Claustrum
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Morphological diversity of single neurons in molecularly defined cell types Open
Dendritic and axonal morphology reflects the input and output of neurons and is a defining feature of neuronal types 1,2 , yet our knowledge of its diversity remains limited. Here, to systematically examine complete single-neuron morpholog…
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Organization of the connections between claustrum and cortex in the mouse Open
The connections between the claustrum and the cortex in mouse are systematically investigated with adeno‐associated virus (AAV), an anterograde viral tracer. We first define the boundary and the three‐dimensional structure of the claustrum…
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Models of psychedelic drug action: modulation of cortical-subcortical circuits Open
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have recaptured the imagination of both science and popular culture, and may have efficacy in treating a wide range of psychiatric disorders. Human and anima…
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Synaptic Organization of the Neuronal Circuits of the Claustrum Open
The claustrum, a poorly understood subcortical structure located between the cortex and the striatum, forms widespread connections with almost all cortical areas, but the cellular organization of claustral circuits remains largely unknown.…
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The Neural Correlates of Time: A Meta-analysis of Neuroimaging Studies Open
During the last two decades, our inner sense of time has been repeatedly studied with the help of neuroimaging techniques. These investigations have suggested the specific involvement of different brain areas in temporal processing. At lea…
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Organization of the Claustrum-to-Entorhinal Cortical Connection in Mice Open
The claustrum, a subcortical structure situated between the insular cortex and striatum, is reciprocally connected with almost all neocortical regions. Based on this connectivity, the claustrum has been postulated to integrate multisensory…
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The relationship between the claustrum and endopiriform nucleus: A perspective towards consensus on cross‐species homology Open
With the emergence of interest in studying the claustrum, a recent special issue of the Journal of Comparative Neurology dedicated to the claustrum (Volume 525, Issue 6, pp. 1313–1513) brought to light questions concerning the relationship…
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A Role for the Claustrum in Salience Processing? Open
The claustrum (CLA) is a subcortical structure, present only in mammals, whose function remains uncertain. Previously, using resting-state functional magnetic resonance imaging (rs-fMRI) in awake head-fixed rats, we found evidence that the…
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Deconstructing white matter connectivity of human amygdala nuclei with thalamus and cortex subdivisions in vivo Open
Structural alterations in long‐range amygdala connections are proposed to crucially underlie several neuropsychiatric disorders. While progress has been made in elucidating the function of these connections, our understanding of their stru…
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In search of common developmental and evolutionary origin of the claustrum and subplate Open
The human claustrum, a major hub of widespread neocortical connections, is a thin, bilateral sheet of gray matter located between the insular cortex and the striatum. The subplate is a largely transient cortical structure that contains som…
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The Claustrum-Prefrontal Cortex Pathway Regulates Impulsive-Like Behavior Open
The claustrum connects with a broad range of cortical areas including the prefrontal cortex (PFC). However, the function of the claustrum (CLA) and its neural projections remains largely unknown. Here, we elucidated the role of the neural …
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Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses Open
The processing of stress responses involves brain-wide communication among cortical and subcortical regions; however, the underlying mechanisms remain elusive. Here, we show that the claustrum (CLA) is crucial for the control of stress-ind…
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Subcortical connections of the perirhinal, postrhinal, and entorhinal cortices of the rat. II. efferents Open
This is the second of two studies detailing the subcortical connections of the perirhinal (PER), the postrhinal (POR) and entorhinal (EC) cortices of the rat. In the present study, we analyzed the subcortical efferents of the rat PER areas…
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Non-Newly Generated, “Immature” Neurons in the Sheep Brain Are Not Restricted to Cerebral Cortex Open
A newly proposed form of brain structural plasticity consists of non-newly generated, “immature” neurons of the adult cerebral cortex. Similar to newly generated neurons, these cells express the cytoskeletal protein Doublecortin (DCX), yet…
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New Breakthroughs in Understanding the Role of Functional Interactions between the Neocortex and the Claustrum Open
Almost all areas of the neocortex are connected with the claustrum, a nucleus located between the neocortex and the striatum, yet the functions of corticoclaustral and claustrocortical connections remain largely obscure. As major efforts t…
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Flexible and Stable Value Coding Areas in Caudate Head and Tail Receive Anatomically Distinct Cortical and Subcortical Inputs Open
