Terminal (telecommunication)
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A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2 Open
Hitting SARS-CoV-2 in a new spot A key target for therapeutic antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the spike protein, a trimeric protein complex with each monomer comprising an S1 and an S2 dom…
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A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing Open
TDP-43 is an RNA-binding protein active in splicing that concentrates into membraneless ribonucleoprotein granules and forms aggregates in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Although best known for its predominant…
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c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease Open
c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration, cell death, and regulation of cellular senescence. It h…
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Catalytic Enantioselective Functionalization of Unactivated Terminal Alkenes Open
Terminal alkenes are readily available functional groups which appear in α‐olefins produced by the chemical industry, and they appear in the products of many contemporary synthetic reactions. While the organic transformations that apply to…
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Efficient Semitransparent Perovskite Solar Cells for 23.0%‐Efficiency Perovskite/Silicon Four‐Terminal Tandem Cells Open
Here, we have investigated semi-transparent perovskite solar cells and infrared enhanced silicon heterojunction cells for high-efficiency tandem devices. A semi-transparent metal electrode with good electrical conductivity and optical tran…
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Vertical organic synapse expandable to 3D crossbar array Open
Recently, three-terminal synaptic devices have attracted considerable attention owing to their nondestructive weight-update behavior, which is attributed to the completely separated terminals for reading and writing. However, the structura…
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LTR_FINDER_parallel: parallelization of LTR_FINDER enabling rapid identification of long terminal repeat retrotransposons Open
Annotation of plant genomes is still a challenging task due to the abundance of repetitive sequences, especially long terminal repeat (LTR) retrotransposons. LTR_FINDER is a widely used program for the identification of LTR retrotransposon…
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Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase Open
Background: Ibrutinib is a Bruton tyrosine kinase inhibitor with remarkable efficacy against B-cell cancers. Ibrutinib also increases the risk of atrial fibrillation (AF), which remains poorly understood. Methods: We performed electrophysi…
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Output Feedback Active Suspension Control With Higher Order Terminal Sliding Mode Open
The control of an automotive suspension system using hydraulic actuators is a highly complex nonlinear control task dealing with system nonlinearities, external disturbances, and uncertainties. In this work, an output feedback active suspe…
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Prevalence of dry eye disease in visual display terminal workers: a systematic review and meta-analysis Open
Objective To evaluate the prevalence and risk factors of dry eye disease (DED) in workers using visual display terminals (VDT). Design Systematic review and meta-analysis. Data sources We searched PubMed, Cochrane Library, Embase and Scien…
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Exploiting the synthetic lethality between terminal respiratory oxidases to kill <i>Mycobacterium tuberculosis</i> and clear host infection Open
Significance New drugs are needed to combat multidrug-resistant tuberculosis. The electron transport chain (ETC) maintains the electrochemical potential across the cytoplasmic membrane and allows production of ATP, the energy currency of a…
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Direct Observation of an Iron-Bound Terminal Hydride in [FeFe]-Hydrogenase by Nuclear Resonance Vibrational Spectroscopy Open
[FeFe]-hydrogenases catalyze the reversible reduction of protons to molecular hydrogen with extremely high efficiency. The active site ("H-cluster") consists of a [4Fe-4S]H cluster linked through a bridging cysteine to a [2Fe]H subsite coo…
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UBE2O remodels the proteome during terminal erythroid differentiation Open
Removing orphan proteins from the system The degradation of excess subunits of protein complexes is a major quality-control problem for the cell. How such “orphans” are recognized and tagged for degradation is poorly understood. Two papers…
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Distributed synthesis and stability of cooperative distributed model predictive control for linear systems Open
This paper presents a new formulation and synthesis approach for stabilizing cooperative distributed model predictive control (MPC) for networks of linear systems, which are coupled in their dynamics. The controller is defined by a network…
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Research and application on multi‐terminal and DC grids based on VSC‐HVDC technology in China Open
