PEG ratio ≈ PEG ratio
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Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery Open
The Effects of Surface Polyethylene Glycol on Nanoparticles' Fate. a. Mechanical properties. b. Stability. c. Drug encapsulation. d. Plasma proteins adsorption. e. Mucus penetration. f. Active targeting. g. Cellular internalization. h. Cir…
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FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol Open
The aim of this study was to prepare a novel targeting drug delivery system for 2-Methoxyestradiol (2ME) in order to improve the clinical application of this antitumor drug. It is based in nanoparticles (NPs) of titanium dioxide (TiO2) coa…
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The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation Open
Poly(ethylene glycol) (PEG) is widely used as a gold standard in bioconjugation and nanomedicine to prolong blood circulation time and improve drug efficacy. The conjugation of PEG to proteins, peptides, oligonucleotides (DNA, small interf…
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Role of oxygen functional groups in reduced graphene oxide for lubrication Open
Functionalized and fully characterized graphene-based lubricant additives are potential 2D materials for energy-efficient tribological applications in machine elements, especially at macroscopic contacts. Two different reduced graphene oxi…
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Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals Open
Conjugation of polyethylene glycols (PEGs) to proteins or drug delivery nanosystems is a widely accepted method to increase the therapeutic index of complex nano-biopharmaceuticals. Nevertheless, these drugs and agents are often immunogeni…
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PEGylated liposomes: immunological responses Open
A commonly held view is that nanocarriers conjugated to polyethylene glycol (PEG) are non-immunogenic. However, many studies have reported that unexpected immune responses have occurred against PEG-conjugated nanocarriers. One unanticipate…
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Cytotoxicity of dendrimers Open
Drug delivery systems are molecular platforms in which an active compound is packed into or loaded on a biocompatible nanoparticle. Such a solution improves the activity of the applied drug or decreases its side effects. Dendrimers are pro…
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An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair Open
We report here an injectable, self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic wound regeneration. The hydrogel was prepared by coordinative cross-linking of multi-arm thiolated polyethylene glyc…
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Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery Open
To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is…
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Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population Open
Circulating antibodies (Ab) that specifically bind polyethylene glycol (PEG), a biocompatible polymer routinely used in protein and nanoparticle therapeutics, have been associated with reduced efficacy of and/or adverse reactions to therap…
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Polymer–Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs Open
Therapeutic nucleic acids hold great promise for the treatment of disease but require vectors for safe and effective delivery. Synthetic nanoparticle vectors composed of poly(β‐amino esters) (PBAEs) and nucleic acids have previously demons…
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Ionically Conductive Self‐Healing Binder for Low Cost Si Microparticles Anodes in Li‐Ion Batteries Open
A self‐healing polymer (SHP) with abundant hydrogen bonds, appropriate viscoelasticity, and stretchability is a promising binder to improve cycle performance of Si microparticle anodes in lithium (Li) ion batteries. Besides high capacity a…
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Polydopamine Nanoparticles as a Versatile Molecular Loading Platform to Enable Imaging-guided Cancer Combination Therapy Open
Cancer combination therapy to treat tumors with different therapeutic approaches can efficiently improve treatment efficacy and reduce side effects. Herein, we develop a theranostic nano-platform based on polydopamine (PDA) nanoparticles, …
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Charge-based precipitation of extracellular vesicles Open
Vesicular-mediated communication between cells appears critical in many biological processes. Extracellular vesicles (EVs) released from healthy and diseased cells are involved in a network of exchange of biologically active molecules. Sin…
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3D-printing of transparent bio-microfluidic devices in PEG-DA Open
The 3D-printed devices are highly transparent and cells can be cultured on PEG-DA-250 prints for several days.
