Loop (graph theory)
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Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments Open
Hi-C experiments explore the 3D structure of the genome, generating terabases of data to create high-resolution contact maps. Here, we introduce Juicer, an open-source tool for analyzing terabase-scale Hi-C datasets. Juicer allows users wi…
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Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes Open
In this 6-month trial involving patients with type 1 diabetes, the use of a closed-loop system was associated with a greater percentage of time spent in a target glycemic range than the use of a sensor-augmented insulin pump. (Funded by th…
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Real-time imaging of DNA loop extrusion by condensin Open
Live imaging of DNA loop extrusion To spatially organize chromosomes, ring-shaped protein complexes including condensin and cohesin have been hypothesized to extrude DNA loops. Condensin has been shown to exhibit a DNA-translocating motor …
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Human cohesin compacts DNA by loop extrusion Open
Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al. now show that in the presence of the NIPBLMA…
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Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging Open
Animal genomes are folded into loops and topologically associating domains (TADs) by CTCF and loop-extruding cohesins, but the live dynamics of loop formation and stability remain unknown. Here, we directly visualized chromatin looping at …
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A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes Open
In this 16-week trial involving children with type 1 diabetes, the glucose level was in the target range for a greater percentage of time with the use of a closed-loop system than with the use of a sensor-augmented insulin pump. (Funded by…
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Phosphorus recovery and recycling – closing the loop Open
The natural phosphorus cycle has been disrupted by human activity, which necessitates the development of new methods for the sustainable production of phosphorus compounds, and efficient recovery and recycling schemes.
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A closed-loop hand prosthesis with simultaneous intraneural tactile and position feedback Open
Bionic hand provides accurate tactile and position information and leads to improved performance during sensing tasks.
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A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation Open
Mitosis-specific role of ATR The ATR (ataxia telangiectasia mutated and Rad3-related) kinase plays important roles in the S phase and during the DNA damage response to safeguard genome integrity. Kabeche et al. identified a distinct ATR ac…
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Emerging Evidence of Chromosome Folding by Loop Extrusion Open
Chromosome organization poses a remarkable physical problem with many biological consequences: How can molecular interactions between proteins at the nanometer scale organize micron-long chromatinized DNA molecules, insulating or facilitat…
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Augmenting the algorithm: Emerging human-in-the-loop work configurations Open
How do configurations of humans and algorithms evolve as firms adopt artificial intelligence (AI) capabilities, and what are the implications for work and organization? We explored these questions through a two-year long case study of an o…
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An Integrated Hybrid Approach for Circular supplier selection and Closed loop Supply Chain Network Design under Uncertainty Open
In recent decades, reverse logistics has garnered considerable attention since it recovers value of returning products, satisfies environmental requirements, and pays attention to customers’ rights. Suppliers, as the first layer of the sup…
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A Single-Loop Kriging Surrogate Modeling for Time-Dependent Reliability Analysis Open
Current surrogate modeling methods for time-dependent reliability analysis implement a double-loop procedure, with the computation of extreme value response in the outer loop and optimization in the inner loop. The computational effort of …
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Feedback loops and the longer-term: towards feedback spirals Open
A key challenge for feedback practice involves promoting student uptake through the closing of feedback loops. This paper investigates feedback loops by using the concepts of single and double-loop learning to interrogate student responses…
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A short review of loop quantum gravity Open
An outstanding open issue in our quest for physics beyond Einstein is the unification of general relativity (GR) and quantum physics. Loop quantum gravity (LQG) is a leading approach toward this goal. At its heart is the central lesson of …
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Wilson loop approach to fragile topology of split elementary band representations and topological crystalline insulators with time-reversal symmetry Open
