Systemic disease
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The blood-brain barrier in systemic inflammation Open
The blood-brain barrier (BBB) plays a key role in maintaining the specialized microenvironment of the central nervous system (CNS), and enabling communication with the systemic compartment. BBB changes occur in several CNS pathologies. Her…
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Systemic Lupus Erythematosus Disease Activity Index Open
A clinical index for the measurement of disease activity in systemic lupus erythematosus. The index utilizes 24 weighted variables that measure disease activity, damage from disease, and health status.
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Systemic sclerosis Open
Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue disease. Once considered an untreatable and unpredictable condition, research advancements have improved our understanding of its disease pat…
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Oral health’s inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions Open
The landscape in dentistry is changing as emerging studies continue to reveal that periodontal health impacts systemic health, and vice versa. Population studies, clinical studies, and in vitro animal studies underscore the critical import…
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Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Interplay among Drugs, Viruses, and Immune System Open
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe multiorgan hypersensitivity reaction mostly caused by a limited number of eliciting drugs in patients with a genetic predisposition. Patients with DRESS syn…
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Manifestations of systemic diseases and conditions that affect the periodontal attachment apparatus: Case definitions and diagnostic considerations Open
Objectives This review proposes case definitions and diagnostic considerations of systemic disorders and conditions that affect the periodontal attachment apparatus. Importance Periodontal diseases and certain systemic disorders share simi…
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From focal sepsis to periodontal medicine: a century of exploring the role of the oral microbiome in systemic disease Open
The oral microbiome is established within a few minutes after birth and consists of stable multi‐species communities that engage in a dynamic equilibrium with the host immune system. Dental caries, endodontic infections and periodontal dis…
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Primary systemic amyloidosis Open
Ope n Pe e r Re v ie w on Qe ios Ope n Pe e r Re v ie w on Qe ios Primary systemic amyloidosis
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Manifestations of systemic diseases and conditions that affect the periodontal attachment apparatus: Case definitions and diagnostic considerations Open
Objectives This review proposes case definitions and diagnostic considerations of systemic disorders and conditions that affect the periodontal attachment apparatus. Importance Periodontal diseases and certain systemic disorders share simi…
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Systemic therapy of brain metastases: non–small cell lung cancer, breast cancer, and melanoma Open
Brain metastases (BM) occur frequently in many cancers, particularly non-small cell lung cancer (NSCLC), breast cancer, and melanoma. The development of BM is associated with poor prognosis and has an adverse impact on survival and quality…
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Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus Open
Intestinal dysbiosis is implicated in Systemic Lupus Erythematosus (SLE). However, the evidence of gut microbiome changes in SLE is limited, and the association of changed gut microbiome with the activity of SLE, as well as its functional …
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One year in review 2022: systemic lupus erythematosus Open
Systemic lupus erythematosus (SLE) is a chronic multisystem auto-immune disease with extremely varied clinical manifestations and a complex pathogenesis. New insights in SLE about pathogenetic pathways, biomarkers, and data on clinical man…
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Systemic Juvenile Idiopathic Arthritis–Associated Lung Disease: Characterization and Risk Factors Open
Objective Systemic juvenile idiopathic arthritis (JIA) is associated with a recently recognized, albeit poorly defined and characterized, lung disease (LD). The objective of this study was to describe the clinical characteristics, risk fac…
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Etiology, Risk Factors, and Biomarkers in Systemic Sclerosis with Interstitial Lung Disease Open
Systemic sclerosis (SSc) is a complex, multiorgan, autoimmune disease. Lung fibrosis occurs in ∼80% of patients with SSc; 25% to 30% develop progressive interstitial lung disease (ILD). The pathogenesis of fibrosis in SSc-associated ILD (S…
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Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis Open
There is evidence that Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling plays a role in the pathogenesis of sarcoidosis. We treated a patient with cutaneous sarcoidosis with the JAK inhibitor tofacitinib…
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Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases Open
Objective Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could be classified into groups defined by molecular pattern. This stud…
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COVID‐19 Outcomes in Patients With Systemic Autoimmune Rheumatic Diseases Compared to the General Population: A US Multicenter, Comparative Cohort Study Open
Objective Patients with systemic autoimmune rheumatic diseases (ARDs) continue to be concerned about risks of severe coronavirus disease 2019 (COVID‐19) outcomes. This study was undertaken to evaluate the risks of severe outcomes in COVID‐…
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Primary Sjögren’s syndrome and the eye Open
Primary Sjögren syndrome is an autoimmune disease that mainly affects exocrine glands such as the salivary and lacrimal glands. In addition, systemic involvement is common. Primary Sjögren syndrome is of particular interest to ophthalmolog…
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Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy Open
Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune rheumatic disease characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby sicca syndrome and/or systemic manifestations are the clinical…
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Periodontitis and Its Inflammatory Changes Linked to Various Systemic Diseases: A Review of Its Underlying Mechanisms Open
Periodontitis is a chronic inflammatory disease of the gums. The incidence of periodontitis is increasing all over the world. In patients with periodontitis, there is gradual destruction of the periodontal ligament and the alveolar bone, a…
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A cohort autopsy study defines COVID-19 systemic pathogenesis Open
Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely un…
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Systemic sclerosis – multidisciplinary disease: clinical features and treatment Open
Systemic sclerosis is a chronic autoimmune disease of still not fully understood pathogenesis. Fibrosis, vascular wall damage, and disturbances of innate and acquired immune responses with autoantibody production are prominent features. Sy…
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A review of the influence of periodontal treatment in systemic diseases Open
The effects and consequences of periodontal diseases might not be confined to the oral cavity. A great body of evidence has arisen supporting the claim demonstrating an association with several systemic conditions and diseases. With differ…
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Gender differences in systemic sclerosis: relationship to clinical features, serologic status and outcomes Open
Introduction There is a strong female preponderance reported in many connective tissue diseases and in almost all systemic sclerosis (SSc) case series. Methods We compared gender differences in SSc patients in a large single-center cohort,…
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New Horizons in the Genetic Etiology of Systemic Lupus Erythematosus and Lupus-Like Disease: Monogenic Lupus and Beyond Open
Systemic lupus erythematosus (SLE) is a clinically and genetically heterogeneous autoimmune disease. The etiology of lupus and the contribution of genetic, environmental, infectious and hormonal factors to this phenotype have yet to be elu…
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Metabolic Profiling of Systemic Lupus Erythematosus and Comparison with Primary Sjögren’s Syndrome and Systemic Sclerosis Open
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease which can affect most organ systems including skin, joints and the kidney. Clinically, SLE is a heterogeneous disease and shares features of several other rheu…
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Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus Open
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus tha…
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Sarcoidosis: Epidemiology and clinical insights Open
Sarcoidosis is characterized by noncaseating granulomas which form in almost any part of the body, primarily in the lungs and/or thoracic lymph nodes. Environmental exposures in genetically susceptible individuals are believed to cause sar…
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Long‐Term Clinical Outcomes in a Cohort of Adults With Childhood‐Onset Systemic Lupus Erythematosus Open
Objective Childhood‐onset systemic lupus erythematosus ( SLE ) is a severe, lifelong, multisystem autoimmune disease. Long‐term outcome data are limited. This study was undertaken to identify clinical characteristics and health‐related qua…
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Interleukin 17, inflammation, and cardiovascular risk in patients with psoriasis Open
In addition to being recognized as a chronic inflammatory disease that manifests in the skin, psoriasis is increasingly understood to be a systemic disease that causes immune dysregulation throughout the body. The systemic nature of psoria…