Nephropathy ≈ Nephropathy
View article: Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy Open
In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years. (Funded by Janssen Research and D…
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Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus Open
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by development of autoantibodies to nuclear and cytoplasmic antigens. A small subset of SLE patients who had the typical clinical features of SLE was reported to sho…
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A Novel Porcine Circovirus Distantly Related to Known Circoviruses Is Associated with Porcine Dermatitis and Nephropathy Syndrome and Reproductive Failure Open
Porcine circovirus-associated disease (PCVAD) is clinically manifested by postweaning multisystemic wasting syndrome (PMWS), respiratory and enteric disease, reproductive failure, and porcine dermatitis and nephropathy syndrome (PDNS). Por…
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IgA Nephropathy Open
IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international collaborative efforts have led to important discoveries that have improved our understanding of some of the key steps involved in the immunopathogenes…
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Diabetic kidney disease: world wide difference of prevalence and risk factors. Open
Diabetic kidney disease - which is defined by elevated urine albumin excretion or reduced glomerular filtration rate (GFR) or both - is a serious complication that occurs in 20% to 40% of all diabetics. In this review we try to highlight t…
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Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy Open
clinicaltrials.gov Identifier: NCT01560052.
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Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update Open
Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory ph…
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From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research Open
Diabetes, a silent killer, is one of the most widely prevalent conditions of the present time. According to the 2017 International Diabetes Federation (IDF) statistics, the global prevalence of diabetes among the age group of 20–79 years i…
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Ochratoxin A: 50 Years of Research Open
Since ochratoxin A (OTA) was discovered, it has been ubiquitous as a natural contaminant of moldy food and feed. The multiple toxic effects of OTA are a real threat for human beings and animal health. For example, OTA can cause porcine nep…
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Evaluating a New International Risk-Prediction Tool in IgA Nephropathy Open
In this study, the 2 full prediction models were shown to be accurate and validated methods for predicting disease progression and patient risk stratification in IgAN in multi-ethnic cohorts, with additional applications to clinical trial …
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Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications Open
Oxidative stress is a critical factor in the pathogenesis and progression of diabetes and its associated complications. The imbalance between reactive oxygen species (ROS) production and the body’s antioxidant defence mechanisms leads to c…
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Rituximab for Severe Membranous Nephropathy: A 6-Month Trial with Extended Follow-Up Open
Randomized trials of rituximab in primary membranous nephropathy (PMN) have not been conducted. We undertook a multicenter, randomized, controlled trial at 31 French hospitals (NCT01508468). Patients with biopsy-proven PMN and nephrotic sy…
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COVID-19–Associated Kidney Injury: A Case Series of Kidney Biopsy Findings Open
Significance Statement AKI is a known complication of severe COVID-19. Autopsy series of patients who died with COVID-19 reported acute tubular necrosis in the kidney, and a few patient reports noted the presence of collapsing glomerulopat…
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Gut Microbiota and Complications of Type-2 Diabetes Open
The gut microbiota has been linked to the emergence of obesity, metabolic syndrome and the onset of type 2 diabetes through decreased glucose tolerance and insulin resistance. Uncontrolled diabetes can lead to serious health consequences s…
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Oxidative Stress in the Pathogenesis and Evolution of Chronic Kidney Disease: Untangling Ariadne’s Thread Open
Amplification of oxidative stress is present since the early stages of chronic kidney disease (CKD), holding a key position in the pathogenesis of renal failure. Induction of renal pro-oxidant enzymes with excess generation of reactive oxy…
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Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies Open
Glycemic homeostasis refers to glucose balance or control within circulation in living organisms. It is normally and largely compromised in diabetes. The compromise when exacerbated, leads to several complications including retinopathy, ne…
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Dietary Fiber Protects against Diabetic Nephropathy through Short-Chain Fatty Acid–Mediated Activation of G Protein–Coupled Receptors GPR43 and GPR109A Open
Significance Statement The gut microbiota and its metabolites, in particular short-chain fatty acids derived from gut microbes’ fermentation of fiber, are emerging therapeutic targets for systemic inflammatory and metabolic diseases, inclu…
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Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management Open
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. C…
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New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura) Open
Immunoglobulin A vasculitis (IgAV), also referred to as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. The pathogenesis of IgAV is still largely unknown. The disease is characterized by IgA1-immune deposits, com…
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Diabetes in Iran: Prospective Analysis from First Nationwide Diabetes Report of National Program for Prevention and Control of Diabetes (NPPCD-2016) Open
We estimated proportions of different types of diabetes, comorbidities, treatment (the use of oral glucose-lowering agents and insulin), control (hyperglycemia, dyslipidemia and hypertension) and chronic microvascular and macrovascular com…
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Postmortem Kidney Pathology Findings in Patients with COVID-19 Open
Significance Statement More than one third of hospitalized patients with coronavirus disease 2019 (COVID-19) develop AKI. The pathogenesis of AKI in this setting is poorly understood, and pathologic descriptions are limited. The authors ex…
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Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy Open
Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting in elevated cost for public health systems. DN is the main cause of chronic kidney disease (CKD) and its incidence increases the number of patient…
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A Multicenter Study of the Predictive Value of Crescents in IgA Nephropathy Open
The Oxford Classification of IgA nephropathy does not account for glomerular crescents. However, studies that reported no independent predictive role of crescents on renal outcomes excluded individuals with severe renal insufficiency. In a…
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Long-Term Outcomes in IgA Nephropathy Open
Background IgA nephropathy can progress to kidney failure, and risk assessment soon after diagnosis has advantages both for clinical management and the development of new therapeutics. We present relationships among proteinuria, eGFR slope…
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Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs Open
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used medications associated with nephrotoxicity, especially when used chronically. Factors such as advanced age and comorbidities, which in themselves already lead to a decrease i…
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Classification and Differential Diagnosis of Diabetic Nephropathy Open
Diabetic nephropathy (DN) is a major cause of end-stage renal disease throughout the world in both developed and developing countries. This review briefly introduces the characteristic pathological changes of DN and Tervaert pathological c…
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Nephrotoxicity of immune checkpoint inhibitors beyond tubulointerstitial nephritis: single-center experience Open
Our data demonstrate that CPI related AKI occurs relatively late after CPI therapy. Our biopsy data demonstrate that ATIN is the most common pathological finding; however it can frequently co-occur with other glomerular pathologies, which …
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Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy Open
ClinicalTrials.gov Identifier: NCT01560052.
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Protective Role for Antioxidants in Acute Kidney Disease Open
Acute kidney injury causes significant morbidity and mortality in the community and clinic. Various pathologies, including renal and cardiovascular disease, traumatic injury/rhabdomyolysis, sepsis, and nephrotoxicity, that cause acute kidn…
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A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction Open
IgA nephropathy frequently leads to progressive CKD. Although interest surrounds use of immunosuppressive agents added to standard therapy, several recent studies have questioned efficacy of these agents. Depleting antibody–producing B cel…