuhan, China. Participants Among a cohort of 799 patients, 113 …
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Durable Remissions with Ivosidenib in <i>IDH1</i> -Mutated Relapsed or Refractory AML Open
In patients with advanced IDH1-mutated relapsed or refractory AML, ivosidenib at a dose of 500 mg daily was associated with a low frequency of grade 3 or higher treatment-related adverse events and with transfusion independence, durable re…
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Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children Open
Atypical clinical findings of pregnant women with COVID-19 could increase the difficulty in initial identification. Consolidation was more common in the pregnant groups. The clinically-diagnosed cases were vulnerable to more pulmonary invo…
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The clinical characteristics and outcomes of patients with diabetes and secondary hyperglycaemia with coronavirus disease 2019: A single‐centre, retrospective, observational study in Wuhan Open
Aim To explore whether coronavirus disease 2019 (COVID‐19) patients with diabetes and secondary hyperglycaemia have different clinical characteristics and prognoses than those without significantly abnormal glucose metabolism. Materials an…
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Early Predictors of Clinical Deterioration in a Cohort of 239 Patients Hospitalized for Covid-19 Infection in Lombardy, Italy Open
We described features of hospitalized Covid-19 patients and identified predictors of clinical deterioration. We included patients consecutively admitted at Humanitas Research Hospital (Rozzano, Milan, Italy); retrospectively extracted demo…
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The hematologic consequences of obesity Open
The prevalence of obesity is increasing and progressively influencing physician‐patient interactions. While there is a sizable amount of data demonstrating that obesity is a state of low‐grade inflammation, to our knowledge, there is no si…
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Prognostic Value of Leukocytosis and Lymphopenia for Coronavirus Disease Severity Open
To evaluate lymphopenia as a marker for coronavirus disease severity, we conducted a meta-analysis of 10 studies. Severe illness was associated with lower lymphocyte and higher leukocyte counts. Using these markers for early identification…
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Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis Open
Background Understanding the factors associated with disease severity and mortality in Coronavirus disease (COVID-19) is imperative to effectively triage patients. We performed a systematic review to determine the demographic, clinical, la…
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Insights Into the Pathogenesis of Sweet's Syndrome Open
Sweet's syndrome, also known as Acute Febrile Neutrophilic Dermatosis, is a rare inflammatory condition. It is considered to be the prototype disease of neutrophilic dermatoses, and presents with acute onset dermal neutrophilic lesions, le…
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Polycythemia vera: 2024 update on diagnosis, risk‐stratification, and management Open
Disease Overview Polycythemia vera (PV) is a JAK2 ‐mutated myeloproliferative neoplasm characterized by clonal erythrocytosis; other features include leukocytosis, thrombocytosis, splenomegaly, pruritus, constitutional symptoms, microcircu…
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Leukocytosis and thrombosis in essential thrombocythemia and polycythemia vera: a systematic review and meta-analysis Open
In the last years, a growing amount of evidence has been produced regarding the role of leukocytosis as a risk factor for thrombosis in patients with myeloproliferative neoplasms, predominantly in polycythemia vera (PV) and essential throm…
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Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study Open
Our study highlighted the dynamic and complex nature of the immune response to trauma, with immune alterations consistent with both activation and suppression evident within 1 hour of injury. The relationship of these changes, especially i…
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Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea Open
The clinical features of MERS-CoV infection in the Republic of Korea were similar to those of previous outbreaks in the Middle East. However, the overall mortality rate (20.4%) was lower than that in previous reports. Enhanced surveillance…
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Risk factors for adverse clinical outcomes with COVID-19 in China: a multicenter, retrospective, observational study Open
Background: The risk factors for adverse events of Coronavirus Disease-19 (COVID-19) have not been well described. We aimed to explore the predictive value of clinical, laboratory and CT imaging characteristics on admission for short-term …
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Leukocyte Count and Intracerebral Hemorrhage Expansion Open
Background and Purpose— Acute leukocytosis is a well-established response to intracerebral hemorrhage (ICH). Leukocytes, because of their interaction with platelets and coagulation factors, may in turn play a role in hemostasis. We investi…
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Cytokine Response to Exercise and Its Modulation Open
