Silent period
View article: Human motor cortical beta bursts relate to movement planning and response errors
Human motor cortical beta bursts relate to movement planning and response errors Open
Motor cortical beta activity (13-30 Hz) is a hallmark signature of healthy and pathological movement, but its behavioural relevance remains unclear. Using high-precision magnetoencephalography (MEG), we show that during the classical event…
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Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior Open
Low-intensity transcranial ultrasound (TUS) can non-invasively modulate human neural activity. We investigated how different fundamental sonication parameters influence the effects of TUS on the motor cortex (M1) of 16 healthy subjects by …
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Effects of transcranial magnetic stimulation in modulating cortical excitability in patients with stroke: a systematic review and meta-analysis Open
Background Transcranial magnetic stimulation (TMS) has attracted plenty of attention as it has been proved to be effective in facilitating motor recovery in patients with stroke. The aim of this study was to systematically review the effec…
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Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis Open
ClinicalTrials.gov Identifier: NCT02450552.
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Selective Suppression of Local Interneuron Circuits in Human Motor Cortex Contributes to Movement Preparation Open
Changes in neural activity occur in the motor cortex before movement, but the nature and purpose of this preparatory activity is unclear. To investigate this in the human (male and female) brain noninvasively, we used transcranial magnetic…
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Physical activity levels determine exercise-induced changes in brain excitability Open
Emerging evidence suggests that regular physical activity can impact cortical function and facilitate plasticity. In the present study, we examined how physical activity levels influence corticospinal excitability and intracortical circuit…
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Time Course of Corticospinal Excitability and Intracortical Inhibition Just before Muscle Relaxation Open
Using transcranial magnetic stimulation (TMS), we investigated how short-interval intracortical inhibition (SICI) was involved with transient motor cortex (M1) excitability changes observed just before the transition from muscle contractio…
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Altered cortical beta‐band oscillations reflect motor system degeneration in amyotrophic lateral sclerosis Open
Continuous rhythmic neuronal oscillations underpin local and regional cortical communication. The impact of the motor system neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) on the neuronal oscillations subserving movement mi…
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Altered motor cortex physiology and dysexecutive syndrome in patients with fatigue and cognitive difficulties after mild COVID‐19 Open
Background and purpose Fatigue and cognitive difficulties are reported as the most frequently persistent symptoms in patients after mild SARS‐CoV‐2 infection. An extensive neurophysiological and neuropsychological assessment of such patien…
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Cortical hyperexcitability evolves with disease progression in ALS Open
Objective Cortical hyperexcitability has been established as an early feature of amyotrophic lateral sclerosis (ALS). The evolution of cortical hyperexcitability with ALS progression remains to be fully elucidated. This study aims to inves…
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Evidence for interhemispheric imbalance in stroke patients as revealed by combining transcranial magnetic stimulation and electroencephalography Open
Interhemispheric interactions in stroke patients are frequently characterized by abnormalities, in terms of balance and inhibition. Previous results showed an impressive variability, mostly given to the instability of motor‐evoked potentia…
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Fatigue‐related group III/IV muscle afferent feedback facilitates intracortical inhibition during locomotor exercise Open
Key Points This study investigated the influence of group III/IV muscle afferents on corticospinal excitability during cycling exercise and focused on GABA B neuron‐mediated inhibition as a potential underlying mechanism. The study provide…
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Clinical and electrophysiological impact of repetitive low-frequency transcranial magnetic stimulation on the sensory–motor network in patients with restless legs syndrome Open
Background: Based on the hyperexcitability and disinhibition observed in patients with restless legs syndrome (RLS) following transcranial magnetic stimulation (TMS), we conducted a study with low-frequency repetitive TMS (rTMS) over the p…
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GABA and primary motor cortex inhibition in young and older adults: a multimodal reliability study Open
The effects of healthy aging on γ-aminobutyric acid (GABA) within primary motor cortex (M1) remain poorly understood. Studies have reported contrasting results, potentially due to limitations with the common assessment technique. The aim o…
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Neurophysiological adaptations in the untrained side in conjunction with cross-education of muscle strength: a systematic review and meta-analysis Open
We reviewed the evidence from randomized controlled trials (RCTs) focusing on the neurophysiological adaptations in the untrained side associated with cross-education of strength (CE) and pooled data into definite effect estimates for neur…
