Chronic periodontitis
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Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions Open
A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as “chronic” or “aggressive” are now grouped under a single category (“periodontitis”) and are further characterized based on a…
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Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line Open
Periodontal disease represents a group of oral inflammatory infections initiated by oral pathogens which exist as a complex biofilms on the tooth surface and cause destruction to tooth supporting tissues. The severity of this disease range…
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Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues Open
Periodontitis is an infection-driven inflammatory disease in which the composition of biofilms plays a significant role. Dental plaque accumulation at the gingival margin initiates an inflammatory response that, in turn, causes microbial a…
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Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases Open
Periodontal diseases, such as chronic periodontitis, share common inflammatory risk factors with other systemic and chronic inflammatory disorders. Mucosal tissues, such as oral epithelia, are exposed to environmental stressors, such as to…
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Microbial colonization of the periodontal pocket and its significance for periodontal therapy Open
The aim of this paper was to evaluate strategies for periodontal therapy from the perspective of periodontal disease being a consequence of microbial colonization of the periodontal pocket environment. In classic bacterial infections the d…
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Effect of periodontal treatment in patients with periodontitis and diabetes: systematic review and meta-analysis Open
SRP has an impact on metabolic control and reduction of systemic inflammation of patients with T2D.
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Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors Open
Periodontitis is a common intraoral infection and is inextricably linked to systemic diseases. Recently, the regulation between host immunologic response and periodontal pathogens has become a hotspot to explain the mechanism of periodonti…
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Oxidative stress‐related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta‐analysis Open
Aim Oxidative stress ( OS ) biomarkers have been detected in saliva and gingival crevicular fluid ( GCF ) during chronic periodontitis ( CP ) progression; however, the relationship between OS biomarkers and CP progression remains elusive. …
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Association between obesity and periodontal disease. A systematic review of epidemiological studies and controlled clinical trials Open
The association between obesity and periodontitis was consistent with a compelling pattern of increased risk of periodontitis in overweight or obese individuals. Although the underlying pathophysiological mechanism remains unclear, it has …
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Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment Open
The skin, oral cavity, digestive and reproductive tracts of the human body harbor symbiotic and commensal microorganisms living harmoniously with the host. The oral cavity houses one of the most heterogeneous microbial communities found in…
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Periodontal regeneration with autologous periodontal ligament-derived cell sheets – A safety and efficacy study in ten patients Open
The results of this study validate the safety and efficacy of autologous PDL-derived cell sheets in severe periodontal defects, and the stability of this efficacy during mid-long-term follow up. This cytotherapeutic approach, based on cell…
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Effects of <i>Bifidobacterium</i> probiotic on the treatment of chronic periodontitis: A randomized clinical trial Open
Aim This randomized placebo‐controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp . lactis ( B. lactis ) HN019‐containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generali…
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Hyaluronic acid: Perspectives in dentistry. A systematic review Open
To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the soft periodontal tissue, gingiva, and periodontal ligament as well as to the hard tissue such as alveolar bone and cementum. Topic…
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Antimicrobial photodynamic therapy for the treatment of periodontitis and peri-implantitis: An American Academy of Periodontology best evidence review. Open
aPDT may provide similar clinical improvements in PD and CAL when compared with conventional periodontal therapy for both periodontitis and peri-implantitis patients. The restricted base of evidence for some treatment approaches and condit…
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Chronic Inflammation as a Link between Periodontitis and Carcinogenesis Open
Periodontitis is characterized by a chronic inflammation produced in response to a disease-associated multispecies bacterial community in the subgingival region. Although the inflammatory processes occur locally in the oral cavity, several…
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The Effect of Periodontitis on Expression of Interleukin-21: A Systematic Review Open
