Nephrology ≈ NephrologyNephrology
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Multinational Assessment of Accuracy of Equations for Predicting Risk of Kidney Failure Open
Kidney failure risk equations developed in a Canadian population showed high discrimination and adequate calibration when validated in 31 multinational cohorts. However, in some regions the addition of a calibration factor may be necessary.
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Cell-Free DNA and Active Rejection in Kidney Allografts Open
Histologic analysis of the allograft biopsy specimen is the standard method used to differentiate rejection from other injury in kidney transplants. Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive test of allograft injury that may …
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Assessment of Global Kidney Health Care Status Open
This survey demonstrated significant interregional and intraregional variability in the current capacity for kidney care across the world, including important gaps in services and workforce. Assuming the responses accurately reflect the st…
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The proximal tubule is the primary target of injury and progression of kidney disease: role of the glomerulotubular junction Open
There is an alarming global increase in the incidence of end-stage kidney disease, for which early biomarkers and effective treatment options are lacking. Largely based on the histology of the end-stage kidney and on the model of unilatera…
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Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2 Open
Significance Statement The cause of kidney injury in COVID-19 is unclear. In an autopsy study of a single patient with COVID-19 and acute oliguric renal failure, the authors identified intracellular viral arrays within proximal tubular epi…
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Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases Open
Extracellular vesicles are cell-derived membrane particles ranging from 30 to 5,000 nm in size, including exosomes, microvesicles, and apoptotic bodies. They are released under physiological conditions, but also upon cellular activation, s…
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An update on the global disparities in kidney disease burden and care across world countries and regions Open
International Society of Nephrology.
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Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group Open
Contains fulltext : 192663.pdf (Publisher’s version ) (Open Access)
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AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19 Open
Significance Statement Although AKI is an important sequela of coronavirus disease 2019 (COVID-19), data on AKI treated with RRT (AKI-RRT) in patients with COVID-19 are limited. In a multicenter cohort study of 3099 critically ill adults w…
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Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study Open
Objective To develop and validate an integrative system to predict long term kidney allograft failure. Design International cohort study. Setting Three cohorts including kidney transplant recipients from 10 academic medical centres from Eu…
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Chronic kidney disease in children Open
Chronic kidney disease (CKD) is a major health problem worldwide. Although relatively uncommon in children, it can be a devastating illness with many long-term consequences. CKD presents unique features in childhood and may be considered, …
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Renal association clinical practice guideline on Anaemia of Chronic Kidney Disease Open
Anaemia is a commonly diagnosed complication among patients suffering with chronic kidney disease. If left untreated, it may affect patient quality of life. There are several causes for anaemia in this patient population. As the kidney fun…
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Oxidative Stress in Hemodialysis Patients: A Review of the Literature Open
Hemodialysis (HD) patients are at high risk for all‐cause mortality and cardiovascular events. In addition to traditional risk factors, excessive oxidative stress (OS) and chronic inflammation emerge as novel and major contributors to acce…
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Atherosclerosis in Chronic Kidney Disease Open
Patients with chronic kidney disease (CKD) are at an increased risk of premature mortality, mainly from cardiovascular causes. The association between CKD on hemodialysis and accelerated atherosclerosis was described >40 years ago. However…
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Status of care for end stage kidney disease in countries and regions worldwide: international cross sectional survey Open
Objective To determine the global capacity (availability, accessibility, quality, and affordability) to deliver kidney replacement therapy (dialysis and transplantation) and conservative kidney management. Design International cross sectio…
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A more tubulocentric view of diabetic kidney disease Open
