Neurostimulation
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Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial Open
Animal and human studies indicate that electrical stimulation of dorsal root ganglion (DRG) neurons may modulate neuropathic pain signals. ACCURATE, a pivotal, prospective, multicenter, randomized comparative effectiveness trial, was condu…
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Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder Open
Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive…
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The anatomical basis for transcutaneous auricular vagus nerve stimulation Open
The array of end organ innervations of the vagus nerve, coupled with increased basic science evidence, has led to vagus nerve stimulation (VNS) being explored as a management option in a number of clinical disorders, such as heart failure,…
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Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy Open
This study provides Class IV evidence that brain-responsive neurostimulation significantly reduces focal seizures with acceptable safety over 9 years.
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Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy Open
Summary Objective Evaluate the seizure‐reduction response and safety of mesial temporal lobe ( MTL ) brain‐responsive stimulation in adults with medically intractable partial‐onset seizures of mesial temporal lobe origin. Methods Subjects …
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<span>EAN</span> guidelines on central neurostimulation therapy in chronic pain conditions Open
Background and purpose Our aim was to update previous European Federation of Neurological Societies guidelines on neurostimulation for neuropathic pain, expanding the search to new techniques and to chronic pain conditions other than neuro…
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Directional deep brain stimulation of the subthalamic nucleus: A pilot study using a novel neurostimulation device Open
Introduction A novel neurostimulation system allows steering current in horizontal directions by combining segmented leads and multiple independent current control. The aim of this study was to evaluate directional DBS effects on parkinson…
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Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas Open
Summary Objective Evaluate the seizure‐reduction response and safety of brain‐responsive stimulation in adults with medically intractable partial‐onset seizures of neocortical origin. Methods Patients with partial seizures of neocortical o…
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Vagus nerve stimulation: Surgical technique of implantation and revision and related morbidity Open
Summary Indications for vagus nerve stimulation ( VNS ) therapy include focal, multifocal epilepsy, drop attacks (tonic/atonic seizures), Lennox‐Gastaut syndrome, tuberous sclerosis complex ( TSC )–related multifocal epilepsy, and unsucces…
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Brain-responsive neurostimulation for epilepsy (RNS® System) Open
Controlled clinical trials in adults with medically intractable focal seizures treated with the RNS® System demonstrate that closed-loop responsive neurostimulation to the seizure focus reduces the frequency of disabling seizures, is well …
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Non-invasive temporal interference electrical stimulation of the human hippocampus Open
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal …
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Towards network-guided neuromodulation for epilepsy Open
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of research to identify critical nodes within dynamic epileptic networks with the aim to target therapies that halt the onset and propagation of seizures.…
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Neuroimaging of Pain Open
Neuroimaging research has demonstrated definitive involvement of the central nervous system in the development, maintenance, and experience of chronic pain. Structural and functional neuroimaging has helped elucidate central nervous system…
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Seizure Cycles in Focal Epilepsy Open
Findings in this large cohort establish the high prevalence of plural seizure cycles and help explain the natural variability in seizure timing. The results have the potential to inform the scheduling of diagnostic studies, the delivery of…
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Acute migraine therapy with external trigeminal neurostimulation (ACME): A randomized controlled trial Open
Objective To assess the safety and efficacy of external trigeminal nerve stimulation for acute pain relief during migraine attacks with or without aura via a sham-controlled trial. Methods This was a double-blind, randomized, sham-controll…
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Association of Closed-Loop Brain Stimulation Neurophysiological Features With Seizure Control Among Patients With Focal Epilepsy Open
These findings suggest that RNS effectiveness may be explained by long-term, stimulation-induced modulation of seizure network activity rather than by direct effects on each detected seizure.
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Moderate effects of noninvasive brain stimulation of the frontal cortex for improving negative symptoms in schizophrenia: Meta-analysis of controlled trials Open
The available evidence indicates that noninvasive prefrontal neurostimulation can improve negative symptoms. This finding suggests a causal role for the lateral frontal cortex in self-initiated goal-directed behavior. The evidence is stron…
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Consensus Paper: Experimental Neurostimulation of the Cerebellum Open
The cerebellum is best known for its role in controlling motor behaviors. However, recent work supports the view that it also influences non-motor behaviors. The contribution of the cerebellum towards different brain functions is underscor…
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Deep brain and cortical stimulation for epilepsy Open
Except for one very small RCT, only short-term RCTs on intracranial neurostimulation for epilepsy are available. Compared to sham stimulation, one to three months of anterior thalamic DBS ((multi)focal epilepsy), responsive ictal onset zon…
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Transcranial Focused Ultrasound (tFUS) and Transcranial Unfocused Ultrasound (tUS) Neuromodulation: From Theoretical Principles to Stimulation Practices Open
Transcranial focused ultrasound is an emerging technique for non-invasive neurostimulation. Compared to magnetic or electric non-invasive brain stimulation, this technique has a higher spatial resolution and can reach deep structures. In a…
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Non-motor outcomes depend on location of neurostimulation in Parkinson’s disease Open
Deep brain stimulation of the subthalamic nucleus improves non-motor symptoms in Parkinson’s disease, but with considerable inter-individual variability. Petry-Schmelzer et al. show that neurostimulation in specific subregions of the subth…
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Explainable Artificial Intelligence for Neuroscience: Behavioral Neurostimulation Open
The use of Artificial Intelligence and machine learning in basic research and clinical neuroscience is increasing. AI methods enable the interpretation of large multimodal datasets that can provide unbiased insights into the fundamental pr…
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Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound Open
Recently developed brain stimulation techniques have significantly advanced our ability to manipulate the brain's function. However, stimulating specific neurons in a desired region without significant surgical invasion remains a challenge…
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Progressive gait ataxia following deep brain stimulation for essential tremor: adverse effect or lack of efficacy? Open
Thalamic deep brain stimulation is a mainstay treatment for severe and drug-refractory essential tremor, but postoperative management may be complicated in some patients by a progressive cerebellar syndrome including gait ataxia, dysmetria…
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Direct Electrical Neurostimulation with Organic Pigment Photocapacitors Open
An efficient nanoscale semiconducting optoelectronic system is reported, which is optimized for neuronal stimulation: the organic electrolytic photocapacitor. The devices comprise a thin (80 nm) trilayer of metal and p–n semiconducting org…
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Probabilistic mapping of the antidystonic effect of pallidal neurostimulation: a multicentre imaging study Open
Deep brain stimulation of the internal globus pallidus is a highly effective and established therapy for primary generalized and cervical dystonia, but therapeutic success is compromised by a non-responder rate of up to 25%, even in carefu…
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Supervised transcranial direct current stimulation (tDCS) at home: A guide for clinical research and practice Open
These guidelines provide a reference and standard for practice when employing the use of tDCS outside of the clinic setting.
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Miniaturised Wireless Power Transfer Systems for Neurostimulation: A Review Open
In neurostimulation, wireless power transfer is an efficient technology to overcome several limitations affecting medical devices currently used in clinical practice. Several methods were developed over the years for wireless power transfe…
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Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders Open
In this position statement, developed by The International College of Obsessive-Compulsive Spectrum Disorders, a group of international experts responds to recent developments in the evidence-based management of obsessive-compulsive disord…
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Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation Open
Transcutaneous vagus nerve stimulation (tVNS) is a non‐invasive neurostimulation technique that is currently being tested as a potential treatment for a myriad of neurological and psychiatric disorders. However, the working mechanisms unde…