Strenuous exercise induces such inflammatory responses as leukocytosis (neutrophilia) and symptoms as delayed-onset muscle soreness and swelling. However, the association between inflammatory mediator cytokines and oxidative stress is not …
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Prognostic factors for VTE and bleeding in hospitalized medical patients: a systematic review and meta-analysis Open
There may be many predictors of venous thromboembolism (VTE) and bleeding in hospitalized medical patients, but until now, systematic reviews and assessments of the certainty of the evidence have not been published. We conducted a systemat…
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Diagnosis and Treatment of Chronic Myelomonocytic Leukemias in Adults Open
Chronic myelomonocytic leukemia (CMML) is a disease of the elderly, and by far the most frequent overlap myelodysplastic/myeloproliferative neoplasm in adults. Aside from the chronic monocytosis that remains the cornerstone of its diagnosi…
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Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the Possibility of Vertical Transmission. Open
There were no differences in the clinical characteristics of pregnant women and non-pregnant COVID-19 patients. COVID-19 infection has caused higher incidence of fetal distress and premature labor in pregnant women. Although the possibilit…
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Pertussis in Young Infants Throughout the World Open
In typical pertussis in young infants, the child will appear deceptively well; he or she will have coryza, sneezing, and a mild cough. There is no fever. This progresses to gagging, gasping, eye bulging, bradycardia, cyanosis, and vomiting…
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Pertussis leukocytosis: mechanisms, clinical relevance and treatment Open
The significant and sometimes dramatic rise in the number of circulating white blood cells (leukocytosis) in infants suffering from pertussis (whooping cough) has been recognized for over a century. Although pertussis is a disease that aff…
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Leukoerythroblastic reaction in a patient with <span>COVID</span>‐19 infection Open
A 46-year-old previously healthy female developed flu-like symptoms several days prior to presenting to a local hospital. The patient did not note a recent travel history, specifically denying travel to China. Sick contact exposure was not…
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Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19 Open
Sepsis is a life-threatening systemic illness attributed to a dysregulated host response to infection. Sepsis is a global burden killing ~11 million persons annually. In December 2019, a novel pneumonia condition termed coronavirus disease…
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Perforation risk in pediatric appendicitis: assessment and management Open
Perforated appendicitis, as defined by a visible hole in the appendix or an appendicolith free within the abdomen, carries significant morbidity in the pediatric population. Accurate diagnosis is challenging as there is no single symptom o…
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Acute aorto‐iliac and mesenteric arterial thromboses as presenting features of COVID‐19 Open
SARS-CoV-2 infection has been reported to induce a hypercoagulable state,1 which is associated with disease severity and poor outcomes.2, 3 Rates of thromboembolic events and use of augmented thromboprophylaxis in patients with COVID-19 ar…
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Biological Safety and Biodistribution of Chitosan Nanoparticles Open
The effect of unmodified chitosan nanoparticles with a size of ~100 nm and a weakly positive charge on blood coagulation, metabolic activity of cultured cardiomyocytes, general toxicity, biodistribution, and reactive changes in rat organs …
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Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC) Open
Sickle cell disease (SCD) consists of a group of hemoglobinopathies in which individuals present highly variable clinical manifestations. Sickle cell anemia (SCA) is the most severe form, while SC hemoglobinopathy (HbSC) is thought to be m…
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Prognostic Relevance of Altered Lymphocyte Subpopulations in Critical Illness and Sepsis Open
Lymphopenia and functional defects in lymphocytes may impact the prognosis in patients with critical illness or sepsis. Therefore, we prospectively analyzed peripheral blood leukocytes from 63 healthy volunteers, 50 non-critically ill stan…
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A systems biology approach to investigating the influence of exercise and fitness on the composition of leukocytes in peripheral blood Open
Our data suggests that leukocytes subsets are differentially mobilized into the peripheral blood and dependent on the intensity and duration of exercise. Pre-existing compositional differences of leukocytes were associated with various fit…
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Live Attenuated Pertussis Vaccine BPZE1 Protects Baboons Against Bordetella pertussis Disease and Infection Open
Evidence suggests that the resurgence of pertussis in many industrialized countries may result from the failure of current vaccines to prevent nasopharyngeal colonization by Bordetella pertussis, the principal causative agent of whooping c…