Local field potential
View article
Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function Open
The need to breathe links the mammalian olfactory system inextricably to the respiratory rhythms that draw air through the nose. In rodents and other small animals, slow oscillations of local field potential activity are driven at the rate…
View article
The rate of transient beta frequency events predicts behavior across tasks and species Open
Beta oscillations (15-29Hz) are among the most prominent signatures of brain activity. Beta power is predictive of healthy and abnormal behaviors, including perception, attention and motor action. In non-averaged signals, beta can emerge a…
View article
Local Field Potentials: Myths and Misunderstandings Open
The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, …
View article
Subthalamic synchronized oscillatory activity correlates with motor impairment in patients with Parkinson's disease Open
Objective Beta band oscillations in the subthalamic nucleus (STN) have been proposed as a pathophysiological signature in patients with Parkinson's disease (PD). The aim of this study was to investigate the potential association between os…
View article
Toward an electrophysiological “sweet spot” for deep brain stimulation in the subthalamic nucleus Open
Enhanced beta‐band activity recorded in patients suffering from Parkinson‘s Disease (PD) has been described as a potential physiomarker for disease severity. Beta power is suppressed by Levodopa intake and STN deep brain stimulation (DBS) …
View article
Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines Open
Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique, care must be taken to ensure that the tool itself does not unduly affect the system under study. Here we report aberrant electrical activity, similar …
View article
Sparse orthogonal population representation of spatial context in the retrosplenial cortex Open
Sparse orthogonal coding is a key feature of hippocampal neural activity, which is believed to increase episodic memory capacity and to assist in navigation. Some retrosplenial cortex (RSC) neurons convey distributed spatial and navigation…
View article
Eight-hours adaptive deep brain stimulation in patients with Parkinson disease Open
This study provides Class IV evidence that for patients with advanced PD, aDBS is safe, well tolerated, and effective in controlling PD motor symptoms.
View article
Hitchhiker’s Guide to Voltammetry: Acute and Chronic Electrodes for in Vivo Fast-Scan Cyclic Voltammetry Open
Fast-scan cyclic voltammetry (FSCV) has been used for over 20 years to study rapid neurotransmission in awake and behaving animals. These experiments were first carried out with carbon-fiber microelectrodes (CFMs) encased in borosilicate g…
View article
Neural signatures of perceptual inference Open
Generative models, such as predictive coding, posit that perception results from a combination of sensory input and prior prediction, each weighted by its precision (inverse variance), with incongruence between these termed prediction erro…
View article
Non-invasive temporal interference electrical stimulation of the human hippocampus Open
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal …
View article
Replay of cortical spiking sequences during human memory retrieval Open
Human brain activity during memory Animal studies suggest that sequence replay of neuronal activity may underlie memory retrieval and consolidation. However, there is no direct evidence that the replay of spiking activity sequences is impo…
View article
A theta rhythm in macaque visual cortex and its attentional modulation Open
Significance Theta rhythms, ≈3–8 Hz, have been found in many different parts of the brain. They are predominant in the rodent hippocampus, yet have also been described in the neocortex, primarily in frontal and parietal areas in relation t…
View article
Hippocampal Respiration-Driven Rhythm Distinct from Theta Oscillations in Awake Mice Open
We have recently described a slow oscillation in the hippocampus of urethane-anesthetized mice, which couples to nasal respiration and is clearly distinct from co-occurring theta oscillations. Here we set out to investigate whether such ty…
View article
Organic electronics for high-resolution electrocorticography of the human brain Open
Conducting polymer–based electrodes can acquire population and individual neural activity from the surface of the human brain.