Purpose. Inflammation and tissue breakdown are led by an array of inflammatory destructive mediators associated with initiation and progression of inflammatory diseases like periodontitis. Current evidence shows that these inflammatory med…
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Possible role of <i>Porphyromonas gingivalis</i> in orodigestive cancers Open
There is increasing evidence for an association between periodontitis/tooth loss and oral, gastrointestinal, and pancreatic cancers. Periodontal disease, which is characterized by chronic inflammation and microbial dysbiosis, is a signific…
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Endpoints of active periodontal therapy Open
Aim Position paper on endpoints of active periodontal therapy for designing treatment guidelines. The question was as follows: How are, for an individual patient, commonly applied periodontal probing measures—recorded after active periodon…
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Periodontitis, Low-Grade Inflammation and Systemic Health: A Scoping Review Open
Background and objectives: Periodontitis is a multifactorial chronic inflammatory infectious disease in which an infection is necessary, but not sufficient, for development of the condition. Individual susceptibility strictly linked to the…
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The Microbiome of Peri-Implantitis: A Systematic Review and Meta-Analysis Open
This review aimed to systematically compare microbial profiles of peri-implantitis to those of periodontitis and healthy implants. Therefore, an electronic search in five databases was conducted. For inclusion, studies assessing the microb…
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Defining the gut microbiota in individuals with periodontal diseases: an exploratory study Open
Background: This exploratory study aimed to characterize the gut microbiome of individuals with different periodontal conditions, and correlate it with periodontal inflammation and tissue destruction. Methods: Stool samples were obtained f…
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Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis Open
Single-cell RNA sequencing (scRNA-seq) enables specific profiling of cell populations at single-cell resolution. The osteoimmunology microenvironment in the occurrence and development of periodontitis remains poorly understood at the singl…
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Red complex: Polymicrobial conglomerate in oral flora: A review Open
Oral diseases are the complex host responses composed of a broad array of inflammatory cells, and cytokines, chemokines, and mediators derived from the cells resident in the gingival tissues, as well as from the emigrating inflammatory cel…
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Current Knowledge on Correlations Between Highly Prevalent Dental Conditions and Chronic Diseases: An Umbrella Review Open
The quality of included systematic reviews was heterogeneous. The most frequently reported correlations were found for periodontitis with T2DM and for periodontitis with cardiovascular disease. However, the strength of evidence for these a…
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Periodontitis and Its Inflammatory Changes Linked to Various Systemic Diseases: A Review of Its Underlying Mechanisms Open
Periodontitis is a chronic inflammatory disease of the gums. The incidence of periodontitis is increasing all over the world. In patients with periodontitis, there is gradual destruction of the periodontal ligament and the alveolar bone, a…
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Malondialdehyde as a marker of oxidative stress in periodontitis patients Open
Higher salivary MDA levels seem to reflect increased oxygen radical activity during periodontal inflammation. Thus, MDA can be used as a marker of oxidative stress in patients with periodontitis.
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Nutrition as a Key Modifiable Factor for Periodontitis and Main Chronic Diseases Open
Nutrition is recognized as an essential component in the prevention of a number of chronic diseases, including periodontal disease. Based on these considerations, a better understanding is required regarding how the diet, and more particul…
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Adjunctive laser or antimicrobial photodynamic therapy to non‐surgical mechanical instrumentation in patients with untreated periodontitis: A systematic review and meta‐analysis Open
Aim To compare the adjunctive effects of lasers or antimicrobial photodynamic therapy (aPDT) to non‐surgical mechanical instrumentation alone in untreated periodontitis patients. Materials and Methods Two focused questions were addressed u…
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The role of probiotic bacteria in managing periodontal disease: a systematic review Open
An electronic search was performed in the MEDLINE, SCOPUS and Cochrane Library databases up to March 2016 using the terms 'periodontitis', 'chronic periodontitis', 'probiotic(s)', 'prebiotic(s)', 'symbiotic(s)', 'Bifidobacterium and 'Lacto…
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The adjunctive use of host modulators in non‐surgical periodontal therapy. A systematic review of randomized, placebo‐controlled clinical studies Open
Background Considering the role of the inflammatory host response in the pathogenesis of periodontitis, different host modulators have been proposed to enhance the outcomes of non‐surgical periodontal therapy (NSPT), but their efficacy has…