Critical illness
View article: Management of Chronic Kidney Disease Patients in the Intensive Care Unit: Mixing Acute and Chronic Illness
Management of Chronic Kidney Disease Patients in the Intensive Care Unit: Mixing Acute and Chronic Illness Open
Patients with chronic kidney disease (CKD) are at high risk for developing critical illness and for admission to intensive care units (ICU). ‘Critically ill CKD patients' frequently develop an acute worsening of renal function (i.e. acute-…
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Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient Open
This document represents the first collaboration between 2 organizations-the American Society for Parenteral and Enteral Nutrition and the Society of Critical Care Medicine-to describe best practices in nutrition therapy in critically ill …
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Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the disease it causes, coronavirus disease 2019 (COVID-19), is an emerging health threat.1 Until February 2020, most cases were described in non-US health systems.2,3 One…
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Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19 Open
The authors describe a 69-year-old man with Covid-19 diagnosed in January 2020 in Wuhan, China, along with two other critically ill patients with Covid-19 who were also seen in the same intensive care unit. Coagulopathy and antiphospholipi…
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Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19 Open
Among critically ill patients with COVID-19 in this cohort study, the risk of in-hospital mortality in this study was lower in patients treated with tocilizumab in the first 2 days of ICU admission compared with patients whose treatment di…
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Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness Open
The use of haloperidol or ziprasidone, as compared with placebo, in patients with acute respiratory failure or shock and hypoactive or hyperactive delirium in the ICU did not significantly alter the duration of delirium. (Funded by the Nat…
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Early versus Late Parenteral Nutrition in Critically Ill Children Open
In critically ill children, withholding parenteral nutrition for 1 week in the ICU was clinically superior to providing early parenteral nutrition. (Funded by the Flemish Agency for Innovation through Science and Technology and others; Cli…
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Early Sedation with Dexmedetomidine in Critically Ill Patients Open
Among patients undergoing mechanical ventilation in the ICU, those who received early dexmedetomidine for sedation had a rate of death at 90 days similar to that in the usual-care group and required supplemental sedatives to achieve the pr…
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Acute kidney injury in the critically ill: an updated review on pathophysiology and management Open
Acute kidney injury (AKI) is now recognized as a heterogeneous syndrome that not only affects acute morbidity and mortality, but also a patient's long-term prognosis. In this narrative review, an update on various aspects of AKI in critica…
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Factors associated with hospitalization and critical illness among 4,103 patients with Covid-19 disease in New York City Open
Background Little is known about factors associated with hospitalization and critical illness in Covid-19 positive patients. Methods We conducted a cross-sectional analysis of all patients with laboratory-confirmed Covid-19 treated at an a…
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Extreme Dysbiosis of the Microbiome in Critical Illness Open
Critical illness may be associated with the loss of normal, “health promoting” bacteria, allowing overgrowth of disease-promoting pathogenic bacteria (dysbiosis), which, in turn, makes patients susceptible to hospital-acquired infections, …
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Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions Open
This study compares levels of tumor necrosis factor α, IL-6, and IL-8 in critically ill patients with coronavirus disease 2019 (COVID-19) vs those with other critical illness to better characterize the contribution of cytokine storm to COV…
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Shock induced endotheliopathy (SHINE) in acute critical illness - a unifying pathophysiologic mechanism Open
One quarter of patients suffering from acute critical illness such as severe trauma, sepsis, myocardial infarction (MI) or post cardiac arrest syndrome (PCAS) develop severe hemostatic aberrations and coagulopathy, which are associated wit…
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Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients Open
Rationale: Recent studies have revealed that, in critically ill patients, lung microbiota are altered and correlate with alveolar inflammation. The clinical significance of altered lung bacteria in critical illness is unknown.Objectives: T…
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Effect of Palliative Care–Led Meetings for Families of Patients With Chronic Critical Illness Open
clinicaltrials.gov Identifier: NCT01230099.
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Nutrition therapy and critical illness: practical guidance for the ICU, post-ICU, and long-term convalescence phases Open
Background Although mortality due to critical illness has fallen over decades, the number of patients with long-term functional disabilities has increased, leading to impaired quality of life and significant healthcare costs. As an essenti…
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AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19 Open
Significance Statement Although AKI is an important sequela of coronavirus disease 2019 (COVID-19), data on AKI treated with RRT (AKI-RRT) in patients with COVID-19 are limited. In a multicenter cohort study of 3099 critically ill adults w…
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High-Flow Nasal Cannula in Critically III Patients with Severe COVID-19 Open
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Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup Open
The ADQI 21 conference found significant knowledge gaps about organ crosstalk between lung and kidney and its relevance for critically ill patients. Lung protective ventilation, conservative fluid management and early recognition and treat…
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Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19 Open
Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this viru…
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Early rehabilitation to prevent postintensive care syndrome in patients with critical illness: a systematic review and meta-analysis Open
Introduction We examined the effectiveness of early rehabilitation for the prevention of postintensive care syndrome (PICS), characterised by an impaired physical, cognitive or mental health status, among survivors of critical illness. Met…
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Updated guidelines to reduce venous thromboembolism in trauma patients: A Western Trauma Association critical decisions algorithm Open
This is a recommended evaluation and management algorithm from the Western Trauma Association (WTA) Algorithms Committee focused on the management of pharmacologic prophylaxis for venous thromboembolism (VTE) prevention in trauma patients.…
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Pilot trial of high-dose vitamin C in critically ill COVID-19 patients Open
Background Few specific medications have been proven effective for the treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, we tested whether high-dose vitamin C infusion was effective for severe COVID-19. Methods T…
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The risks of long-term use of proton pump inhibitors: a critical review Open
Proton pump inhibitors (PPIs) are among the most frequently prescribed medications. Their use is likely even higher than estimated due to an increase in the number of PPIs available without a prescription. Appropriate indications for PPI u…
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Risk Factors of Ventilator-Associated Pneumonia in Critically III Patients Open
Ventilator-associated pneumonia (VAP), a hospital acquired pneumonia that occurs more than 48 h after mechanical ventilation, is a common complication of mechanical ventilation with a high mortality rate. VAP can cause patients to have dif…
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Training for Lung Ultrasound Score Measurement in Critically Ill Patients Open
than 5 ml/kg PBW, mean EFFi increased from 0.722 to 0.736, or by 1.8 6 0.8% (mean 6 SD).The exact value chosen for VANA appears not to be critical.Therefore, a moderate error in flow sensor calibration is of low importance.In future studie…
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Opioid Tolerance in Critical Illness Open
This review describes the indications for opioid therapy in patients in the intensive care unit, mechanisms of opioid tolerance, and current and potential mitigation strategies for opioid tolerance.
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Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative Open
Objectives: To date, there are no published guidelines to direct RBC transfusion decision-making specifically for critically ill children. We present the recommendations from the Pediatric Critical Care Transfusion and Anemia Expertise Ini…
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Skeletal Muscle Ultrasound in Critical Care: A Tool in Need of Translation Open
With the emerging interest in documenting and understanding muscle atrophy and function in critically ill patients and survivors, ultrasonography has transformational potential for measurement of muscle quantity and quality. We discuss the…
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Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy Open
ICU patients with COVID-19 frequently have hypertension. Many could be managed with noninvasive ventilation, despite the risk of aerosolization. The use of a severity scale augmented clinician management.