We present a general methodology towards the systematic characterization of\ncrystalline topological insulating phases with time reversal symmetry (TRS).~In\nparticular, taking the two-dimensional spinful hexagonal lattice as a proof of\np…
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CT-ICP: Real-time Elastic LiDAR Odometry with Loop Closure Open
Multi-beam LiDAR sensors are increasingly used in robotics, particularly with\nautonomous cars for localization and perception tasks, both relying on the\nability to build a precise map of the environment. For this, we propose a new\nreal-…
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Bootstrapping a Five-Loop Amplitude Using Steinmann Relations Open
The analytic structure of scattering amplitudes is restricted by Steinmann relations, which enforce the vanishing of certain discontinuities of discontinuities. We show that these relations dramatically simplify the function space for the …
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Meta-Learning with Implicit Gradients Open
A core capability of intelligent systems is the ability to quickly learn new tasks by drawing on prior experience. Gradient (or optimization) based meta-learning has recently emerged as an effective approach for few-shot learning. In this …
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Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care Open
BACKGROUND: In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing evidence that a closed-loop delivery system (artificial pancreas) can improve glucose control in pat…
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One Year Clinical Experience of the First Commercial Hybrid Closed-Loop System Open
OBJECTIVE In September 2016, the U.S. Food and Drug Administration approved the Medtronic 670G “hybrid” closed-loop system. In Auto Mode, this system automatically controls basal insulin delivery based on continuous glucose monitoring data…
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A systematic and efficient method to compute multi-loop master integrals Open
We propose a novel method to compute multi-loop master integrals by constructing and numerically solving a system of ordinary differential equations, with almost trivial boundary conditions. Thus it can be systematically applied to problem…
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Type-II nodal loops: Theory and material realization Open
Nodal loop appears when two bands, typically one electron-like and one hole-like, are crossing each other linearly along a one-dimensional manifold in the reciprocal space. Here we propose a new type of nodal loop which emerges from crossi…
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LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network Open
Rationale: The forkhead box A1 (FOXA1) is a crucial transcription factor in initiation and development of breast, lung and prostate cancer. Previous studies about the FOXA1 transcriptional network were mainly focused on protein-coding gene…
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Closed-Loop Neuroscience and Non-Invasive Brain Stimulation: A Tale of Two Loops Open
Closed-loop neuroscience is receiving increasing attention with recent technological advances that enable complex feedback loops to be implemented with millisecond resolution on commodity hardware. We summarize emerging conceptual and meth…
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Two-loop integrand decomposition into master integrals and surface terms Open
Loop amplitudes are conveniently expressed in terms of master integrals whose\ncoefficients carry the process dependent information. Similarly before\nintegration, the loop integrands may be expressed as a linear combination of\npropagator…
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The full four-loop cusp anomalous dimension in $$ \mathcal{N} $$ = 4 super Yang-Mills and QCD Open
A bstract We present the complete formula for the cusp anomalous dimension at four loops in QCD and in maximally supersymmetric Yang-Mills. In the latter theory it is given by $$ {\left.{\Gamma}_{\mathrm{cusp},\mathrm{A}}\right|}_{\alpha_s…
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Self-Similar Conformations and Dynamics in Entangled Melts and Solutions of Nonconcatenated Ring Polymers Open
A scaling model of self-similar conformations and dynamics of nonconcatenated entangled ring polymers is developed. Topological constraints force these ring polymers into compact conformations with fractal dimension df = 3 that we call fra…
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Toward Human-in-the-Loop AI: Enhancing Deep Reinforcement Learning via Real-Time Human Guidance for Autonomous Driving Open
Due to its limited intelligence and abilities, machine learning is currently unable to handle various situations thus cannot completely replace humans in real-world applications. Because humans exhibit robustness and adaptability in comple…
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iBoW-LCD: An Appearance-Based Loop-Closure Detection Approach Using Incremental Bags of Binary Words Open
In this paper, we introduce iBoW-LCD, a novel appearance-based loop closure detection method. The presented approach makes use of an incremental Bag-of-Words (BoW) scheme based on binary descriptors to retrieve previously seen similar imag…