Anatomically distinct areas within the basal ganglia encode flexible- and stable-value memories for visual objects (Hikosaka et al., 2014), but an important question remains: do they receive inputs from the same or different brain areas or…
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New-Onset Refractory Status Epilepticus with Claustrum Damage: Definition of the Clinical and Neuroimaging Features Open
New-onset refractory status epilepticus (NORSE) is a rare but challenging condition occurring in a previously healthy patient, often with no identifiable cause. We describe the electro-clinical features and outcomes in a group of patients …
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Topographic gradients define the projection patterns of the claustrum core and shell in mice Open
The claustrum is densely connected to the cortex and participates in brain functions such as attention and sleep. Although some studies have reported the widely divergent organization of claustrum projections, others describe parallel clau…
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Regional and cell-type-specific afferent and efferent projections of the mouse claustrum Open
The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and subcortical regions. Its regional anatomy and cell-type-specific connections in the mouse remain not fully determined. Using multimodal reference d…
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Thalamus and claustrum control parallel layer 1 circuits in retrosplenial cortex Open
The granular retrosplenial cortex (RSG) is critical for both spatial and non-spatial behaviors, but the underlying neural codes remain poorly understood. Here, we use optogenetic circuit mapping in mice to reveal a double dissociation that…
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The claustrum-medial prefrontal cortex network controls attentional set-shifting Open
SUMMARY In various mental disorders, dysfunction of the prefrontal cortex contributes to cognitive deficits. Here we studied how the claustrum (CLA), a nucleus sharing reciprocal connections with the cortex, may participate in these cognit…
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The claustrum: Considerations regarding its anatomy, functions and a programme for research Open
The claustrum is a highly conserved but enigmatic structure, with connections to the entire cortical mantle, as well as to an extended and extensive range of heterogeneous subcortical structures. Indeed, the human claustrum is thought to h…
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Spatially patterned excitatory neuron subtypes and projections of the claustrum Open
The claustrum is a functionally and structurally complex brain region, whose very spatial extent remains debated. Histochemical-based approaches typically treat the claustrum as a relatively narrow anatomical region that primarily projects…
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A Re-evaluation of the Anatomy of the Claustrum in Rodents and Primates—Analyzing the Effect of Pallial Expansion Open
The components of the claustrum have been identified by gene expression in mice, but there is still uncertainty about the location of homologous components in primates. To aid interpretation of homologous elements between rodents and prima…
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Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types Open
Ever since the seminal findings of Ramon y Cajal, dendritic and axonal morphology has been recognized as a defining feature of neuronal types. Yet our knowledge concerning the diversity of neuronal morphologies, in particular distal axonal…
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Human lesions and animal studies link the claustrum to perception, salience, sleep and pain Open
The claustrum is the most densely interconnected region in the human brain. Despite the accumulating data from clinical and experimental studies, the functional role of the claustrum remains unknown. Here, we systematically review claustru…
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The Claustrum is Involved in Cognitive Processes Related to the Classical Conditioning of Eyelid Responses in Behaving Rabbits Open
It is assumed that the claustrum (CL) is involved in sensorimotor integration and cognitive processes. We recorded the firing activity of identified CL neurons during classical eyeblink conditioning in rabbits, using a delay paradigm in wh…
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Identification of Mouse Claustral Neuron Types Based on Their Intrinsic Electrical Properties Open
Although its dense connections with other brain areas suggests that the claustrum is involved in higher-order brain functions, little is known about the properties of claustrum neurons. Using whole-cell patch clamp recordings in acute brai…
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Interhemispheric connections between the infralimbic and entorhinal cortices: The endopiriform nucleus has limbic connections that parallel the sensory and motor connections of the claustrum Open
We have previously shown that the claustrum is part of an interhemispheric circuit that interconnects somesthetic–motor and visual–motor cortical regions. The role of the claustrum in processing limbic information, however, is poorly under…
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Altered Functional Connectivity of the Basal Nucleus of Meynert in Mild Cognitive Impairment: A Resting-State fMRI Study Open
Background: Cholinergic dysfunction plays an important role in mild cognitive impairment (MCI). The basal nucleus of Meynert (BNM) provides the main source of cortical cholinergic innervation. Previous studies have characterized structural…