Temporal lobe ≈ Temporal lobe
View article: SARS-CoV-2 is associated with changes in brain structure in UK Biobank
SARS-CoV-2 is associated with changes in brain structure in UK Biobank Open
There is strong evidence of brain-related abnormalities in COVID-19 1–13 . However, it remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing…
View article
Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery Open
In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were th…
View article
White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network Open
Objective White matter hyperintensities (WMHs) are areas of increased signal on T2‐weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel cerebrovascular disease. Increased WMH volume is associated with ris…
View article
In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum Open
Objective To determine the in vivo cortical spreading pattern of tau and amyloid and to establish positron emission tomography (PET) image‐based tau staging in the Alzheimer disease (AD) spectrum. Methods We included 195 participants (53 A…
View article
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium Open
Significance Left–right asymmetry is a key feature of the human brain's structure and function. It remains unclear which cortical regions are asymmetrical on average in the population and how biological factors such as age, sex, and geneti…
View article
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline Open
A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer’s disease neuropathological hallmarks (that is, amyloid-β plaques and tau neurofibrillary tangles) can preserve their…
View article
Extensive migration of young neurons into the infant human frontal lobe Open
Building the human brain As the brain develops, neurons migrate from zones of proliferation to their final locations, where they begin to build circuits. Paredes et al. have discovered that shortly after birth, a group of neurons that prol…
View article
Identification of Common Neural Circuit Disruptions in Emotional Processing Across Psychiatric Disorders Open
These findings demonstrate a pattern of neurocircuit disruption across major psychiatric disorders in regions and networks key to adaptive emotional reactivity and regulation. More specifically, disruption corresponded prominently to the "…
View article
Thalamic pathology and memory loss in early Alzheimer’s disease: moving the focus from the medial temporal lobe to Papez circuit Open
It is widely assumed that incipient protein pathology in the medial temporal lobe instigates the loss of episodic memory in Alzheimer's disease, one of the earliest cognitive deficits in this type of dementia. Within this region, the hippo…
View article
Architecture of the Entorhinal Cortex A Review of Entorhinal Anatomy in Rodents with Some Comparative Notes Open
The entorhinal cortex (EC) is the major input and output structure of the hippocampal formation, forming the nodal point in cortico-hippocampal circuits. Different division schemes including two or many more subdivisions have been proposed…
View article
Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition Open
The advent of tau-targeted positron emission tomography tracers such as flortaucipir (18F-AV-1451, also known as 18F-T807) have made it possible to investigate the sequence of development of tau and amyloid-β in relationship to age, and to…
View article
Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults Open
Early tau deposition was elevated in women compared with men in individuals on the Alzheimer disease trajectory. These findings lend support to a growing body of literature that highlights a biological underpinning for sex differences in A…
View article
The Significance of the Default Mode Network (DMN) in Neurological and Neuropsychiatric Disorders: A Review. Open
The relationship of cortical structure and specific neuronal circuitry to global brain function, particularly its perturbations related to the development and progression of neuropathology, is an area of great interest in neurobehavioral s…
View article
Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression Open
The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of depression is reported, with 421 patients with major depressive disorder and 488 control subjects. Resting state functional connectivity betwee…
View article
Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy Open
Summary Objective Evaluate the seizure‐reduction response and safety of mesial temporal lobe ( MTL ) brain‐responsive stimulation in adults with medically intractable partial‐onset seizures of mesial temporal lobe origin. Methods Subjects …
View article
Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory Open
Coupled ripples in memory Short-lived, high-frequency oscillations in the brain called ripples have been implicated as substrates for memory formation. There is, however, little evidence linking ripple activity with awake memory retrieval …
View article
Layer-Wise Relevance Propagation for Explaining Deep Neural Network Decisions in MRI-Based Alzheimer's Disease Classification Open
Deep neural networks have led to state-of-the-art results in many medical imaging tasks including Alzheimer’s disease (AD) detection based on structural magnetic resonance imaging (MRI) data. However, the network decisions are often percei…
View article
Strong Evidence for Pattern Separation in Human Dentate Gyrus Open
A fundamental property of an episodic memory system is the ability to minimize interference between similar episodes. The dentate gyrus (DG) subregion of the hippocampus is widely viewed to realize this function through a computation refer…
View article
Medial temporal lobe connectivity and its associations with cognition in early Alzheimer’s disease Open
Human episodic memory critically depends on subregions of the medial temporal lobe, which are part of functional brain systems such as the anterior-temporal and the posterior-medial system. Here we analysed how Alzheimer’s pathology affect…
View article
Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections Open
SEE BERNASCONI DOI101093/AWW202 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Temporal lobe epilepsy, the most prevalent form of chronic focal epilepsy, is associated with a high prevalence of cognitive impairment but the responsible underl…
View article
Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory Open
A way to prevent generalized seizures? Temporal lobe epilepsy is the most common form of epilepsy in adults. Patients have spontaneous seizures and risk developing serious cognitive impairment. Bui et al. studied an animal model of tempora…
View article
Practice guideline summary: Use of fMRI in the presurgical evaluation of patients with epilepsy Open
The use of fMRI may be considered an option for lateralizing language functions in place of intracarotid amobarbital procedure (IAP) in patients with medial temporal lobe epilepsy (MTLE; Level C), temporal epilepsy in general (Level C), or…
View article
Deep brain activities can be detected with magnetoencephalography Open
The hippocampus and amygdala are key brain structures of the medial temporal lobe, involved in cognitive and emotional processes as well as pathological states such as epilepsy. Despite their importance, it is still unclear whether their n…
View article
The Semantic Network at Work and Rest: Differential Connectivity of Anterior Temporal Lobe Subregions Open
The anterior temporal lobe (ATL) makes a critical contribution to semantic cognition. However, the functional connectivity of the ATL and the functional network underlying semantic cognition has not been elucidated. In addition, subregions…
View article
On the right side? A longitudinal study of left- versus right-lateralized semantic dementia Open
The typical presentation of semantic dementia is associated with marked, left predominant anterior temporal lobe atrophy and with changes in language. About 30% of individuals, however, present with predominant right anterior temporal lobe…
View article
Female advantage in verbal memory Open
Women show better verbal memory than men in aMCI despite similar levels of brain hypometabolism. The lifelong advantage that females show over males in verbal memory might represent a form of cognitive reserve that delays verbal memory dec…
View article
Sleep as a Potential Biomarker of Tau and β-Amyloid Burden in the Human Brain Open
Recent proposals suggest that sleep may be a factor associated with accumulation of two core pathological features of Alzheimer's disease (AD): tau and β-amyloid (Aβ). Here we combined PET measures of Aβ and tau, electroencephalogram sleep…
View article
Hippocampal–diencephalic–cingulate networks for memory and emotion: An anatomical guide Open
This review brings together current knowledge from tract tracing studies to update and reconsider those limbic connections initially highlighted by Papez for their presumed role in emotion. These connections link hippocampal and parahippoc…
View article
Distinct subtypes of Alzheimer’s disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications Open
Atrophy patterns on MRI can reliably predict three neuropathological subtypes of Alzheimer’s disease (AD): typical, limbic-predominant, or hippocampal-sparing. A method to enable their investigation in the clinical routine is still lacking…
View article
Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank Open
Measurement of hippocampal volume has proven useful to diagnose and track progression in several brain disorders, most notably in Alzheimer's disease (AD). For example, an objective evaluation of a patient's hippocampal volume status may p…