Voltage source converter (VSC)‐based high‐voltage direct current (HVDC) and multi‐terminal (MT)/DC grid technologies are the new HVDC transmission technologies after ultra‐high voltage alternative current (UHVAC) and UHVDC transmission tec…
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Dynamic Capabilities in Complex Projects: The Case of London Heathrow Terminal 5 Open
Whereas existing approaches and empirical studies of dynamic capabilities focus on the strategic innovation activities of firms (i.e., permanent organizations executing multiple projects and programs), this article identifies how certain t…
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Precise quantification of translation inhibition by mRNA structures that overlap with the ribosomal footprint in N-terminal coding sequences Open
A mRNA's translation rate is controlled by several sequence determinants, including the presence of RNA structures within the N-terminal regions of its coding sequences. However, the physical rules that govern when such mRNA structures wil…
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Ammonia as a Carbon-Free Energy Carrier: NH<sub>3</sub> Cracking to H<sub>2</sub> Open
In the energy transition from fossil fuels to renewables,hydrogenis a realistic alternative to achieving the decarbonization target.However, its chemical and physical properties make its storage andtransport expensive. To ensure the cost-e…
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Marginal regression models for recurrent and terminal events Open
A major complication in the analysis of recurrent event data from med- ical studies is the presence of death. We consider the marginal mean function for the cumulative number of recurrent events over time, acknowledging the fact that death…
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Two-Terminal Transport Measurements with Cold Atoms Open
In recent years, the ability of cold atom experiments to explore condensed-matter-related questions has dramatically progressed. Transport experiments, in particular, have expanded to the point in which conductance and other transport coef…
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Fast and selective labeling of N-terminal cysteines at neutral pH <i>via</i> thiazolidino boronate formation Open
Facile labeling of proteins of interest is highly desirable in proteomic research as well as in the development of protein therapeutics.
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A Regio- and Enantioselective CuH-Catalyzed Ketone Allylation with Terminal Allenes Open
We report a method for the highly enantioselective CuH-catalyzed allylation of ketones that employs terminal allenes as allylmetal surrogates. Ketones and allenes bearing diverse and sensitive functional groups are efficiently coupled with…
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Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC) Open
Purpose: Persistent androgen receptor (AR) signaling drives castration-resistant prostate cancer (CRPC) and confers resistance to AR-targeting therapies. Novel therapeutic strategies to overcome this are urgently required. We evaluated how…
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A Planar Switchable 3-D-Coverage Phased Array Antenna and Its User Effects for 28-GHz Mobile Terminal Applications Open
This paper introduces a planar switchable 3D-coverage phased array for 28 GHz mobile terminal applications. In order to realize 3D-coverage beam scan with a simple planar array, chassis surface waves are efficiently excited and controlled …
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Small-Signal Modeling and Stability Prediction of Parallel Droop-Controlled Inverters Based on Terminal Characteristics of Individual Inverters Open
Parallel droop-controlled inverters with renewable energy sources are widely employed in islanded ac microgrids, where dynamic interactions among them may cause small-signal stability issues. Since the active power-frequency droop scheme i…
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Selective N-terminal functionalization of native peptides and proteins Open
A highly site-selective modification of peptides/proteins with aldehydes or carbohydrates under mild conditions was achieved.
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Dynamic Behavior of Terminal Sliding Mode Control Open
This paper proposes two new definitions and related theorems in analyzing the transient behavior of terminal sliding mode control (TSMC) for nonlinear systems. The first one is named critical trajectory (CT), which is used to characterize …
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N‐Terminal Methionine Processing Open
Protein synthesis is initiated by methionine in eukaryotes and by formylmethionine in prokaryotes. N‐terminal methionine can be co‐translationally cleaved by the enzyme methionine aminopeptidase (MAP). When recombinant proteins are express…
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Nitrogen Fixation via a Terminal Fe(IV) Nitride Open
Terminal iron nitrides (Fe≡N) have been proposed as intermediates of (bio)catalytic nitrogen fixation, yet experimental evidence to support this hypothesis has been lacking. In particular, no prior synthetic examples of terminal Fe≡N speci…
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Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation Open
Formyl benzeno boronic acids rapidly and selectively react withN-terminal cysteines to yield a reversible boronated thiazolidine that may be used in the interactive orthogonal modification of peptides.