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The After-Effect of Accelerated Intermittent Theta Burst Stimulation at Different Session Intervals Open
Objective The study aims to investigate the after-effect of three sessions of intermittent theta-burst stimulation (iTBS) on motor cortical excitability. The iTBS was induced over the primary motor cortex (M1) at different time intervals. …
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Improvement of sensory deficits in fragile X mice by increasing cortical interneuron activity after the critical period Open
Changes in the function of inhibitory interneurons (INs) during cortical development could contribute to the pathophysiology of neurodevelopmental disorders. Using all-optical in vivo approaches, we find that parvalbumin (PV) INs and their…
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Impact of Spinal Manipulation on Cortical Drive to Upper and Lower Limb Muscles Open
This study investigates whether spinal manipulation leads to changes in motor control by measuring the recruitment pattern of motor units in both an upper and lower limb muscle and to see whether such changes may at least in part occur at …
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Accelerated Transcranial Ultrasound Neuromodulation in Parkinson's Disease: A Pilot Study Open
Objective Low‐intensity transcranial focused ultrasound (TUS) is a novel method for neuromodulation. We aimed to study the feasibility of stimulating the bilateral primary motor cortices (M1) with accelerated theta‐burst TUS (a‐tbTUS) on n…
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Fatigue diminishes motoneuronal excitability during cycling exercise Open
Exercise-induced fatigue influences the excitability of the motor pathway during single-joint isometric contractions. This study sought to investigate the influence of fatigue on corticospinal excitability during cycling exercise. Eight me…
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Physiological Processes Underlying Short Interval Intracortical Facilitation in the Human Motor Cortex Open
Short interval intracortical facilitation (SICF) may be elicited by a paired pulse transcranial magnetic stimulation (TMS) paradigm, whereby a suprathreshold first stimulus (S1) precedes a perithreshold second stimulus (S2). Other facilita…
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Threshold tracking primary motor cortex inhibition: the influence of current direction Open
Paired‐pulse transcranial magnetic stimulation ( TMS ) can be used to probe inhibitory activity in primary motor cortex (M1). Recruitment of descending volleys with TMS depends on the induced current direction in M1. Anterior‐posterior ( A…
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Acute Low-Intensity Aerobic Exercise Modulates Intracortical Inhibitory and Excitatory Circuits in an Exercised and a Non-exercised Muscle in the Primary Motor Cortex Open
Recent studies have reported that acute aerobic exercise modulates intracortical excitability in the primary motor cortex (M1). However, whether acute low-intensity aerobic exercise can also modulate M1 intracortical excitability, particul…
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Sham-derived effects and the minimal reliability of theta burst stimulation Open
Theta-burst stimulation (TBS) is a patterned form of repetitive transcranial magnetic stimulation (rTMS) that has been used to induce long-term modulation ( plasticity ) of corticospinal excitability in a drastically shorter duration proto…
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bihemispheric-tDCS and Upper Limb Rehabilitation Improves Retention of Motor Function in Chronic Stroke: A Pilot Study Open
bihemispheric-tDCS improved retention of gains in motor function, which appears to be modulated through intracortical inhibitory pathways in the contralesional primary motor cortex (M1). The findings provide preliminary evidence for the be…
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A critical period of corticomuscular and EMG–EMG coherence detection in healthy infants aged 9–25 weeks Open
Key points The early postnatal development of functional corticospinal connections in human infants is not fully clarified. Corticospinal drive to upper and lower limb muscle shows developmental changes with an increased functional couplin…
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Corticospinal and intracortical excitability differ between athletes early after ACLR and matched controls Open
Neuromuscular impairments, such as quadriceps weakness and activation deficits, persist after anterior cruciate ligament reconstruction (ACLR). Recent research demonstrating changes in the function of the primary motor cortex after ACLR po…
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Resting Motor Threshold, MEP and TEP Variability During Daytime Open
Humans show a variation in physiological processes during the day. To reliably assess (changes in) cortical excitability with transcranial magnetic stimulation (TMS), it is relevant to know the natural variation in TMS readouts during the …
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Bilateral Knee Extensor Fatigue Modulates Force and Responsiveness of the Corticospinal Pathway in the Non-fatigued, Dominant Elbow Flexors Open
Exercise-induced fatigue affects muscle performance and modulates corticospinal excitability in non-exercised muscles. The purpose of this study was to investigate the effect of bilateral knee extensor fatigue on dominant elbow flexor (EF)…
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Neurophysiological impairments in multiple sclerosis—Central and peripheral motor pathways Open
A systematic review of the literature was conducted comparing neurophysiological outcomes in persons with multiple sclerosis (PwMS) to healthy controls (HC), in studies of the central nervous system (CNS) function comprising motor evoked p…