Organogenesis ≈ Organogenesis
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Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays Open
Spatially resolved transcriptomic technologies are promising tools to study complex biological processes such as mammalian embryogenesis. However, the imbalance between resolution, gene capture, and field of view of current methodologies p…
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Mechanisms of ROS Regulation of Plant Development and Stress Responses Open
Plants are subjected to various environmental stresses throughout their life cycle. Reactive oxygen species (ROS) play important roles in maintaining normal plant growth, and improving their tolerance to stress. This review describes the p…
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Specification of tissue-resident macrophages during organogenesis Open
INTRODUCTION Embryonic development and tissue homeostasis depend on cooperation between specialized cell types. Resident macrophages are professional phagocytes that survey their surroundings; eliminate unfit cells, microorganisms, and met…
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The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution Open
Mapping the vertebrate developmental landscape As embryos develop, numerous cell types with distinct functions and morphologies arise from pluripotent cells. Three research groups have used single-cell RNA sequencing to analyze the transcr…
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Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish Open
Pluripotent stem cell (PSC)-derived organoids are miniature, three-dimensional human tissues generated by the application of developmental biological principles to PSCs in vitro. The approach to generate organoids uses a combination of dir…
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Differential TOR activation and cell proliferation in <i>Arabidopsis</i> root and shoot apexes Open
Significance The modulation of growth and development is central to sessile plants. Shoot and root meristems share almost identical molecular machineries but are responsible for different types of aboveground and underground organogenesis.…
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An m <sup>6</sup> A-YTH Module Controls Developmental Timing and Morphogenesis in Arabidopsis Open
Methylation of N6-adenosine (m6A) in mRNA is an important posttranscriptional gene regulatory mechanism in eukaryotes. m6A provides a binding site for effector proteins ("readers") that influence pre-mRNA splicing, mRNA degradation, or tra…
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Transcription Factors WOX11/12 Directly Activate <i>WOX5/7</i> to Promote Root Primordia Initiation and Organogenesis Open
De novo organogenesis, which gives rise to adventitious roots and shoots, is a type of plant regeneration for survival after wounding. In Arabidopsis (Arabidopsis thaliana), two main cell fate transition steps are required to establish the…
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Cellular and molecular mechanisms of tooth root development Open
The tooth root is an integral, functionally important part of our dentition. The formation of a functional root depends on epithelial-mesenchymal interactions and integration of the root with the jaw bone, blood supply and nerve innervatio…
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DELLA proteins are common components of symbiotic rhizobial and mycorrhizal signalling pathways Open
Legumes form symbiotic associations with either nitrogen-fixing bacteria or arbuscular mycorrhizal fungi. Formation of these two symbioses is regulated by a common set of signalling components that act downstream of recognition of rhizobia…
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ATP-dependent chromatin remodeling during mammalian development Open
Precise gene expression ensures proper stem and progenitor cell differentiation, lineage commitment and organogenesis during mammalian development. ATP-dependent chromatin-remodeling complexes utilize the energy from ATP hydrolysis to reor…
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Molecular and cellular mechanisms of tooth development, homeostasis and repair Open
The tooth provides an excellent system for deciphering the molecular mechanisms of organogenesis, and has thus been of longstanding interest to developmental and stem cell biologists studying embryonic morphogenesis and adult tissue renewa…
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Cellular, Molecular, and Physiological Aspects of In Vitro Plant Regeneration Open
Plants generally have the highest regenerative ability because they show a high degree of developmental plasticity. Although the basic principles of plant regeneration date back many years, understanding the cellular, molecular, and physio…
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Neuro–Immune Cell Units: A New Paradigm in Physiology Open
The interplay between the immune and nervous systems has been acknowledged in the past, but only more recent studies have started to unravel the cellular and molecular players of such interactions. Mounting evidence indicates that environm…
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Conserved and Divergent Features of Human and Mouse Kidney Organogenesis Open
Human kidney function is underpinned by approximately 1,000,000 nephrons, although the number varies substantially, and low nephron number is linked to disease. Human kidney development initiates around 4 weeks of gestation and ends around…
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Prostate organogenesis: tissue induction, hormonal regulation and cell type specification Open
Prostate organogenesis is a complex process that is primarily mediated by the presence of androgens and subsequent mesenchyme-epithelial interactions. The investigation of prostate development is partly driven by its potential relevance to…
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<i>YUCCA</i>-mediated auxin biogenesis is required for cell fate transition occurring during<i>de novo</i>root organogenesis in Arabidopsis Open
Many plant organs have the ability to regenerate a new plant after detachment or wounding via de novo organogenesis. During de novo root organogenesis from Arabidopsis thaliana leaf explants, endogenic auxin is essential for the fate trans…
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Engineering stem cell-derived 3D brain organoids in a perfusable organ-on-a-chip system Open
We present a new strategy to engineer hiPSC-derived 3D brain organoids by combining stem cell biology with organs-on-a-chip technology.