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Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales Open
Extracellular vesicles (EVs) provide a complex means of intercellular signalling between cells at local and distant sites, both within and between different organs. According to their cell‐type specific signatures, EVs can function as a no…
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Biodegradable Hybrid Stomatocyte Nanomotors for Drug Delivery Open
We report the self-assembly of a biodegradable platinum nanoparticle-loaded stomatocyte nanomotor containing both PEG-b-PCL and PEG-b-PS as a potential candidate for anticancer drug delivery. Well-defined stomatocyte structures could be fo…
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Clickable PEG hydrogel microspheres as building blocks for 3D bioprinting Open
Clickable poly(ethylene glycol) hydrogel microspheres can be 3D printed and photochemically annealed to produce complex cell-laden structures.
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Polyethylene glycol (PEG) is a cause of anaphylaxis to the Pfizer/BioNTech mRNA COVID‐19 vaccine Open
The authors declare no conflict of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.
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The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model Open
Oxidative stress (OS) plays an important role in the pathology of certain human diseases. Scientists have developed great interest regarding the determination of oxidative stress caused after the administration of nano-graphene composites …
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In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS<sub>2</sub> (M = Mo, W, Ti) Nanosheets Open
With unique 2D structures and intriguing physicochemical properties, various types of transition metal dichalcogenides (TMDCs) have attracted much attention in many fields including nanomedicine. Hence, it is of great importance to careful…
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A Water-Miscible Quinone Flow Battery with High Volumetric Capacity and Energy Density Open
A water-miscible anthraquinone with polyethylene glycol (PEG)-based solubilizing groups is introduced as the redox-active molecule in a negative electrolyte (negolyte) for aqueous redox flow batteries, exhibiting the highest volumetric cap…
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Confinement of Therapeutic Enzymes in Selectively Permeable Polymer Vesicles by Polymerization-Induced Self-Assembly (PISA) Reduces Antibody Binding and Proteolytic Susceptibility Open
Covalent PEGylation of biologics has been widely employed to reduce immunogenicity, while improving stability and half-life in vivo. This approach requires covalent protein modification, creating a new entity. An alternative approach is st…
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Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery Open
Polysarcosine (pSar) is a polypeptoid based on the endogenous amino acid sarcosine (N-methylated glycine), which has previously shown potent stealth properties. Here, lipid nanoparticles (LNPs) for therapeutic application of messenger RNA …
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Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration Open
The fabrication of highly biocompatible hydrogels with multiple unique healing abilities for the whole healing process, for example, multifunctional hydrogels with injectable, degradation, antibacterial, antihypoxic, and wound healing–prom…
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Brush Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime Open
For nanocarriers with low protein affinity, we show that the interaction of nanocarriers with cells is mainly affected by the density, the molecular weight, and the conformation of polyethylene glycol (PEG) chains bound to the nanocarrier …
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PEGylated Lipid Nanoparticle Formulations: Immunological Safety and Efficiency Perspective Open
Lipid nanoparticles (LNPs) have been recognized as efficient vehicles to transport a large variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 mRNA vaccines, LNPs play a significant role in protect…
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Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy Open
Here, we show how dynamic nuclear polarization (DNP) NMR spectroscopy experiments permit the atomic level structural characterization of loaded and empty lipid nanoparticles (LNPs). The LNPs used here were synthesized by the microfluidic m…
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3D‐Bioprinted Osteoblast‐Laden Nanocomposite Hydrogel Constructs with Induced Microenvironments Promote Cell Viability, Differentiation, and Osteogenesis both In Vitro and In Vivo Open
An osteoblast‐laden nanocomposite hydrogel construct, based on polyethylene glycol diacrylate (PEGDA)/laponite XLG nanoclay ([Mg 5.34 Li 0.66 Si 8 O 20 (OH) 4 ]Na 0.66, clay )/hyaluronic acid sodium salt (HA) bio‐inks, is developed by a tw…
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Dense and Dynamic Polyethylene Glycol Shells Cloak Nanoparticles from Uptake by Liver Endothelial Cells for Long Blood Circulation Open
Research into long-circulating nanoparticles has in the past focused on reducing their clearance by macrophages. By engineering a hierarchical polyethylene glycol (PEG) structure on nanoparticle surfaces, we revealed an alternative mechani…