View article
Selective entrainment of gamma subbands by different slow network oscillations Open
Significance Theta-gamma coupling has been largely documented in hippocampal and neocortical areas and hypothesized to constitute a network mechanism for information processing. However, we identify here another global slow rhythm at near-…
View article
Hippocampal Non-Theta-Contingent Eyeblink Classical Conditioning: A Model System for Neurobiological Dysfunction Open
Typical information processing is thought to depend on the integrity of neurobiological oscillations that may underlie coordination and timing of cells and assemblies within and between structures. The 3-7 Hz bandwidth of hippocampal theta…
View article
Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance Open
Considerable evidence suggests a role of beta-band oscillations in voluntary movements. However, most of the studies linking beta power to motor performance are based on data averaged across trials that ignore the fast dynamics of oscillat…
View article
A Respiration-Coupled Rhythm in the Rat Hippocampus Independent of Theta and Slow Oscillations Open
During slow-wave sleep and deep anesthesia, the rat hippocampus displays a slow oscillation (SO) that follows “up-and-down” state transitions in the neocortex. There has been recent debate as to whether this local field potential (LFP) rhy…
View article
Fast near-whole–brain imaging in adult Drosophila during responses to stimuli and behavior Open
Whole-brain recordings give us a global perspective of the brain in action. In this study, we describe a method using light field microscopy to record near-whole brain calcium and voltage activity at high speed in behaving adult flies. We …
View article
The roles of alpha oscillation in working memory retention Open
Introduction Brain processes of working memory involve oscillatory activities at multiple frequencies in local and long‐range neural networks. The current study addressed the specific roles of alpha oscillations during memory encoding and …
View article
Pallidal Deep-Brain Stimulation Disrupts Pallidal Beta Oscillations and Coherence with Primary Motor Cortex in Parkinson's Disease Open
In Parkinson's disease (PD), subthalamic nucleus beta band oscillations are decreased by therapeutic deep-brain stimulation (DBS) and this has been proposed as important to the mechanism of therapy. The globus pallidus is a common alternat…
View article
A mechanism for inter-areal coherence through communication based on connectivity and oscillatory power Open
Inter-areal coherence between field potentials is a widespread phenomenon in cortex. Coherence has been hypothesized to reflect phase-synchronization between oscillators and flexibly gate communication according to behavioral and cognitive…
View article
Directional local field potentials: A tool to optimize deep brain stimulation Open
Background: Although recently introduced directional DBS leads provide control of the stimulation field, programing is time‐consuming. Objectives: Here, we validate local field potentials recorded from directional contacts as a predictor o…
View article
Biointegrated and Wirelessly Powered Implantable Brain Devices: A Review Open
Implantable neural interfacing devices have added significantly to neural engineering by introducing the low-frequency oscillations of small populations of neurons known as local field potential as well as high-frequency action potentials …
View article
An update on adaptive deep brain stimulation in Parkinson's disease Open
Advancing conventional open‐loop DBS as a therapy for PD is crucial for overcoming important issues such as the delicate balance between beneficial and adverse effects and limited battery longevity that are currently associated with treatm…
View article
Multimodal Modeling of Neural Network Activity: Computing LFP, ECoG, EEG, and MEG Signals With LFPy 2.0 Open
Recordings of extracellular electrical, and later also magnetic, brain signals have been the dominant technique for measuring brain activity for decades. The interpretation of such signals is however nontrivial, as the measured signals res…
View article
Spontaneous cortical activity is transiently poised close to criticality Open
Brain activity displays a large repertoire of dynamics across the sleep-wake cycle and even during anesthesia. It was suggested that criticality could serve as a unifying principle underlying the diversity of dynamics. This view has been s…
View article
Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents Open
Penetrating flexible electrode arrays can simultaneously record thousands of individual neurons in the brains of live animals. However, it has been challenging to spatially map and longitudinally monitor the dynamics of large three-dimensi…
View article
Chronic multisite brain recordings from a totally implantable bidirectional neural interface: experience in 5 patients with Parkinson's disease Open
OBJECTIVE Dysfunction of distributed neural networks underlies many brain disorders. The development of neuromodulation therapies depends on a better understanding of these networks. Invasive human brain recordings have a favorable tempora…