Protocol (science)
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Gene Set Knowledge Discovery with Enrichr Open
Profiling samples from patients, tissues, and cells with genomics, transcriptomics, epigenomics, proteomics, and metabolomics ultimately produces lists of genes and proteins that need to be further analyzed and integrated in the context of…
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Midwives’ contribution to normal childbirth care. Cross-sectional study in public health Settings. MidconBirth Study protocol Open
This paper presents the Protocol for a multicentre study that seeks to analyse the relationship between midwife care during childbirth and spontaneous vaginal birth. Each participating hospital collects outcome data from a sample of all wo…
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The “All of Us” Research Program Open
Knowledge gained from observational cohort studies has dramatically advanced the prevention and treatment of diseases. Many of these cohorts, however, are small, lack diversity, or do not provide comprehensive phenotype data. The All of Us…
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A scoping review on the conduct and reporting of scoping reviews Open
The number of scoping reviews conducted per year has steadily increased since 2012. Scoping reviews are used to inform research agendas and identify implications for policy or practice. As such, improvements in reporting and conduct are im…
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Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS<sup>®</sup>) Society Recommendations: 2018 Open
Background This is the fourth updated Enhanced Recovery After Surgery (ERAS ® ) Society guideline presenting a consensus for optimal perioperative care in colorectal surgery and providing graded recommendations for each ERAS item within th…
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Semistructured interviewing in primary care research: a balance of relationship and rigour Open
Semistructured in-depth interviews are commonly used in qualitative research and are the most frequent qualitative data source in health services research. This method typically consists of a dialogue between researcher and participant, gu…
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MOT16: A Benchmark for Multi-Object Tracking Open
Standardized benchmarks are crucial for the majority of computer vision applications. Although leaderboards and ranking tables should not be over-claimed, benchmarks often provide the most objective measure of performance and are therefore…
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Palette: Image-to-Image Diffusion Models Open
This paper develops a unified framework for image-to-image translation based on conditional diffusion models and evaluates this framework on four challenging image-to-image translation tasks, namely colorization, inpainting, uncropping, an…
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SDP: Session Description Protocol Open
This memo defines the Session Description Protocol (SDP). SDP is intended for describing multimedia sessions for the purposes of session announcement, session invitation, and other forms of multimedia session initiation. This document obso…
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Conversational agents in healthcare: a systematic review Open
Objective Our objective was to review the characteristics, current applications, and evaluation measures of conversational agents with unconstrained natural language input capabilities used for health-related purposes. Methods We searched …
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Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score Open
Objective To develop and validate a pragmatic risk score to predict mortality in patients admitted to hospital with coronavirus disease 2019 (covid-19). Design Prospective observational cohort study. Setting International Severe Acute Resp…
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Guidelines for Perioperative Care in Cardiac Surgery Open
Enhanced Recovery After Surgery (ERAS) evidence-based protocols for perioperative care can lead to improvements in clinical outcomes and cost savings. This article aims to present consensus recommendations for the optimal perioperative man…
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Blockchain Technology in Healthcare: A Systematic Review Open
Since blockchain was introduced through Bitcoin, research has been ongoing to extend its applications to non-financial use cases. Healthcare is one industry in which blockchain is expected to have significant impacts. Research in this area…
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Bulletproofs: Short Proofs for Confidential Transactions and More Open
We propose Bulletproofs, a new non-interactive zero-knowledge proof protocol with very short proofs and without a trusted setup; the proof size is only logarithmic in the witness size. Bulletproofs are especially well suited for efficient …
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Fragrance Skin Sensitization Evaluation and Human Testing: 30-Year Experience Open
The HRIPT outcomes from 154 studies on 134 substances using 16,512 volunteers were obtained. Most studies confirmed that at the selected induction/challenge dose, sensitization was not induced. In 0.12% of subjects (n = 20), there was indu…
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HotStuff Open
We present HotStuff, a leader-based Byzantine fault-tolerant replication protocol for the partially synchronous model. Once network communication becomes synchronous, HotStuff enables a correct leader to drive the protocol to consensus at …
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Consensus on Exercise Reporting Template (CERT): Explanation and Elaboration Statement Open
Exercise is effective for prevention and management of acute and chronic health conditions. However, trial descriptions of exercise interventions are often suboptimal, leaving readers unclear about the content of effective programmes. To a…
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Protein Sequence Analysis Using the MPI Bioinformatics Toolkit Open
The MPI Bioinformatics Toolkit ( https://toolkit.tuebingen.mpg.de ) provides interactive access to a wide range of the best‐performing bioinformatics tools and databases, including the state‐of‐the‐art protein sequence comparison methods H…
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Implementation Mapping: Using Intervention Mapping to Develop Implementation Strategies Open
Background: The ultimate impact of a health innovation depends not only on its effectiveness but also on its reach in the population and the extent to which it is implemented with high levels of completeness and fidelity. Implementation sc…
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Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension Open
The CONSORT 2010 statement provides minimum guidelines for reporting randomized trials. Its widespread use has been instrumental in ensuring transparency in the evaluation of new interventions. More recently, there has been a growing recog…
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A standard protocol for reporting species distribution models Open
Species distribution models (SDMs) constitute the most common class of models across ecology, evolution and conservation. The advent of ready‐to‐use software packages and increasing availability of digital geoinformation have considerably …
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International Ethical Guidelines for Health-related Research involving Humans Open
Progress towards a world where all can enjoy optimal health and health care is crucially dependent on all kinds of research including research involving humans. Involving humans in medical research is necessary to improve the knowledge bas…
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The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) and how to select an outcome measurement instrument Open
In summary, we plea for more standardization in the use of outcome measurement instruments, for conducting high quality systematic reviews on measurement instruments in which the best available outcome measurement instrument is recommended…
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A protocol for conducting and presenting results of regression‐type analyses Open
Summary Scientific investigation is of value only insofar as relevant results are obtained and communicated, a task that requires organizing, evaluating, analysing and unambiguously communicating the significance of data. In this context, …
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The STROCSS statement: Strengthening the Reporting of Cohort Studies in Surgery Open
We present the STROCSS guideline for surgical cohort, cross-sectional and case-control studies consisting of a 17-item checklist. We hope its use will increase the transparency and reporting quality of such studies. This guideline is also …
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Sanger Tree of Life Sample Preparation: Triage and Dissection v1 Open
This protocol describes the process of sample preparation for the extraction of DNA and/or RNA from the wide variety of samples processed by the Tree of Life Core Laboratory as part of the Tree of Life Programme. It also describes the tria…
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The ODD Protocol for Describing Agent-Based and Other Simulation Models: A Second Update to Improve Clarity, Replication, and Structural Realism Open
© 2020, University of Surrey. All rights reserved. The Overview, Design concepts and Details (ODD) protocol for describing Individual-and Agent-Based Models (ABMs) is now widely accepted and used to document such models in journal articles…
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Sanger Tree of Life Wet Laboratory Protocol Collection v1 Open
This is the collection of Sanger Tree of Life Wet Laboratory protocols used for the generation of reference level genome assemblies. This collection currently contains protocols which cover all stages of the wet laboratory processes perfor…
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The QUIC Transport Protocol Open
We present our experience with QUIC, an encrypted, multiplexed, and low-latency transport protocol designed from the ground up to improve transport performance for HTTPS traffic and to enable rapid deployment and continued evolution of tra…
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Brian 2, an intuitive and efficient neural simulator Open
Brian 2 allows scientists to simply and efficiently simulate spiking neural network models. These models can feature novel dynamical equations, their interactions with the environment, and experimental protocols. To preserve high performan…