Diabetic nephropathy (DN) is a common complication of Diabetes Mellitus (DM) Types 1 and 2, and prevention of end stage renal disease (ESRD) remains a major challenge. Despite its high prevalence, the pathogenesis of DN is still controvers…
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Pharmacology behind Common Drug Nephrotoxicities Open
Patients are exposed to numerous prescribed and over-the-counter medications. Unfortunately, drugs remain a relatively common cause of acute and chronic kidney injury. A combination of factors including the innate nephrotoxicity of drugs, …
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APOL1 Nephropathy: From Genetics to Clinical Applications Open
Rates of many types of severe kidney disease are much higher in Black individuals than most other ethnic groups. Much of this disparity can now be attributed to genetic variants in the apoL1 (APOL1) gene found only in individuals with rece…
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Everolimus with Reduced Calcineurin Inhibitor Exposure in Renal Transplantation Open
Background Everolimus permits reduced calcineurin inhibitor (CNI) exposure, but the efficacy and safety outcomes of this treatment after kidney transplant require confirmation. Methods In a multicenter noninferiority trial, we randomized 2…
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Chronic kidney disease and the global NCDs agenda Open
2017 is an important year for the international nephrology community. March 9 was World Kidney Day, the theme this year being ‘Kidney disease and obesity: healthy lifestyles for healthy kidneys’, highlighting the crucial link between the k…
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2015 Japanese Society for Dialysis Therapy: Guidelines for Renal Anemia in Chronic Kidney Disease Open
Renal anemia is a complication of chronic kidney disease. Guidelines for safe and effective treatment in patients with renal anemia are needed. The Japanese Society for Dialysis Therapy (JSDT) published guidelines for the treatment of rena…
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SGLT2i: beyond the glucose-lowering effect Open
Sodium/glucose cotransporter-2 inhibitors (SGLT2i) are a new type of glucose-lowering drug that can reduce blood glucose by inhibiting its reabsorption in proximal tubules and by promoting urinary glucose excretion. SGLT2i are widely used …
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A review of clinical characteristics and genetic backgrounds in Alport syndrome Open
Alport syndrome (AS) is a progressive hereditary renal disease that is characterized by sensorineural hearing loss and ocular abnormalities. It is divided into three modes of inheritance, namely, X-linked Alport syndrome (XLAS), autosomal …
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Brazilian Dialysis Census: analysis of data from the 2009-2018 decade Open
Introduction: National data on chronic dialysis treatment are essential for the development of health policies that aim to improve patient treatment. Objective: To present data from the Brazilian Society of Nephrology on patients with chro…
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Clinical practice guideline exercise and lifestyle in chronic kidney disease Open
Availability of data and materials: All data and material used in the production of this guideline can be found within the references.
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Clinical Pharmacology of Antibiotics Open
Antimicrobial pharmacology and its effect on prescribing is quite complex. Selecting an antibiotic that will optimally treat an infection while minimizing adverse effects and the development of resistance is only the first step, as one mus…
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Cardiovascular disease in the kidney transplant recipient: epidemiology, diagnosis and management strategies Open
Kidney transplantation (KT) is the optimal therapy for end-stage kidney disease (ESKD), resulting in significant improvement in survival as well as quality of life when compared with maintenance dialysis. The burden of cardiovascular disea…
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Complications associated with ureterorenoscopy (URS) related to treatment of urolithiasis: the Clinical Research Office of Endourological Society URS Global study Open
INTRODUCTION: Ureterorenoscopy (URS) is a popular and growing option for management of ureteric and renal stones. The CROES URS Global Study was set up to assess the outcomes of URS in a large worldwide cohort of patients involving multipl…
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The Prognostic Value of Histopathologic Lesions in Native Kidney Biopsy Specimens: Results from the Boston Kidney Biopsy Cohort Study Open
Background Few studies have evaluated whether histopathologic lesions on kidney biopsy provide prognostic information beyond clinical and laboratory data. Methods We enrolled 676 individuals undergoing native kidney biopsy at three tertiar…
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Delayed Graft Function: The AKI of Kidney Transplantation Open
With the growing wait list of individuals waiting for kidney transplantation, there has been renewed interest in the quality and function of donor organs. In particular, concern about the development of delayed allograft function (DGF) aft…