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New Insights Into Tissue Culture Plant-Regeneration Mechanisms Open
Plant regeneration occurs when plants repair or replace damaged structures based on the totipotency and pluripotency of their cells. Tissue culture is one of the most widely used regenerative technologies. Recently, a series of breakthroug…
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Systematic reconstruction of cellular trajectories across mouse embryogenesis Open
Mammalian embryogenesis is characterized by rapid cellular proliferation and diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells expressing a panoply of molecular programs. Although intensively studied…
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Os<span>MADS</span>57 together with Os<span>TB</span>1 coordinates transcription of its target <i>Os<span>WRKY</span>94</i> and <i>D14</i> to switch its organogenesis to defense for cold adaptation in rice Open
Summary Plants modify their development to adapt to their environment, protecting themselves from detrimental conditions such as chilling stress by triggering a variety of signaling pathways; however, little is known about how plants coord…
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Kidney organoids: accurate models or fortunate accidents Open
There are now many reports of human kidney organoids generated via the directed differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of mammalian kidney organogenesis. Such kidney organoids potentially …
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Mechanical regulation of musculoskeletal system development Open
During embryogenesis, the musculoskeletal system develops while containing within itself a force generator in the form of the musculature. This generator becomes functional relatively early in development, exerting an increasing mechanical…
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Cadmium and arsenic affect root development in Oryza sativa L. negatively interacting with auxin Open
Cadmium (Cd) and arsenic (As), non essential, but toxic, elements for animals and plants are frequently present in paddy fields. Oryza sativa L., a staple food for at least the half of world population, easily absorbs As and Cd by the root…
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Advances and challenges on the in vitro production of secondary metabolites from medicinal plants Open
The production of secondary metabolites from medicinal plants, also called Plant-Derived Medicinal Compounds (PDMC), is gaining ground in the last decade. Concomitant to the increase in the knowledge about pharmacological properties of the…
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A single-cell atlas of mouse lung development Open
Lung organogenesis requires precise timing and coordination to effect spatial organization and function of the parenchymal cells. To provide a systematic broad-based view of the mechanisms governing the dynamic alterations in parenchymal c…
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A Remote <i>cis</i>-Regulatory Region Is Required for <i>NIN</i> Expression in the Pericycle to Initiate Nodule Primordium Formation in <i>Medicago truncatula</i> Open
The legume-rhizobium symbiosis results in nitrogen-fixing root nodules, and their formation involves both intracellular infection initiated in the epidermis and nodule organogenesis initiated in inner root cell layers. NODULE INCEPTION (NI…
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PLETHORA transcription factors orchestrate de novo organ patterning during <i>Arabidopsis</i> lateral root outgrowth Open
Significance Root architecture is an important trait that is shaped by the formation of primary roots, lateral roots, and adventitious roots. Here, we show that three PLETHORA (PLT) transcription factors are the key molecular triggers for …
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Temporal integration of auxin information for the regulation of patterning Open
Positional information is essential for coordinating the development of multicellular organisms. In plants, positional information provided by the hormone auxin regulates rhythmic organ production at the shoot apex, but the spatio-temporal…
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What Makes Adventitious Roots? Open
The spermatophyte root system is composed of a primary root that develops from an embryonically formed root meristem, and of different post-embryonic root types: lateral and adventitious roots. Adventitious roots, arising from the stem of …